Langzeitergebnisse der Ganzhautelektronenbestrahlung (GET) in der Therapie der Mycosis fungoides View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-03

AUTHORS

M. Hagedorn, E. Hasche, B. Kober, C. Sander

ABSTRACT

BACKGROUND AND OBJECTIVE: Total skin electron beam therapy (TSEBT) is an important therapeutic option for the treatment of mycosis fungoides. The aim of this study was to find out long term results in 10 patients with the clinical and histological diagnosis of mycosis fungoides. PATIENTS AND METHODS: Between 1982 and 1997 we performed a total skin electron beam therapy in 10 patients. One patient was in stage I A; 5, in stage I B; 3, in stage II B; and one, in stage IV A. The indication for TSEBT was disease progression in spite of PUVA therapy. The doses of electron beam therapy were 30- 36 Gy at 5-6 MeV. In 7 of 10 cases additional local electron beam therapy was given, because individual lesions persisted or recurred after a short time. RESULTS: Complete remission was achieved in 5 patients. The follow- up has been up to 10 years. One patient died of systemic lymphoma 10 years after electron beam therapy. Three patients died of illnesses unrelated to mycosis fungoides. One patient developed a high grade T-cell lymphoma. CONCLUSIONS: Total skin electron beam therapy is a very effective, but technically difficult therapy for mycosis fungoides, especially in stage I B and II B. Particularly interesting has been the long duration of complete response of three patients, who had follicular mucinosis preceding their mycosis fungoides. More... »

PAGES

256-264

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00105-002-0419-8

DOI

http://dx.doi.org/10.1007/s00105-002-0419-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1075251738

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12634995


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