FOXM1 plays a role in autophagy by transcriptionally regulating Beclin-1 and LC3 genes in human triple-negative breast cancer cells View Full Text


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Article Info

DATE

2019-04

AUTHORS

Zuhal Hamurcu, Nesrin Delibaşı, Ufuk Nalbantoglu, Elif Funda Sener, Nursultan Nurdinov, Bayram Tascı, Serpil Taheri, Yusuf Özkul, Hamiyet Donmez-Altuntas, Halit Canatan, Bulent Ozpolat

ABSTRACT

Triple-negative breast cancer (TNBC) is associated with poor prognosis owing to its aggressive and heterogeneous nature, and the lack of therapeutic targets. Although Forkhead Box M1 (FOXM1) is one of the most important oncogenes contributing to tumorigenesis, progression, and drug resistance in TNBC, the underlying molecular mechanisms are not well understood. Emerging evidence indicates that autophagy plays a critical role in cell survival and protective mechanism in TNBC. However, signaling pathways that are involved in the regulation of autophagy remain to be elucidated. In the present study, we examined the role of FOXM1 in regulating autophagy in TNBC cells and found that FOXM1 is upregulated during induction of autophagy. We found that inhibition of FOXM1 suppressed starvation and rapamycin-induced autophagy and expression of the major autophagy regulators, LC3 and Beclin-1. Further studies demonstrated that FOXM1 directly binds to the promotors of LC3 and Beclin-1 genes and transcriptionally regulates their expression by chromatin immunoprecipitation (ChIP) and luciferase gene reporter assays. In conclusion, our study provides the first evidence about the role of FOXM1 in regulating expression of LC3 and Beclin-1 and autophagy in TNBC cells. Our findings provide novel insight into the role of FOXM1 regulation of the autophagic survival pathway and potential molecular target for treating TNBC. KEY MESSAGES: • FOXM1 promotes tumorigenesis and progression of TNBC. However, the underlying molecular mechanism by which FOXM1 promotes TNBC tumorigenesis is unclear. The goal of our study was to determine the role of FOXM1 in the regulation of autophagy that plays a role in TNBC progression. Our findings show that FOXM1 binds to promoters of the genes encoding the major autophagy proteins, Beclin and LC3, and provide new insights into the regulation of autophagy, which is being targeted in many clinical trials. More... »

PAGES

491-508

References to SciGraph publications

  • 2018-12. The exploration of contrasting pathways in Triple Negative Breast Cancer (TNBC) in BMC CANCER
  • 1999-01. Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer* in BRITISH JOURNAL OF CANCER
  • 2018-03. Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasion by inhibition of Cyclin-D1 and uPAR/Integrin β1/ Src signaling in triple negative breast cancer cells in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2018-05. Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2016-08. Retraction Note to: FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors in BREAST CANCER RESEARCH AND TREATMENT
  • 2017-03. Roles of FoxM1 in cell regulation and breast cancer targeting therapy in MEDICAL ONCOLOGY
  • 2018-06. Mechanism and medical implications of mammalian autophagy in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-03. High expression of LC3B is associated with progression and poor outcome in triple-negative breast cancer in MEDICAL ONCOLOGY
  • 2009-12. Pro-proliferative FoxM1 is a target of p53-mediated repression in ONCOGENE
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2017-06. FOXM1 transcriptionally regulates expression of integrin β1 in triple-negative breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-03. Eukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells in CELL STRESS AND CHAPERONES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00109-019-01750-8

    DOI

    http://dx.doi.org/10.1007/s00109-019-01750-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111980701

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30729279


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