Manifestationen im Zentralnervensystem nach COVID-19 View Full Text


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Article Info

DATE

2022-05-12

AUTHORS

Ameli Gerhard, Harald Prüß, Christiana Franke

ABSTRACT

Numerous diseases of the central nervous system (CNS), especially in the postacute phase after an infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been described. These include neuroimmunologically mediated diseases, such as encephalopathy, encephalitis, myelitis, acute disseminated encephalomyelitis (ADEM), acute necrotizing hemorrhagic leukoencephalitis (ANHLE) and neuromyelitis optica spectrum disorder (NMOSD) as well as others, such as posterior reversible encephalopathy syndrome (PRES), opsoclonus myoclonus ataxia (OMA) and cerebrovascular diseases. A parainfectious or postinfectious association is discussed but the pathophysiological mechanisms are so far unknown. Underlying mechanisms could be a virus-triggered overactivation of the immune system with hyperinflammation and cytokine storm but possibly also the development of specific autoantibodies against CNS tissue. Direct damage due to the invasion of SARS-CoV‑2 into the brain or spinal cord does not seem to play a relevant role. An exact clinical phenotyping and initiation of additional diagnostics are recommended, also to rule out other causes. To date no medicinal treatment options for CNS manifestations of long COVID exist; however, first results regarding inflammation and autoimmunity are promising and could lead to new treatment approaches. More... »

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1-8

References to SciGraph publications

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  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • 2020-11-30. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19 in NATURE NEUROSCIENCE
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  • 2022-02-07. Long-term cardiovascular outcomes of COVID-19 in NATURE MEDICINE
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  • 2020-08-24. An inflammatory cytokine signature predicts COVID-19 severity and survival in NATURE MEDICINE
  • 2021-06-17. Delayed presentation of postinfectious encephalitis associated with SARS-CoV-2 infection: a case report in NEUROLOGICAL SCIENCES
  • 2020-11-23. SARS-CoV-2-associated encephalitis: arguments for a post-infectious mechanism in CRITICAL CARE
  • 2022-01-22. Neuromyelitis optica spectrum disorder following COVID-19 infection with increase in pre-existing anti-aquaporin-4 antibodies in JOURNAL OF NEUROLOGY
  • 2022-05-10. Intravenous immunoglobulins for treatment of severe COVID-19-related acute encephalopathy in JOURNAL OF NEUROLOGY
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    http://scigraph.springernature.com/pub.10.1007/s00115-022-01294-2

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