Neue Sicht des kortiko-striato-thalamo-kortikalen Regelkreises bei M. Parkinson View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-08-24

AUTHORS

H. Braak, K. Del Tredici

ABSTRACT

The traditional model of corticostriatal-thalamocortical projections, with indirect and direct pathways, provides a simplified and useful explanation for the motor deficits (hypokinesia, bradykinesia) that develop in the course of sporadic Parkinson’s disease. In the classic model, major emphasis is placed on the dopamine deficiency in the dorsal striatum that occurs as a result of neuronal loss in the substantia nigra of the midbrain. Nevertheless, because the pathological process that underlies Parkinson’s disease also involves many key nondopaminergic connectivities, a revised model is needed that incorporates these projections. The focus on damage to nondopaminergic and extranigral sites is becoming increasingly important for clinical practice. More... »

PAGES

1440-1445

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00115-008-2542-y

DOI

http://dx.doi.org/10.1007/s00115-008-2542-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009173588

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18726081


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