Prävention thromboembolischer Komplikationen in der Unfallchirurgie durch Dosisanpassung von niedermolekularem Heparin anhand TAT- und D-Dimer-Werten View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-12

AUTHORS

A. Mayer, M. Hansen, D. Peetz, G. Hafner, N. Vogel, W. Prellwitz, P. M. Rommens

ABSTRACT

Deep vein thrombosis (DVT) is reported in up to 40% of trauma patients. The individual risk is nearly unpredictable. A daily single dose of a low molecular weight heparin (LMWH) was adminstered as prophylaxis to 518 trauma patients who were examined preoperatively and up to 10 days postoperatively in a prospective study. They were divided into two groups: group I comprised surgery of the hip and femur as well as total knee replacement and group II knee and lower leg surgery. Thrombin-antithrombin complex and D-dimer were analyzed. A second daily dose of LMWH was added if D-dimer exceeded the cutoff. If ultrasound was suspicious for DVT venography was added. Deep vein thrombosis was seen in five cases (group I=4, group II=1), without pulmonary embolism. TAT and D-dimer were significantly higher in group I than in group II (p<0.005). One hundred patients, 79 of them belonging to group I, were treated with a second dose of LMWH. The daily cutoff had the highest sensitivity and specificity for day 4. Due to individual monitoring of coagulation markers, the risk for thromboembolism compared to actual data in the literature seems to be reduced. More... »

PAGES

1020-1028

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00113-003-0667-9

DOI

http://dx.doi.org/10.1007/s00113-003-0667-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014707718

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14727038


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