Cerebral derailment after myocardial infarct: mechanisms and effects of the signaling from the ischemic heart to brain View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-21

AUTHORS

Paolo Gelosa, Laura Castiglioni, Joanna Rzemieniec, Majeda Muluhie, Marina Camera, Luigi Sironi

ABSTRACT

Myocardial infarction (MI) is the leading cause of death among ischemic heart diseases and is associated with several long-term cardiovascular complications, such as angina, re-infarction, arrhythmias, and heart failure. However, MI is frequently accompanied by non-cardiovascular multiple comorbidities, including brain disorders such as stroke, anxiety, depression, and cognitive impairment. Accumulating experimental and clinical evidence suggests a causal relationship between MI and stroke, but the precise underlying mechanisms have not yet been elucidated. Indeed, the risk of stroke remains a current challenge in patients with MI, in spite of the improvement of medical treatment among this patient population has reduced the risk of stroke. In this review, the effects of the signaling from the ischemic heart to the brain, such as neuroinflammation, neuronal apoptosis, and neurogenesis, and the possible actors mediating these effects, such as systemic inflammation, immunoresponse, extracellular vesicles, and microRNAs, are discussed. More... »

PAGES

23-41

References to SciGraph publications

  • 2017-06-09. Role of the immune system in cardiac tissue damage and repair following myocardial infarction in INFLAMMATION RESEARCH
  • 2018-11-21. Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs in STEM CELL RESEARCH & THERAPY
  • 2019-02-18. Tumour Necrosis Factor-α Inhibition Improves Stroke Outcome in a Mouse Model of Rheumatoid Arthritis in SCIENTIFIC REPORTS
  • 2005-12-25. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation in NATURE GENETICS
  • 2008-09-07. Mincle is an ITAM-coupled activating receptor that senses damaged cells in NATURE IMMUNOLOGY
  • 2014-04-06. Bone Marrow Mesenchymal Stem Cell-Derived Microvesicles Protect Rat Pheochromocytoma PC12 Cells from Glutamate-Induced Injury via a PI3K/Akt Dependent Pathway in NEUROCHEMICAL RESEARCH
  • 2019-02-27. Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells in NATURE COMMUNICATIONS
  • 2020-04-21. Brain–heart interaction after acute ischemic stroke in CRITICAL CARE
  • 2016-03-19. Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons in MOLECULAR NEUROBIOLOGY
  • 2016-08-24. HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease in JOURNAL OF NEUROINFLAMMATION
  • 2016-07-07. Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro in CELLULAR AND MOLECULAR BIOENGINEERING
  • 2019-12-13. The Level of Circulating Microparticles in Patients with Coronary Heart Disease: a Systematic Review and Meta-Analysis in JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
  • 2020-03-02. Risk of Ischemic Stroke After Acute Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery in SCIENTIFIC REPORTS
  • 2013-05-04. Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris in BMC MEDICAL GENOMICS
  • 2017-09-13. Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease? in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2018-01-08. In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation in JOURNAL OF NEUROINFLAMMATION
  • 2016-07-13. Lentiviral Delivery of miR-133b Improves Functional Recovery After Spinal Cord Injury in Mice in MOLECULAR NEUROBIOLOGY
  • 2009-08-29. Tumor necrosis factor-alpha participates in apoptosis in the limbic system after myocardial infarction in APOPTOSIS
  • 2019-02-01. Effect of intravenous injection of antagomiR-1 on brain ischemia in MOLECULAR BIOLOGY REPORTS
  • 2014-01-25. Conditioned medium of human adipose-derived mesenchymal stem cells mediates protection in neurons following glutamate excitotoxicity by regulating energy metabolism and GAP-43 expression in METABOLIC BRAIN DISEASE
  • 2010-06. Phagocyte partnership during the onset and resolution of inflammation in NATURE REVIEWS IMMUNOLOGY
  • 2018-10-10. The Janus face of HMGB1 in heart disease: a necessary update in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2010-10-01. MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction in BASIC RESEARCH IN CARDIOLOGY
  • 2019-11-06. Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys in GEROSCIENCE
  • 2014-05-08. miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2019-11-13. Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats in JOURNAL OF NEUROINFLAMMATION
  • 2015-06-16. Towards a molecular understanding of microRNA-mediated gene silencing in NATURE REVIEWS GENETICS
  • 2013-09-15. B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction in NATURE MEDICINE
  • 2012-11-28. Purinergic signalling in the rostral ventro-lateral medulla controls sympathetic drive and contributes to the progression of heart failure following myocardial infarction in rats in BASIC RESEARCH IN CARDIOLOGY
  • 2014-09-20. Roles of microRNA-1 in hypoxia-induced apoptotic insults to neuronal cells in ARCHIVES OF TOXICOLOGY
  • 2013-09-27. Circulating microparticles in patients with coronary heart disease and its correlation with interleukin-6 and C-reactive protein in MOLECULAR BIOLOGY REPORTS
  • 2020-10-14. Microglia in depression: current perspectives in SCIENCE CHINA LIFE SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00109-021-02154-3

    DOI

    http://dx.doi.org/10.1007/s00109-021-02154-3

    DIMENSIONS

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    PUBMED

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