Aberrant epigenetic regulation of bromodomain Brd4 in human colon cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05

AUTHORS

R. M. Rodriguez, C. Huidobro, R. G. Urdinguio, C. Mangas, B. Soldevilla, G. Domínguez, F. Bonilla, A. F. Fernandez, M. F. Fraga

ABSTRACT

The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human colon cancer cell lines and primary tumors. Ectopic re-expression of BRD4 in these colon cancer cell lines markedly reduced in vivo tumor growth, suggesting a role of BRD4 in human colon cancer. More... »

PAGES

587-595

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00109-011-0837-0

DOI

http://dx.doi.org/10.1007/s00109-011-0837-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015571426

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22120039


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