Inflammatory mediators and islet β-cell failure: a link between type 1 and type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-08

AUTHORS

Marc Y. Donath, Joachim Størling, Kathrin Maedler, Thomas Mandrup-Poulsen

ABSTRACT

Pancreatic islet beta-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute or relative insulin deficiency. beta-cell death in type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes beta-cell death occurs as the combined consequence of increased circulating glucose and saturated fatty acids together with adipocyte secreted factors and chronic activation of the innate immune system. In both diabetes types intra-islet inflammatory mediators seem to trigger a final common pathway leading to beta-cell apoptosis. Therefore anti-inflammatory therapeutic approaches designed to block beta-cell apoptosis could be a significant new development in type 1 and 2 diabetes. More... »

PAGES

455-470

References to SciGraph publications

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  • Journal

    TITLE

    Journal of Molecular Medicine

    ISSUE

    8

    VOLUME

    81

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00109-003-0450-y

    DOI

    http://dx.doi.org/10.1007/s00109-003-0450-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021422582

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12879149


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