Chirurgie periampullärer Pankreaskarzinome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-07-14

AUTHORS

Thomas Hank, Ulla Klaiber, Klaus Sahora, Martin Schindl, Oliver Strobel

ABSTRACT

Periampullary neoplasms are a heterogeneous group of different tumor entities arising from the periampullary region, of which pancreatic ductal adenocarcinoma (PDAC) is the most common subgroup with 60–70%. As typical for pancreatic adenocarcinomas, periampullary pancreatic cancer is characterized by an aggressive growth and early systemic progression. Due to the anatomical location in close relationship to the papilla of Vater symptoms occur at an earlier stage of the disease, so that treatment options and prognosis are overall more favorable compared to pancreatic carcinomas at other locations. Nevertheless, the principles of treatment for periampullary pancreatic cancer are not substantially different from the standards for pancreatic cancer at other locations. A potentially curative approach for non-metastatic periampullary pancreatic cancer is a multimodal therapy concept, which includes partial pancreatoduodenectomy as a radical oncological resection in combination with a systemic adjuvant chemotherapy. As a result, long-term survival can be achieved in patients with favorable prognostic factors. In addition, with the continous development of surgery and systemic treatment potentially curative treatment concepts for advanced initially nonresectable tumors were also established, after completion of neoadjuvant treatment. This article presents the current surgical principles of a radical oncological resection for periampullary pancreatic cancer in the context of a multimodal treatment concept with an outlook for future developments of treatment. More... »

PAGES

776-787

References to SciGraph publications

  • 2018-08-07. Underutilization of Surgery in Periampullary Cancer Treatment in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2015-06-09. Extended Versus Standard Lymphadenectomy for Pancreatic Head Cancer: Meta-Analysis of Randomized Controlled Trials in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2012-02-14. Pancreatectomy Combined with Superior Mesenteric Vein–Portal Vein Resection for Pancreatic Cancer: A Meta-analysis in WORLD JOURNAL OF SURGERY
  • 2018-11-05. Neoadjuvant and adjuvant chemotherapy in pancreatic cancer in LANGENBECK'S ARCHIVES OF SURGERY
  • 2007-12. Pancreatic anastomosis after pancreaticoduodenectomy: how we do it in INDIAN JOURNAL OF SURGERY
  • 2008-03-20. Most Pancreatic Cancer Resections are R1 Resections in ANNALS OF SURGICAL ONCOLOGY
  • 2009-04-24. Pretreatment Assessment of Resectable and Borderline Resectable Pancreatic Cancer: Expert Consensus Statement in ANNALS OF SURGICAL ONCOLOGY
  • 2018-10-19. Optimizing the outcomes of pancreatic cancer surgery in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2019-09-10. The Relative Role of Bile Bacterial Isolation on Outcome in Stent-Bearing Patients Undergoing Pancreatoduodenectomy in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2014-07-22. Question Sets and Answers in SURGERY
  • 2012-09-07. Intestinal-type and Pancreatobiliary-type Adenocarcinomas: How Does Ampullary Carcinoma Differ from Other Periampullary Malignancies? in ANNALS OF SURGICAL ONCOLOGY
  • 2002-12. How to do a safe pancreatic anastomosis in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2002-02. Technical considerations to maintain a low frequency of postoperative biliary stent-associated infections in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2020-08-20. Comparison of surgical outcomes between isolated pancreaticojejunostomy, isolated gastrojejunostomy, and conventional pancreaticojejunostomy after pancreaticoduodenectomy: a systematic review and meta-analysis in BMC GASTROENTEROLOGY
  • 2012-02-17. 15-Year Experience with Surgical Treatment of Duodenal Carcinoma: a Comparison of Periampullary and Extra-Ampullary Duodenal Carcinomas in JOURNAL OF GASTROINTESTINAL SURGERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00104-021-01462-1

    DOI

    http://dx.doi.org/10.1007/s00104-021-01462-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1139693339

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34259884


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