Lymphknotenmetastasen beim ypT1/2-Rektumkarzinom nach neoadjuvanter Radiochemotherapie View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07

AUTHORS

T. Sprenger, H. Rothe, T. Beissbarth, L.-C. Conradi, A. Kauffels, K. Homayounfar, C. L. Behnes, C. Rödel, T. Liersch, M. Ghadimi

ABSTRACT

BACKGROUND: For patients with rectal cancer and complete remission (ypT0) or with good response and residual tumor restricted only to the bowel wall (ypT1-2) after neoadjuvant chemoradiotherapy (CRT), local excision has been suggested as an alternative to avoid the significant morbidity and functional deficits associated with total mesorectal excision (TME). The aim of this investigation was to investigate the incidence, distribution and tumor-related localization of mesorectal lymph node (LN) metastases in TME specimens with complete remission (ypT0), intramural (ypT1-2) and extramural (ypT3-4) residual tumor tissue. PATIENTS AND METHODS: Specimens of TME from 81 patients with locally advanced rectal cancer (UICC II-III) undergoing neoadjuvant CRT within the phase III German rectal cancer trial CAO/ARO/AIO-04 were prospectively evaluated. The entire mesorectal compartment was microscopically screened after complete paraffin embedding. The number and localization of all detectable LN metastases were documented in relation to the primary tumor. RESULTS: Whereas 50 patients (62 %) had ypT3-4 rectal cancer after neoadjuvant CRT, 20 patients (25 %) presented with residual tumor within the bowel wall (ypT1-2), 11 patients (14 %) had pathological complete remission (ypT0), an average of 28 ± 13.7 LN were detected per specimen and 25 patients (31 %) had residual LN metastases after CRT. Although the incidence of LN metastases was higher in the ypT3-4 group (40 %), 25 % of patients in the ypT1-2 group with intramural residual tumor had a mean number of 2.2 residual LN metastases of which 55 % were located far from the primary lesion in the proximal mesorectum. None of the patients with ypT0 status (complete response) had residual LN metastases. CONCLUSION: Even in patients with good response and post-CRT tumor tissue restricted only to the bowel wall (ypT1-2), there is still a considerable risk for residual LN metastases. Local excision of residual rectal cancer was accompanied by a higher rate of local failure and radical surgery with TME should remain the standard treatment in these patients. To date, valid selection criteria for patients eligible for organ-sparing surgery are still lacking. More... »

PAGES

593-601

References to SciGraph publications

  • 2007-11. Local Excision for ypT2 Rectal Cancer—Much Ado About Something in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2005-06. Surgical Salvage of Recurrent Rectal Cancer After Transanal Excision in DISEASES OF THE COLON & RECTUM
  • 2002-07. Salvage Radical Surgery After Failed Local Excision for Early Rectal Cancer in DISEASES OF THE COLON & RECTUM
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00104-016-0170-9

    DOI

    http://dx.doi.org/10.1007/s00104-016-0170-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023063438

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27106241


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenocarcinoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemoradiotherapy, Adjuvant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Combined Modality Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphatic Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm, Residual", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rectum", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Klinik f\u00fcr Allgemein-, Viszeral- und Kinderchirurgie, Universit\u00e4tsmedizin G\u00f6ttingen, Robert-Koch-Str.\u00a040, 37099, G\u00f6ttingen, Deutschland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sprenger", 
            "givenName": "T.", 
            "id": "sg:person.0774340162.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774340162.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Medizinisches Versorgungszentrum G\u00f6ttingen (MVZ), 37081, G\u00f6ttingen, Deutschland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rothe", 
            "givenName": "H.", 
            "id": "sg:person.01017436554.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017436554.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institut f\u00fcr Medizinische Statistik, Universit\u00e4tsmedizin G\u00f6ttingen, 37099, G\u00f6ttingen, Deutschland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beissbarth", 
            "givenName": "T.", 
            "id": "sg:person.01251610614.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251610614.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Klinik f\u00fcr Allgemein-, Viszeral- und Kinderchirurgie, Universit\u00e4tsmedizin G\u00f6ttingen, Robert-Koch-Str.\u00a040, 37099, G\u00f6ttingen, Deutschland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Conradi", 
            "givenName": "L.-C.", 
            "id": "sg:person.0743775217.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743775217.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Klinik f\u00fcr Allgemein-, Viszeral- und Kinderchirurgie, Universit\u00e4tsmedizin G\u00f6ttingen, Robert-Koch-Str.\u00a040, 37099, G\u00f6ttingen, Deutschland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kauffels", 
            "givenName": "A.", 
            "id": "sg:person.0576467457.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576467457.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Klinik f\u00fcr Allgemein-, Viszeral- und Kinderchirurgie, Universit\u00e4tsmedizin G\u00f6ttingen, Robert-Koch-Str.\u00a040, 37099, G\u00f6ttingen, Deutschland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Homayounfar", 
            "givenName": "K.", 
            "id": "sg:person.01105275146.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105275146.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institut f\u00fcr Pathologie, Universit\u00e4tsmedizin G\u00f6ttingen, 37099, G\u00f6ttingen, Deutschland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Behnes", 
            "givenName": "C. L.", 
            "id": "sg:person.01134013017.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134013017.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.411088.4", 
              "name": [
                "Klinik f\u00fcr Strahlentherapie und Onkologie, Universit\u00e4tsklinikum Frankfurt, 60590, Frankfurt/Main, Deutschland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "R\u00f6del", 
            "givenName": "C.", 
            "id": "sg:person.01110566562.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110566562.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Klinik f\u00fcr Allgemein-, Viszeral- und Kinderchirurgie, Universit\u00e4tsmedizin G\u00f6ttingen, Robert-Koch-Str.\u00a040, 37099, G\u00f6ttingen, Deutschland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liersch", 
            "givenName": "T.", 
            "id": "sg:person.01162543062.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162543062.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Klinik f\u00fcr Allgemein-, Viszeral- und Kinderchirurgie, Universit\u00e4tsmedizin G\u00f6ttingen, Robert-Koch-Str.\u00a040, 37099, G\u00f6ttingen, Deutschland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ghadimi", 
            "givenName": "M.", 
            "id": "sg:person.01051011043.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051011043.33"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10350-004-6320-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000344348", 
              "https://doi.org/10.1007/s10350-004-6320-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/s10350-004-6320-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000344348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/s10350-004-6320-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000344348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2007.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001740762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2013.54.3769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004216080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/dcr.0b013e318273f56f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005021047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/dcr.0b013e318273f56f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005021047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2168.1999.01040.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006800332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(10)70172-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007782854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.7105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008304265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.7105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008304265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/dcr.0b013e318278ff8a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019937258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/dcr.0b013e318278ff8a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019937258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.9809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020148507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/dcr.0b013e3181a0af4b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022640261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/dcr.0b013e3181a0af4b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022640261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/dcr.0b013e31824f873f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022827726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/dcr.0b013e31824f873f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022827726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10350-004-0930-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024773795", 
              "https://doi.org/10.1007/s10350-004-0930-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/s10350-004-0930-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024773795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.1800830326", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025338929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(12)70187-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026397736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.40.1836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027178418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.37.7176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028237539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/dcr.0000000000000022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028555643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/dcr.0000000000000022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028555643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa040694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031672074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.0050202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034165254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2013.12.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034852948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4143/crt.2014.46.3.243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035729951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31822b8cfa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041303220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31822b8cfa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041303220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.6126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042068463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.02.1329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042089423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-007-0271-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043917114", 
              "https://doi.org/10.1007/s11605-007-0271-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.1800691019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044032523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.4989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044879924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.4989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044879924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ssu.10017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045964116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.17.3062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048208444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3182886ced", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051034559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3182886ced", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051034559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076895672", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-07", 
        "datePublishedReg": "2016-07-01", 
        "description": "BACKGROUND: For patients with rectal cancer and complete remission (ypT0) or with good response and residual tumor restricted only to the bowel wall (ypT1-2) after neoadjuvant chemoradiotherapy (CRT), local excision has been suggested as an alternative to avoid the significant morbidity and functional deficits associated with total mesorectal excision (TME). The aim of this investigation was to investigate the incidence, distribution and tumor-related localization of mesorectal lymph node (LN) metastases in TME specimens with complete remission (ypT0), intramural (ypT1-2) and extramural (ypT3-4) residual tumor tissue.\nPATIENTS AND METHODS: Specimens of TME from 81 patients with locally advanced rectal cancer (UICC II-III) undergoing neoadjuvant CRT within the phase III German rectal cancer trial CAO/ARO/AIO-04 were prospectively evaluated. The entire mesorectal compartment was microscopically screened after complete paraffin embedding. The number and localization of all detectable LN metastases were documented in relation to the primary tumor.\nRESULTS: Whereas 50 patients (62\u2009%) had ypT3-4 rectal cancer after neoadjuvant CRT, 20 patients (25\u2009%) presented with residual tumor within the bowel wall (ypT1-2), 11 patients (14\u2009%) had pathological complete remission (ypT0), an average of 28\u00a0\u00b1 13.7 LN were detected per specimen and 25 patients (31\u2009%) had residual LN metastases after CRT. Although the incidence of LN metastases was higher in the ypT3-4 group (40\u2009%), 25\u2009% of patients in the ypT1-2 group with intramural residual tumor had a mean number of 2.2 residual LN metastases of which 55\u2009% were located far from the primary lesion in the proximal mesorectum. None of the patients with ypT0 status (complete response) had residual LN metastases.\nCONCLUSION: Even in patients with good response and post-CRT tumor tissue restricted only to the bowel wall (ypT1-2), there is still a considerable risk for residual LN metastases. Local excision of residual rectal cancer was accompanied by a higher rate of local failure and radical surgery with TME should remain the standard treatment in these patients. To date, valid selection criteria for patients eligible for organ-sparing surgery are still lacking.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00104-016-0170-9", 
        "inLanguage": [
          "de"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1059014", 
            "issn": [
              "0009-4722", 
              "1433-0385"
            ], 
            "name": "Der Chirurg", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "87"
          }
        ], 
        "name": "Lymphknotenmetastasen beim ypT1/2-Rektumkarzinom nach neoadjuvanter Radiochemotherapie", 
        "pagination": "593-601", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6de0dcce2bd8b2c5cb1c12bdb59d7a0f845187ef2faf4ce4a12dd734c7950716"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27106241"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "16140410R"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00104-016-0170-9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1023063438"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00104-016-0170-9", 
          "https://app.dimensions.ai/details/publication/pub.1023063438"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000532.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs00104-016-0170-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00104-016-0170-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00104-016-0170-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00104-016-0170-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00104-016-0170-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    315 TRIPLES      21 PREDICATES      78 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00104-016-0170-9 schema:about N01dc3fba052c44bd853439666a7894c1
    2 N13914c034a034e6d8ffdbc28255c3841
    3 N221df6337f1b4badb5590288d0b52db2
    4 N373df00a325a4adb815f220b00465deb
    5 N4e62729279ae461c9be5b3313ab4aa1d
    6 N594f1907f1834ea182777df22ed82f55
    7 N6464d321608d48ce9145388cc681d460
    8 N9e001c3b3afb41369587b674d08d25d3
    9 Nb9e8a7d3312742b191d5e1c56c5dcbe8
    10 Nc80865142f7a459ab8d5c448f2fb7821
    11 Nca087129a7f34b61b6138611b8768201
    12 Ncc3ab0956d854cc98608004b042bf86f
    13 Nd23449e3e4624210801a043876e50da7
    14 Ndf22577c136b4a85a86a36df7a430120
    15 Ne1e9a437904045f8a2875f21be4b45a3
    16 Nef3ab5b18a2342f082baa61dfd09da15
    17 anzsrc-for:11
    18 anzsrc-for:1112
    19 schema:author N984f35a3013246228fec8d001b1d3832
    20 schema:citation sg:pub.10.1007/s10350-004-0930-3
    21 sg:pub.10.1007/s10350-004-6320-z
    22 sg:pub.10.1007/s11605-007-0271-3
    23 https://app.dimensions.ai/details/publication/pub.1076895672
    24 https://doi.org/10.1002/bjs.1800691019
    25 https://doi.org/10.1002/bjs.1800830326
    26 https://doi.org/10.1002/bjs.4989
    27 https://doi.org/10.1002/bjs.6126
    28 https://doi.org/10.1002/bjs.7105
    29 https://doi.org/10.1002/bjs.9809
    30 https://doi.org/10.1002/ssu.10017
    31 https://doi.org/10.1007/dcr.0b013e3181a0af4b
    32 https://doi.org/10.1007/s10350-004-0930-3
    33 https://doi.org/10.1007/s10350-004-6320-z
    34 https://doi.org/10.1016/j.ijrobp.2007.10.016
    35 https://doi.org/10.1016/j.ijrobp.2013.12.012
    36 https://doi.org/10.1016/s1470-2045(10)70172-8
    37 https://doi.org/10.1016/s1470-2045(12)70187-0
    38 https://doi.org/10.1046/j.1365-2168.1999.01040.x
    39 https://doi.org/10.1056/nejmoa040694
    40 https://doi.org/10.1097/dcr.0000000000000022
    41 https://doi.org/10.1097/dcr.0b013e31824f873f
    42 https://doi.org/10.1097/dcr.0b013e318273f56f
    43 https://doi.org/10.1097/dcr.0b013e318278ff8a
    44 https://doi.org/10.1097/pas.0b013e3182886ced
    45 https://doi.org/10.1097/sla.0b013e31822b8cfa
    46 https://doi.org/10.1200/jco.2005.02.1329
    47 https://doi.org/10.1200/jco.2008.17.3062
    48 https://doi.org/10.1200/jco.2011.37.7176
    49 https://doi.org/10.1200/jco.2011.40.1836
    50 https://doi.org/10.1200/jco.2013.54.3769
    51 https://doi.org/10.1371/journal.pmed.0050202
    52 https://doi.org/10.4143/crt.2014.46.3.243
    53 schema:datePublished 2016-07
    54 schema:datePublishedReg 2016-07-01
    55 schema:description BACKGROUND: For patients with rectal cancer and complete remission (ypT0) or with good response and residual tumor restricted only to the bowel wall (ypT1-2) after neoadjuvant chemoradiotherapy (CRT), local excision has been suggested as an alternative to avoid the significant morbidity and functional deficits associated with total mesorectal excision (TME). The aim of this investigation was to investigate the incidence, distribution and tumor-related localization of mesorectal lymph node (LN) metastases in TME specimens with complete remission (ypT0), intramural (ypT1-2) and extramural (ypT3-4) residual tumor tissue. PATIENTS AND METHODS: Specimens of TME from 81 patients with locally advanced rectal cancer (UICC II-III) undergoing neoadjuvant CRT within the phase III German rectal cancer trial CAO/ARO/AIO-04 were prospectively evaluated. The entire mesorectal compartment was microscopically screened after complete paraffin embedding. The number and localization of all detectable LN metastases were documented in relation to the primary tumor. RESULTS: Whereas 50 patients (62 %) had ypT3-4 rectal cancer after neoadjuvant CRT, 20 patients (25 %) presented with residual tumor within the bowel wall (ypT1-2), 11 patients (14 %) had pathological complete remission (ypT0), an average of 28 ± 13.7 LN were detected per specimen and 25 patients (31 %) had residual LN metastases after CRT. Although the incidence of LN metastases was higher in the ypT3-4 group (40 %), 25 % of patients in the ypT1-2 group with intramural residual tumor had a mean number of 2.2 residual LN metastases of which 55 % were located far from the primary lesion in the proximal mesorectum. None of the patients with ypT0 status (complete response) had residual LN metastases. CONCLUSION: Even in patients with good response and post-CRT tumor tissue restricted only to the bowel wall (ypT1-2), there is still a considerable risk for residual LN metastases. Local excision of residual rectal cancer was accompanied by a higher rate of local failure and radical surgery with TME should remain the standard treatment in these patients. To date, valid selection criteria for patients eligible for organ-sparing surgery are still lacking.
    56 schema:genre research_article
    57 schema:inLanguage de
    58 schema:isAccessibleForFree false
    59 schema:isPartOf N37900babade04ac2bd5d6c37a4d5a56a
    60 N658587846d074d2999cb0f872c94d1ff
    61 sg:journal.1059014
    62 schema:name Lymphknotenmetastasen beim ypT1/2-Rektumkarzinom nach neoadjuvanter Radiochemotherapie
    63 schema:pagination 593-601
    64 schema:productId N1a7ec47092fb4f27beaaa8177590a3cb
    65 N736f59a3ad7243a5a522825733c25fd0
    66 N951cc24e3a484589831106d705648d92
    67 N9a39187251ad45089e98e542fd33917e
    68 Nbed208efc5a64c34a13e2d6d05b65a44
    69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023063438
    70 https://doi.org/10.1007/s00104-016-0170-9
    71 schema:sdDatePublished 2019-04-10T21:40
    72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    73 schema:sdPublisher N5914eea1e2ca4161ad8c0b22fe566cbe
    74 schema:url http://link.springer.com/10.1007%2Fs00104-016-0170-9
    75 sgo:license sg:explorer/license/
    76 sgo:sdDataset articles
    77 rdf:type schema:ScholarlyArticle
    78 N01dc3fba052c44bd853439666a7894c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    79 schema:name Middle Aged
    80 rdf:type schema:DefinedTerm
    81 N07ef0e86f3e842dead1d640048f384b8 schema:name Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37099, Göttingen, Deutschland
    82 rdf:type schema:Organization
    83 N13914c034a034e6d8ffdbc28255c3841 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    84 schema:name Lymphatic Metastasis
    85 rdf:type schema:DefinedTerm
    86 N183980d5138341e2b0446d4b586666c7 schema:name Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37099, Göttingen, Deutschland
    87 rdf:type schema:Organization
    88 N1a7ec47092fb4f27beaaa8177590a3cb schema:name nlm_unique_id
    89 schema:value 16140410R
    90 rdf:type schema:PropertyValue
    91 N221df6337f1b4badb5590288d0b52db2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Neoplasm Staging
    93 rdf:type schema:DefinedTerm
    94 N35c3c0eaf5d64435906e22438abf84d3 schema:name Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37099, Göttingen, Deutschland
    95 rdf:type schema:Organization
    96 N373df00a325a4adb815f220b00465deb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Chemoradiotherapy, Adjuvant
    98 rdf:type schema:DefinedTerm
    99 N37900babade04ac2bd5d6c37a4d5a56a schema:volumeNumber 87
    100 rdf:type schema:PublicationVolume
    101 N3c462de0a9c44fc3874437a4f2d4846c rdf:first sg:person.01110566562.10
    102 rdf:rest Ne6ace107baff4b66b2fdd6efcb537d6f
    103 N42277e4ca96f4985821cc34eeb364efb schema:name Institut für Pathologie, Universitätsmedizin Göttingen, 37099, Göttingen, Deutschland
    104 rdf:type schema:Organization
    105 N4baea590cc2f4b5b8abd23ad3a7d3f15 rdf:first sg:person.01017436554.42
    106 rdf:rest N51d92cf0bbab40139a642e366f276c38
    107 N4bd1ba9a17ed4bb588fbf64bfaed4530 rdf:first sg:person.0576467457.96
    108 rdf:rest Nb1db300c92d14615936a524872322caa
    109 N4e62729279ae461c9be5b3313ab4aa1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Humans
    111 rdf:type schema:DefinedTerm
    112 N5000fd35e9b84bab9afd3c41f24a3ee9 schema:name Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37099, Göttingen, Deutschland
    113 rdf:type schema:Organization
    114 N51d92cf0bbab40139a642e366f276c38 rdf:first sg:person.01251610614.75
    115 rdf:rest N56fb3d8e4c19492ea06ed17b737ca2db
    116 N56fb3d8e4c19492ea06ed17b737ca2db rdf:first sg:person.0743775217.45
    117 rdf:rest N4bd1ba9a17ed4bb588fbf64bfaed4530
    118 N5914eea1e2ca4161ad8c0b22fe566cbe schema:name Springer Nature - SN SciGraph project
    119 rdf:type schema:Organization
    120 N594f1907f1834ea182777df22ed82f55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Male
    122 rdf:type schema:DefinedTerm
    123 N6464d321608d48ce9145388cc681d460 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Aged
    125 rdf:type schema:DefinedTerm
    126 N658587846d074d2999cb0f872c94d1ff schema:issueNumber 7
    127 rdf:type schema:PublicationIssue
    128 N71c0190c914e464f9d6f81eb24c5dca2 schema:name Medizinisches Versorgungszentrum Göttingen (MVZ), 37081, Göttingen, Deutschland
    129 rdf:type schema:Organization
    130 N736f59a3ad7243a5a522825733c25fd0 schema:name doi
    131 schema:value 10.1007/s00104-016-0170-9
    132 rdf:type schema:PropertyValue
    133 N809bac7a35bd46e4964e8f30c84ab249 schema:name Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37099, Göttingen, Deutschland
    134 rdf:type schema:Organization
    135 N835a965f88b6410395dbed52dabd5a08 schema:name Klinik für Allgemein-, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37099, Göttingen, Deutschland
    136 rdf:type schema:Organization
    137 N938c6eb824974b78b265997c75d67bc0 schema:name Institut für Medizinische Statistik, Universitätsmedizin Göttingen, 37099, Göttingen, Deutschland
    138 rdf:type schema:Organization
    139 N951cc24e3a484589831106d705648d92 schema:name pubmed_id
    140 schema:value 27106241
    141 rdf:type schema:PropertyValue
    142 N984f35a3013246228fec8d001b1d3832 rdf:first sg:person.0774340162.90
    143 rdf:rest N4baea590cc2f4b5b8abd23ad3a7d3f15
    144 N9a39187251ad45089e98e542fd33917e schema:name readcube_id
    145 schema:value 6de0dcce2bd8b2c5cb1c12bdb59d7a0f845187ef2faf4ce4a12dd734c7950716
    146 rdf:type schema:PropertyValue
    147 N9e001c3b3afb41369587b674d08d25d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Prospective Studies
    149 rdf:type schema:DefinedTerm
    150 Nb1db300c92d14615936a524872322caa rdf:first sg:person.01105275146.12
    151 rdf:rest Ne5775f5336144d8a805442ebac839870
    152 Nb9e8a7d3312742b191d5e1c56c5dcbe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Disease-Free Survival
    154 rdf:type schema:DefinedTerm
    155 Nbed208efc5a64c34a13e2d6d05b65a44 schema:name dimensions_id
    156 schema:value pub.1023063438
    157 rdf:type schema:PropertyValue
    158 Nc80865142f7a459ab8d5c448f2fb7821 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Neoplasm, Residual
    160 rdf:type schema:DefinedTerm
    161 Nca087129a7f34b61b6138611b8768201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Adenocarcinoma
    163 rdf:type schema:DefinedTerm
    164 Ncc3ab0956d854cc98608004b042bf86f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Rectal Neoplasms
    166 rdf:type schema:DefinedTerm
    167 Nd23449e3e4624210801a043876e50da7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Prognosis
    169 rdf:type schema:DefinedTerm
    170 Ndf22577c136b4a85a86a36df7a430120 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Female
    172 rdf:type schema:DefinedTerm
    173 Ne1e9a437904045f8a2875f21be4b45a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Rectum
    175 rdf:type schema:DefinedTerm
    176 Ne5775f5336144d8a805442ebac839870 rdf:first sg:person.01134013017.69
    177 rdf:rest N3c462de0a9c44fc3874437a4f2d4846c
    178 Ne6ace107baff4b66b2fdd6efcb537d6f rdf:first sg:person.01162543062.71
    179 rdf:rest Ne9dc9f71753d48d483f3e68b142c8749
    180 Ne9dc9f71753d48d483f3e68b142c8749 rdf:first sg:person.01051011043.33
    181 rdf:rest rdf:nil
    182 Nef3ab5b18a2342f082baa61dfd09da15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Combined Modality Therapy
    184 rdf:type schema:DefinedTerm
    185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    186 schema:name Medical and Health Sciences
    187 rdf:type schema:DefinedTerm
    188 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    189 schema:name Oncology and Carcinogenesis
    190 rdf:type schema:DefinedTerm
    191 sg:journal.1059014 schema:issn 0009-4722
    192 1433-0385
    193 schema:name Der Chirurg
    194 rdf:type schema:Periodical
    195 sg:person.01017436554.42 schema:affiliation N71c0190c914e464f9d6f81eb24c5dca2
    196 schema:familyName Rothe
    197 schema:givenName H.
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017436554.42
    199 rdf:type schema:Person
    200 sg:person.01051011043.33 schema:affiliation N5000fd35e9b84bab9afd3c41f24a3ee9
    201 schema:familyName Ghadimi
    202 schema:givenName M.
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051011043.33
    204 rdf:type schema:Person
    205 sg:person.01105275146.12 schema:affiliation N35c3c0eaf5d64435906e22438abf84d3
    206 schema:familyName Homayounfar
    207 schema:givenName K.
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105275146.12
    209 rdf:type schema:Person
    210 sg:person.01110566562.10 schema:affiliation https://www.grid.ac/institutes/grid.411088.4
    211 schema:familyName Rödel
    212 schema:givenName C.
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110566562.10
    214 rdf:type schema:Person
    215 sg:person.01134013017.69 schema:affiliation N42277e4ca96f4985821cc34eeb364efb
    216 schema:familyName Behnes
    217 schema:givenName C. L.
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134013017.69
    219 rdf:type schema:Person
    220 sg:person.01162543062.71 schema:affiliation N183980d5138341e2b0446d4b586666c7
    221 schema:familyName Liersch
    222 schema:givenName T.
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162543062.71
    224 rdf:type schema:Person
    225 sg:person.01251610614.75 schema:affiliation N938c6eb824974b78b265997c75d67bc0
    226 schema:familyName Beissbarth
    227 schema:givenName T.
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251610614.75
    229 rdf:type schema:Person
    230 sg:person.0576467457.96 schema:affiliation N835a965f88b6410395dbed52dabd5a08
    231 schema:familyName Kauffels
    232 schema:givenName A.
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576467457.96
    234 rdf:type schema:Person
    235 sg:person.0743775217.45 schema:affiliation N07ef0e86f3e842dead1d640048f384b8
    236 schema:familyName Conradi
    237 schema:givenName L.-C.
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743775217.45
    239 rdf:type schema:Person
    240 sg:person.0774340162.90 schema:affiliation N809bac7a35bd46e4964e8f30c84ab249
    241 schema:familyName Sprenger
    242 schema:givenName T.
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774340162.90
    244 rdf:type schema:Person
    245 sg:pub.10.1007/s10350-004-0930-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024773795
    246 https://doi.org/10.1007/s10350-004-0930-3
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1007/s10350-004-6320-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1000344348
    249 https://doi.org/10.1007/s10350-004-6320-z
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/s11605-007-0271-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043917114
    252 https://doi.org/10.1007/s11605-007-0271-3
    253 rdf:type schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1076895672 schema:CreativeWork
    255 https://doi.org/10.1002/bjs.1800691019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044032523
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1002/bjs.1800830326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025338929
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1002/bjs.4989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044879924
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1002/bjs.6126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042068463
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1002/bjs.7105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008304265
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1002/bjs.9809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020148507
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/ssu.10017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045964116
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1007/dcr.0b013e3181a0af4b schema:sameAs https://app.dimensions.ai/details/publication/pub.1022640261
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1007/s10350-004-0930-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024773795
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1007/s10350-004-6320-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1000344348
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.ijrobp.2007.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001740762
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.ijrobp.2013.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034852948
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/s1470-2045(10)70172-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007782854
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/s1470-2045(12)70187-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026397736
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1046/j.1365-2168.1999.01040.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006800332
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1056/nejmoa040694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031672074
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1097/dcr.0000000000000022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028555643
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1097/dcr.0b013e31824f873f schema:sameAs https://app.dimensions.ai/details/publication/pub.1022827726
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1097/dcr.0b013e318273f56f schema:sameAs https://app.dimensions.ai/details/publication/pub.1005021047
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1097/dcr.0b013e318278ff8a schema:sameAs https://app.dimensions.ai/details/publication/pub.1019937258
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1097/pas.0b013e3182886ced schema:sameAs https://app.dimensions.ai/details/publication/pub.1051034559
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1097/sla.0b013e31822b8cfa schema:sameAs https://app.dimensions.ai/details/publication/pub.1041303220
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1200/jco.2005.02.1329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042089423
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1200/jco.2008.17.3062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048208444
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1200/jco.2011.37.7176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028237539
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1200/jco.2011.40.1836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027178418
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1200/jco.2013.54.3769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004216080
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1371/journal.pmed.0050202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034165254
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.4143/crt.2014.46.3.243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035729951
    312 rdf:type schema:CreativeWork
    313 https://www.grid.ac/institutes/grid.411088.4 schema:alternateName University Hospital Frankfurt
    314 schema:name Klinik für Strahlentherapie und Onkologie, Universitätsklinikum Frankfurt, 60590, Frankfurt/Main, Deutschland
    315 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...