In-vitro-Diagnostik und Monitoring bei Insektengifthyposensibilisierung View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-09

AUTHORS

M.M. Neis, G. Wurpts, L. Wilbers, H.F. Merk

ABSTRACT

Specific immunotherapy (SIT) of hymenoptera venom allergy, in particular, has become an example for the effectiveness of the treatment of IgE-mediated allergic diseases. In vitro diagnostic procedures and the measurement of serum tryptase for risk assessment are well-established in the process of diagnose finding and therapy preparation. For monitoring and validation of the effectiveness of the SIT, however, in vitro diagnostic procedures remain controversial. Potentially useful approaches include detection of specific IgE, specific IgG4, basophile activation - represented by the CD 63 expression - and the lymphocyte proliferation and its IL10 release. Preliminary data suggest that the latter method appear appropriate, whereas the detection of basophile activation did not produce definite results. More... »

PAGES

677

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00105-011-2160-7

DOI

http://dx.doi.org/10.1007/s00105-011-2160-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001065323

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21861175


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