New insights into the role of angiotensin-converting enzyme obtained from the analysis of genetically modified mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-04-29

AUTHORS

Xiao Z. Shen, Hong D. Xiao, Ping Li, Chentao X. Lin, Sandrine Billet, Derick Okwan-Duodu, Jon W. Adams, Ellen A. Bernstein, Yi Xu, Sebastien Fuchs, Kenneth E. Bernstein

ABSTRACT

Angiotensin-converting enzyme (ACE) has been well-recognized for its role in blood pressure regulation. ACE is made by many tissues, though it is most abundantly expressed on the luminal surface of vascular endothelium. ACE knockout mice show a profound phenotype with low blood pressure, but also with hemopoietic and developmental defects, which complicates understanding the biological functions of ACE in individual tissue types. Using a promoter-swapping strategy, several mouse lines with unique ACE tissue expression patterns were studied. These include mice with ACE expression in the liver (ACE 3/3), the heart (ACE 8/8), and macrophages (ACE 10/10). We also investigated mice with a selective inactivation of either the N- or C-terminal ACE catalytic domain. Our studies indicate that ACE plays a role in many other physiologic processes beyond simple blood pressure control. More... »

PAGES

679-684

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00109-008-0325-3

DOI

http://dx.doi.org/10.1007/s00109-008-0325-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022792161

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18443752


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