Ubiquitous points of control over regulatory T cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-06

AUTHORS

Fan Pan, Joseph Barbi

ABSTRACT

Posttranslational modification by ubiquitin tagging is crucial for regulating the stability, activity and cellular localization of many target proteins involved in processes including DNA repair, cell cycle progression, protein quality control, and signal transduction. It has long been appreciated that ubiquitin-mediated events are important for certain signaling pathways leading to leukocyte activation and the stimulation of effector function. Now it is clear that the activities of molecules and pathways central to immune regulation are also modified and controlled by ubiquitin tagging. Among the mechanisms of immune control, regulatory T cells (or Tregs) are themselves particularly sensitive to such regulation. E3 ligases and deubiquitinases both influence Tregs through their effects on the signaling pathways pertinent to these cells or through the direct, posttranslational regulation of Foxp3. In this review, we will summarize and discuss several examples of ubiquitin-mediated control over multiple aspects of Treg biology including the generation, function and phenotypic fidelity of these cells. Fully explored and exploited, these potential opportunities for Treg modulation may lead to novel immunotherapies for both positive and negative fine-tuning of immune restraint. More... »

PAGES

555-569

References to SciGraph publications

  • 2006-05. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells in NATURE
  • 2009-06. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation in NATURE IMMUNOLOGY
  • 2013-02. Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells in NATURE IMMUNOLOGY
  • 2000-01. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b in NATURE
  • 2008-03. The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1 in NATURE IMMUNOLOGY
  • 2008-07. How regulatory T cells work in NATURE REVIEWS IMMUNOLOGY
  • 2010-02-11. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate in NATURE
  • 2013-06. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways in NATURE IMMUNOLOGY
  • 2009-08. Breaking the chains: structure and function of the deubiquitinases in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2011-10. The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity in NATURE IMMUNOLOGY
  • 2001-09. Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells in NATURE IMMUNOLOGY
  • 2004-05. Persistent Toll-like receptor signals are required for reversal of regulatory T cell–mediated CD8 tolerance in NATURE IMMUNOLOGY
  • 2010-07. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells in NATURE IMMUNOLOGY
  • 2007. Characteristics and Biological Functions of TRAF6 in TNF RECEPTOR ASSOCIATED FACTORS (TRAFS)
  • 2014-01. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis in NATURE MEDICINE
  • 2013-09. Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis in NATURE
  • 2013-12. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation in NATURE
  • 2012-05. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells in NATURE IMMUNOLOGY
  • 2013-03. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis in NATURE MEDICINE
  • 2007-03. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 in NATURE IMMUNOLOGY
  • 2009-07. The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR in NATURE IMMUNOLOGY
  • 2012-01. CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt in NATURE COMMUNICATIONS
  • 2012-08. Aiolos promotes TH17 differentiation by directly silencing Il2 expression in NATURE IMMUNOLOGY
  • 2012-02. Extrathymically generated regulatory T cells control mucosal TH2 inflammation in NATURE
  • 2012-10. A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells in NATURE IMMUNOLOGY
  • 2009-03. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses in NATURE
  • 2009-09. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo in NATURE IMMUNOLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00109-014-1156-z

    DOI

    http://dx.doi.org/10.1007/s00109-014-1156-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020790654

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24777637


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