Ontology type: schema:ScholarlyArticle
2003-02
AUTHORSMarcin Kwissa, Andrea Kröger, Hansjörg Hauser, Jörg Reimann, Reinhold Schirmbeck
ABSTRACTImmune responses elicited by plasmid DNA vaccination can be enhanced and modulated by codelivery of cytokine-encoding plasmids. We studied whether priming of cytotoxic T lymphocyte (CTL) responses against hepatitis B surface antigen (HBsAg) by DNA vaccines injected either intramusculary or intradermally with the gene gun is enhanced by codelivery of cytokine-encoding plasmids. From a panel of tested cytokine plasmids only mouse IFNbeta, IL-15, and GM-CSF encoding plasmids showed an effect. Intradermal gene gun vaccination with 1 micro g plasmid DNA encoding intracellular HBsAg (large LS) showed enhanced CTL priming when IFNbeta, IL15, or GM-CSF encoding plasmids were codelivered; this was not observed when a DNA vaccine encoding secreted HBsAg (small S) was injected. Intramuscular injection of low (5 micro g) doses of a DNA vaccine encoding large HBsAg did not prime CTL when delivered without cytokines, with IFNbeta or IL15-encoding plasmids. However, codelivery with GM-CSF encoding plasmid DNA primed potent, specific CTL immunity detected either in a cytotoxic assay or by determining the frequency of L(d)-restricted CD8(+) T cells specifically inducible to IFNgamma production. The codelivery of GM-CSF encoding plasmids with the DNA vaccine furthermore enhanced CTL priming to a subdominant, D(d)-restricted epitope of HBsAg. The adjuvant effect of cytokine-encoding plasmids on CTL priming by DNA vaccines is thus complex and depends on: (a) the type of cytokine (or combination of cytokines) codelivered, (b) the type (intracellular vs. secreted) and dose (1-50 micro g) of the DNA vaccine, (c) the method of DNA vaccine delivery ("naked" vs. particle-coated DNA), and (d) the (intramuscular vs. intradermal) route of delivery of the DNA vaccine. More... »
PAGES91-101
http://scigraph.springernature.com/pub.10.1007/s00109-002-0395-6
DOIhttp://dx.doi.org/10.1007/s00109-002-0395-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1025225104
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12601525
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "CD8-Positive T-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Transfer Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Vectors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Granulocyte-Macrophage Colony-Stimulating Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interferon-beta",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interleukin-15",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred BALB C",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Plasmids",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vaccines, DNA",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Ulm",
"id": "https://www.grid.ac/institutes/grid.6582.9",
"name": [
"Institute for Medical Microbiology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany"
],
"type": "Organization"
},
"familyName": "Kwissa",
"givenName": "Marcin",
"id": "sg:person.01121452067.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121452067.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "GBF German Research Centre for Biotechnology",
"id": "https://www.grid.ac/institutes/grid.418123.d",
"name": [
"German Research Center for Biotechnology, Braunschweig, Germany"
],
"type": "Organization"
},
"familyName": "Kr\u00f6ger",
"givenName": "Andrea",
"id": "sg:person.01052563154.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052563154.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "GBF German Research Centre for Biotechnology",
"id": "https://www.grid.ac/institutes/grid.418123.d",
"name": [
"German Research Center for Biotechnology, Braunschweig, Germany"
],
"type": "Organization"
},
"familyName": "Hauser",
"givenName": "Hansj\u00f6rg",
"id": "sg:person.01004447754.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004447754.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Ulm",
"id": "https://www.grid.ac/institutes/grid.6582.9",
"name": [
"Institute for Medical Microbiology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany"
],
"type": "Organization"
},
"familyName": "Reimann",
"givenName": "J\u00f6rg",
"id": "sg:person.0652222532.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652222532.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Ulm",
"id": "https://www.grid.ac/institutes/grid.6582.9",
"name": [
"Institute for Medical Microbiology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany"
],
"type": "Organization"
},
"familyName": "Schirmbeck",
"givenName": "Reinhold",
"id": "sg:person.0625347542.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625347542.58"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1002/(sici)1521-4141(199812)28:12<4149::aid-immu4149>3.0.co;2-d",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001732440"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1521-4141(199812)28:12<4149::aid-immu4149>3.0.co;2-d",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001732440"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-1759(96)00035-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001888887"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.186.10.1621",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003222546"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0167-5699(97)01201-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004490790"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0264-410x(00)00030-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011550921"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0378-1119(88)90023-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011569095"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0378-1119(88)90023-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011569095"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000050038",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013299390"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.92.7.2889",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015066078"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1074-7613(00)80256-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021808958"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/1074-7613(95)90085-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023275782"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1521-4141(199905)29:05<1740::aid-immu1740>3.0.co;2-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024835243"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1521-4141(199905)29:05<1740::aid-immu1740>3.0.co;2-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024835243"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1521-4141(199811)28:11<3530::aid-immu3530>3.0.co;2-c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024952415"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm0897-849",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029267096",
"https://doi.org/10.1038/nm0897-849"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.93.13.6291",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039231731"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0264-410x(97)00036-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039736806"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.93.20.10972",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040312455"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0264-410x(98)00177-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041756613"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/6964",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043337681",
"https://doi.org/10.1038/6964"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/6964",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043337681",
"https://doi.org/10.1038/6964"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/icb.1997.62",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048780453",
"https://doi.org/10.1038/icb.1997.62"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1521-4141(199806)28:06<1832::aid-immu1832>3.0.co;2-j",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049733339"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1521-4141(199806)28:06<1832::aid-immu1832>3.0.co;2-j",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049733339"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0264-410x(00)00495-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049990154"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1074-7613(95)80001-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050289346"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/cimm.1993.1169",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050787526"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0264-410x(97)00302-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050867100"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0966-842x(97)01145-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052609843"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/hum.1995.6.11-1447",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059271500"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/hum.1996.7.13-1535",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059271684"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/oli.1.1998.8.351",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059303108"
],
"type": "CreativeWork"
}
],
"datePublished": "2003-02",
"datePublishedReg": "2003-02-01",
"description": "Immune responses elicited by plasmid DNA vaccination can be enhanced and modulated by codelivery of cytokine-encoding plasmids. We studied whether priming of cytotoxic T lymphocyte (CTL) responses against hepatitis B surface antigen (HBsAg) by DNA vaccines injected either intramusculary or intradermally with the gene gun is enhanced by codelivery of cytokine-encoding plasmids. From a panel of tested cytokine plasmids only mouse IFNbeta, IL-15, and GM-CSF encoding plasmids showed an effect. Intradermal gene gun vaccination with 1 micro g plasmid DNA encoding intracellular HBsAg (large LS) showed enhanced CTL priming when IFNbeta, IL15, or GM-CSF encoding plasmids were codelivered; this was not observed when a DNA vaccine encoding secreted HBsAg (small S) was injected. Intramuscular injection of low (5 micro g) doses of a DNA vaccine encoding large HBsAg did not prime CTL when delivered without cytokines, with IFNbeta or IL15-encoding plasmids. However, codelivery with GM-CSF encoding plasmid DNA primed potent, specific CTL immunity detected either in a cytotoxic assay or by determining the frequency of L(d)-restricted CD8(+) T cells specifically inducible to IFNgamma production. The codelivery of GM-CSF encoding plasmids with the DNA vaccine furthermore enhanced CTL priming to a subdominant, D(d)-restricted epitope of HBsAg. The adjuvant effect of cytokine-encoding plasmids on CTL priming by DNA vaccines is thus complex and depends on: (a) the type of cytokine (or combination of cytokines) codelivered, (b) the type (intracellular vs. secreted) and dose (1-50 micro g) of the DNA vaccine, (c) the method of DNA vaccine delivery (\"naked\" vs. particle-coated DNA), and (d) the (intramuscular vs. intradermal) route of delivery of the DNA vaccine.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00109-002-0395-6",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1057918",
"issn": [
"0946-2716",
"1432-1440"
],
"name": "Journal of Molecular Medicine",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "81"
}
],
"name": "Cytokine-facilitated priming of CD8+ T cell responses by DNA vaccination",
"pagination": "91-101",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"782c2a2706e74c058fa4cfb116337da6be8c049340c7eaa5b2622bc68d685448"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"12601525"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9504370"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00109-002-0395-6"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1025225104"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00109-002-0395-6",
"https://app.dimensions.ai/details/publication/pub.1025225104"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T15:43",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000481.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s00109-002-0395-6"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00109-002-0395-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00109-002-0395-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00109-002-0395-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00109-002-0395-6'
This table displays all metadata directly associated to this object as RDF triples.
235 TRIPLES
21 PREDICATES
69 URIs
33 LITERALS
21 BLANK NODES