Refluxösophagitis View Full Text


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Article Info

DATE

2005-02-08

AUTHORS

I. Schiefke, J. Mössner, K. Caca

ABSTRACT

Gastroesophageal reflux disease (GERD) is one of the most prevalent diseases in the industrialized countries. Approximately 15–25% of adults suffer from reflux symptoms, characterized mainly by heartburn and/or regurgitation. Currently, antisecretory medication with proton pump inhibitors (PPI) or antireflux surgery are the established options for GERD-treatment. PPI are the therapeutic gold standard in acute, long-term or on-demand therapy of GERD. Since PPI do not restore the antireflux barrier but merely suppress acid secretion a life-long tablet adherence is required in most cases. In view of limitations of PPI and the potential risks of laparoscopic surgery, several endoscopic antireflux techniques were developed and may evolve as a valuable third option. However, so far objective long-term data are lacking for choosing the appropriate patient who will benefit most from endoluminal antireflux therapy. More... »

PAGES

315-328

References to SciGraph publications

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  • 2000-10-01. The role of diet and lifestyle measures in the pathogenesis and treatment of gastroesophageal reflux disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2002-05-01. Barrett's esophagus: prevalence in symptomatic relatives in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2001-07-01. Quality of life in patients with endoscopy-negative heartburn: reliability and sensitivity of disease-specific instruments in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2004-05-01. Gastroesophageal Reflux Disease: A Typical Spectrum Disease (A New Conceptual Framework is Not Needed) in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2003-11. Arzneimittelinteraktionen in DER INTERNIST
  • 2001-01-01. Esomeprazole once daily for 6 months is effective therapy for maintaining healed erosive esophagitis and for controlling gastroesophageal reflux disease symptoms: a randomized, double-blind, placebo-controlled study of efficacy and safety in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 1999-10-01. Association of obesity with hiatal hernia and esophagitis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2001-11-12. Safety and long-term outcome of laparoscopic antireflux surgery in patients in their eighties and older in SURGICAL ENDOSCOPY
  • 2003-12-29. Comparative results of endoluminal gastroplasty and laparoscopic antireflux surgery for the treatment of GERD in SURGICAL ENDOSCOPY
  • 2003-11-29. Health-related quality of life improves with treatment-related GERD symptom resolution after adjusting for baseline severity in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 1997-05. Laparoscopic vs conventional Nissen fundoplication in SURGICAL ENDOSCOPY
  • 1990-06. Duodenogastric reflux in patients with Barrett's esophagus in DIGESTIVE DISEASES AND SCIENCES
  • 2001-06-01. Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2002-03-01. Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2002-08-01. Gastroesophageal reflux disease—should we adopt a new conceptual framework? in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 1999-06-01. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 1998-02. Indikation zur Antirefluxchirurgie des Oesophagus in DIE CHIRURGIE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00108-005-1373-1

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    http://dx.doi.org/10.1007/s00108-005-1373-1

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15700122


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    45 schema:description Gastroesophageal reflux disease (GERD) is one of the most prevalent diseases in the industrialized countries. Approximately 15–25% of adults suffer from reflux symptoms, characterized mainly by heartburn and/or regurgitation. Currently, antisecretory medication with proton pump inhibitors (PPI) or antireflux surgery are the established options for GERD-treatment. PPI are the therapeutic gold standard in acute, long-term or on-demand therapy of GERD. Since PPI do not restore the antireflux barrier but merely suppress acid secretion a life-long tablet adherence is required in most cases. In view of limitations of PPI and the potential risks of laparoscopic surgery, several endoscopic antireflux techniques were developed and may evolve as a valuable third option. However, so far objective long-term data are lacking for choosing the appropriate patient who will benefit most from endoluminal antireflux therapy.
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