LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02

AUTHORS

Madhuri S. Salker, Yogesh Singh, Ruban R. Peter Durairaj, Jing Yan, Md Alauddin, Ni Zeng, Jennifer H. Steel, Shaqiu Zhang, Jaya Nautiyal, Zoe Webster, Sara Y. Brucker, Diethelm Wallwiener, B. Anne Croy, Jan J. Brosens, Florian Lang

ABSTRACT

Early embryo development and endometrial differentiation are initially independent processes, and synchronization, imposed by a limited window of implantation, is critical for reproductive success. A putative negative regulator of endometrial receptivity is LEFTY2, a member of the transforming growth factor (TGF)-β family. LEFTY2 is highly expressed in decidualizing human endometrial stromal cells (HESCs) during the late luteal phase of the menstrual cycle, coinciding with the closure of the window of implantation. Here, we show that flushing of the uterine lumen in mice with recombinant LEFTY2 inhibits the expression of key receptivity genes, including Cox2, Bmp2, and Wnt4, and blocks embryo implantation. In Ishikawa cells, a human endometrial epithelial cell line, LEFTY2 downregulated the expression of calcium release-activated calcium channel protein 1, encoded by ORAI1, and inhibited store-operated Ca2+ entry (SOCE). Furthermore, LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, as well as YM-58483, inhibited, whereas the Ca2+ ionophore, ionomycin, strongly upregulated COX2, BMP2 and WNT4 expression in decidualizing HESCs. These findings suggest that LEFTY2 closes the implantation window, at least in part, by downregulating Orai1, which in turn limits SOCE and antagonizes expression of Ca2+-sensitive receptivity genes. KEY MESSAGES: •Endometrial receptivity is negatively regulated by LEFTY2. •LEFTY2 inhibits the expression of key murine receptivity genes, including Cox2, Bmp2 and Wnt4, and blocks embryo implantation. •LEFTY2 downregulates the expression of Orai1 and inhibits SOCE. •LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, and YM-58483 inhibit COX2, BMP2, and WNT4 expression in endometrial cells. •Targeting LEFTY2 and Orai1 may represent a novel approach for treating unexplained infertility. More... »

PAGES

173-182

References to SciGraph publications

  • 2000-10. The versatility and universality of calcium signalling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-05. Uterine Selection of Human Embryos at Implantation in SCIENTIFIC REPORTS
  • 2003-07. Calcium signalling: dynamics, homeostasis and remodelling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1998-10. Calcium - a life and death signal in NATURE
  • 2009-12. Expression of nodal signalling components in cycling human endometrium and in endometrial cancer in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2013. Physiology and Pathophysiology of the Epithelial Barrier of the Female Reproductive Tract in BIOLOGY AND REGULATION OF BLOOD-TISSUE BARRIERS
  • 2012-07. Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation in NATURE MEDICINE
  • 2005. Role of EBAF/Lefty in Implantation and Uterine Bleeding in NEW MECHANISMS FOR TISSUE-SELECTIVE ESTROGEN-FREE CONTRACEPTION
  • 1996-05. Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos in NATURE
  • 2009-06. STIMulating store-operated Ca2+ entry in NATURE CELL BIOLOGY
  • 2011-11. Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure in NATURE MEDICINE
  • 1997-03. Regulation of Cl− Secretion by Extracellular ATP in Cultured Mouse Endometrial Epithelium in THE JOURNAL OF MEMBRANE BIOLOGY
  • 2004-12. Trophoblast-uterine interactions at implantation in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 1988-03. Intracellular free calcium rise triggers nuclear envelope breakdown in the sea urchin embryo in NATURE
  • 2006-03. Roadmap to embryo implantation: clues from mouse models in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00109-017-1610-9

    DOI

    http://dx.doi.org/10.1007/s00109-017-1610-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1099699835

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29230527


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Paediatrics and Reproductive Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Women\u2019s Health, Eberhard-Karls University Tuebingen, Calwerstr 7, D-72076, Tuebingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salker", 
            "givenName": "Madhuri S.", 
            "id": "sg:person.01350603674.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350603674.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Medical Genetics and Applied Genomics, Eberhard-Karls University Tuebingen, Calwerstr 7, D-72076, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Singh", 
            "givenName": "Yogesh", 
            "id": "sg:person.01173764167.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173764167.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Warwick", 
              "id": "https://www.grid.ac/institutes/grid.7372.1", 
              "name": [
                "Division of Biomedical Sciences, Warwick Medical School, CV2 2DX, Coventry, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Durairaj", 
            "givenName": "Ruban R. Peter", 
            "id": "sg:person.016065732143.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016065732143.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Physiology I, Eberhard-Karls University Tuebingen, Wilhelmstr 56, D-72074, Tuebingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yan", 
            "givenName": "Jing", 
            "id": "sg:person.01150313530.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150313530.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Women\u2019s Health, Eberhard-Karls University Tuebingen, Calwerstr 7, D-72076, Tuebingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alauddin", 
            "givenName": "Md", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Physiology I, Eberhard-Karls University Tuebingen, Wilhelmstr 56, D-72074, Tuebingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zeng", 
            "givenName": "Ni", 
            "id": "sg:person.014030545175.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014030545175.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, W12 0NN, London, UK", 
                "ES Cell and Transgenics Facility, Medical Research Council Clinical Sciences Centre, Imperial College London, Du Cane Road, W12 0NN, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Steel", 
            "givenName": "Jennifer H.", 
            "id": "sg:person.01042061752.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042061752.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Physiology I, Eberhard-Karls University Tuebingen, Wilhelmstr 56, D-72074, Tuebingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Shaqiu", 
            "id": "sg:person.015237773235.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015237773235.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, W12 0NN, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nautiyal", 
            "givenName": "Jaya", 
            "id": "sg:person.01171112016.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171112016.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "ES Cell and Transgenics Facility, Medical Research Council Clinical Sciences Centre, Imperial College London, Du Cane Road, W12 0NN, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Webster", 
            "givenName": "Zoe", 
            "id": "sg:person.0773064241.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773064241.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Women\u2019s Health, Eberhard-Karls University Tuebingen, Calwerstr 7, D-72076, Tuebingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brucker", 
            "givenName": "Sara Y.", 
            "id": "sg:person.01210274423.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210274423.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Women\u2019s Health, Eberhard-Karls University Tuebingen, Calwerstr 7, D-72076, Tuebingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wallwiener", 
            "givenName": "Diethelm", 
            "id": "sg:person.01355547357.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355547357.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Queen's University", 
              "id": "https://www.grid.ac/institutes/grid.410356.5", 
              "name": [
                "Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Anne Croy", 
            "givenName": "B.", 
            "id": "sg:person.014233174654.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014233174654.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospitals Coventry and Warwickshire NHS Trust", 
              "id": "https://www.grid.ac/institutes/grid.15628.38", 
              "name": [
                "Division of Biomedical Sciences, Warwick Medical School, CV2 2DX, Coventry, UK", 
                "Tommy\u2019s National Centre for Miscarriage Research, University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Rd, CV2 2DX, Coventry, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brosens", 
            "givenName": "Jan J.", 
            "id": "sg:person.01272265215.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272265215.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
              "id": "https://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Physiology I, Eberhard-Karls University Tuebingen, Wilhelmstr 56, D-72074, Tuebingen, Germany", 
                "Department of Molecular Medicine II, Heinrich Heine University D\u00fcsseldorf, Universit\u00e4tsstr 1, D-40225, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lang", 
            "givenName": "Florian", 
            "id": "sg:person.0616343200.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616343200.81"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1152/ajpcell.00034.2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000362700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molehr/2.2.77", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001463749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/humrep/deh849", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002632619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0052252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003341164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2007.05022.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003936332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/332364a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005395234", 
              "https://doi.org/10.1038/332364a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-2-48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006665514", 
              "https://doi.org/10.1186/1477-7827-2-48"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(02)09417-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007752483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m406577200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008516032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4614-4711-5_10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009155717", 
              "https://doi.org/10.1007/978-1-4614-4711-5_10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molehr/gat066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011255972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1103315108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012177345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-0-12-407870-3.00005-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012427549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0003-2697(87)90021-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013321498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-7-122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013867775", 
              "https://doi.org/10.1186/1477-7827-7-122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mam.2012.12.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013975492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2010.090403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014041713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/27094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016044529", 
              "https://doi.org/10.1038/27094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017372393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1502264112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017933597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2009.00818.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018064870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2009.00818.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018064870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018564964", 
              "https://doi.org/10.1038/nm.2498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molehr/4.6.595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018750167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/chan.24302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019048420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2006-0075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020132461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2015-1914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020427232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cbf.3069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021467900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep03894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021488332", 
              "https://doi.org/10.1038/srep03894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0739-7240(98)00036-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021633001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lfs.2010.09.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022453463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199906103402304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022554114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023151791", 
              "https://doi.org/10.1038/nrg1808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023151791", 
              "https://doi.org/10.1038/nrg1808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cphy.c110046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023187245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.164004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023346908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023407245", 
              "https://doi.org/10.1038/35036035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023407245", 
              "https://doi.org/10.1038/35036035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023407245", 
              "https://doi.org/10.1038/35036035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000227813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023956267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/381151a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024588930", 
              "https://doi.org/10.1038/381151a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/joe-09-0119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025433096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2010.05944.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026349195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/3-540-27147-3_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031412838", 
              "https://doi.org/10.1007/3-540-27147-3_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/ecp.10.23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032419191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0082180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035430271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000066963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036086509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2008.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038352413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2008.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038352413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bc20100152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038413745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2012.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038457988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000341448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039730516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0609-669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040600604", 
              "https://doi.org/10.1038/ncb0609-669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m010783200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040700808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cellbio.19.041603.094522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041445840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1523410113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041732680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m201793200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043267924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000343353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043576934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045139557", 
              "https://doi.org/10.1038/nrm1155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045139557", 
              "https://doi.org/10.1038/nrm1155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2771", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046526214", 
              "https://doi.org/10.1038/nm.2771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000322327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046806324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2011.05.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047759973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000356667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049842534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2015.03.120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050060032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.00020.2014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050239622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000354472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051334858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002329900186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051343574", 
              "https://doi.org/10.1007/s002329900186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0010287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051563650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2004.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051573576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcdb.2007.10.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052459516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000356664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053007285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-2000-12565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057401889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.281.5381.1309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062562276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1064244146", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2005-0684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064247549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2009-1081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064250237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo.140.10.7070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064282710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.2014-1045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064286079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.85.7.2526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064301473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jcem.85.7.6674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064323604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/rep-09-0271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067717244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/e380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070917856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.14.4984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071360761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078026006", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1401875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079174740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.1997.77.4.901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083167275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.1998.78.1.247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083208642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.1998.274.1.f1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083209297"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-02", 
        "datePublishedReg": "2018-02-01", 
        "description": "Early embryo development and endometrial differentiation are initially independent processes, and synchronization, imposed by a limited window of implantation, is critical for reproductive success. A putative negative regulator of endometrial receptivity is LEFTY2, a member of the transforming growth factor (TGF)-\u03b2 family. LEFTY2 is highly expressed in decidualizing human endometrial stromal cells (HESCs) during the late luteal phase of the menstrual cycle, coinciding with the closure of the window of implantation. Here, we show that flushing of the uterine lumen in mice with recombinant LEFTY2 inhibits the expression of key receptivity genes, including Cox2, Bmp2, and Wnt4, and blocks embryo implantation. In Ishikawa cells, a human endometrial epithelial cell line, LEFTY2 downregulated the expression of calcium release-activated calcium channel protein 1, encoded by ORAI1, and inhibited store-operated Ca2+ entry (SOCE). Furthermore, LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, as well as YM-58483, inhibited, whereas the Ca2+ ionophore, ionomycin, strongly upregulated COX2, BMP2 and WNT4 expression in decidualizing HESCs. These findings suggest that LEFTY2 closes the implantation window, at least in part, by downregulating Orai1, which in turn limits SOCE and antagonizes expression of Ca2+-sensitive receptivity genes.\nKEY MESSAGES: \u2022Endometrial receptivity is negatively regulated by LEFTY2. \u2022LEFTY2 inhibits the expression of key murine receptivity genes, including Cox2, Bmp2 and Wnt4, and blocks embryo implantation. \u2022LEFTY2 downregulates the expression of Orai1 and inhibits SOCE. \u2022LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, and YM-58483 inhibit COX2, BMP2, and WNT4 expression in endometrial cells. \u2022Targeting LEFTY2 and Orai1 may represent a novel approach for treating unexplained infertility.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00109-017-1610-9", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1057918", 
            "issn": [
              "0946-2716", 
              "1432-1440"
            ], 
            "name": "Journal of Molecular Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "96"
          }
        ], 
        "name": "LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry", 
        "pagination": "173-182", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a2a08c3bf8fbb94645f1d1c345a14c78bd518fea655796d581efc99ede01929b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29230527"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9504370"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00109-017-1610-9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1099699835"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00109-017-1610-9", 
          "https://app.dimensions.ai/details/publication/pub.1099699835"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:22", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000603.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s00109-017-1610-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00109-017-1610-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00109-017-1610-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00109-017-1610-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00109-017-1610-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    448 TRIPLES      21 PREDICATES      112 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00109-017-1610-9 schema:about anzsrc-for:11
    2 anzsrc-for:1114
    3 schema:author N4f20094813444e08bc5baafd71876544
    4 schema:citation sg:pub.10.1007/3-540-27147-3_8
    5 sg:pub.10.1007/978-1-4614-4711-5_10
    6 sg:pub.10.1007/s002329900186
    7 sg:pub.10.1038/27094
    8 sg:pub.10.1038/332364a0
    9 sg:pub.10.1038/35036035
    10 sg:pub.10.1038/381151a0
    11 sg:pub.10.1038/ncb0609-669
    12 sg:pub.10.1038/nm.2498
    13 sg:pub.10.1038/nm.2771
    14 sg:pub.10.1038/nrg1808
    15 sg:pub.10.1038/nrm1155
    16 sg:pub.10.1038/srep03894
    17 sg:pub.10.1186/1477-7827-2-48
    18 sg:pub.10.1186/1477-7827-7-122
    19 https://app.dimensions.ai/details/publication/pub.1064244146
    20 https://app.dimensions.ai/details/publication/pub.1078026006
    21 https://doi.org/10.1002/cbf.3069
    22 https://doi.org/10.1002/cphy.c110046
    23 https://doi.org/10.1016/0003-2697(87)90021-2
    24 https://doi.org/10.1016/b978-0-12-407870-3.00005-6
    25 https://doi.org/10.1016/j.bbamcr.2004.09.001
    26 https://doi.org/10.1016/j.bbrc.2015.03.120
    27 https://doi.org/10.1016/j.ceca.2011.05.015
    28 https://doi.org/10.1016/j.ceca.2012.05.005
    29 https://doi.org/10.1016/j.lfs.2010.09.013
    30 https://doi.org/10.1016/j.mam.2012.12.011
    31 https://doi.org/10.1016/j.semcdb.2007.10.007
    32 https://doi.org/10.1016/j.ymeth.2008.09.009
    33 https://doi.org/10.1016/s0140-6736(02)09417-5
    34 https://doi.org/10.1016/s0739-7240(98)00036-8
    35 https://doi.org/10.1042/bc20100152
    36 https://doi.org/10.1055/s-2000-12565
    37 https://doi.org/10.1056/nejm199906103402304
    38 https://doi.org/10.1073/pnas.1103315108
    39 https://doi.org/10.1073/pnas.1502264112
    40 https://doi.org/10.1073/pnas.1523410113
    41 https://doi.org/10.1074/jbc.m010783200
    42 https://doi.org/10.1074/jbc.m201793200
    43 https://doi.org/10.1074/jbc.m406577200
    44 https://doi.org/10.1093/humrep/deh849
    45 https://doi.org/10.1093/molehr/2.2.77
    46 https://doi.org/10.1093/molehr/4.6.595
    47 https://doi.org/10.1093/molehr/gat066
    48 https://doi.org/10.1111/j.1471-4159.2007.05022.x
    49 https://doi.org/10.1111/j.1600-065x.2009.00818.x
    50 https://doi.org/10.1111/j.1749-6632.2010.05944.x
    51 https://doi.org/10.1126/science.281.5381.1309
    52 https://doi.org/10.1146/annurev.cellbio.19.041603.094522
    53 https://doi.org/10.1152/ajpcell.00034.2016
    54 https://doi.org/10.1152/ajprenal.1998.274.1.f1
    55 https://doi.org/10.1152/physrev.00020.2014
    56 https://doi.org/10.1152/physrev.1997.77.4.901
    57 https://doi.org/10.1152/physrev.1998.78.1.247
    58 https://doi.org/10.1159/000066963
    59 https://doi.org/10.1159/000227813
    60 https://doi.org/10.1159/000322327
    61 https://doi.org/10.1159/000341448
    62 https://doi.org/10.1159/000343353
    63 https://doi.org/10.1159/000354472
    64 https://doi.org/10.1159/000356664
    65 https://doi.org/10.1159/000356667
    66 https://doi.org/10.1172/jci119415
    67 https://doi.org/10.1210/en.2005-0684
    68 https://doi.org/10.1210/en.2009-1081
    69 https://doi.org/10.1210/en.2015-1914
    70 https://doi.org/10.1210/endo.140.10.7070
    71 https://doi.org/10.1210/er.2014-1045
    72 https://doi.org/10.1210/jc.85.7.2526
    73 https://doi.org/10.1210/jcem.85.7.6674
    74 https://doi.org/10.1242/jcs.164004
    75 https://doi.org/10.1371/journal.pone.0010287
    76 https://doi.org/10.1371/journal.pone.0052252
    77 https://doi.org/10.1371/journal.pone.0082180
    78 https://doi.org/10.1530/rep-09-0271
    79 https://doi.org/10.1586/ecp.10.23
    80 https://doi.org/10.1634/stemcells.2006-0075
    81 https://doi.org/10.1677/joe-09-0119
    82 https://doi.org/10.2353/ajpath.2010.090403
    83 https://doi.org/10.2741/e380
    84 https://doi.org/10.3748/wjg.14.4984
    85 https://doi.org/10.4049/jimmunol.1401875
    86 https://doi.org/10.4161/chan.24302
    87 schema:datePublished 2018-02
    88 schema:datePublishedReg 2018-02-01
    89 schema:description Early embryo development and endometrial differentiation are initially independent processes, and synchronization, imposed by a limited window of implantation, is critical for reproductive success. A putative negative regulator of endometrial receptivity is LEFTY2, a member of the transforming growth factor (TGF)-β family. LEFTY2 is highly expressed in decidualizing human endometrial stromal cells (HESCs) during the late luteal phase of the menstrual cycle, coinciding with the closure of the window of implantation. Here, we show that flushing of the uterine lumen in mice with recombinant LEFTY2 inhibits the expression of key receptivity genes, including Cox2, Bmp2, and Wnt4, and blocks embryo implantation. In Ishikawa cells, a human endometrial epithelial cell line, LEFTY2 downregulated the expression of calcium release-activated calcium channel protein 1, encoded by ORAI1, and inhibited store-operated Ca2+ entry (SOCE). Furthermore, LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, as well as YM-58483, inhibited, whereas the Ca2+ ionophore, ionomycin, strongly upregulated COX2, BMP2 and WNT4 expression in decidualizing HESCs. These findings suggest that LEFTY2 closes the implantation window, at least in part, by downregulating Orai1, which in turn limits SOCE and antagonizes expression of Ca2+-sensitive receptivity genes. KEY MESSAGES: •Endometrial receptivity is negatively regulated by LEFTY2. •LEFTY2 inhibits the expression of key murine receptivity genes, including Cox2, Bmp2 and Wnt4, and blocks embryo implantation. •LEFTY2 downregulates the expression of Orai1 and inhibits SOCE. •LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, and YM-58483 inhibit COX2, BMP2, and WNT4 expression in endometrial cells. •Targeting LEFTY2 and Orai1 may represent a novel approach for treating unexplained infertility.
    90 schema:genre research_article
    91 schema:inLanguage en
    92 schema:isAccessibleForFree true
    93 schema:isPartOf N84a405cf87034ee6aff163cb024cdad1
    94 N9307b6520ad54355b967797c6d4715ae
    95 sg:journal.1057918
    96 schema:name LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry
    97 schema:pagination 173-182
    98 schema:productId Nccbf1462afa04f40ad2a4ff27ad26d5b
    99 Nd392fe5761a44caa862a5074d4f28c2d
    100 Nec62e3096c554280863a8534c2b40ab1
    101 Nf139715932a24ac68cd072f9c78e7785
    102 Nf360ae4f12fb474282d428e60cbe9e10
    103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099699835
    104 https://doi.org/10.1007/s00109-017-1610-9
    105 schema:sdDatePublished 2019-04-11T01:22
    106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    107 schema:sdPublisher Ndc49125cdd8b43f2af7c0605aa8d40d6
    108 schema:url http://link.springer.com/10.1007/s00109-017-1610-9
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset articles
    111 rdf:type schema:ScholarlyArticle
    112 N1cd16682174b4045bdbcef3dc7386185 rdf:first sg:person.01173764167.14
    113 rdf:rest N78f90c9479fb4d80bd8b8d84668202c5
    114 N229a6cd800f94d5591b5aafa33cfda59 rdf:first sg:person.01355547357.45
    115 rdf:rest N4746174098a44554a8ff79d23663347b
    116 N2d7fa903f51447d2bd11b81bd038985c rdf:first sg:person.01171112016.15
    117 rdf:rest Nf65e802b0be94be39ed82b79bbf90297
    118 N3a22fa46c92b46ad97e70102ff0921c6 rdf:first sg:person.01272265215.99
    119 rdf:rest N68842858fef44dd380819fe63d07ae19
    120 N4746174098a44554a8ff79d23663347b rdf:first sg:person.014233174654.69
    121 rdf:rest N3a22fa46c92b46ad97e70102ff0921c6
    122 N4e8ff62a145b476b8bedc98f66df3c87 rdf:first sg:person.01210274423.03
    123 rdf:rest N229a6cd800f94d5591b5aafa33cfda59
    124 N4f20094813444e08bc5baafd71876544 rdf:first sg:person.01350603674.18
    125 rdf:rest N1cd16682174b4045bdbcef3dc7386185
    126 N5edf94f1f9e141148545447c50c40eec rdf:first sg:person.01042061752.36
    127 rdf:rest N6cc406fda11f430582d59057378aad9d
    128 N68842858fef44dd380819fe63d07ae19 rdf:first sg:person.0616343200.81
    129 rdf:rest rdf:nil
    130 N6cc406fda11f430582d59057378aad9d rdf:first sg:person.015237773235.29
    131 rdf:rest N2d7fa903f51447d2bd11b81bd038985c
    132 N78f90c9479fb4d80bd8b8d84668202c5 rdf:first sg:person.016065732143.33
    133 rdf:rest Ndbb092006c9248f791bc70753102e92b
    134 N82ca67f2fe5947d6bd4b82d1bf6a3220 rdf:first Na76a75ac816f4442b766b31adc29dd30
    135 rdf:rest Nc3f2d096db224fef979f562766a3ab28
    136 N84a405cf87034ee6aff163cb024cdad1 schema:volumeNumber 96
    137 rdf:type schema:PublicationVolume
    138 N9307b6520ad54355b967797c6d4715ae schema:issueNumber 2
    139 rdf:type schema:PublicationIssue
    140 Na76a75ac816f4442b766b31adc29dd30 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    141 schema:familyName Alauddin
    142 schema:givenName Md
    143 rdf:type schema:Person
    144 Nc3f2d096db224fef979f562766a3ab28 rdf:first sg:person.014030545175.81
    145 rdf:rest N5edf94f1f9e141148545447c50c40eec
    146 Nccbf1462afa04f40ad2a4ff27ad26d5b schema:name doi
    147 schema:value 10.1007/s00109-017-1610-9
    148 rdf:type schema:PropertyValue
    149 Nd392fe5761a44caa862a5074d4f28c2d schema:name readcube_id
    150 schema:value a2a08c3bf8fbb94645f1d1c345a14c78bd518fea655796d581efc99ede01929b
    151 rdf:type schema:PropertyValue
    152 Ndbb092006c9248f791bc70753102e92b rdf:first sg:person.01150313530.09
    153 rdf:rest N82ca67f2fe5947d6bd4b82d1bf6a3220
    154 Ndc49125cdd8b43f2af7c0605aa8d40d6 schema:name Springer Nature - SN SciGraph project
    155 rdf:type schema:Organization
    156 Nec62e3096c554280863a8534c2b40ab1 schema:name nlm_unique_id
    157 schema:value 9504370
    158 rdf:type schema:PropertyValue
    159 Nf139715932a24ac68cd072f9c78e7785 schema:name pubmed_id
    160 schema:value 29230527
    161 rdf:type schema:PropertyValue
    162 Nf360ae4f12fb474282d428e60cbe9e10 schema:name dimensions_id
    163 schema:value pub.1099699835
    164 rdf:type schema:PropertyValue
    165 Nf65e802b0be94be39ed82b79bbf90297 rdf:first sg:person.0773064241.33
    166 rdf:rest N4e8ff62a145b476b8bedc98f66df3c87
    167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Medical and Health Sciences
    169 rdf:type schema:DefinedTerm
    170 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Paediatrics and Reproductive Medicine
    172 rdf:type schema:DefinedTerm
    173 sg:journal.1057918 schema:issn 0946-2716
    174 1432-1440
    175 schema:name Journal of Molecular Medicine
    176 rdf:type schema:Periodical
    177 sg:person.01042061752.36 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    178 schema:familyName Steel
    179 schema:givenName Jennifer H.
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042061752.36
    181 rdf:type schema:Person
    182 sg:person.01150313530.09 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    183 schema:familyName Yan
    184 schema:givenName Jing
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150313530.09
    186 rdf:type schema:Person
    187 sg:person.01171112016.15 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    188 schema:familyName Nautiyal
    189 schema:givenName Jaya
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171112016.15
    191 rdf:type schema:Person
    192 sg:person.01173764167.14 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    193 schema:familyName Singh
    194 schema:givenName Yogesh
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173764167.14
    196 rdf:type schema:Person
    197 sg:person.01210274423.03 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    198 schema:familyName Brucker
    199 schema:givenName Sara Y.
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210274423.03
    201 rdf:type schema:Person
    202 sg:person.01272265215.99 schema:affiliation https://www.grid.ac/institutes/grid.15628.38
    203 schema:familyName Brosens
    204 schema:givenName Jan J.
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272265215.99
    206 rdf:type schema:Person
    207 sg:person.01350603674.18 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    208 schema:familyName Salker
    209 schema:givenName Madhuri S.
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350603674.18
    211 rdf:type schema:Person
    212 sg:person.01355547357.45 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    213 schema:familyName Wallwiener
    214 schema:givenName Diethelm
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355547357.45
    216 rdf:type schema:Person
    217 sg:person.014030545175.81 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    218 schema:familyName Zeng
    219 schema:givenName Ni
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014030545175.81
    221 rdf:type schema:Person
    222 sg:person.014233174654.69 schema:affiliation https://www.grid.ac/institutes/grid.410356.5
    223 schema:familyName Anne Croy
    224 schema:givenName B.
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014233174654.69
    226 rdf:type schema:Person
    227 sg:person.015237773235.29 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    228 schema:familyName Zhang
    229 schema:givenName Shaqiu
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015237773235.29
    231 rdf:type schema:Person
    232 sg:person.016065732143.33 schema:affiliation https://www.grid.ac/institutes/grid.7372.1
    233 schema:familyName Durairaj
    234 schema:givenName Ruban R. Peter
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016065732143.33
    236 rdf:type schema:Person
    237 sg:person.0616343200.81 schema:affiliation https://www.grid.ac/institutes/grid.411327.2
    238 schema:familyName Lang
    239 schema:givenName Florian
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616343200.81
    241 rdf:type schema:Person
    242 sg:person.0773064241.33 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    243 schema:familyName Webster
    244 schema:givenName Zoe
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773064241.33
    246 rdf:type schema:Person
    247 sg:pub.10.1007/3-540-27147-3_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031412838
    248 https://doi.org/10.1007/3-540-27147-3_8
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1007/978-1-4614-4711-5_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009155717
    251 https://doi.org/10.1007/978-1-4614-4711-5_10
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1007/s002329900186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051343574
    254 https://doi.org/10.1007/s002329900186
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/27094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016044529
    257 https://doi.org/10.1038/27094
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/332364a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005395234
    260 https://doi.org/10.1038/332364a0
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/35036035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023407245
    263 https://doi.org/10.1038/35036035
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/381151a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024588930
    266 https://doi.org/10.1038/381151a0
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/ncb0609-669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040600604
    269 https://doi.org/10.1038/ncb0609-669
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nm.2498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018564964
    272 https://doi.org/10.1038/nm.2498
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nm.2771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046526214
    275 https://doi.org/10.1038/nm.2771
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nrg1808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023151791
    278 https://doi.org/10.1038/nrg1808
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nrm1155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045139557
    281 https://doi.org/10.1038/nrm1155
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/srep03894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021488332
    284 https://doi.org/10.1038/srep03894
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1186/1477-7827-2-48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006665514
    287 https://doi.org/10.1186/1477-7827-2-48
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1186/1477-7827-7-122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013867775
    290 https://doi.org/10.1186/1477-7827-7-122
    291 rdf:type schema:CreativeWork
    292 https://app.dimensions.ai/details/publication/pub.1064244146 schema:CreativeWork
    293 https://app.dimensions.ai/details/publication/pub.1078026006 schema:CreativeWork
    294 https://doi.org/10.1002/cbf.3069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021467900
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1002/cphy.c110046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023187245
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/0003-2697(87)90021-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013321498
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/b978-0-12-407870-3.00005-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012427549
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.bbamcr.2004.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051573576
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/j.bbrc.2015.03.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050060032
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/j.ceca.2011.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047759973
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/j.ceca.2012.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038457988
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/j.lfs.2010.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022453463
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.mam.2012.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013975492
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.semcdb.2007.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052459516
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.ymeth.2008.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038352413
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/s0140-6736(02)09417-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007752483
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/s0739-7240(98)00036-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021633001
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1042/bc20100152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038413745
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1055/s-2000-12565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057401889
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1056/nejm199906103402304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022554114
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1073/pnas.1103315108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012177345
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1073/pnas.1502264112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017933597
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1073/pnas.1523410113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041732680
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1074/jbc.m010783200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040700808
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1074/jbc.m201793200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043267924
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1074/jbc.m406577200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008516032
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1093/humrep/deh849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002632619
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1093/molehr/2.2.77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001463749
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1093/molehr/4.6.595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018750167
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1093/molehr/gat066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011255972
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1111/j.1471-4159.2007.05022.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003936332
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1111/j.1600-065x.2009.00818.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018064870
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1111/j.1749-6632.2010.05944.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026349195
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1126/science.281.5381.1309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562276
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1146/annurev.cellbio.19.041603.094522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041445840
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1152/ajpcell.00034.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000362700
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1152/ajprenal.1998.274.1.f1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083209297
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1152/physrev.00020.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050239622
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1152/physrev.1997.77.4.901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083167275
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1152/physrev.1998.78.1.247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083208642
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1159/000066963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036086509
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1159/000227813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023956267
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1159/000322327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046806324
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1159/000341448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039730516
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1159/000343353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043576934
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1159/000354472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051334858
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1159/000356664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053007285
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1159/000356667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049842534
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1172/jci119415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017372393
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1210/en.2005-0684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247549
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1210/en.2009-1081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064250237
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1210/en.2015-1914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020427232
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1210/endo.140.10.7070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064282710
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1210/er.2014-1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286079
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1210/jc.85.7.2526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064301473
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1210/jcem.85.7.6674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064323604
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1242/jcs.164004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023346908
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1371/journal.pone.0010287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051563650
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1371/journal.pone.0052252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003341164
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1371/journal.pone.0082180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035430271
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1530/rep-09-0271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067717244
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1586/ecp.10.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032419191
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1634/stemcells.2006-0075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020132461
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1677/joe-09-0119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025433096
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.2353/ajpath.2010.090403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014041713
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.2741/e380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070917856
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.3748/wjg.14.4984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071360761
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.4049/jimmunol.1401875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079174740
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.4161/chan.24302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019048420
    425 rdf:type schema:CreativeWork
    426 https://www.grid.ac/institutes/grid.10392.39 schema:alternateName University of Tübingen
    427 schema:name Department of Medical Genetics and Applied Genomics, Eberhard-Karls University Tuebingen, Calwerstr 7, D-72076, Tübingen, Germany
    428 Department of Physiology I, Eberhard-Karls University Tuebingen, Wilhelmstr 56, D-72074, Tuebingen, Germany
    429 Department of Women’s Health, Eberhard-Karls University Tuebingen, Calwerstr 7, D-72076, Tuebingen, Germany
    430 rdf:type schema:Organization
    431 https://www.grid.ac/institutes/grid.15628.38 schema:alternateName University Hospitals Coventry and Warwickshire NHS Trust
    432 schema:name Division of Biomedical Sciences, Warwick Medical School, CV2 2DX, Coventry, UK
    433 Tommy’s National Centre for Miscarriage Research, University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Rd, CV2 2DX, Coventry, UK
    434 rdf:type schema:Organization
    435 https://www.grid.ac/institutes/grid.410356.5 schema:alternateName Queen's University
    436 schema:name Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
    437 rdf:type schema:Organization
    438 https://www.grid.ac/institutes/grid.411327.2 schema:alternateName Heinrich Heine University Düsseldorf
    439 schema:name Department of Molecular Medicine II, Heinrich Heine University Düsseldorf, Universitätsstr 1, D-40225, Düsseldorf, Germany
    440 Department of Physiology I, Eberhard-Karls University Tuebingen, Wilhelmstr 56, D-72074, Tuebingen, Germany
    441 rdf:type schema:Organization
    442 https://www.grid.ac/institutes/grid.7372.1 schema:alternateName University of Warwick
    443 schema:name Division of Biomedical Sciences, Warwick Medical School, CV2 2DX, Coventry, UK
    444 rdf:type schema:Organization
    445 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
    446 schema:name Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, W12 0NN, London, UK
    447 ES Cell and Transgenics Facility, Medical Research Council Clinical Sciences Centre, Imperial College London, Du Cane Road, W12 0NN, London, UK
    448 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...