Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-09

AUTHORS

T. Lapidot, Yfat Fajerman, Orit Kollet

ABSTRACT

Many events and requirements of the developmental program of human hematopoietic stem cells have not yet been discovered. A major impediment has been the lack of an appropriate experimental system. At present the conditions for maintaining human stem cells in vitro are not fully known. As a result within a short period the small stem cell pool is lost due to differentiation, making it difficult to examine the correlation between these cells and their function in vivo. Most of our knowledge of hematopoietic stem cells is from animal models in which purified stem cell canididates are assayed based on their functional ability to rescue lethally conditioned recipients. The permanent correction of many genetic disorders of the hematopoietic system requires efficient methods for introducing genes into stem cells in vitro. However, progress has been hindered by the absence of preclinical models that assay the repopulating capacity of primitive human cells. In addition, the development of therapy for malignant diseases also requires assays to identify the target leukemic stem cells based on their ability to initiate the disease. The recent development of methods to transplant or implant both normal and leukemic cells into immune-deficient mice provides the foundation for human stem cell assays. These models assay the repopulating capacity of primitive human cells and provide an important approach to identify and characterize human stem cells, both normal and leukemic. This review focuses on the development of functional assays for normal and leukemic human stem cells and on the new insights that these models are beginning to provide on the organization of the human stem cell hierarchy. More... »

PAGES

664-673

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001090050150

DOI

http://dx.doi.org/10.1007/s001090050150

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010017710

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9351705


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD34", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoiesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred NOD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sheep", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cells", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "Department of Immunology, Weizmann Institute of Science,  Rehovot 76100, Israel, IL"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lapidot", 
        "givenName": "T.", 
        "id": "sg:person.0760144763.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760144763.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "Department of Immunology, Weizmann Institute of Science,  Rehovot 76100, Israel, IL"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fajerman", 
        "givenName": "Yfat", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "Department of Immunology, Weizmann Institute of Science,  Rehovot 76100, Israel, IL"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kollet", 
        "givenName": "Orit", 
        "id": "sg:person.01324562545.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324562545.78"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90643-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001082055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.183.6.2551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001412648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1991.tb00614.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002672267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.7.2804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010787745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1296-1329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019796366", 
          "https://doi.org/10.1038/nm1296-1329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/335256a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020872822", 
          "https://doi.org/10.1038/335256a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.iy.09.040191.001543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024226494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.2.459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028051421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1991.tb00620.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035139558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.17.8032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035630978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1030660309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042805327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.183.4.1797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044033062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cb.11.110195.000343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049287270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.178.3.787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052691164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/4.2.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059645299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/5.12.1509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059711855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1372131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062478159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1826797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062508799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.273.5272.242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062553596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7528940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062647442"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-09", 
    "datePublishedReg": "1997-09-01", 
    "description": "Many events and requirements of the developmental program of human hematopoietic stem cells have not yet been discovered. A major impediment has been the lack of an appropriate experimental system. At present the conditions for maintaining human stem cells in vitro are not fully known. As a result within a short period the small stem cell pool is lost due to differentiation, making it difficult to examine the correlation between these cells and their function in vivo. Most of our knowledge of hematopoietic stem cells is from animal models in which purified stem cell canididates are assayed based on their functional ability to rescue lethally conditioned recipients. The permanent correction of many genetic disorders of the hematopoietic system requires efficient methods for introducing genes into stem cells in vitro. However, progress has been hindered by the absence of preclinical models that assay the repopulating capacity of primitive human cells. In addition, the development of therapy for malignant diseases also requires assays to identify the target leukemic stem cells based on their ability to initiate the disease. The recent development of methods to transplant or implant both normal and leukemic cells into immune-deficient mice provides the foundation for human stem cell assays. These models assay the repopulating capacity of primitive human cells and provide an important approach to identify and characterize human stem cells, both normal and leukemic. This review focuses on the development of functional assays for normal and leukemic human stem cells and on the new insights that these models are beginning to provide on the organization of the human stem cell hierarchy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s001090050150", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1057918", 
        "issn": [
          "0946-2716", 
          "1432-1440"
        ], 
        "name": "Journal of Molecular Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "75"
      }
    ], 
    "name": "Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesis", 
    "pagination": "664-673", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2fb9b967a111f0074f0b914ab328e216aed4997478843bd64d2d25057db435e6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9351705"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9504370"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s001090050150"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010017710"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s001090050150", 
      "https://app.dimensions.ai/details/publication/pub.1010017710"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000503.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs001090050150"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001090050150'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001090050150'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001090050150'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001090050150'


 

This table displays all metadata directly associated to this object as RDF triples.

204 TRIPLES      21 PREDICATES      64 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s001090050150 schema:about N0c5d1aad480245fcb0957e705375ff79
2 N21e3cbf6d67149b78f9e1006240fa953
3 N2badcf564c024626819abc9a97705236
4 N318a2a6ca2e54331819f847a82e641cb
5 N31c7b1ab205146a18399c91db855f7b0
6 N3e76f725e7f9464aa4c3b2488e5b3881
7 N581744939e464564b0afccb85370118b
8 N72edd83ad2e946bb8bef8b01642c82b0
9 N8067cf790078479a82a2e4e0f24a87bc
10 Nb821d74d9e9347e188a8359988e8edff
11 Nb852c38ce0a44b7783eed3f6fbae5cbb
12 Nc4e0b3d8d9fc4b1180b2e00a809b71fc
13 Ne6e9bf6ab68648d7b4bd48af71403296
14 Ne74037a5cdeb4523b4d257b6d02dbf3d
15 Nfe08f8ba98d643258c489c7e48a4e84c
16 anzsrc-for:10
17 anzsrc-for:1004
18 schema:author N2b9bcb212b6b440aaddcfc4709a3ba34
19 schema:citation sg:pub.10.1038/335256a0
20 sg:pub.10.1038/nm1296-1329
21 https://doi.org/10.1002/jcp.1030660309
22 https://doi.org/10.1016/0092-8674(91)90643-d
23 https://doi.org/10.1073/pnas.89.7.2804
24 https://doi.org/10.1073/pnas.91.17.8032
25 https://doi.org/10.1073/pnas.91.2.459
26 https://doi.org/10.1084/jem.178.3.787
27 https://doi.org/10.1084/jem.183.4.1797
28 https://doi.org/10.1084/jem.183.6.2551
29 https://doi.org/10.1093/hmg/4.2.163
30 https://doi.org/10.1093/intimm/5.12.1509
31 https://doi.org/10.1111/j.1600-065x.1991.tb00614.x
32 https://doi.org/10.1111/j.1600-065x.1991.tb00620.x
33 https://doi.org/10.1126/science.1372131
34 https://doi.org/10.1126/science.1826797
35 https://doi.org/10.1126/science.273.5272.242
36 https://doi.org/10.1126/science.7528940
37 https://doi.org/10.1146/annurev.cb.11.110195.000343
38 https://doi.org/10.1146/annurev.iy.09.040191.001543
39 schema:datePublished 1997-09
40 schema:datePublishedReg 1997-09-01
41 schema:description Many events and requirements of the developmental program of human hematopoietic stem cells have not yet been discovered. A major impediment has been the lack of an appropriate experimental system. At present the conditions for maintaining human stem cells in vitro are not fully known. As a result within a short period the small stem cell pool is lost due to differentiation, making it difficult to examine the correlation between these cells and their function in vivo. Most of our knowledge of hematopoietic stem cells is from animal models in which purified stem cell canididates are assayed based on their functional ability to rescue lethally conditioned recipients. The permanent correction of many genetic disorders of the hematopoietic system requires efficient methods for introducing genes into stem cells in vitro. However, progress has been hindered by the absence of preclinical models that assay the repopulating capacity of primitive human cells. In addition, the development of therapy for malignant diseases also requires assays to identify the target leukemic stem cells based on their ability to initiate the disease. The recent development of methods to transplant or implant both normal and leukemic cells into immune-deficient mice provides the foundation for human stem cell assays. These models assay the repopulating capacity of primitive human cells and provide an important approach to identify and characterize human stem cells, both normal and leukemic. This review focuses on the development of functional assays for normal and leukemic human stem cells and on the new insights that these models are beginning to provide on the organization of the human stem cell hierarchy.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N2a63a86be9944c4d891fd0a735561e52
46 Nd8d98e72d5c84c4aa53fe6b533619fcd
47 sg:journal.1057918
48 schema:name Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesis
49 schema:pagination 664-673
50 schema:productId N1d8da08064ad494895113d5468503be5
51 N21019c9d2db841edbb57b051ff6f65d5
52 N37d114f7f7d045de83b4ff3112707724
53 N4ab12ae94078439db5778b68f9296533
54 N92f5ebc425db4be2a7661a1ee37e5997
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010017710
56 https://doi.org/10.1007/s001090050150
57 schema:sdDatePublished 2019-04-11T01:05
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N4d2a46b7094841a1b201a9502425ecac
60 schema:url http://link.springer.com/10.1007%2Fs001090050150
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N0c5d1aad480245fcb0957e705375ff79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Bone Marrow Transplantation
66 rdf:type schema:DefinedTerm
67 N1d8da08064ad494895113d5468503be5 schema:name pubmed_id
68 schema:value 9351705
69 rdf:type schema:PropertyValue
70 N21019c9d2db841edbb57b051ff6f65d5 schema:name doi
71 schema:value 10.1007/s001090050150
72 rdf:type schema:PropertyValue
73 N21e3cbf6d67149b78f9e1006240fa953 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Hematopoiesis
75 rdf:type schema:DefinedTerm
76 N2a63a86be9944c4d891fd0a735561e52 schema:issueNumber 9
77 rdf:type schema:PublicationIssue
78 N2b9bcb212b6b440aaddcfc4709a3ba34 rdf:first sg:person.0760144763.90
79 rdf:rest N2eff8e4cc87c4cbe81b99477da7cc173
80 N2badcf564c024626819abc9a97705236 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Leukemia
82 rdf:type schema:DefinedTerm
83 N2eff8e4cc87c4cbe81b99477da7cc173 rdf:first N8b01ba9b14864799b8b583e7a96bec86
84 rdf:rest Ndd332a5b4e4a47ea957797c316480e3b
85 N318a2a6ca2e54331819f847a82e641cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Cell Transplantation
87 rdf:type schema:DefinedTerm
88 N31c7b1ab205146a18399c91db855f7b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Cytokines
90 rdf:type schema:DefinedTerm
91 N37d114f7f7d045de83b4ff3112707724 schema:name readcube_id
92 schema:value 2fb9b967a111f0074f0b914ab328e216aed4997478843bd64d2d25057db435e6
93 rdf:type schema:PropertyValue
94 N3e76f725e7f9464aa4c3b2488e5b3881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Sheep
96 rdf:type schema:DefinedTerm
97 N4ab12ae94078439db5778b68f9296533 schema:name nlm_unique_id
98 schema:value 9504370
99 rdf:type schema:PropertyValue
100 N4d2a46b7094841a1b201a9502425ecac schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N581744939e464564b0afccb85370118b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Stem Cells
104 rdf:type schema:DefinedTerm
105 N72edd83ad2e946bb8bef8b01642c82b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mice, Inbred NOD
107 rdf:type schema:DefinedTerm
108 N8067cf790078479a82a2e4e0f24a87bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Humans
110 rdf:type schema:DefinedTerm
111 N8b01ba9b14864799b8b583e7a96bec86 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
112 schema:familyName Fajerman
113 schema:givenName Yfat
114 rdf:type schema:Person
115 N92f5ebc425db4be2a7661a1ee37e5997 schema:name dimensions_id
116 schema:value pub.1010017710
117 rdf:type schema:PropertyValue
118 Nb821d74d9e9347e188a8359988e8edff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Organ Transplantation
120 rdf:type schema:DefinedTerm
121 Nb852c38ce0a44b7783eed3f6fbae5cbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Disease Models, Animal
123 rdf:type schema:DefinedTerm
124 Nc4e0b3d8d9fc4b1180b2e00a809b71fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Mice, SCID
126 rdf:type schema:DefinedTerm
127 Nd8d98e72d5c84c4aa53fe6b533619fcd schema:volumeNumber 75
128 rdf:type schema:PublicationVolume
129 Ndd332a5b4e4a47ea957797c316480e3b rdf:first sg:person.01324562545.78
130 rdf:rest rdf:nil
131 Ne6e9bf6ab68648d7b4bd48af71403296 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mice
133 rdf:type schema:DefinedTerm
134 Ne74037a5cdeb4523b4d257b6d02dbf3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Antigens, CD34
136 rdf:type schema:DefinedTerm
137 Nfe08f8ba98d643258c489c7e48a4e84c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Animals
139 rdf:type schema:DefinedTerm
140 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
141 schema:name Technology
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
144 schema:name Medical Biotechnology
145 rdf:type schema:DefinedTerm
146 sg:journal.1057918 schema:issn 0946-2716
147 1432-1440
148 schema:name Journal of Molecular Medicine
149 rdf:type schema:Periodical
150 sg:person.01324562545.78 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
151 schema:familyName Kollet
152 schema:givenName Orit
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324562545.78
154 rdf:type schema:Person
155 sg:person.0760144763.90 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
156 schema:familyName Lapidot
157 schema:givenName T.
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760144763.90
159 rdf:type schema:Person
160 sg:pub.10.1038/335256a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020872822
161 https://doi.org/10.1038/335256a0
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/nm1296-1329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019796366
164 https://doi.org/10.1038/nm1296-1329
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1002/jcp.1030660309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042805327
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/0092-8674(91)90643-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1001082055
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1073/pnas.89.7.2804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010787745
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1073/pnas.91.17.8032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035630978
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1073/pnas.91.2.459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028051421
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1084/jem.178.3.787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052691164
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1084/jem.183.4.1797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044033062
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1084/jem.183.6.2551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001412648
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1093/hmg/4.2.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059645299
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1093/intimm/5.12.1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059711855
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1111/j.1600-065x.1991.tb00614.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002672267
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1111/j.1600-065x.1991.tb00620.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035139558
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1126/science.1372131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062478159
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1126/science.1826797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062508799
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1126/science.273.5272.242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553596
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1126/science.7528940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062647442
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1146/annurev.cb.11.110195.000343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049287270
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1146/annurev.iy.09.040191.001543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024226494
201 rdf:type schema:CreativeWork
202 https://www.grid.ac/institutes/grid.13992.30 schema:alternateName Weizmann Institute of Science
203 schema:name Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel, IL
204 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...