Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways View Full Text


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Article Info

DATE

1996-10

AUTHORS

A. J. Whitmarsh, R. J. Davis

ABSTRACT

Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that are activated by dual phosphorylation on threonine and tyrosine residues in response to a wide array of extracellular stimuli. Three distinct groups of MAP kinases have been identified in mammalian cells [extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38]. These MAP kinases are mediators of signal transduction from the cell surface to the nucleus. One nuclear target of these MAP kinase signaling pathways is the transcription factor AP-1. MAP kinases regulate AP-1 transcriptional activity by multiple mechanisms. Here we review recent progress towards understanding AP-1 regulation by the ERK, JNK, and p38 MAP kinase signal transduction pathways. More... »

PAGES

589-607

References to SciGraph publications

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  • 1996-03. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis in NATURE
  • 1995-08. Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents in NATURE
  • 1995-03-01. Receptors and G proteins as primary components of transmembrane signal transduction in JOURNAL OF MOLECULAR MEDICINE
  • 1994-06. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits in NATURE
  • 1996-02. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors in NATURE
  • 1992-04. Nuclear factor of activated T cells contains Fos and Jun in NATURE
  • 1994-01. A brain serine/threonine protein kinase activated by Cdc42 and Rac1 in NATURE
  • 1995-08. Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway in NATURE
  • 1989-07. Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction in NATURE
  • 1993-04. p53 is required for radiation-induced apoptosis in mouse thymocytes in NATURE
  • 1993-04. Thymocyte apoptosis induced by p53-dependent and independent pathways in NATURE
  • 1994-12. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis in NATURE
  • 1994-05. The stress-activated protein kinase subfamily of c-Jun kinases in NATURE
  • 1995-08. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF in NATURE
  • 1996-01. Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice in NATURE
  • 1995-10. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase in NATURE
  • 1993-05. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras in NATURE
  • Journal

    TITLE

    Journal of Molecular Medicine

    ISSUE

    10

    VOLUME

    74

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s001090050063

    DOI

    http://dx.doi.org/10.1007/s001090050063

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016860240

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8912180


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