NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

R. Abi Nahed, D. Reynaud, A. J. Borg, W. Traboulsi, A. Wetzel, V. Sapin, S. Brouillet, M. N. Dieudonné, M. Dakouane-Giudicelli, M. Benharouga, P. Murthi, Nadia Alfaidy

ABSTRACT

Fetal growth restriction (FGR) the leading cause of perinatal mortality and morbidity is highly related to abnormal placental development, and placentas from FGR pregnancies are often characterized by increased inflammation. However, the mechanisms of FGR-associated inflammation are far from being understood. NLRP7, a member of a family of receptors involved in the innate immune responses, has been shown to be associated with gestational trophoblastic diseases. Here, we characterized the expression and the functional role of NLRP7 in the placenta and investigated its involvement in the pathogenesis of FGR. We used primary trophoblasts and placental explants that were collected during early pregnancy, and established trophoblast-derived cell lines, human placental villi, and serum samples from early pregnancy (n = 38) and from FGR (n = 40) and age-matched controls (n = 32). Our results show that NLRP7 (i) is predominantly expressed in the trophoblasts during the hypoxic period of placental development and its expression is upregulated by hypoxia and (ii) increases trophoblast proliferation ([3H]-thymidine) and controls the precocious differentiation of trophoblasts towards syncytium (syncytin 1 and 2 and β-hCG production and xCELLigence analysis) and towards invasive extravillous trophoblast (2D and 3D cultures). We have also demonstrated that NLRP7 inflammasome activation in trophoblast cells increases IL-1β, but not IL-18 secretion. In relation to the FGR, we demonstrated that major components of NLRP7 inflammasome machinery are increased and that IL-1β but not IL-18 circulating levels are increased in FGR. Altogether, our results identified NLRP7 as a critical placental factor and provided evidence for its deregulation in FGR. NLRP7 inflammasome is abundantly expressed by trophoblast cells. It is regulated by a key parameter of placental development, hypoxia. It controls trophoblast proliferation, migration, and invasion and exhibits anti-apoptotic role. NLRP7 machinery is deregulated in FGR pregnancies. KEY MESSAGES: NLRP7 inflammasome is abundantly expressed by trophoblast cells. It is regulated by a key parameter of placental development, hypoxia. It controls trophoblast proliferation, migration, and invasion and exhibits anti-apoptotic role. NLRP7 machinery is deregulated in FGR pregnancies. More... »

PAGES

355-367

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00109-018-01737-x

DOI

http://dx.doi.org/10.1007/s00109-018-01737-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111265887

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30617930


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Atomic Energy and Alternative Energies Commission", 
          "id": "https://www.grid.ac/institutes/grid.5583.b", 
          "name": [
            "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 1036, Grenoble, France", 
            "Universit\u00e9 Grenoble-Alpes, 38000, Grenoble, France", 
            "Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abi Nahed", 
        "givenName": "R.", 
        "id": "sg:person.0651201536.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651201536.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Atomic Energy and Alternative Energies Commission", 
          "id": "https://www.grid.ac/institutes/grid.5583.b", 
          "name": [
            "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 1036, Grenoble, France", 
            "Universit\u00e9 Grenoble-Alpes, 38000, Grenoble, France", 
            "Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reynaud", 
        "givenName": "D.", 
        "id": "sg:person.010453763077.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010453763077.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416259.d", 
          "name": [
            "Department of Medicine, School of Clinical Sciences, Monash University and the Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia", 
            "Department of Maternal-Fetal Medicine, Pregnancy Research Centre, The Royal Women\u2019s Hospital, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borg", 
        "givenName": "A. J.", 
        "id": "sg:person.01077173735.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077173735.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Atomic Energy and Alternative Energies Commission", 
          "id": "https://www.grid.ac/institutes/grid.5583.b", 
          "name": [
            "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 1036, Grenoble, France", 
            "Universit\u00e9 Grenoble-Alpes, 38000, Grenoble, France", 
            "Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Traboulsi", 
        "givenName": "W.", 
        "id": "sg:person.01065014505.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065014505.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Couple Enfant", 
          "id": "https://www.grid.ac/institutes/grid.492672.c", 
          "name": [
            "Universit\u00e9 Grenoble-Alpes, 38000, Grenoble, France", 
            "H\u00f4pital Couple-Enfant, Centre Clinique et Biologique d\u2019Assistance M\u00e9dicale \u00e0 la Procr\u00e9ation-CECOS, Centre Hospitalier Universitaire de Grenoble, 38700, La Tronche, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wetzel", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genetique Reproduction and Developpement", 
          "id": "https://www.grid.ac/institutes/grid.463855.9", 
          "name": [
            "GReD, UMR CNRS 6293 INSERM 1103 Universit\u00e9 Clermont Auvergne, CRBC, UFR de M\u00e9decine et des Professions Param\u00e9dicales, 63000, Clermont-Ferrand, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sapin", 
        "givenName": "V.", 
        "id": "sg:person.01031461152.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031461152.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Couple Enfant", 
          "id": "https://www.grid.ac/institutes/grid.492672.c", 
          "name": [
            "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 1036, Grenoble, France", 
            "Universit\u00e9 Grenoble-Alpes, 38000, Grenoble, France", 
            "H\u00f4pital Couple-Enfant, Centre Clinique et Biologique d\u2019Assistance M\u00e9dicale \u00e0 la Procr\u00e9ation-CECOS, Centre Hospitalier Universitaire de Grenoble, 38700, La Tronche, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brouillet", 
        "givenName": "S.", 
        "id": "sg:person.01001612611.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001612611.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Saclay", 
          "id": "https://www.grid.ac/institutes/grid.460789.4", 
          "name": [
            "GIG - EA 7404 Universit\u00e9 de Versailles-Saint-Quentin-en-Yvelines, Universit\u00e9 Paris-Saclay, Unit\u00e9 de Formation et de Recherche des Sciences de la Sant\u00e9 Simone Veil, Montigny-le-Bretonneux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dieudonn\u00e9", 
        "givenName": "M. N.", 
        "id": "sg:person.01151603513.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151603513.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9l\u00e9gation Paris 11", 
          "id": "https://www.grid.ac/institutes/grid.457369.a", 
          "name": [
            "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 1179, Montigny-Le-Bretonneux, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dakouane-Giudicelli", 
        "givenName": "M.", 
        "id": "sg:person.0645647300.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645647300.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9l\u00e9gation Alpes", 
          "id": "https://www.grid.ac/institutes/grid.457026.2", 
          "name": [
            "Universit\u00e9 Grenoble-Alpes, 38000, Grenoble, France", 
            "Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, Grenoble, France", 
            "Unit\u00e9 Mixte de Recherche 5249, Laboratoire de Chimie et Biologie des M\u00e9taux, Centre National de la Recherche Scientifique, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benharouga", 
        "givenName": "M.", 
        "id": "sg:person.0665124615.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665124615.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Medicine, School of Clinical Sciences, Monash University and the Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia", 
            "Department of Maternal-Fetal Medicine, Pregnancy Research Centre, The Royal Women\u2019s Hospital, Parkville, Victoria, Australia", 
            "Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murthi", 
        "givenName": "P.", 
        "id": "sg:person.0635551333.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635551333.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Atomic Energy and Alternative Energies Commission", 
          "id": "https://www.grid.ac/institutes/grid.5583.b", 
          "name": [
            "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 1036, Grenoble, France", 
            "Universit\u00e9 Grenoble-Alpes, 38000, Grenoble, France", 
            "Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, Grenoble, France", 
            "Unit\u00e9 INSERM U1036, Laboratoire BCI \u2013BIG, CEA Grenoble 17, rue des Martyrs, 38054, Grenoble cedex 9, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alfaidy", 
        "givenName": "Nadia", 
        "id": "sg:person.0713762500.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713762500.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmra0707601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000357678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/plac.2002.0900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001696901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/plac.2002.0900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001696901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mob.2002.119176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006141700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2013.00333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006650937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007566914", 
          "https://doi.org/10.1038/nri2873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007566914", 
          "https://doi.org/10.1038/nri2873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007943902", 
          "https://doi.org/10.1038/ni.1985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1297-9589(01)00179-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009241813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/aji.12449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009761005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2013.06.305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012425899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.2009.02428.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012432859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.2009.02428.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012432859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.021908.132612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014798076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.semperi.2008.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014980582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/plac.2002.0792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018974094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9378(97)70081-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019199286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9378(97)70081-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019199286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003081-199203000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021012908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2008.00554.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021392517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2010.00960.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022831619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0306164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024353994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)61577-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025693100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2016.09.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025730130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026474097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2015.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026587037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-012-1141-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027314631", 
          "https://doi.org/10.1007/s00018-012-1141-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7580.2008.00978.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028134186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.111.226670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031384491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.111.226670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031384491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9378(96)70103-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032709441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7580.2008.01036.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033065967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2012.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033924121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/plac.1999.0450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033961446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/01.pdr.0000181381.82856.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035342516", 
          "https://doi.org/10.1203/01.pdr.0000181381.82856.23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/01.pdr.0000181381.82856.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035342516", 
          "https://doi.org/10.1203/01.pdr.0000181381.82856.23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/01.pdr.0000181381.82856.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035342516", 
          "https://doi.org/10.1203/01.pdr.0000181381.82856.23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2012.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038794718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-immunol-031210-101405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040658091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmedgenet-2014-102546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042039554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-0378(00)00064-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042794983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.2004.00273.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042799827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20130295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047625657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.22620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048013656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3349/ymj.2016.57.1.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049081027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2012.03.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050979867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1601179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051347552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1933719116675058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053971327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1933719116675058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053971327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.116.144139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060111245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2005-0912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2011-1196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064251042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep-12-0433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067717644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/molmed.2015.00071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068965751", 
          "https://doi.org/10.2119/molmed.2015.00071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/molmed.2015.00071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068965751", 
          "https://doi.org/10.2119/molmed.2015.00071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1871527315666160321111829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069222405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2017.00036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074201804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1601600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083403636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biolre/iox009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084178293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5653/cerm.2017.44.1.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084858892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5653/cerm.2017.44.1.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084858892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-17-0811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091621421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2017.470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092087731", 
          "https://doi.org/10.1038/cddis.2017.470"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03", 
    "datePublishedReg": "2019-03-01", 
    "description": "Fetal growth restriction (FGR) the leading cause of perinatal mortality and morbidity is highly related to abnormal placental development, and placentas from FGR pregnancies are often characterized by increased inflammation. However, the mechanisms of FGR-associated inflammation are far from being understood. NLRP7, a member of a family of receptors involved in the innate immune responses, has been shown to be associated with gestational trophoblastic diseases. Here, we characterized the expression and the functional role of NLRP7 in the placenta and investigated its involvement in the pathogenesis of FGR. We used primary trophoblasts and placental explants that were collected during early pregnancy, and established trophoblast-derived cell lines, human placental villi, and serum samples from early pregnancy (n\u2009=\u200938) and from FGR (n\u2009=\u200940) and age-matched controls (n\u2009=\u200932). Our results show that NLRP7 (i) is predominantly expressed in the trophoblasts during the hypoxic period of placental development and its expression is upregulated by hypoxia and (ii) increases trophoblast proliferation ([3H]-thymidine) and controls the precocious differentiation of trophoblasts towards syncytium (syncytin 1 and 2 and \u03b2-hCG production and xCELLigence analysis) and towards invasive extravillous trophoblast (2D and 3D cultures). We have also demonstrated that NLRP7 inflammasome activation in trophoblast cells increases IL-1\u03b2, but not IL-18 secretion. In relation to the FGR, we demonstrated that major components of NLRP7 inflammasome machinery are increased and that IL-1\u03b2 but not IL-18 circulating levels are increased in FGR. Altogether, our results identified NLRP7 as a critical placental factor and provided evidence for its deregulation in FGR. NLRP7 inflammasome is abundantly expressed by trophoblast cells. It is regulated by a key parameter of placental development, hypoxia. It controls trophoblast proliferation, migration, and invasion and exhibits anti-apoptotic role. NLRP7 machinery is deregulated in FGR pregnancies. KEY MESSAGES: NLRP7 inflammasome is abundantly expressed by trophoblast cells. It is regulated by a key parameter of placental development, hypoxia. It controls trophoblast proliferation, migration, and invasion and exhibits anti-apoptotic role. NLRP7 machinery is deregulated in FGR pregnancies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00109-018-01737-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1057918", 
        "issn": [
          "0946-2716", 
          "1432-1440"
        ], 
        "name": "Journal of Molecular Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "97"
      }
    ], 
    "name": "NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation", 
    "pagination": "355-367", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b0a36d3f6c6f5f207323b707466b4ea0fd4e8ed65c4f1f08884ecac1e6cbf9ed"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30617930"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9504370"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00109-018-01737-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111265887"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00109-018-01737-x", 
      "https://app.dimensions.ai/details/publication/pub.1111265887"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54331_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00109-018-01737-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00109-018-01737-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00109-018-01737-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00109-018-01737-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00109-018-01737-x'


 

This table displays all metadata directly associated to this object as RDF triples.

341 TRIPLES      21 PREDICATES      82 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00109-018-01737-x schema:about anzsrc-for:11
2 anzsrc-for:1114
3 schema:author N97e0d0d28c3845899d5807013ba6068a
4 schema:citation sg:pub.10.1007/s00018-012-1141-z
5 sg:pub.10.1038/cddis.2017.470
6 sg:pub.10.1038/ni.1985
7 sg:pub.10.1038/nri2873
8 sg:pub.10.1203/01.pdr.0000181381.82856.23
9 sg:pub.10.2119/molmed.2015.00071
10 https://doi.org/10.1002/ana.22620
11 https://doi.org/10.1016/j.ajog.2012.03.024
12 https://doi.org/10.1016/j.ajpath.2015.12.010
13 https://doi.org/10.1016/j.bbrc.2016.09.157
14 https://doi.org/10.1016/j.immuni.2012.02.001
15 https://doi.org/10.1016/j.placenta.2013.06.305
16 https://doi.org/10.1016/j.tem.2012.05.006
17 https://doi.org/10.1016/s0002-9378(96)70103-5
18 https://doi.org/10.1016/s0002-9378(97)70081-4
19 https://doi.org/10.1016/s0140-6736(11)61577-8
20 https://doi.org/10.1016/s0165-0378(00)00064-4
21 https://doi.org/10.1016/s1297-9589(01)00179-5
22 https://doi.org/10.1053/j.semperi.2008.02.006
23 https://doi.org/10.1053/plac.1999.0450
24 https://doi.org/10.1053/plac.2002.0792
25 https://doi.org/10.1053/plac.2002.0900
26 https://doi.org/10.1056/nejmra0707601
27 https://doi.org/10.1067/mob.2002.119176
28 https://doi.org/10.1084/jem.20130295
29 https://doi.org/10.1093/biolre/iox009
30 https://doi.org/10.1095/biolreprod.116.144139
31 https://doi.org/10.1097/00003081-199203000-00015
32 https://doi.org/10.1111/aji.12449
33 https://doi.org/10.1111/j.1469-7580.2008.00978.x
34 https://doi.org/10.1111/j.1469-7580.2008.01036.x
35 https://doi.org/10.1111/j.1471-0528.2004.00273.x
36 https://doi.org/10.1111/j.1471-0528.2009.02428.x
37 https://doi.org/10.1111/j.1582-4934.2008.00554.x
38 https://doi.org/10.1111/j.1600-0897.2010.00960.x
39 https://doi.org/10.1136/jmedgenet-2014-102546
40 https://doi.org/10.1146/annurev-immunol-031210-101405
41 https://doi.org/10.1146/annurev.immunol.021908.132612
42 https://doi.org/10.1158/1078-0432.ccr-17-0811
43 https://doi.org/10.1161/atvbaha.111.226670
44 https://doi.org/10.1177/1933719116675058
45 https://doi.org/10.1189/jlb.0306164
46 https://doi.org/10.1210/en.2005-0912
47 https://doi.org/10.1210/en.2011-1196
48 https://doi.org/10.1371/journal.ppat.1002452
49 https://doi.org/10.1530/rep-12-0433
50 https://doi.org/10.2174/1871527315666160321111829
51 https://doi.org/10.3349/ymj.2016.57.1.5
52 https://doi.org/10.3389/fimmu.2013.00333
53 https://doi.org/10.3389/fimmu.2017.00036
54 https://doi.org/10.4049/jimmunol.1601179
55 https://doi.org/10.4049/jimmunol.1601600
56 https://doi.org/10.5653/cerm.2017.44.1.40
57 schema:datePublished 2019-03
58 schema:datePublishedReg 2019-03-01
59 schema:description Fetal growth restriction (FGR) the leading cause of perinatal mortality and morbidity is highly related to abnormal placental development, and placentas from FGR pregnancies are often characterized by increased inflammation. However, the mechanisms of FGR-associated inflammation are far from being understood. NLRP7, a member of a family of receptors involved in the innate immune responses, has been shown to be associated with gestational trophoblastic diseases. Here, we characterized the expression and the functional role of NLRP7 in the placenta and investigated its involvement in the pathogenesis of FGR. We used primary trophoblasts and placental explants that were collected during early pregnancy, and established trophoblast-derived cell lines, human placental villi, and serum samples from early pregnancy (n = 38) and from FGR (n = 40) and age-matched controls (n = 32). Our results show that NLRP7 (i) is predominantly expressed in the trophoblasts during the hypoxic period of placental development and its expression is upregulated by hypoxia and (ii) increases trophoblast proliferation ([<sup>3</sup>H]-thymidine) and controls the precocious differentiation of trophoblasts towards syncytium (syncytin 1 and 2 and β-hCG production and xCELLigence analysis) and towards invasive extravillous trophoblast (2D and 3D cultures). We have also demonstrated that NLRP7 inflammasome activation in trophoblast cells increases IL-1β, but not IL-18 secretion. In relation to the FGR, we demonstrated that major components of NLRP7 inflammasome machinery are increased and that IL-1β but not IL-18 circulating levels are increased in FGR. Altogether, our results identified NLRP7 as a critical placental factor and provided evidence for its deregulation in FGR. NLRP7 inflammasome is abundantly expressed by trophoblast cells. It is regulated by a key parameter of placental development, hypoxia. It controls trophoblast proliferation, migration, and invasion and exhibits anti-apoptotic role. NLRP7 machinery is deregulated in FGR pregnancies. KEY MESSAGES: NLRP7 inflammasome is abundantly expressed by trophoblast cells. It is regulated by a key parameter of placental development, hypoxia. It controls trophoblast proliferation, migration, and invasion and exhibits anti-apoptotic role. NLRP7 machinery is deregulated in FGR pregnancies.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N3ff7f959ced14474a262d1fdf2b5a36f
64 Ncd66c8d386a04445a53cb48f7f0b156b
65 sg:journal.1057918
66 schema:name NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation
67 schema:pagination 355-367
68 schema:productId N2d889b69a7994350b8544d13ff2969ec
69 N7ab09718ebf84d80b9f1fc6392da77d4
70 N90a43a1b705e4e08a16a72eb66f8e289
71 N92daaf706c1942658bb5cac16e1b93e5
72 Nd9f2f3e390b64568a8439cae6d9a6b40
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111265887
74 https://doi.org/10.1007/s00109-018-01737-x
75 schema:sdDatePublished 2019-04-11T10:20
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N22ea4de71c1746ba97160a5f3bb63348
78 schema:url https://link.springer.com/10.1007%2Fs00109-018-01737-x
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N1da88c9c26c74c83b293c09fe677a4d0 rdf:first sg:person.01065014505.07
83 rdf:rest N3b10219c8b7c4cf4b02b48039c4a0198
84 N22af790fbfb2479095f0f626f9aa2aec rdf:first sg:person.0645647300.60
85 rdf:rest N58d9f82c998448f79ae6f2b8d3ea8c38
86 N22ea4de71c1746ba97160a5f3bb63348 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N2bcf9098f7f54aa9b243dfb84363c37b rdf:first sg:person.010453763077.41
89 rdf:rest Neeeb06afeb3740ff85d647ce9b86b996
90 N2d889b69a7994350b8544d13ff2969ec schema:name dimensions_id
91 schema:value pub.1111265887
92 rdf:type schema:PropertyValue
93 N3b10219c8b7c4cf4b02b48039c4a0198 rdf:first Nb34f54b4c6014149b3467402082cd38d
94 rdf:rest N478a600988dc4e91b91e0a068551d164
95 N3ff7f959ced14474a262d1fdf2b5a36f schema:issueNumber 3
96 rdf:type schema:PublicationIssue
97 N478a600988dc4e91b91e0a068551d164 rdf:first sg:person.01031461152.05
98 rdf:rest N9b1ade18ece747c48569b909cc9133ab
99 N58d9f82c998448f79ae6f2b8d3ea8c38 rdf:first sg:person.0665124615.13
100 rdf:rest Nb911e85134054e1bace8ea1e3a4cf1ab
101 N7ab09718ebf84d80b9f1fc6392da77d4 schema:name readcube_id
102 schema:value b0a36d3f6c6f5f207323b707466b4ea0fd4e8ed65c4f1f08884ecac1e6cbf9ed
103 rdf:type schema:PropertyValue
104 N90a43a1b705e4e08a16a72eb66f8e289 schema:name pubmed_id
105 schema:value 30617930
106 rdf:type schema:PropertyValue
107 N92daaf706c1942658bb5cac16e1b93e5 schema:name doi
108 schema:value 10.1007/s00109-018-01737-x
109 rdf:type schema:PropertyValue
110 N97e0d0d28c3845899d5807013ba6068a rdf:first sg:person.0651201536.76
111 rdf:rest N2bcf9098f7f54aa9b243dfb84363c37b
112 N9b1ade18ece747c48569b909cc9133ab rdf:first sg:person.01001612611.83
113 rdf:rest Na27b0f932e2f496aaed76baa3b473ad8
114 Na27b0f932e2f496aaed76baa3b473ad8 rdf:first sg:person.01151603513.82
115 rdf:rest N22af790fbfb2479095f0f626f9aa2aec
116 Nb34f54b4c6014149b3467402082cd38d schema:affiliation https://www.grid.ac/institutes/grid.492672.c
117 schema:familyName Wetzel
118 schema:givenName A.
119 rdf:type schema:Person
120 Nb911e85134054e1bace8ea1e3a4cf1ab rdf:first sg:person.0635551333.27
121 rdf:rest Nbaafc2f027124ed0aa5c3639640012d1
122 Nbaafc2f027124ed0aa5c3639640012d1 rdf:first sg:person.0713762500.05
123 rdf:rest rdf:nil
124 Ncd66c8d386a04445a53cb48f7f0b156b schema:volumeNumber 97
125 rdf:type schema:PublicationVolume
126 Nd9f2f3e390b64568a8439cae6d9a6b40 schema:name nlm_unique_id
127 schema:value 9504370
128 rdf:type schema:PropertyValue
129 Neeeb06afeb3740ff85d647ce9b86b996 rdf:first sg:person.01077173735.44
130 rdf:rest N1da88c9c26c74c83b293c09fe677a4d0
131 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
132 schema:name Medical and Health Sciences
133 rdf:type schema:DefinedTerm
134 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
135 schema:name Paediatrics and Reproductive Medicine
136 rdf:type schema:DefinedTerm
137 sg:journal.1057918 schema:issn 0946-2716
138 1432-1440
139 schema:name Journal of Molecular Medicine
140 rdf:type schema:Periodical
141 sg:person.01001612611.83 schema:affiliation https://www.grid.ac/institutes/grid.492672.c
142 schema:familyName Brouillet
143 schema:givenName S.
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001612611.83
145 rdf:type schema:Person
146 sg:person.01031461152.05 schema:affiliation https://www.grid.ac/institutes/grid.463855.9
147 schema:familyName Sapin
148 schema:givenName V.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031461152.05
150 rdf:type schema:Person
151 sg:person.010453763077.41 schema:affiliation https://www.grid.ac/institutes/grid.5583.b
152 schema:familyName Reynaud
153 schema:givenName D.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010453763077.41
155 rdf:type schema:Person
156 sg:person.01065014505.07 schema:affiliation https://www.grid.ac/institutes/grid.5583.b
157 schema:familyName Traboulsi
158 schema:givenName W.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065014505.07
160 rdf:type schema:Person
161 sg:person.01077173735.44 schema:affiliation https://www.grid.ac/institutes/grid.416259.d
162 schema:familyName Borg
163 schema:givenName A. J.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077173735.44
165 rdf:type schema:Person
166 sg:person.01151603513.82 schema:affiliation https://www.grid.ac/institutes/grid.460789.4
167 schema:familyName Dieudonné
168 schema:givenName M. N.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151603513.82
170 rdf:type schema:Person
171 sg:person.0635551333.27 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
172 schema:familyName Murthi
173 schema:givenName P.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635551333.27
175 rdf:type schema:Person
176 sg:person.0645647300.60 schema:affiliation https://www.grid.ac/institutes/grid.457369.a
177 schema:familyName Dakouane-Giudicelli
178 schema:givenName M.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645647300.60
180 rdf:type schema:Person
181 sg:person.0651201536.76 schema:affiliation https://www.grid.ac/institutes/grid.5583.b
182 schema:familyName Abi Nahed
183 schema:givenName R.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651201536.76
185 rdf:type schema:Person
186 sg:person.0665124615.13 schema:affiliation https://www.grid.ac/institutes/grid.457026.2
187 schema:familyName Benharouga
188 schema:givenName M.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665124615.13
190 rdf:type schema:Person
191 sg:person.0713762500.05 schema:affiliation https://www.grid.ac/institutes/grid.5583.b
192 schema:familyName Alfaidy
193 schema:givenName Nadia
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713762500.05
195 rdf:type schema:Person
196 sg:pub.10.1007/s00018-012-1141-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1027314631
197 https://doi.org/10.1007/s00018-012-1141-z
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/cddis.2017.470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092087731
200 https://doi.org/10.1038/cddis.2017.470
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/ni.1985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007943902
203 https://doi.org/10.1038/ni.1985
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/nri2873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007566914
206 https://doi.org/10.1038/nri2873
207 rdf:type schema:CreativeWork
208 sg:pub.10.1203/01.pdr.0000181381.82856.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035342516
209 https://doi.org/10.1203/01.pdr.0000181381.82856.23
210 rdf:type schema:CreativeWork
211 sg:pub.10.2119/molmed.2015.00071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068965751
212 https://doi.org/10.2119/molmed.2015.00071
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1002/ana.22620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048013656
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.ajog.2012.03.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050979867
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.ajpath.2015.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026587037
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.bbrc.2016.09.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025730130
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.immuni.2012.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038794718
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.placenta.2013.06.305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012425899
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.tem.2012.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033924121
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0002-9378(96)70103-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032709441
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0002-9378(97)70081-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019199286
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0140-6736(11)61577-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025693100
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0165-0378(00)00064-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042794983
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s1297-9589(01)00179-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009241813
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1053/j.semperi.2008.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014980582
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1053/plac.1999.0450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033961446
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1053/plac.2002.0792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018974094
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1053/plac.2002.0900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001696901
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmra0707601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000357678
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1067/mob.2002.119176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006141700
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1084/jem.20130295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047625657
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1093/biolre/iox009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084178293
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1095/biolreprod.116.144139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060111245
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1097/00003081-199203000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021012908
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/aji.12449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009761005
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1111/j.1469-7580.2008.00978.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028134186
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1111/j.1469-7580.2008.01036.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033065967
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1471-0528.2004.00273.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042799827
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/j.1471-0528.2009.02428.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012432859
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/j.1582-4934.2008.00554.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021392517
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1111/j.1600-0897.2010.00960.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022831619
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1136/jmedgenet-2014-102546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042039554
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1146/annurev-immunol-031210-101405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040658091
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1146/annurev.immunol.021908.132612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014798076
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1158/1078-0432.ccr-17-0811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091621421
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1161/atvbaha.111.226670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031384491
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1177/1933719116675058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053971327
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1189/jlb.0306164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024353994
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1210/en.2005-0912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247625
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1210/en.2011-1196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064251042
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1371/journal.ppat.1002452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026474097
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1530/rep-12-0433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067717644
293 rdf:type schema:CreativeWork
294 https://doi.org/10.2174/1871527315666160321111829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069222405
295 rdf:type schema:CreativeWork
296 https://doi.org/10.3349/ymj.2016.57.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049081027
297 rdf:type schema:CreativeWork
298 https://doi.org/10.3389/fimmu.2013.00333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006650937
299 rdf:type schema:CreativeWork
300 https://doi.org/10.3389/fimmu.2017.00036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074201804
301 rdf:type schema:CreativeWork
302 https://doi.org/10.4049/jimmunol.1601179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051347552
303 rdf:type schema:CreativeWork
304 https://doi.org/10.4049/jimmunol.1601600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083403636
305 rdf:type schema:CreativeWork
306 https://doi.org/10.5653/cerm.2017.44.1.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084858892
307 rdf:type schema:CreativeWork
308 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
309 schema:name Department of Maternal-Fetal Medicine, Pregnancy Research Centre, The Royal Women’s Hospital, Parkville, Victoria, Australia
310 Department of Medicine, School of Clinical Sciences, Monash University and the Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia
311 Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.416259.d schema:alternateName Royal Women's Hospital
314 schema:name Department of Maternal-Fetal Medicine, Pregnancy Research Centre, The Royal Women’s Hospital, Parkville, Victoria, Australia
315 Department of Medicine, School of Clinical Sciences, Monash University and the Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia
316 rdf:type schema:Organization
317 https://www.grid.ac/institutes/grid.457026.2 schema:alternateName Délégation Alpes
318 schema:name Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, Grenoble, France
319 Unité Mixte de Recherche 5249, Laboratoire de Chimie et Biologie des Métaux, Centre National de la Recherche Scientifique, Grenoble, France
320 Université Grenoble-Alpes, 38000, Grenoble, France
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.457369.a schema:alternateName Délégation Paris 11
323 schema:name Institut National de la Santé et de la Recherche Médicale, Unité 1179, Montigny-Le-Bretonneux, France
324 rdf:type schema:Organization
325 https://www.grid.ac/institutes/grid.460789.4 schema:alternateName University of Paris-Saclay
326 schema:name GIG - EA 7404 Université de Versailles-Saint-Quentin-en-Yvelines, Université Paris-Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.463855.9 schema:alternateName Genetique Reproduction and Developpement
329 schema:name GReD, UMR CNRS 6293 INSERM 1103 Université Clermont Auvergne, CRBC, UFR de Médecine et des Professions Paramédicales, 63000, Clermont-Ferrand, France
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.492672.c schema:alternateName Hôpital Couple Enfant
332 schema:name Hôpital Couple-Enfant, Centre Clinique et Biologique d’Assistance Médicale à la Procréation-CECOS, Centre Hospitalier Universitaire de Grenoble, 38700, La Tronche, France
333 Institut National de la Santé et de la Recherche Médicale, Unité 1036, Grenoble, France
334 Université Grenoble-Alpes, 38000, Grenoble, France
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.5583.b schema:alternateName Atomic Energy and Alternative Energies Commission
337 schema:name Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, Grenoble, France
338 Institut National de la Santé et de la Recherche Médicale, Unité 1036, Grenoble, France
339 Unité INSERM U1036, Laboratoire BCI –BIG, CEA Grenoble 17, rue des Martyrs, 38054, Grenoble cedex 9, France
340 Université Grenoble-Alpes, 38000, Grenoble, France
341 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...