Ontology type: schema:ScholarlyArticle
2012-02-05
AUTHORSJ. Vry, U. Schara, S. Lutz, J. Kirschner
ABSTRACTDuchenne muscular dystrophy (DMD) is not only the most frequent but also one of the most severe neuromuscular disorders in childhood. The natural course of the disease is characterized by progressive muscle weakness with loss of ambulation around the age of 10 years. In the second decade life-shortening respiratory insufficiency and cardiomyopathy emerge, leading to an early death in the second decade if untreated. Even if DMD can still not be cured, with a proactive, multidisciplinary, symptomatic treatment, the quality of life can be improved and life expectancy into the fourth decade is possible. The main therapeutic elements comprise physiotherapy, orthopedic and rehabilitative interventions as well as a long-term treatment with corticosteroids, non-invasive ventilation in cases of respiratory insufficiency and an early medicinal treatment of heart failure. More... »
PAGES177-186
http://scigraph.springernature.com/pub.10.1007/s00112-011-2603-3
DOIhttp://dx.doi.org/10.1007/s00112-011-2603-3
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