Targeting the Wnt signaling pathway for breast cancer bone metastasis therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-25

AUTHORS

Jingyao Cui, Haoran Chen, Kaiwen Zhang, Xin Li

ABSTRACT

Osteolytic bone destruction is found in approximately 60% of advanced breast cancer patients. With the pathogenesis of bone metastasis being unclear, traditional antiresorptive therapeutic strategies might not be ideal for treatment. The Wnt pathway is a highly organized cascade involved in multiple stages of cancer bone metastasis, and Wnt-targeted therapeutic strategies have shown promise in achieving favorable outcomes. In this review, we summarize the current progress of pharmacological Wnt modulators against breast cancer bone metastasis, discuss emerging therapeutic strategies based on Wnt pathway-related targets for bone therapy, and highlight opportunities to better harness the Wnt pathway for bone metastasis therapeutics to further reveal the implications of the Wnt pathway in bone metastasis pathology and provide new ideas for the development of Wnt-based intervention strategies against breast cancer bone metastasis. More... »

PAGES

373-384

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00109-021-02159-y

    DOI

    http://dx.doi.org/10.1007/s00109-021-02159-y

    DIMENSIONS

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    PUBMED

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    59 development
    60 development of Wnt
    61 favorable outcome
    62 highlight opportunities
    63 idea
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    65 intervention strategies
    66 metastasis
    67 metastasis therapy
    68 modulator
    69 multiple stages
    70 new ideas
    71 opportunities
    72 osteolytic bone destruction
    73 outcomes
    74 pathogenesis
    75 pathology
    76 pathway
    77 patients
    78 progress
    79 promise
    80 review
    81 stage
    82 strategies
    83 target
    84 therapeutic strategies
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    86 therapy
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