Mitochondrial complex I deficiency and cardiovascular diseases: current evidence and future directions View Full Text


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Article Info

DATE

2019-03-12

AUTHORS

Maurizio Forte, Silvia Palmerio, Franca Bianchi, Massimo Volpe, Speranza Rubattu

ABSTRACT

Compelling evidence demonstrates the emerging role of mitochondrial complex I deficiency in the onset and development of cardiovascular diseases (CVDs). In particular, defects in single subunits of mitochondrial complex I have been associated with cardiac hypertrophy, ischemia/reperfusion injury, as well as diabetic complications and stroke in pre-clinical studies. Moreover, data obtained in humans revealed that genes coding for complex I proteins were associated with different CVDs. In this review, we discuss recent experimental studies that underline the contributory role of mitochondrial complex I deficiency in the etiopathogenesis of several CVDs, with a particular focus on those involving loss of function models of mitochondrial complex I. We also discuss human studies and potential therapeutic strategies able to rescue mitochondrial function in CVDs. More... »

PAGES

1-13

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00109-019-01771-3

    DOI

    http://dx.doi.org/10.1007/s00109-019-01771-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112702998

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30863992


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

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    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00109-019-01771-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00109-019-01771-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00109-019-01771-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00109-019-01771-3'


     

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