Impfgranulom bei Spättypallergie gegen Aluminiumsalze View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05

AUTHORS

R.U. Wahl, G. Wurpts, H.F. Merk

ABSTRACT

BACKGROUND: Aluminium salts are common adjuvants in all established inactivated vaccines. They are necessary to activate the humoral immune system. In the 1990s a Swedish study on an acellular vaccination against pertussis was started. Until 2013, 745 of 760,000 children with pruritic subcutaneous nodules were identified. In 77 % of these children a contact allergy to aluminium could be proven. Contact allergy to aluminium induced by vaccines causes pruritic subcutaneous nodules at the vaccination site. During infections of the upper respiratory tract the pruritus often escalates with inflammatory, erythematous and urticarial plaques. CONCLUSIONS: The use of solutions containing aluminium salts for specific immunotherapy is contraindicated in the case of contact allergy to aluminium. Intramuscular injections of inactivated vaccines can be employed to avoid granuloma formation. More... »

PAGES

384-387

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00105-014-2793-4

DOI

http://dx.doi.org/10.1007/s00105-014-2793-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020607878

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24736873


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