Sympathetic nerve-adipocyte interactions in response to acute stress View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-11-04

AUTHORS

Gabryella S. P. Santos, Alinne C. Costa, Caroline C. Picoli, Beatriz G. S. Rocha, Sheu O. Sulaiman, Debora C. Radicchi, Mauro C. X. Pinto, Miguel L. Batista, Jaime H. Amorim, Vasco A. C. Azevedo, Rodrigo R. Resende, Niels O. S. Câmara, Akiva Mintz, Alexander Birbrair

ABSTRACT

Psychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated approaches in combination with pharmacological blockage, that sympathetic nerves, activated by psychological stress, induce brown adipocytes to produce IL-6. Strikingly, this cytokine promotes gluconeogenesis in hepatocytes, that results in the decline of tolerance to inflammatory organ damage. The comprehension arising from this research will be crucial for the handling of many inflammatory diseases. Here, we review recent advances in our comprehension of the sympathetic nerve-adipocyte axis in the tissue microenvironment. More... »

PAGES

151-165

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00109-021-02157-0

    DOI

    http://dx.doi.org/10.1007/s00109-021-02157-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1142402053

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34735579


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