Primär kutane Lymphome – eine Fallserie von 163 Patienten View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06-07

AUTHORS

D. Nashan, C. M. Friedrich, E. Geissler, A. Schmitt-Graeff, F. Klein, F. Meiss

ABSTRACT

BackgroundIn addition to a broad and clinically diverse spectrum of known primary cutaneous lymphomas, for which an incidence of 1–3:100,000 is postulated, each year further entities are specified and defined. The goal is the presentation of a case series from daily clinical routine.MethodsOver a period of 6 years and 2 months, patients consulting the Department of Dermatology, Medical Center University of Freiburg, were registered. Subsequently, collectives of mycosis fungoides (MF), Sezary syndrome (SS), CD30+ lymphoproliferative diseases, single cases with rare primary cutaneous lymphomas, and subcollectives of B‑cell lymphomas were examined. The high number of MF cases allowed the additional quantitative analyses of the types of therapies used in this group.ResultsYearly 16–25 new diagnoses of primary cutaneous lymphoma are made. The evaluation of 163 primary cutaneous lymphoma revealed 111 cases with MF (68.1%), including 9 particular variants, 15 primary cutaneous CD30+ lymphoproliferative diseases (9.2%) dominated by 10 lymphomatoid papulosis (LyP), in addition to 5 primary cutaneous anaplastic large cell lymphoma (PCALCL), 6 SS (3.68%), and 24 cutaneous B‑cell lymphomas (14-72%). Three cases with rare primary cutaneous T/NK cell lymphomas are addressed in detail. In all, 82% of MF cases were stage IA and IB. The descending use of therapies for stage I–III included steroids and diverse UV therapies followed by bexarotene, interferon-α, methotrexate, and extracorporal photophoresis.ConclusionsDiagnoses of cutaneous lymphomas belong to a vast spectrum of differential diagnoses. This registry describes frequent findings and shows rare variants. You can only diagnose what you know; accordingly, a collection of case reports, which we wish to encourage, can help in processing and specification of entities. More... »

PAGES

1014-1020

References to SciGraph publications

  • 2015-12-16. Subkutanes pannikulitisartiges T-Zell-Lymphom in DER HAUTARZT
  • 2017-04-14. The diagnosis and management of NK/T-cell lymphomas in JOURNAL OF HEMATOLOGY & ONCOLOGY
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    http://scigraph.springernature.com/pub.10.1007/s00105-018-4212-8

    DOI

    http://dx.doi.org/10.1007/s00105-018-4212-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104457514

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29881891


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