Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-04-12

AUTHORS

Ines Pagel-Langenickel, Jens Buttgereit, Michael Bader, Thomas H. Langenickel

ABSTRACT

Natriuretic peptides (NP) represent a family of structurally homologous but genetically distinct peptide hormones involved in regulation of fluid and electrolyte balance, blood pressure, fat metabolism, cell proliferation, and long bone growth. Recent work suggests a role for natriuretic peptide receptor B (NPR-B) signaling in regulation of cardiac growth by either a direct effect on cardiomyocytes or by modulation of other signaling pathways including the autonomic nervous system. The research links NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in cardiovascular physiology and disease and will evaluate these new findings in the context of the known function of this receptor, with a perspective on how future research might further elucidate NPR-B function. More... »

PAGES

797-810

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00109-007-0183-4

DOI

http://dx.doi.org/10.1007/s00109-007-0183-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039932240

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17429599


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