TGF-β1 als pathophysiologischer Faktor bei der Frakturheilung View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-02

AUTHORS

G. Zimmermann, A. Moghaddam, M. Reumann, B. Wangler, L. Breier, A. Wentzensen, P. Henle, S. Weiss

ABSTRACT

AimTGF-β1 is an important local and systemic regulatory molecule during fracture healing. Various authors have shown differences in the systemic levels of TGF-β1 over the time taken for bone healing in distraction osteogenesis and osteotomies. Previous studies have shown characteristic differences in the physiological levels of growth factors between normal fracture healing and delayed fracture union. The aim of the present study was to evaluate possible differences in sera levels of patients with normal and delayed union fracture healing.MethodsPatients with long bone shaft fractures were recruited prospectively. Peripheral blood samples were collected over a period of 1 year using a standardized time schedule. At the end of the individual’s investigation period, TGF-β1 levels were determined. To achieve a homogeneous collective of patients, only those with a maximum of two fractures were included in the study. After matching for four criteria, we compared patients with normal fracture healing to patients with delayed unions. The fact of delayed union was accepted in case of failed consolidation 4 months after trauma.ResultsDuring a prospective study period of 1 year, 15 patients with normal fracture healing could be compared to 15 patients suffering from delayed union. By determining the absolute sera levels we found a typical increase of TGF-β1 up to 2 weeks after fracture in both groups, with a subsequent decrease up to the sixth week after fracture. However, a decline in serum concentration occurred earlier in patients with delayed union, causing significantly lower TGF-β1 levels in the non-union group 4 weeks after trauma (P=0.00006).ConclusionEven with a relatively small number of patients, we could show a significant difference in serum concentrations of TGF-β1 between the investigated groups. If these results can be verified within a larger collective, TGF-β1 could be used as a predictive cytokine for delayed fracture healing. More... »

PAGES

130-136

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00113-006-1199-x

DOI

http://dx.doi.org/10.1007/s00113-006-1199-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023422471

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17160396


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87 osteotomy
88 pathophysiologischer Faktor bei
89 patients
90 period
91 peripheral blood samples
92 physiological levels
93 possible differences
94 predictive cytokine
95 present study
96 previous studies
97 prospective study period
98 regulatory molecules
99 results
100 samples
101 schedule
102 serum concentrations
103 serum levels
104 shaft fractures
105 significant differences
106 sixth week
107 small number
108 standardized time schedule
109 study
110 study period
111 subsequent decrease
112 systemic levels
113 systemic regulatory molecule
114 time
115 time schedule
116 trauma
117 typical increase
118 union fracture healing
119 weeks
120 years
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