Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-12

AUTHORS

Tarja A. Kunnas, Terho Lehtimäki, Reijo Laaksonen, Erkki Ilveskoski, Tuula Janatuinen, Risto Vesalainen, Pirjo Nuutila, Pekka J. Karhunen, Juhani Knuuti, Seppo T. Nikkari

ABSTRACT

The objective was to study whether coronary blood flow or its response to pravastatin are affected by genetic variation in the endothelial nitric oxide synthase (eNOS) gene. Vascular endothelial nitric oxide maintains endothelium-dependent vasodilatation and also mediates antithrombotic actions. Its formation is catalyzed by eNOS, a constitutive enzyme, which has a polymorphic site in intron 4 (4a/b). Some clinical studies have suggested an association of the rare a-allele of eNOS with coronary artery disease and myocardial infarction. We carried out a double-blind placebo-controlled study involving 43 men (aged 35+/-4 years), who were randomized to receive either 40 mg/day pravastatin ( n=21) or placebo ( n=22) for 6 months. Myocardial blood flow was measured by positron emission tomography (PET) using (15)O-labeled water. PET was performed at rest and after stimulation by adenosine infusion. PET and lipid analyses were carried out at baseline and after 6 months. eNOS genotyping was done by PCR. At baseline there were no differences in basal or adenosine-stimulated coronary blood flow between subjects with either eNOS bb or ba genotypes. At the end of the study genotypes reacted differently between pravastatin and placebo groups with respect to the change in adenosine-stimulated flow (ANCOVA P=0.008). More specifically, after pravastatin treatment the adenosine-stimulated flow increased by 54.5% in men with the eNOS ba genotype, whereas in the men with the bb genotype no significant change in flow was observed ( P=0.002 for ba versus bb). In the placebo group there were no significant changes in blood flow from the baseline values ( P=0.916 for ba versus bb). After pravastatin treatment both genotype groups showed a similar decrease in serum total cholesterol and low-density lipoprotein cholesterol ( P<0.00001 for both). Our results suggest that adenosine-stimulated myocardial perfusion improves after treatment with pravastatin in subjects with the eNOS ba genotype but not in those with the bb genotype. This effect is not dependent on the decrease of serum cholesterol. More... »

PAGES

802-807

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00109-002-0398-3

DOI

http://dx.doi.org/10.1007/s00109-002-0398-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020191122

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12483466


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticholesteremic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Circulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipid Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide Synthase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide Synthase Type III", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Placebos", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pravastatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Random Allocation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Emission-Computed", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Tampere", 
          "id": "https://www.grid.ac/institutes/grid.5509.9", 
          "name": [
            "Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kunnas", 
        "givenName": "Tarja A.", 
        "id": "sg:person.01072330432.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072330432.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tampere", 
          "id": "https://www.grid.ac/institutes/grid.5509.9", 
          "name": [
            "Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lehtim\u00e4ki", 
        "givenName": "Terho", 
        "id": "sg:person.0654341265.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654341265.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland", 
            "Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laaksonen", 
        "givenName": "Reijo", 
        "id": "sg:person.01276707545.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276707545.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tampere", 
          "id": "https://www.grid.ac/institutes/grid.5509.9", 
          "name": [
            "Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ilveskoski", 
        "givenName": "Erkki", 
        "id": "sg:person.0721225364.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721225364.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turku", 
          "id": "https://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Turku PET Center, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Janatuinen", 
        "givenName": "Tuula", 
        "id": "sg:person.0710420212.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710420212.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Turku PET Center, University of Turku, Turku, Finland", 
            "Department of Medicine, Turku University Central Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vesalainen", 
        "givenName": "Risto", 
        "id": "sg:person.01022516275.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022516275.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turku", 
          "id": "https://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Turku PET Center, University of Turku, Turku, Finland", 
            "Department of Internal Medicine, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nuutila", 
        "givenName": "Pirjo", 
        "id": "sg:person.0763376117.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763376117.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tampere", 
          "id": "https://www.grid.ac/institutes/grid.5509.9", 
          "name": [
            "Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karhunen", 
        "givenName": "Pekka J.", 
        "id": "sg:person.0713367624.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713367624.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turku", 
          "id": "https://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Turku PET Center, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knuuti", 
        "givenName": "Juhani", 
        "id": "sg:person.01163336756.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163336756.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tampere", 
          "id": "https://www.grid.ac/institutes/grid.5509.9", 
          "name": [
            "Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland", 
            "Department of Medical Biochemistry, University of Tampere Medical School, University of Tampere, 33014, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nikkari", 
        "givenName": "Seppo T.", 
        "id": "sg:person.014572011304.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014572011304.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/01.cir.90.2.808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002215803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(98)00222-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004095645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001090000124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006894710", 
          "https://doi.org/10.1007/s001090000124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.89.4.1530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007381324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.99.13.1678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008976298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.78.1.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011572434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-002-0365-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013853352", 
          "https://doi.org/10.1007/s00109-002-0365-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0196-41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015592412", 
          "https://doi.org/10.1038/nm0196-41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.82.5.1595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016329142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/heart.85.3.342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024005180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1399-6576.2000.440903.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025544563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.102.25.3104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029350752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(01)02090-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033629365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199312303292706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035952712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198610233151702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038104523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.116.4.880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041598295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.116.4.880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041598295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.99.22.2871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043530596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mgme.2000.3033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044341769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc4401.098293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045393683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(97)10806-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047276640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.97.12.1129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047904564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/003655100750044884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050191337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199502233320801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052364608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.103.1.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053228187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.32.3.521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053648920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043798-200108000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060301996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043798-200108000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060301996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043798-200108000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060301996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.17.11.3147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063334541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.47.2.248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070738320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.2000.279.6.h2649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074731268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.2001.280.2.f193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074768288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080284174", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082512558", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-12", 
    "datePublishedReg": "2002-12-01", 
    "description": "The objective was to study whether coronary blood flow or its response to pravastatin are affected by genetic variation in the endothelial nitric oxide synthase (eNOS) gene. Vascular endothelial nitric oxide maintains endothelium-dependent vasodilatation and also mediates antithrombotic actions. Its formation is catalyzed by eNOS, a constitutive enzyme, which has a polymorphic site in intron 4 (4a/b). Some clinical studies have suggested an association of the rare a-allele of eNOS with coronary artery disease and myocardial infarction. We carried out a double-blind placebo-controlled study involving 43 men (aged 35+/-4 years), who were randomized to receive either 40 mg/day pravastatin ( n=21) or placebo ( n=22) for 6 months. Myocardial blood flow was measured by positron emission tomography (PET) using (15)O-labeled water. PET was performed at rest and after stimulation by adenosine infusion. PET and lipid analyses were carried out at baseline and after 6 months. eNOS genotyping was done by PCR. At baseline there were no differences in basal or adenosine-stimulated coronary blood flow between subjects with either eNOS bb or ba genotypes. At the end of the study genotypes reacted differently between pravastatin and placebo groups with respect to the change in adenosine-stimulated flow (ANCOVA P=0.008). More specifically, after pravastatin treatment the adenosine-stimulated flow increased by 54.5% in men with the eNOS ba genotype, whereas in the men with the bb genotype no significant change in flow was observed ( P=0.002 for ba versus bb). In the placebo group there were no significant changes in blood flow from the baseline values ( P=0.916 for ba versus bb). After pravastatin treatment both genotype groups showed a similar decrease in serum total cholesterol and low-density lipoprotein cholesterol ( P<0.00001 for both). Our results suggest that adenosine-stimulated myocardial perfusion improves after treatment with pravastatin in subjects with the eNOS ba genotype but not in those with the bb genotype. This effect is not dependent on the decrease of serum cholesterol.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00109-002-0398-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1057918", 
        "issn": [
          "0946-2716", 
          "1432-1440"
        ], 
        "name": "Journal of Molecular Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "80"
      }
    ], 
    "name": "Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study", 
    "pagination": "802-807", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "60340a49d22091502177a07f117f6b761b699acb63512f5f06836153cffa9d96"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12483466"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9504370"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00109-002-0398-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020191122"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00109-002-0398-3", 
      "https://app.dimensions.ai/details/publication/pub.1020191122"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00109-002-0398-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00109-002-0398-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00109-002-0398-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00109-002-0398-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00109-002-0398-3'


 

This table displays all metadata directly associated to this object as RDF triples.

318 TRIPLES      21 PREDICATES      80 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00109-002-0398-3 schema:about N042cc3d41a974ba58e5645f6e0fdaf0c
2 N05f62f65e28341d9ab621cc85e77e405
3 N24961321955541d4b54e1f999befe412
4 N313c545713a2493da27b3b502ba78b83
5 N36b426db604c4dcc971d85e6eeaea623
6 N3bf95c7be363424d9b47c4c7c1221fd4
7 N46da1853cad041ee9df14b375a86a7d0
8 N50392b3aaad140e397bac3e50ac3e61d
9 N5988523ca57f4008a0a791cfaa47f24a
10 N932c32137da14bf68b47207ce7fbcb44
11 Naedb44c8ae14414590f27af3ebcb57db
12 Nb5678b1de34747e390e07df0a53c2bf1
13 Nb74c22b09c694711a028a6e75866c264
14 Nbd1590aec75240a59372d3827c84dc07
15 Ncd827a880402497fb9d57a696d95b218
16 Nce67fd1f9fe246a9a254ede2e572cdd7
17 Ndff7c626a24547b38afb9d6f326c4540
18 Ne0ece20f1fec45e4bfff44cac5741536
19 Nf040fb6f4d664d649a6a0c08084a3950
20 anzsrc-for:11
21 anzsrc-for:1102
22 schema:author Nb2c0c842332e4e1b93a95e06fd435a74
23 schema:citation sg:pub.10.1007/s00109-002-0365-z
24 sg:pub.10.1007/s001090000124
25 sg:pub.10.1038/nm0196-41
26 https://app.dimensions.ai/details/publication/pub.1080284174
27 https://app.dimensions.ai/details/publication/pub.1082512558
28 https://doi.org/10.1006/mgme.2000.3033
29 https://doi.org/10.1016/s0002-9149(01)02090-2
30 https://doi.org/10.1016/s0002-9149(97)10806-2
31 https://doi.org/10.1016/s0735-1097(98)00222-8
32 https://doi.org/10.1034/j.1399-6576.2000.440903.x
33 https://doi.org/10.1056/nejm198610233151702
34 https://doi.org/10.1056/nejm199312303292706
35 https://doi.org/10.1056/nejm199502233320801
36 https://doi.org/10.1080/003655100750044884
37 https://doi.org/10.1097/00043798-200108000-00008
38 https://doi.org/10.1136/heart.85.3.342
39 https://doi.org/10.1152/ajpheart.2000.279.6.h2649
40 https://doi.org/10.1152/ajprenal.2001.280.2.f193
41 https://doi.org/10.1161/01.atv.17.11.3147
42 https://doi.org/10.1161/01.cir.102.25.3104
43 https://doi.org/10.1161/01.cir.103.1.113
44 https://doi.org/10.1161/01.cir.78.1.104
45 https://doi.org/10.1161/01.cir.82.5.1595
46 https://doi.org/10.1161/01.cir.89.4.1530
47 https://doi.org/10.1161/01.cir.90.2.808
48 https://doi.org/10.1161/01.cir.97.12.1129
49 https://doi.org/10.1161/01.cir.99.13.1678
50 https://doi.org/10.1161/01.cir.99.22.2871
51 https://doi.org/10.1161/01.hyp.32.3.521
52 https://doi.org/10.1161/hc4401.098293
53 https://doi.org/10.1378/chest.116.4.880
54 https://doi.org/10.2337/diab.47.2.248
55 schema:datePublished 2002-12
56 schema:datePublishedReg 2002-12-01
57 schema:description The objective was to study whether coronary blood flow or its response to pravastatin are affected by genetic variation in the endothelial nitric oxide synthase (eNOS) gene. Vascular endothelial nitric oxide maintains endothelium-dependent vasodilatation and also mediates antithrombotic actions. Its formation is catalyzed by eNOS, a constitutive enzyme, which has a polymorphic site in intron 4 (4a/b). Some clinical studies have suggested an association of the rare a-allele of eNOS with coronary artery disease and myocardial infarction. We carried out a double-blind placebo-controlled study involving 43 men (aged 35+/-4 years), who were randomized to receive either 40 mg/day pravastatin ( n=21) or placebo ( n=22) for 6 months. Myocardial blood flow was measured by positron emission tomography (PET) using (15)O-labeled water. PET was performed at rest and after stimulation by adenosine infusion. PET and lipid analyses were carried out at baseline and after 6 months. eNOS genotyping was done by PCR. At baseline there were no differences in basal or adenosine-stimulated coronary blood flow between subjects with either eNOS bb or ba genotypes. At the end of the study genotypes reacted differently between pravastatin and placebo groups with respect to the change in adenosine-stimulated flow (ANCOVA P=0.008). More specifically, after pravastatin treatment the adenosine-stimulated flow increased by 54.5% in men with the eNOS ba genotype, whereas in the men with the bb genotype no significant change in flow was observed ( P=0.002 for ba versus bb). In the placebo group there were no significant changes in blood flow from the baseline values ( P=0.916 for ba versus bb). After pravastatin treatment both genotype groups showed a similar decrease in serum total cholesterol and low-density lipoprotein cholesterol ( P<0.00001 for both). Our results suggest that adenosine-stimulated myocardial perfusion improves after treatment with pravastatin in subjects with the eNOS ba genotype but not in those with the bb genotype. This effect is not dependent on the decrease of serum cholesterol.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree false
61 schema:isPartOf N2c9f2fca1d874a50bb0da58d074adcdb
62 N963d4ef1e2694a79acc0345a4519bd8a
63 sg:journal.1057918
64 schema:name Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study
65 schema:pagination 802-807
66 schema:productId N352844c3dd7040a4b02a5682dcc0baa1
67 N454933c3f5c54eb895fe438fb085ba2c
68 N6b7d0aad11a54eccb4428301d3368e79
69 N9a4ae6cad11048198d1a7fe9477745a8
70 Nd2bb5c3cb88e4128a05e6936276b8950
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020191122
72 https://doi.org/10.1007/s00109-002-0398-3
73 schema:sdDatePublished 2019-04-11T00:14
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N2359a24fdb8445deaf9a9466ffcb2ccc
76 schema:url http://link.springer.com/10.1007%2Fs00109-002-0398-3
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N042cc3d41a974ba58e5645f6e0fdaf0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Genotype
82 rdf:type schema:DefinedTerm
83 N05f62f65e28341d9ab621cc85e77e405 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Adult
85 rdf:type schema:DefinedTerm
86 N0922824466d540af92baf6324d722c9f rdf:first sg:person.01022516275.52
87 rdf:rest Nff00eb70386b4536979f7944779f680d
88 N1c7b06f8ddb64ef39dd3ae3e7ab1c48e rdf:first sg:person.01276707545.24
89 rdf:rest N1e28a01519ad4fe2bbe180f8d51bda14
90 N1e28a01519ad4fe2bbe180f8d51bda14 rdf:first sg:person.0721225364.61
91 rdf:rest Ne315e5e6bf3746e2b32674b64b7e8f5a
92 N2359a24fdb8445deaf9a9466ffcb2ccc schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 N24961321955541d4b54e1f999befe412 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Tomography, Emission-Computed
96 rdf:type schema:DefinedTerm
97 N2b23cc365217457184219f7d478c001b rdf:first sg:person.0713367624.09
98 rdf:rest N9e61d15e8cd74be5927c90217d4f4912
99 N2c9f2fca1d874a50bb0da58d074adcdb schema:issueNumber 12
100 rdf:type schema:PublicationIssue
101 N313c545713a2493da27b3b502ba78b83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Male
103 rdf:type schema:DefinedTerm
104 N352844c3dd7040a4b02a5682dcc0baa1 schema:name readcube_id
105 schema:value 60340a49d22091502177a07f117f6b761b699acb63512f5f06836153cffa9d96
106 rdf:type schema:PropertyValue
107 N36b426db604c4dcc971d85e6eeaea623 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name DNA
109 rdf:type schema:DefinedTerm
110 N3bf95c7be363424d9b47c4c7c1221fd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Lipid Metabolism
112 rdf:type schema:DefinedTerm
113 N454933c3f5c54eb895fe438fb085ba2c schema:name nlm_unique_id
114 schema:value 9504370
115 rdf:type schema:PropertyValue
116 N46da1853cad041ee9df14b375a86a7d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Myocardium
118 rdf:type schema:DefinedTerm
119 N50392b3aaad140e397bac3e50ac3e61d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Polymerase Chain Reaction
121 rdf:type schema:DefinedTerm
122 N5988523ca57f4008a0a791cfaa47f24a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Random Allocation
124 rdf:type schema:DefinedTerm
125 N6b7d0aad11a54eccb4428301d3368e79 schema:name doi
126 schema:value 10.1007/s00109-002-0398-3
127 rdf:type schema:PropertyValue
128 N76001ce2bfc442ba9a82346c855e2b07 rdf:first sg:person.0654341265.88
129 rdf:rest N1c7b06f8ddb64ef39dd3ae3e7ab1c48e
130 N932c32137da14bf68b47207ce7fbcb44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Anticholesteremic Agents
132 rdf:type schema:DefinedTerm
133 N963d4ef1e2694a79acc0345a4519bd8a schema:volumeNumber 80
134 rdf:type schema:PublicationVolume
135 N9a4ae6cad11048198d1a7fe9477745a8 schema:name pubmed_id
136 schema:value 12483466
137 rdf:type schema:PropertyValue
138 N9e61d15e8cd74be5927c90217d4f4912 rdf:first sg:person.01163336756.79
139 rdf:rest Ne2d31502a53a469fb2fac7b7af7e6164
140 Naedb44c8ae14414590f27af3ebcb57db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Nitric Oxide Synthase
142 rdf:type schema:DefinedTerm
143 Nb2c0c842332e4e1b93a95e06fd435a74 rdf:first sg:person.01072330432.33
144 rdf:rest N76001ce2bfc442ba9a82346c855e2b07
145 Nb5678b1de34747e390e07df0a53c2bf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Placebos
147 rdf:type schema:DefinedTerm
148 Nb74c22b09c694711a028a6e75866c264 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Polymorphism, Genetic
150 rdf:type schema:DefinedTerm
151 Nbd1590aec75240a59372d3827c84dc07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Coronary Circulation
153 rdf:type schema:DefinedTerm
154 Ncd827a880402497fb9d57a696d95b218 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Endothelium, Vascular
156 rdf:type schema:DefinedTerm
157 Nce67fd1f9fe246a9a254ede2e572cdd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 Nd2bb5c3cb88e4128a05e6936276b8950 schema:name dimensions_id
161 schema:value pub.1020191122
162 rdf:type schema:PropertyValue
163 Ndff7c626a24547b38afb9d6f326c4540 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Nitric Oxide Synthase Type III
165 rdf:type schema:DefinedTerm
166 Ne0ece20f1fec45e4bfff44cac5741536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Pravastatin
168 rdf:type schema:DefinedTerm
169 Ne2d31502a53a469fb2fac7b7af7e6164 rdf:first sg:person.014572011304.86
170 rdf:rest rdf:nil
171 Ne315e5e6bf3746e2b32674b64b7e8f5a rdf:first sg:person.0710420212.75
172 rdf:rest N0922824466d540af92baf6324d722c9f
173 Nf040fb6f4d664d649a6a0c08084a3950 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Alleles
175 rdf:type schema:DefinedTerm
176 Nff00eb70386b4536979f7944779f680d rdf:first sg:person.0763376117.17
177 rdf:rest N2b23cc365217457184219f7d478c001b
178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
179 schema:name Medical and Health Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
182 schema:name Cardiorespiratory Medicine and Haematology
183 rdf:type schema:DefinedTerm
184 sg:journal.1057918 schema:issn 0946-2716
185 1432-1440
186 schema:name Journal of Molecular Medicine
187 rdf:type schema:Periodical
188 sg:person.01022516275.52 schema:affiliation https://www.grid.ac/institutes/grid.410552.7
189 schema:familyName Vesalainen
190 schema:givenName Risto
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022516275.52
192 rdf:type schema:Person
193 sg:person.01072330432.33 schema:affiliation https://www.grid.ac/institutes/grid.5509.9
194 schema:familyName Kunnas
195 schema:givenName Tarja A.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072330432.33
197 rdf:type schema:Person
198 sg:person.01163336756.79 schema:affiliation https://www.grid.ac/institutes/grid.1374.1
199 schema:familyName Knuuti
200 schema:givenName Juhani
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163336756.79
202 rdf:type schema:Person
203 sg:person.01276707545.24 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
204 schema:familyName Laaksonen
205 schema:givenName Reijo
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276707545.24
207 rdf:type schema:Person
208 sg:person.014572011304.86 schema:affiliation https://www.grid.ac/institutes/grid.5509.9
209 schema:familyName Nikkari
210 schema:givenName Seppo T.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014572011304.86
212 rdf:type schema:Person
213 sg:person.0654341265.88 schema:affiliation https://www.grid.ac/institutes/grid.5509.9
214 schema:familyName Lehtimäki
215 schema:givenName Terho
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654341265.88
217 rdf:type schema:Person
218 sg:person.0710420212.75 schema:affiliation https://www.grid.ac/institutes/grid.1374.1
219 schema:familyName Janatuinen
220 schema:givenName Tuula
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710420212.75
222 rdf:type schema:Person
223 sg:person.0713367624.09 schema:affiliation https://www.grid.ac/institutes/grid.5509.9
224 schema:familyName Karhunen
225 schema:givenName Pekka J.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713367624.09
227 rdf:type schema:Person
228 sg:person.0721225364.61 schema:affiliation https://www.grid.ac/institutes/grid.5509.9
229 schema:familyName Ilveskoski
230 schema:givenName Erkki
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721225364.61
232 rdf:type schema:Person
233 sg:person.0763376117.17 schema:affiliation https://www.grid.ac/institutes/grid.1374.1
234 schema:familyName Nuutila
235 schema:givenName Pirjo
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763376117.17
237 rdf:type schema:Person
238 sg:pub.10.1007/s00109-002-0365-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1013853352
239 https://doi.org/10.1007/s00109-002-0365-z
240 rdf:type schema:CreativeWork
241 sg:pub.10.1007/s001090000124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006894710
242 https://doi.org/10.1007/s001090000124
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/nm0196-41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015592412
245 https://doi.org/10.1038/nm0196-41
246 rdf:type schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1080284174 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1082512558 schema:CreativeWork
249 https://doi.org/10.1006/mgme.2000.3033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044341769
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0002-9149(01)02090-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033629365
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0002-9149(97)10806-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047276640
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0735-1097(98)00222-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004095645
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1034/j.1399-6576.2000.440903.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025544563
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1056/nejm198610233151702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038104523
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1056/nejm199312303292706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035952712
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1056/nejm199502233320801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052364608
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1080/003655100750044884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050191337
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/00043798-200108000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060301996
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1136/heart.85.3.342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024005180
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1152/ajpheart.2000.279.6.h2649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074731268
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1152/ajprenal.2001.280.2.f193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074768288
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1161/01.atv.17.11.3147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063334541
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1161/01.cir.102.25.3104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029350752
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1161/01.cir.103.1.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053228187
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1161/01.cir.78.1.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011572434
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1161/01.cir.82.5.1595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016329142
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1161/01.cir.89.4.1530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007381324
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1161/01.cir.90.2.808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002215803
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1161/01.cir.97.12.1129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047904564
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1161/01.cir.99.13.1678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008976298
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1161/01.cir.99.22.2871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043530596
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1161/01.hyp.32.3.521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053648920
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1161/hc4401.098293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045393683
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1378/chest.116.4.880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041598295
300 rdf:type schema:CreativeWork
301 https://doi.org/10.2337/diab.47.2.248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070738320
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.1374.1 schema:alternateName University of Turku
304 schema:name Department of Internal Medicine, University of Turku, Turku, Finland
305 Turku PET Center, University of Turku, Turku, Finland
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.410552.7 schema:alternateName Turku University Hospital
308 schema:name Department of Medicine, Turku University Central Hospital, Turku, Finland
309 Turku PET Center, University of Turku, Turku, Finland
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.5509.9 schema:alternateName University of Tampere
312 schema:name Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
313 Department of Medical Biochemistry, University of Tampere Medical School, University of Tampere, 33014, Tampere, Finland
314 rdf:type schema:Organization
315 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
316 schema:name Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
317 Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland
318 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...