Mesenchymale Stammzellen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-03

AUTHORS

R. Meisel, S. Kuci, I. Müller

ABSTRACT

Bindegewebsstammzellen oder mesenchymale Stammzellen besitzen ein breites Differenzierungspotenzial, unterstützen die Blutbildung und die körpereigene Geweberegeneration und supprimieren zahlreiche Komponenten des Immunsystems. Basierend auf diesen Eigenschaften werden sie derzeit in verschiedenen klinischen Einsatzfeldern auf ihre Wirksamkeit und Sicherheit hin untersucht. Im Bereich der pädiatrischen Hämatoonkologie wurden erste, viel versprechende klinische Daten beim Einsatz zur Behandlung der steroidrefraktären Spender-Gegen-Empfänger-Erkrankung nach allogener Stammzelltransplantation und zur Behandlung von Osteonekrosen nach antineoplastischer Therapie berichtet. Sofern sich mesenchymale Stammzellen in prospektiven klinischen Studien als wirksam bezüglich der Immunmodulation und der Unterstützung der endogenen Geweberegeneration zeigen, stehen diesem neuen Zelltherapeutikum vielfältige klinische Anwendungsbereiche z. B. bei Autoimmunerkrankungen in der Pädiatrie offen, die weit über die genannten hämatologisch-onkologischen Applikationen hinausreichen. More... »

PAGES

240-245

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00112-009-2141-4

DOI

http://dx.doi.org/10.1007/s00112-009-2141-4

DIMENSIONS

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