2010-03
AUTHORS ABSTRACTBindegewebsstammzellen oder mesenchymale Stammzellen besitzen ein breites Differenzierungspotenzial, unterstützen die Blutbildung und die körpereigene Geweberegeneration und supprimieren zahlreiche Komponenten des Immunsystems. Basierend auf diesen Eigenschaften werden sie derzeit in verschiedenen klinischen Einsatzfeldern auf ihre Wirksamkeit und Sicherheit hin untersucht. Im Bereich der pädiatrischen Hämatoonkologie wurden erste, viel versprechende klinische Daten beim Einsatz zur Behandlung der steroidrefraktären Spender-Gegen-Empfänger-Erkrankung nach allogener Stammzelltransplantation und zur Behandlung von Osteonekrosen nach antineoplastischer Therapie berichtet. Sofern sich mesenchymale Stammzellen in prospektiven klinischen Studien als wirksam bezüglich der Immunmodulation und der Unterstützung der endogenen Geweberegeneration zeigen, stehen diesem neuen Zelltherapeutikum vielfältige klinische Anwendungsbereiche z. B. bei Autoimmunerkrankungen in der Pädiatrie offen, die weit über die genannten hämatologisch-onkologischen Applikationen hinausreichen. More... »
PAGES240-245
http://scigraph.springernature.com/pub.10.1007/s00112-009-2141-4
DOIhttp://dx.doi.org/10.1007/s00112-009-2141-4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1040349963
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"author": [
{
"affiliation": {
"name": [
"Klinik f\u00fcr Kinder-Onkologie, -H\u00e4matologie und Klinische Immunologie, Zentrum f\u00fcr Kinder- und Jugendmedizin, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstra\u00dfe 5, 40225, D\u00fcsseldorf, Deutschland"
],
"type": "Organization"
},
"familyName": "Meisel",
"givenName": "R.",
"id": "sg:person.01014553347.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014553347.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Frankfurt",
"id": "https://www.grid.ac/institutes/grid.411088.4",
"name": [
"Klinik III: H\u00e4matologie, Onkologie und H\u00e4mostaseologie, Zentrum f\u00fcr Kinder- und Jugendmedizin, Klinikum der Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt am Main, Deutschland"
],
"type": "Organization"
},
"familyName": "Kuci",
"givenName": "S.",
"id": "sg:person.01015400657.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015400657.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Children's Hospital T\u00fcbingen",
"id": "https://www.grid.ac/institutes/grid.488549.c",
"name": [
"Abteilung f\u00fcr Allgemeine P\u00e4diatrie, H\u00e4matologie/Onkologie, Universit\u00e4tsklinik f\u00fcr Kinder- und Jugendmedizin T\u00fcbingen, T\u00fcbingen, Deutschland"
],
"type": "Organization"
},
"familyName": "M\u00fcller",
"givenName": "I.",
"id": "sg:person.01123446510.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123446510.36"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/sj.leu.2404847",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001692977",
"https://doi.org/10.1038/sj.leu.2404847"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature02040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003509222",
"https://doi.org/10.1038/nature02040"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature02040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003509222",
"https://doi.org/10.1038/nature02040"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/14653240500319234",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004050442"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bcmd.2007.06.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004676600"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1634/stemcells.2007-0637",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007670338"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2003-11-3909",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014718402"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2005-04-1496",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015649537"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2007-02-069716",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017439048"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2007-08-105809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021545017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pbc.20244",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024838079"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/14653240600855905",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025538709"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2008.316",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027023613",
"https://doi.org/10.1038/bmt.2008.316"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0608249103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027271675"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10753-007-9025-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028653712",
"https://doi.org/10.1007/s10753-007-9025-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3324/haematol.2009.015065",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031326517"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2404996",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031667034",
"https://doi.org/10.1038/sj.leu.2404996"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0301-472x(01)00769-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031856615"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/6529",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040720175",
"https://doi.org/10.1038/6529"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/6529",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040720175",
"https://doi.org/10.1038/6529"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.284.5411.143",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042379237"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jacc.2009.06.055",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044707993"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2008.217",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046828972",
"https://doi.org/10.1038/leu.2008.217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1681/asn.2005080815",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047916788"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1681/asn.2005080815",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047916788"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(08)60690-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050238865"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.042678299",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052116728"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.exphem.2006.06.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052580432"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/dna.2005.24.458",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059251966"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083326365",
"type": "CreativeWork"
}
],
"datePublished": "2010-03",
"datePublishedReg": "2010-03-01",
"description": "Bindegewebsstammzellen oder mesenchymale Stammzellen besitzen ein breites Differenzierungspotenzial, unterst\u00fctzen die Blutbildung und die k\u00f6rpereigene Geweberegeneration und supprimieren zahlreiche Komponenten des Immunsystems. Basierend auf diesen Eigenschaften werden sie derzeit in verschiedenen klinischen Einsatzfeldern auf ihre Wirksamkeit und Sicherheit hin untersucht. Im Bereich der p\u00e4diatrischen H\u00e4matoonkologie wurden erste, viel versprechende klinische Daten beim Einsatz zur Behandlung der steroidrefrakt\u00e4ren Spender-Gegen-Empf\u00e4nger-Erkrankung nach allogener Stammzelltransplantation und zur Behandlung von Osteonekrosen nach antineoplastischer Therapie berichtet. Sofern sich mesenchymale Stammzellen in prospektiven klinischen Studien als wirksam bez\u00fcglich der Immunmodulation und der Unterst\u00fctzung der endogenen Geweberegeneration zeigen, stehen diesem neuen Zelltherapeutikum vielf\u00e4ltige klinische Anwendungsbereiche z. B. bei Autoimmunerkrankungen in der P\u00e4diatrie offen, die weit \u00fcber die genannten h\u00e4matologisch-onkologischen Applikationen hinausreichen.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00112-009-2141-4",
"inLanguage": [
"de"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1093102",
"issn": [
"0026-9298",
"1433-0474"
],
"name": "Monatsschrift Kinderheilkunde",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "158"
}
],
"name": "Mesenchymale Stammzellen",
"pagination": "240-245",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"c0358cdfbc064b21794518feb31c5f0a7e74a9acc3908215cdb2965a7c05f14c"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00112-009-2141-4"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1040349963"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00112-009-2141-4",
"https://app.dimensions.ai/details/publication/pub.1040349963"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T09:52",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89790_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00112-009-2141-4"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00112-009-2141-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00112-009-2141-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00112-009-2141-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00112-009-2141-4'
This table displays all metadata directly associated to this object as RDF triples.
159 TRIPLES
20 PREDICATES
52 URIs
19 LITERALS
7 BLANK NODES