Ontology type: schema:ScholarlyArticle Open Access: True
2020-05-11
AUTHORSAndreas Ziegler, Ekkehard Wilichowski, Ulrike Schara, Andreas Hahn, Wolfgang Müller-Felber, Jessika Johannsen, Maja von der Hagen, Arpad von Moers, Corinna Stoltenburg, Afshin Saffari, Maggie C. Walter, Ralf A. Husain, Astrid Pechmann, Cornelia Köhler, Veronka Horber, Oliver Schwartz, Janbernd Kirschner
ABSTRACTBackgroundSpinal muscular atrophy (SMA) is a severe, life-limiting neurodegenerative disease. A disease-modifying and approved therapy with nusinersen has been available in Germany since July 2017. Gene therapies offer another promising treatment option through a once in a lifetime administration. In May 2019 a gene replacement therapy for the treatment of SMA was approved for the first time by the U.S. Food and Drug Administration (FDA). An application for approval in Europe has been submitted and is currently pending.ObjectiveThis consensus paper was compiled at the invitation of the German Society for Muscular Diseases (DGM) with the participation of all potential German neuromuscular treatment centers, the German section of the Society for Pediatric Neurology (GNP) and with the involvement of the medical scientific advisory board of the DGM. The aim was to define and establish the necessary prerequisites for a safe and successful application of the new gene replacement therapy in clinical practice.ConclusionGene replacement therapy with onasemnogene abeparvovec has the potential to significantly influence the course of SMA. Long-term data on sustainability of effects and possible adverse effects of gene replacement therapy are not yet available. The application of this innovative therapy must be carried out in specialized and appropriately qualified treatment centers under strict safety conditions. This article makes suggestions for the necessary framework conditions and gives recommendations for a systematic pretreatment and posttreatment assessment schedule under gene therapy. The effectiveness and safety of the therapy should be systematically documented in an industry-independent and disease-specific register. More... »
PAGES518-529
http://scigraph.springernature.com/pub.10.1007/s00115-020-00919-8
DOIhttp://dx.doi.org/10.1007/s00115-020-00919-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1127514887
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/32394004
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"10.1007/s00115-020-00919-8"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"32394004"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00115-020-00919-8",
"https://app.dimensions.ai/details/publication/pub.1127514887"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:26",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_847.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00115-020-00919-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00115-020-00919-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00115-020-00919-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00115-020-00919-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00115-020-00919-8'
This table displays all metadata directly associated to this object as RDF triples.
361 TRIPLES
22 PREDICATES
119 URIs
105 LITERALS
17 BLANK NODES