Multiples Myelom View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-05

AUTHORS

H. Goldschmidt, F. W. Cremer, T. M. Möhler, A. D. Ho

ABSTRACT

Multiple myeloma is one of the 20 most frequent malignancies in Germany. Initial symptoms are usually non-specific. Assessment of bone marrow and laboratory data as well as imaging techniques are essential for diagnosis and prognostic evaluation. Data from molecular cytogenetics have led to a better understanding of the pathogenesis of multiple myeloma. Cytostatic therapy with alcylating agents and glucocorticoids prolongs the survival. High-dose therapy followed by transplantation of autologous hematopoietic stem cells improves prognosis for patients up to the age of 70. Currently, modifications of allogeneic hematopoietic stem cell transplantation, anti-angiogeneic and immunomodulatory drugs as well as proteasome inhibitors are evaluated in clinical trials. Supportive care has derived benefit from the introduction of new bisphosphonates. More... »

PAGES

599-618

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00108-003-0920-x

DOI

http://dx.doi.org/10.1007/s00108-003-0920-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041421263

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12966788


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