Nierenbeteiligung bei Systemerkrankungen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-03

AUTHORS

O. Mehls, R. Waldherr, K. Schärer

ABSTRACT

The most important systemic disorders involving the kidney are systemic lupus erythematosus (SLE) and systemic vasculitis. The kidney is a critical organ for the outcome of the diseases. Early diagnosis and adequate therapy may reverse or even heal glomerulonephritis and kidney vasculitis. This contribution is restricted to SLE, the ANCA-associated forms of vasculitis, and the classic Periarteriitis nodosa. Depending on the size of involved vessels, different forms of glomerulonephritis (small vessel disease) or necroses (medium-sized vessel disease) are noted. All diseases mentioned need aggressive immune suppressive therapy (induction with glucocorticoid steroids and cyclophosphamide). In SLE, this is indicated mainly for diffuse proliferative glomerulonephritis (type IV), very severe forms of focal-proliferative glomerulonephritis (type III), and membranous glomerulonephritis (type V). To avoid toxicity, cyclophosphamide should be substituted by azathioprine or mycophenolate mofetil as early as possible. This can be performed for ANCA-associated forms of vasculitis 3–6 months after the start of therapy as was shown in randomized studies, whereas such studies are missing for SLE. More... »

PAGES

248-256

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00112-004-0903-6

DOI

http://dx.doi.org/10.1007/s00112-004-0903-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040489210


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