Annexin 1 mimetic peptide protects against renal ischemia/reperfusion injury in rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-01

AUTHORS

Fernando N. Facio, Angela A. Sena, Leandro P. Araújo, Gloria E. Mendes, Isac Castro, Marcus A. M. Luz, Luis Yu, Sonia Maria Oliani, Emmanuel A. Burdmann

ABSTRACT

Inflammation is currently recognized as a key mechanism in the pathogenesis of renal ischemia-reperfusion (I/R) injury. The importance of infiltrating neutrophil, lymphocytes, and macrophage in this kind of injury has been assessed with conflicting results. Annexin 1 is a protein with potent neutrophil anti-migratory activity. In order to evaluate the effects of annexin A1 on renal I/R injury, uninephrectomized rats received annexin A1 mimetic peptide Ac2-26 (100 μg) or vehicle before 30 min of renal artery clamping and were compared to sham surgery animals. Annexin A1 mimetic peptide granted a remarkable protection against I/R injury, preventing glomerular filtration rate and urinary osmolality decreases and acute tubular necrosis development. Annexin A1 infusion aborted neutrophil extravasation and attenuated macrophage infiltration but did not prevent tissue lymphocyte traffic. I/R increased annexin A1 expression (assessed by transmission electron microscopy) in renal epithelial cells, which was attenuated by exogenous annexin A1 infusion. Additionally, annexin A1 reduced I/R injury in isolated proximal tubules suspension. Annexin A1 protein afforded striking functional and structural protection against renal I/R. These results point to an important role of annexin A1 in the epithelial cells defense against I/R injury and indicate that neutrophils are key mediators for the development of tissue injury after renal I/R. If these results were confirmed in clinical studies, annexin A1 might emerge as an important tool to protect against I/R injury in renal transplantation and in vascular surgery. More... »

PAGES

51-63

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00109-010-0684-4

DOI

http://dx.doi.org/10.1007/s00109-010-0684-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006996931

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20953576


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