Sexual dimorphism in cardiac remodeling: the molecular mechanisms ruled by sex hormones in the heart View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-23

AUTHORS

Cláudia Ferreira, Fábio Trindade, Rita Ferreira, João Sérgio Neves, Adelino Leite-Moreira, Francisco Amado, Mário Santos, Rita Nogueira-Ferreira

ABSTRACT

Heart failure (HF) is growing in prevalence, due to an increase in aging and comorbidities. Heart failure with reduced ejection fraction (HFrEF) is more common in men, whereas heart failure with preserved ejection fraction (HFpEF) has a higher prevalence in women. However, the reasons for these epidemiological trends are not clear yet. Since HFpEF affects mostly postmenopausal women, sex hormones should play a pivotal role in HFpEF development. Furthermore, for HFpEF, contrary to HFrEF, effective therapeutic approaches are missing. Interestingly, studies evidenced that some therapies can have better results in women than in HFpEF men, emphasizing the necessity of understanding these observations at a molecular level. Thus, herein, we review the molecular mechanisms of estrogen and androgen actions in the heart in physiological conditions and explain how its dysregulation can lead to disease development. This clarification is essential in the road for an effective personalized management of HF, particularly HFpEF, towards the development of sex-specific therapeutic approaches. More... »

PAGES

245-267

References to SciGraph publications

  • 2011-04-12. Antiproliferative effect of estrogen in vascular smooth muscle cells is mediated by Kruppel-like factor-4 and manganese superoxide dismutase in BASIC RESEARCH IN CARDIOLOGY
  • 2016-07-02. Sex differences in the regulation of spatially distinct cardiac mitochondrial subpopulations in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2016-10-12. Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-10-24. The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy in BIOLOGY OF SEX DIFFERENCES
  • 2015-12-29. Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2018-07-27. Heart Function Analysis in Cardiac Patients with Focus on Sex-Specific Aspects in SEX-SPECIFIC ANALYSIS OF CARDIOVASCULAR FUNCTION
  • 2000-12-16. Effects of gender on intracellular [Ca2+] in rat cardiac myocytes in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2019-01-11. Estrogen receptor profiles across tissues from male and female Rattus norvegicus in BIOLOGY OF SEX DIFFERENCES
  • 2019-07-01. The Influence of Sex on Cardiac Physiology and Cardiovascular Diseases in JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
  • 2013-11-05. Effects of dihydrotestosterone on adhesion and proliferation via PI3-K/Akt signaling in endothelial progenitor cells in ENDOCRINE
  • 2014-06-20. Effects of sex hormones on inflammatory response in male and female vascular endothelial cells in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2017-03-17. The effects of oestrogens and their receptors on cardiometabolic health in NATURE REVIEWS ENDOCRINOLOGY
  • 2019-02-06. Sex-specific regulation of cardiac microRNAs targeting mitochondrial proteins in pressure overload in BIOLOGY OF SEX DIFFERENCES
  • 2020-09-24. Cells of the adult human heart in NATURE
  • 2021-01-11. Cellular and molecular pathobiology of heart failure with preserved ejection fraction in NATURE REVIEWS CARDIOLOGY
  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • 2021-02-09. Alterations in the estrogen receptor profile of cardiovascular tissues during aging in GEROSCIENCE
  • 2013-02-17. Sex differences in mechanisms of cardiac excitation–contraction coupling in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2017-05-11. Epidemiology of heart failure with preserved ejection fraction in NATURE REVIEWS CARDIOLOGY
  • 2015-04-17. Activation of GPR30 inhibits cardiac fibroblast proliferation in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2020-03-31. Therapeutic approaches in heart failure with preserved ejection fraction: past, present, and future in CLINICAL RESEARCH IN CARDIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00109-021-02169-w

    DOI

    http://dx.doi.org/10.1007/s00109-021-02169-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1142727498

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34811581


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0304", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medicinal and Biomolecular Chemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Androgens", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Estrogens", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gonadal Steroid Hormones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Failure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocardium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sex Characteristics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ventricular Remodeling", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.7311.4", 
              "name": [
                "LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferreira", 
            "givenName": "Cl\u00e1udia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery and Physiology, Cardiovascular R&D Center (UnIC), Faculty of Medicine, University of Porto, Porto, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.5808.5", 
              "name": [
                "Department of Surgery and Physiology, Cardiovascular R&D Center (UnIC), Faculty of Medicine, University of Porto, Porto, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trindade", 
            "givenName": "F\u00e1bio", 
            "id": "sg:person.0771211162.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771211162.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.7311.4", 
              "name": [
                "LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferreira", 
            "givenName": "Rita", 
            "id": "sg:person.013326044367.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013326044367.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.414556.7", 
              "name": [
                "Department of Surgery and Physiology, Cardiovascular R&D Center (UnIC), Faculty of Medicine, University of Porto, Porto, Portugal", 
                "Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neves", 
            "givenName": "Jo\u00e3o S\u00e9rgio", 
            "id": "sg:person.011246367673.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011246367673.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiothoracic Surgery, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.414556.7", 
              "name": [
                "Department of Surgery and Physiology, Cardiovascular R&D Center (UnIC), Faculty of Medicine, University of Porto, Porto, Portugal", 
                "Department of Cardiothoracic Surgery, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leite-Moreira", 
            "givenName": "Adelino", 
            "id": "sg:person.01207643272.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207643272.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.7311.4", 
              "name": [
                "LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Amado", 
            "givenName": "Francisco", 
            "id": "sg:person.0737765327.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737765327.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UMIB - Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biom\u00e9dica, ICBAS - Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.5808.5", 
              "name": [
                "Department of Cardiology, Hospital Santo Ant\u00f3nio, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal", 
                "UMIB - Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biom\u00e9dica, ICBAS - Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Santos", 
            "givenName": "M\u00e1rio", 
            "id": "sg:person.0752717236.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752717236.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UMIB - Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biom\u00e9dica, ICBAS - Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.5808.5", 
              "name": [
                "Department of Surgery and Physiology, Cardiovascular R&D Center (UnIC), Faculty of Medicine, University of Porto, Porto, Portugal", 
                "UMIB - Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biom\u00e9dica, ICBAS - Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nogueira-Ferreira", 
            "givenName": "Rita", 
            "id": "sg:person.0731713571.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731713571.35"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41586-020-2797-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1131135737", 
              "https://doi.org/10.1038/s41586-020-2797-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-016-2748-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040823382", 
              "https://doi.org/10.1007/s11010-016-2748-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13293-015-0027-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019612135", 
              "https://doi.org/10.1186/s13293-015-0027-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40618-014-0118-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019909652", 
              "https://doi.org/10.1007/s40618-014-0118-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-319-77932-4_23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105855644", 
              "https://doi.org/10.1007/978-3-319-77932-4_23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-015-2405-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027019918", 
              "https://doi.org/10.1007/s11010-015-2405-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrcardio.2017.65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085388588", 
              "https://doi.org/10.1038/nrcardio.2017.65"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2016.122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020568480", 
              "https://doi.org/10.1038/nrm.2016.122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13293-019-0222-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111954609", 
              "https://doi.org/10.1186/s13293-019-0222-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13293-017-0152-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092344725", 
              "https://doi.org/10.1186/s13293-017-0152-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-015-2619-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040624826", 
              "https://doi.org/10.1007/s11010-015-2619-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12265-019-09898-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1117672243", 
              "https://doi.org/10.1007/s12265-019-09898-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41569-020-00480-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1134472590", 
              "https://doi.org/10.1038/s41569-020-00480-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-013-1233-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037025877", 
              "https://doi.org/10.1007/s00424-013-1233-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00392-020-01633-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1126009394", 
              "https://doi.org/10.1007/s00392-020-01633-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrendo.2017.12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129662", 
              "https://doi.org/10.1038/nrendo.2017.12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-011-0174-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015581599", 
              "https://doi.org/10.1007/s00395-011-0174-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13293-019-0219-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111364471", 
              "https://doi.org/10.1186/s13293-019-0219-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12020-013-0081-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008784846", 
              "https://doi.org/10.1007/s12020-013-0081-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11357-021-00331-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1135279131", 
              "https://doi.org/10.1007/s11357-021-00331-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004240000473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011951609", 
              "https://doi.org/10.1007/s004240000473"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-11-23", 
        "datePublishedReg": "2021-11-23", 
        "description": "Heart failure (HF) is growing in prevalence, due to an increase in aging and comorbidities. Heart failure with reduced ejection fraction (HFrEF) is more common in men, whereas heart failure with preserved ejection fraction (HFpEF) has a higher prevalence in women. However, the reasons for these epidemiological trends are not clear yet. Since HFpEF affects mostly postmenopausal women, sex hormones should play a pivotal role in HFpEF development. Furthermore, for HFpEF, contrary to HFrEF, effective therapeutic approaches are missing. Interestingly, studies evidenced that some therapies can have better results in women than in HFpEF men, emphasizing the necessity of understanding these observations at a molecular level. Thus, herein, we review the molecular mechanisms of estrogen and androgen actions in the heart in physiological conditions and explain how its dysregulation can lead to disease development. This clarification is essential in the road for an effective personalized management of HF, particularly HFpEF, towards the development of sex-specific therapeutic approaches.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00109-021-02169-w", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.9566264", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9954810", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9950591", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9758268", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9761118", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9763108", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9763506", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1057918", 
            "issn": [
              "0946-2716", 
              "1432-1440"
            ], 
            "name": "Journal of Molecular Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "100"
          }
        ], 
        "keywords": [
          "heart failure", 
          "ejection fraction", 
          "sex hormones", 
          "therapeutic approaches", 
          "sex-specific therapeutic approaches", 
          "reduced ejection fraction", 
          "effective therapeutic approach", 
          "HFpEF development", 
          "postmenopausal women", 
          "molecular mechanisms", 
          "cardiac remodeling", 
          "androgen action", 
          "high prevalence", 
          "epidemiological trends", 
          "personalized management", 
          "HFpEF", 
          "women", 
          "disease development", 
          "prevalence", 
          "hormone", 
          "pivotal role", 
          "men", 
          "heart", 
          "failure", 
          "comorbidities", 
          "estrogen", 
          "therapy", 
          "physiological conditions", 
          "dysregulation", 
          "remodeling", 
          "sexual dimorphism", 
          "molecular level", 
          "mechanism", 
          "development", 
          "management", 
          "aging", 
          "better results", 
          "levels", 
          "study", 
          "role", 
          "action", 
          "fraction", 
          "increase", 
          "dimorphism", 
          "clarification", 
          "reasons", 
          "results", 
          "trends", 
          "approach", 
          "observations", 
          "necessity", 
          "conditions", 
          "road"
        ], 
        "name": "Sexual dimorphism in cardiac remodeling: the molecular mechanisms ruled by sex hormones in the heart", 
        "pagination": "245-267", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1142727498"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00109-021-02169-w"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34811581"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00109-021-02169-w", 
          "https://app.dimensions.ai/details/publication/pub.1142727498"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-10T10:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_900.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00109-021-02169-w"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00109-021-02169-w'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00109-021-02169-w'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00109-021-02169-w'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00109-021-02169-w'


     

    This table displays all metadata directly associated to this object as RDF triples.

    309 TRIPLES      22 PREDICATES      109 URIs      80 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00109-021-02169-w schema:about N08e8afb9025a4bcab959a6c9efa8a334
    2 N305c94d168f44271a75f8c9d64835cae
    3 N3793e08dd7834ae09658460739efffae
    4 N45977515aa2b4e00b149909dfe958fcb
    5 N5ff6bb65000f46b99035664eed164674
    6 N95ae331ecb3e4ec3a207a1cb2d44681f
    7 Na642502292fa4cfaa258042347be99b7
    8 Ndfecb00e051a4f05963c38333eb8c340
    9 Ne1b8315c8ad04b8caefe53d0426dc320
    10 anzsrc-for:03
    11 anzsrc-for:0304
    12 schema:author Nc85a524487c440b19596c9bf683ece3b
    13 schema:citation sg:pub.10.1007/978-3-319-77932-4_23
    14 sg:pub.10.1007/s00392-020-01633-w
    15 sg:pub.10.1007/s00395-011-0174-z
    16 sg:pub.10.1007/s00424-013-1233-0
    17 sg:pub.10.1007/s004240000473
    18 sg:pub.10.1007/s11010-015-2405-3
    19 sg:pub.10.1007/s11010-015-2619-4
    20 sg:pub.10.1007/s11010-016-2748-4
    21 sg:pub.10.1007/s11357-021-00331-3
    22 sg:pub.10.1007/s12020-013-0081-1
    23 sg:pub.10.1007/s12265-019-09898-x
    24 sg:pub.10.1007/s40618-014-0118-1
    25 sg:pub.10.1038/nrcardio.2017.65
    26 sg:pub.10.1038/nrendo.2017.12
    27 sg:pub.10.1038/nrm.2016.122
    28 sg:pub.10.1038/s41569-020-00480-6
    29 sg:pub.10.1038/s41586-020-2797-4
    30 sg:pub.10.1186/s13293-015-0027-9
    31 sg:pub.10.1186/s13293-017-0152-8
    32 sg:pub.10.1186/s13293-019-0219-9
    33 sg:pub.10.1186/s13293-019-0222-1
    34 schema:datePublished 2021-11-23
    35 schema:datePublishedReg 2021-11-23
    36 schema:description Heart failure (HF) is growing in prevalence, due to an increase in aging and comorbidities. Heart failure with reduced ejection fraction (HFrEF) is more common in men, whereas heart failure with preserved ejection fraction (HFpEF) has a higher prevalence in women. However, the reasons for these epidemiological trends are not clear yet. Since HFpEF affects mostly postmenopausal women, sex hormones should play a pivotal role in HFpEF development. Furthermore, for HFpEF, contrary to HFrEF, effective therapeutic approaches are missing. Interestingly, studies evidenced that some therapies can have better results in women than in HFpEF men, emphasizing the necessity of understanding these observations at a molecular level. Thus, herein, we review the molecular mechanisms of estrogen and androgen actions in the heart in physiological conditions and explain how its dysregulation can lead to disease development. This clarification is essential in the road for an effective personalized management of HF, particularly HFpEF, towards the development of sex-specific therapeutic approaches.
    37 schema:genre article
    38 schema:inLanguage en
    39 schema:isAccessibleForFree false
    40 schema:isPartOf Nb5ad0d6b5a2e4c1d97988d87136f9ee9
    41 Ndd55d84deb3f49b0baa02f08ad48e60f
    42 sg:journal.1057918
    43 schema:keywords HFpEF
    44 HFpEF development
    45 action
    46 aging
    47 androgen action
    48 approach
    49 better results
    50 cardiac remodeling
    51 clarification
    52 comorbidities
    53 conditions
    54 development
    55 dimorphism
    56 disease development
    57 dysregulation
    58 effective therapeutic approach
    59 ejection fraction
    60 epidemiological trends
    61 estrogen
    62 failure
    63 fraction
    64 heart
    65 heart failure
    66 high prevalence
    67 hormone
    68 increase
    69 levels
    70 management
    71 mechanism
    72 men
    73 molecular level
    74 molecular mechanisms
    75 necessity
    76 observations
    77 personalized management
    78 physiological conditions
    79 pivotal role
    80 postmenopausal women
    81 prevalence
    82 reasons
    83 reduced ejection fraction
    84 remodeling
    85 results
    86 road
    87 role
    88 sex hormones
    89 sex-specific therapeutic approaches
    90 sexual dimorphism
    91 study
    92 therapeutic approaches
    93 therapy
    94 trends
    95 women
    96 schema:name Sexual dimorphism in cardiac remodeling: the molecular mechanisms ruled by sex hormones in the heart
    97 schema:pagination 245-267
    98 schema:productId N2427ce1af8c745ed8eff507b7ddc332d
    99 N95e19b55432a4f0cb14be9665bdbb322
    100 Ne6c962fc9cf54646acd72c8c536143a0
    101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1142727498
    102 https://doi.org/10.1007/s00109-021-02169-w
    103 schema:sdDatePublished 2022-05-10T10:28
    104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    105 schema:sdPublisher N5d32165b1ff94099b71209f05b2a35ab
    106 schema:url https://doi.org/10.1007/s00109-021-02169-w
    107 sgo:license sg:explorer/license/
    108 sgo:sdDataset articles
    109 rdf:type schema:ScholarlyArticle
    110 N08e8afb9025a4bcab959a6c9efa8a334 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Gonadal Steroid Hormones
    112 rdf:type schema:DefinedTerm
    113 N2427ce1af8c745ed8eff507b7ddc332d schema:name dimensions_id
    114 schema:value pub.1142727498
    115 rdf:type schema:PropertyValue
    116 N301a91737d8b4078869b89507c8c3867 rdf:first sg:person.013326044367.39
    117 rdf:rest N5b021c506565414994d66435827937f2
    118 N305c94d168f44271a75f8c9d64835cae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Heart Failure
    120 rdf:type schema:DefinedTerm
    121 N3793e08dd7834ae09658460739efffae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Animals
    123 rdf:type schema:DefinedTerm
    124 N45977515aa2b4e00b149909dfe958fcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Sex Characteristics
    126 rdf:type schema:DefinedTerm
    127 N530a16d20ff8438db4178c53f02f81b3 schema:affiliation grid-institutes:grid.7311.4
    128 schema:familyName Ferreira
    129 schema:givenName Cláudia
    130 rdf:type schema:Person
    131 N59e4eeb6c39e49d0afd29e10d44308da rdf:first sg:person.0752717236.98
    132 rdf:rest N8313361205af4d7ebe1eb01b448423b9
    133 N5b021c506565414994d66435827937f2 rdf:first sg:person.011246367673.38
    134 rdf:rest Nf0c5b521839a42ce93bb28cb69328eb2
    135 N5d32165b1ff94099b71209f05b2a35ab schema:name Springer Nature - SN SciGraph project
    136 rdf:type schema:Organization
    137 N5ff6bb65000f46b99035664eed164674 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Androgens
    139 rdf:type schema:DefinedTerm
    140 N8313361205af4d7ebe1eb01b448423b9 rdf:first sg:person.0731713571.35
    141 rdf:rest rdf:nil
    142 N95ae331ecb3e4ec3a207a1cb2d44681f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Estrogens
    144 rdf:type schema:DefinedTerm
    145 N95e19b55432a4f0cb14be9665bdbb322 schema:name doi
    146 schema:value 10.1007/s00109-021-02169-w
    147 rdf:type schema:PropertyValue
    148 N96ae8e5bb6dd4f9b915accc2ce140bc5 rdf:first sg:person.0737765327.38
    149 rdf:rest N59e4eeb6c39e49d0afd29e10d44308da
    150 Na642502292fa4cfaa258042347be99b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Myocardium
    152 rdf:type schema:DefinedTerm
    153 Nb5ad0d6b5a2e4c1d97988d87136f9ee9 schema:issueNumber 2
    154 rdf:type schema:PublicationIssue
    155 Nc85a524487c440b19596c9bf683ece3b rdf:first N530a16d20ff8438db4178c53f02f81b3
    156 rdf:rest Nf9cdb6a81b244530a12c93d2ec405dd2
    157 Ndd55d84deb3f49b0baa02f08ad48e60f schema:volumeNumber 100
    158 rdf:type schema:PublicationVolume
    159 Ndfecb00e051a4f05963c38333eb8c340 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Ventricular Remodeling
    161 rdf:type schema:DefinedTerm
    162 Ne1b8315c8ad04b8caefe53d0426dc320 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Humans
    164 rdf:type schema:DefinedTerm
    165 Ne6c962fc9cf54646acd72c8c536143a0 schema:name pubmed_id
    166 schema:value 34811581
    167 rdf:type schema:PropertyValue
    168 Nf0c5b521839a42ce93bb28cb69328eb2 rdf:first sg:person.01207643272.43
    169 rdf:rest N96ae8e5bb6dd4f9b915accc2ce140bc5
    170 Nf9cdb6a81b244530a12c93d2ec405dd2 rdf:first sg:person.0771211162.32
    171 rdf:rest N301a91737d8b4078869b89507c8c3867
    172 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    173 schema:name Chemical Sciences
    174 rdf:type schema:DefinedTerm
    175 anzsrc-for:0304 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Medicinal and Biomolecular Chemistry
    177 rdf:type schema:DefinedTerm
    178 sg:grant.9566264 http://pending.schema.org/fundedItem sg:pub.10.1007/s00109-021-02169-w
    179 rdf:type schema:MonetaryGrant
    180 sg:grant.9758268 http://pending.schema.org/fundedItem sg:pub.10.1007/s00109-021-02169-w
    181 rdf:type schema:MonetaryGrant
    182 sg:grant.9761118 http://pending.schema.org/fundedItem sg:pub.10.1007/s00109-021-02169-w
    183 rdf:type schema:MonetaryGrant
    184 sg:grant.9763108 http://pending.schema.org/fundedItem sg:pub.10.1007/s00109-021-02169-w
    185 rdf:type schema:MonetaryGrant
    186 sg:grant.9763506 http://pending.schema.org/fundedItem sg:pub.10.1007/s00109-021-02169-w
    187 rdf:type schema:MonetaryGrant
    188 sg:grant.9950591 http://pending.schema.org/fundedItem sg:pub.10.1007/s00109-021-02169-w
    189 rdf:type schema:MonetaryGrant
    190 sg:grant.9954810 http://pending.schema.org/fundedItem sg:pub.10.1007/s00109-021-02169-w
    191 rdf:type schema:MonetaryGrant
    192 sg:journal.1057918 schema:issn 0946-2716
    193 1432-1440
    194 schema:name Journal of Molecular Medicine
    195 schema:publisher Springer Nature
    196 rdf:type schema:Periodical
    197 sg:person.011246367673.38 schema:affiliation grid-institutes:grid.414556.7
    198 schema:familyName Neves
    199 schema:givenName João Sérgio
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011246367673.38
    201 rdf:type schema:Person
    202 sg:person.01207643272.43 schema:affiliation grid-institutes:grid.414556.7
    203 schema:familyName Leite-Moreira
    204 schema:givenName Adelino
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207643272.43
    206 rdf:type schema:Person
    207 sg:person.013326044367.39 schema:affiliation grid-institutes:grid.7311.4
    208 schema:familyName Ferreira
    209 schema:givenName Rita
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013326044367.39
    211 rdf:type schema:Person
    212 sg:person.0731713571.35 schema:affiliation grid-institutes:grid.5808.5
    213 schema:familyName Nogueira-Ferreira
    214 schema:givenName Rita
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731713571.35
    216 rdf:type schema:Person
    217 sg:person.0737765327.38 schema:affiliation grid-institutes:grid.7311.4
    218 schema:familyName Amado
    219 schema:givenName Francisco
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737765327.38
    221 rdf:type schema:Person
    222 sg:person.0752717236.98 schema:affiliation grid-institutes:grid.5808.5
    223 schema:familyName Santos
    224 schema:givenName Mário
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752717236.98
    226 rdf:type schema:Person
    227 sg:person.0771211162.32 schema:affiliation grid-institutes:grid.5808.5
    228 schema:familyName Trindade
    229 schema:givenName Fábio
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771211162.32
    231 rdf:type schema:Person
    232 sg:pub.10.1007/978-3-319-77932-4_23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105855644
    233 https://doi.org/10.1007/978-3-319-77932-4_23
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/s00392-020-01633-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1126009394
    236 https://doi.org/10.1007/s00392-020-01633-w
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1007/s00395-011-0174-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1015581599
    239 https://doi.org/10.1007/s00395-011-0174-z
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1007/s00424-013-1233-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037025877
    242 https://doi.org/10.1007/s00424-013-1233-0
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1007/s004240000473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011951609
    245 https://doi.org/10.1007/s004240000473
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1007/s11010-015-2405-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027019918
    248 https://doi.org/10.1007/s11010-015-2405-3
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1007/s11010-015-2619-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040624826
    251 https://doi.org/10.1007/s11010-015-2619-4
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1007/s11010-016-2748-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040823382
    254 https://doi.org/10.1007/s11010-016-2748-4
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1007/s11357-021-00331-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1135279131
    257 https://doi.org/10.1007/s11357-021-00331-3
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1007/s12020-013-0081-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008784846
    260 https://doi.org/10.1007/s12020-013-0081-1
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1007/s12265-019-09898-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1117672243
    263 https://doi.org/10.1007/s12265-019-09898-x
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1007/s40618-014-0118-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019909652
    266 https://doi.org/10.1007/s40618-014-0118-1
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nrcardio.2017.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085388588
    269 https://doi.org/10.1038/nrcardio.2017.65
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nrendo.2017.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129662
    272 https://doi.org/10.1038/nrendo.2017.12
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nrm.2016.122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020568480
    275 https://doi.org/10.1038/nrm.2016.122
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/s41569-020-00480-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1134472590
    278 https://doi.org/10.1038/s41569-020-00480-6
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/s41586-020-2797-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131135737
    281 https://doi.org/10.1038/s41586-020-2797-4
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1186/s13293-015-0027-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019612135
    284 https://doi.org/10.1186/s13293-015-0027-9
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1186/s13293-017-0152-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092344725
    287 https://doi.org/10.1186/s13293-017-0152-8
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1186/s13293-019-0219-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111364471
    290 https://doi.org/10.1186/s13293-019-0219-9
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1186/s13293-019-0222-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111954609
    293 https://doi.org/10.1186/s13293-019-0222-1
    294 rdf:type schema:CreativeWork
    295 grid-institutes:grid.414556.7 schema:alternateName Department of Cardiothoracic Surgery, Centro Hospitalar Universitário São João, Porto, Portugal
    296 Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário São João, Porto, Portugal
    297 schema:name Department of Cardiothoracic Surgery, Centro Hospitalar Universitário São João, Porto, Portugal
    298 Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário São João, Porto, Portugal
    299 Department of Surgery and Physiology, Cardiovascular R&D Center (UnIC), Faculty of Medicine, University of Porto, Porto, Portugal
    300 rdf:type schema:Organization
    301 grid-institutes:grid.5808.5 schema:alternateName Department of Surgery and Physiology, Cardiovascular R&D Center (UnIC), Faculty of Medicine, University of Porto, Porto, Portugal
    302 UMIB - Unidade Multidisciplinar de Investigação Biomédica, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
    303 schema:name Department of Cardiology, Hospital Santo António, Centro Hospitalar Universitário do Porto, Porto, Portugal
    304 Department of Surgery and Physiology, Cardiovascular R&D Center (UnIC), Faculty of Medicine, University of Porto, Porto, Portugal
    305 UMIB - Unidade Multidisciplinar de Investigação Biomédica, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
    306 rdf:type schema:Organization
    307 grid-institutes:grid.7311.4 schema:alternateName LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal
    308 schema:name LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal
    309 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...