The vasculature niches required for hematopoiesis View Full Text


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Article Info

DATE

2021-10-28

AUTHORS

Zuohua Chi, Liji Chen, Xiaomin Ye, Aimei Liu, Gongwang Yu, Yan Sun

ABSTRACT

Endothelial cells play a critical role in supporting postnatal hematopoiesis in the bone marrow. Unique endothelial cells, together with various perivascular cells, form different types of vascular structures, constructing a vast microvascular delivery and trafficking network for blood cells, oxygen, and nutrition. These blood vessels build distinct hematopoietic stem and progenitor cell niches, which offer not only sites of residence for blood cells but also indispensable signals directing HSPC homing, self-renewal, and multilineage differentiation. Deep insight into the structure and function of the BM vasculature niche and its participation in hematopoiesis is necessary to develop advanced strategies for the reconstitution of hematopoiesis. More... »

PAGES

53-61

References to SciGraph publications

  • 2016-04-13. Distinct bone marrow blood vessels differentially regulate haematopoiesis in NATURE
  • 2008-12-03. Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche in NATURE
  • 2012-01-25. Endothelial and perivascular cells maintain haematopoietic stem cells in NATURE
  • 2021-02-10. In situ mapping identifies distinct vascular niches for myelopoiesis in NATURE
  • 2013-10-09. Arteriolar niches maintain haematopoietic stem cell quiescence in NATURE
  • 2005-06. In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment in NATURE
  • 2014-03-12. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone in NATURE
  • 2014-03-12. Endothelial Notch activity promotes angiogenesis and osteogenesis in bone in NATURE
  • 2021-02-24. A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis in NATURE
  • 2013-02-24. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance in NATURE
  • 2014-10-19. Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion in NATURE MEDICINE
  • 2016-02-10. Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche in NATURE
  • 2016-04-13. Age-dependent modulation of vascular niches for haematopoietic stem cells in NATURE
  • 2015-09-23. Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal in NATURE
  • 2006-03-26. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells in NATURE MEDICINE
  • 2013-04-28. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment in NATURE CELL BIOLOGY
  • 2014-10-19. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells in NATURE MEDICINE
  • 2010-08. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche in NATURE
  • 2013-02-24. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches in NATURE
  • 2017-02-20. Differential cytokine contributions of perivascular haematopoietic stem cell niches in NATURE CELL BIOLOGY
  • 2003-10. Osteoblastic cells regulate the haematopoietic stem cell niche in NATURE
  • 2003-10. Identification of the haematopoietic stem cell niche and control of the niche size in NATURE
  • 2004-02-25. Notch regulation of lymphocyte development and function in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00109-021-02155-2

    DOI

    http://dx.doi.org/10.1007/s00109-021-02155-2

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34709407


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