Urodilatin (INN: Ularitide) Ein neues Peptid in der Intensivbehandlung des akuten Nierenversagens nach Lebertransplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-04

AUTHORS

E.-R. Kuse, M. Meyer, R. Constantin, K. Oldhafer, H.-J. Schlitt, P. Schulz-Knappe, H. J. Überbacher, R. Pichlmayr, W.-G. Forssmann

ABSTRACT

Acute renal failure (ARF) is a serious complication following liver transplantation. Many therapeutic regimens have been used so far but with limited success. Urodilatin (URO) is a new member of the atrial natriuretic peptide (ANP) family. When administered intravenously, URO induces strong diuresis and natriuresis with tolerable hemodynamic side effects. Preliminary non-controlled clinical studies demonstrate beneficial effects using URO as a therapeutic agent in patients suffering from ARF following heart and liver transplantation (HTx, LTx). These results prompted us to initiate this first controlled clinical trial to investigate whether URO infusion can improve renal function in patients with emerging ARF following LTx.Method. We initiated a randomized, double-blind, placebo-controlled study comparing five patients receiving i.v. URO infusion (20 ng/kg bw/min) with four placebo patients after informed consent was obtained. Optional inclusion criteria were oliguria/anuria (<0.5 ml/kg/h), refractory to conventional treatment including administration of furosemide and dopamine, increase of serum creatinine to a least 200% of preoperative values, and BUN levels ≥25 mmol/l. The primary parameters for efficacy was the frequency of hemodialysis/hemofiltration.Results. The frequency of hemodialysis/hemofiltration during URO or placebo infusion was significantly reduced (P=0.03) in the URO-treated patients in comparison with placebo. BUN levels did not differ between two groups, but serum creatinine levels were consistently lower in the URO group. Diuresis tended to be stronger in the URO group, maintaining high levels despite a significant reduction in the administration of furosemide in comparison with placebo.Conclusion. We conclude that URO seems to be a new approach for the treatment of therapy-resistant postoperative ARF following LTx. More... »

PAGES

351-358

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s001010050271

DOI

http://dx.doi.org/10.1007/s001010050271

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1054510475

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8702053


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Kidney Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrial Natriuretic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diuresis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diuretics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Function Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postoperative Complications", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Dialysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Klinik f\u00fcr Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Klinik f\u00fcr Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuse", 
        "givenName": "E.-R.", 
        "id": "sg:person.0664301646.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664301646.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nieders\u00e4chsisches Institut f\u00fcr Peptid-Forschung (IPF), Hannover, XX", 
          "id": "http://www.grid.ac/institutes/grid.420011.6", 
          "name": [
            "Nieders\u00e4chsisches Institut f\u00fcr Peptid-Forschung (IPF), Hannover, XX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meyer", 
        "givenName": "M.", 
        "id": "sg:person.01003113502.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003113502.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinik f\u00fcr Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Klinik f\u00fcr Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Constantin", 
        "givenName": "R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinik f\u00fcr Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Klinik f\u00fcr Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oldhafer", 
        "givenName": "K.", 
        "id": "sg:person.014700460114.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014700460114.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinik f\u00fcr Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Klinik f\u00fcr Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlitt", 
        "givenName": "H.-J.", 
        "id": "sg:person.010361144542.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010361144542.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nieders\u00e4chsisches Institut f\u00fcr Peptid-Forschung (IPF), Hannover, XX", 
          "id": "http://www.grid.ac/institutes/grid.420011.6", 
          "name": [
            "Nieders\u00e4chsisches Institut f\u00fcr Peptid-Forschung (IPF), Hannover, XX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schulz-Knappe", 
        "givenName": "P.", 
        "id": "sg:person.01243260701.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243260701.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boehringer Mannheim GmbH, Mannheim, XX", 
          "id": "http://www.grid.ac/institutes/grid.424277.0", 
          "name": [
            "Boehringer Mannheim GmbH, Mannheim, XX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "\u00dcberbacher", 
        "givenName": "H. J.", 
        "id": "sg:person.01071356132.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071356132.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinik f\u00fcr Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Klinik f\u00fcr Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pichlmayr", 
        "givenName": "R.", 
        "id": "sg:person.0767110303.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767110303.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nieders\u00e4chsisches Institut f\u00fcr Peptid-Forschung (IPF), Hannover, XX", 
          "id": "http://www.grid.ac/institutes/grid.420011.6", 
          "name": [
            "Nieders\u00e4chsisches Institut f\u00fcr Peptid-Forschung (IPF), Hannover, XX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forssmann", 
        "givenName": "W.-G.", 
        "id": "sg:person.01316354712.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316354712.56"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1996-04", 
    "datePublishedReg": "1996-04-01", 
    "description": "Acute renal failure (ARF) is a serious complication following liver transplantation. Many therapeutic regimens have been used so far but with limited success. Urodilatin (URO) is a new member of the atrial natriuretic peptide (ANP) family. When administered intravenously, URO induces strong diuresis and natriuresis with tolerable hemodynamic side effects. Preliminary non-controlled clinical studies demonstrate beneficial effects using URO as a therapeutic agent in patients suffering from ARF following heart and liver transplantation (HTx, LTx). These results prompted us to initiate this first controlled clinical trial to investigate whether URO infusion can improve renal function in patients with emerging ARF following LTx.Method. We initiated a randomized, double-blind, placebo-controlled study comparing five patients receiving i.v. URO infusion (20\u2005ng/kg bw/min) with four placebo patients after informed consent was obtained. Optional inclusion criteria were oliguria/anuria (<0.5\u2005ml/kg/h), refractory to conventional treatment including administration of furosemide and dopamine, increase of serum creatinine to a least 200% of preoperative values, and BUN levels \u226525\u2005mmol/l. The primary parameters for efficacy was the frequency of hemodialysis/hemofiltration.Results. The frequency of hemodialysis/hemofiltration during URO or placebo infusion was significantly reduced (P=0.03) in the URO-treated patients in comparison with placebo. BUN levels did not differ between two groups, but serum creatinine levels were consistently lower in the URO group. Diuresis tended to be stronger in the URO group, maintaining high levels despite a significant reduction in the administration of furosemide in comparison with placebo.Conclusion. We conclude that URO seems to be a new approach for the treatment of therapy-resistant postoperative ARF following LTx.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s001010050271", 
    "inLanguage": "de", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017033", 
        "issn": [
          "0003-2417", 
          "1432-055X"
        ], 
        "name": "Der Anaesthesist", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "45"
      }
    ], 
    "keywords": [
      "acute renal failure", 
      "hemodialysis/hemofiltration", 
      "administration of furosemide", 
      "URO infusion", 
      "URO group", 
      "liver transplantation", 
      "BUN levels", 
      "non-controlled clinical study", 
      "placebo-controlled study", 
      "postoperative acute renal failure", 
      "atrial natriuretic peptide family", 
      "hemodynamic side effects", 
      "serum creatinine levels", 
      "natriuretic peptide family", 
      "placebo patients", 
      "placebo infusion", 
      "renal function", 
      "serum creatinine", 
      "renal failure", 
      "preoperative values", 
      "creatinine levels", 
      "serious complications", 
      "therapeutic regimens", 
      "strong diuresis", 
      "clinical trials", 
      "inclusion criteria", 
      "clinical studies", 
      "urodilatin", 
      "side effects", 
      "patients", 
      "conventional treatment", 
      "beneficial effects", 
      "therapeutic agents", 
      "infusion", 
      "informed consent", 
      "placebo", 
      "LTx", 
      "diuresis", 
      "transplantation", 
      "significant reduction", 
      "hemofiltration", 
      "peptide family", 
      "furosemide", 
      "administration", 
      "treatment", 
      "group", 
      "natriuresis", 
      "anuria", 
      "high levels", 
      "regimens", 
      "complications", 
      "creatinine", 
      "levels", 
      "limited success", 
      "trials", 
      "dopamine", 
      "efficacy", 
      "peptid", 
      "heart", 
      "study", 
      "consent", 
      "effect", 
      "failure", 
      "agents", 
      "frequency", 
      "criteria", 
      "increase", 
      "reduction", 
      "comparison", 
      "new member", 
      "family", 
      "function", 
      "primary parameters", 
      "members", 
      "success", 
      "results", 
      "values", 
      "new approach", 
      "de", 
      "approach", 
      "parameters", 
      "tolerable hemodynamic side effects", 
      "Preliminary non-controlled clinical studies", 
      "Optional inclusion criteria", 
      "therapy-resistant postoperative ARF", 
      "Urodilatin (INN: Ularitide) Ein neues Peptid", 
      "Ein neues Peptid", 
      "neues Peptid", 
      "der Intensivbehandlung des", 
      "Intensivbehandlung des", 
      "Nierenversagens", 
      "Lebertransplantation"
    ], 
    "name": "Urodilatin (INN: Ularitide) Ein neues Peptid in der Intensivbehandlung des akuten Nierenversagens nach Lebertransplantation", 
    "pagination": "351-358", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1054510475"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s001010050271"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8702053"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s001010050271", 
      "https://app.dimensions.ai/details/publication/pub.1054510475"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_293.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s001010050271"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s001010050271'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s001010050271'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s001010050271'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s001010050271'


 

This table displays all metadata directly associated to this object as RDF triples.

283 TRIPLES      21 PREDICATES      135 URIs      126 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s001010050271 schema:about N072b463accc44a3795b3637b53e6ae35
2 N23865db6d8764f6090b72fb367d6d25d
3 N29a51e786729471d914f225c85332fa4
4 N4151292acc704f1797407db39f24d178
5 N68328adcaf1047db9859843410820ac5
6 N763e541103b94cc48d0462029037e197
7 N7b755b6293a644f39ccbe6da2825707b
8 N936e3771580e4a6da424dc6524e7b672
9 Naff59d0f1c864cc982a4da56d77146cd
10 Nc1fc3338cc0b48ca917f5a72de1f3a2c
11 Nc3b475ff819d480b97a8d814f499199b
12 Nd2c0e0a7773149bca92e1ea772728feb
13 Ne2ef78dccbd6414e9a251d561e78bc10
14 Ne33f8f478a9c49aba89c7c67f0dd5c16
15 Nf79dcaad17ee49df88817d27bc966ed8
16 Nffed78312f5d48c7bfdffa4222425802
17 anzsrc-for:11
18 anzsrc-for:1102
19 anzsrc-for:1103
20 schema:author N80f6086a3d9845819dc0128011d919cf
21 schema:datePublished 1996-04
22 schema:datePublishedReg 1996-04-01
23 schema:description Acute renal failure (ARF) is a serious complication following liver transplantation. Many therapeutic regimens have been used so far but with limited success. Urodilatin (URO) is a new member of the atrial natriuretic peptide (ANP) family. When administered intravenously, URO induces strong diuresis and natriuresis with tolerable hemodynamic side effects. Preliminary non-controlled clinical studies demonstrate beneficial effects using URO as a therapeutic agent in patients suffering from ARF following heart and liver transplantation (HTx, LTx). These results prompted us to initiate this first controlled clinical trial to investigate whether URO infusion can improve renal function in patients with emerging ARF following LTx.Method. We initiated a randomized, double-blind, placebo-controlled study comparing five patients receiving i.v. URO infusion (20 ng/kg bw/min) with four placebo patients after informed consent was obtained. Optional inclusion criteria were oliguria/anuria (<0.5 ml/kg/h), refractory to conventional treatment including administration of furosemide and dopamine, increase of serum creatinine to a least 200% of preoperative values, and BUN levels ≥25 mmol/l. The primary parameters for efficacy was the frequency of hemodialysis/hemofiltration.Results. The frequency of hemodialysis/hemofiltration during URO or placebo infusion was significantly reduced (P=0.03) in the URO-treated patients in comparison with placebo. BUN levels did not differ between two groups, but serum creatinine levels were consistently lower in the URO group. Diuresis tended to be stronger in the URO group, maintaining high levels despite a significant reduction in the administration of furosemide in comparison with placebo.Conclusion. We conclude that URO seems to be a new approach for the treatment of therapy-resistant postoperative ARF following LTx.
24 schema:genre article
25 schema:inLanguage de
26 schema:isAccessibleForFree false
27 schema:isPartOf Nbe03ac30c66c4ba8820a4ef92266f76a
28 Nf4f62ae2905341b19e04b68f7034aaaf
29 sg:journal.1017033
30 schema:keywords BUN levels
31 Ein neues Peptid
32 Intensivbehandlung des
33 LTx
34 Lebertransplantation
35 Nierenversagens
36 Optional inclusion criteria
37 Preliminary non-controlled clinical studies
38 URO group
39 URO infusion
40 Urodilatin (INN: Ularitide) Ein neues Peptid
41 acute renal failure
42 administration
43 administration of furosemide
44 agents
45 anuria
46 approach
47 atrial natriuretic peptide family
48 beneficial effects
49 clinical studies
50 clinical trials
51 comparison
52 complications
53 consent
54 conventional treatment
55 creatinine
56 creatinine levels
57 criteria
58 de
59 der Intensivbehandlung des
60 diuresis
61 dopamine
62 effect
63 efficacy
64 failure
65 family
66 frequency
67 function
68 furosemide
69 group
70 heart
71 hemodialysis/hemofiltration
72 hemodynamic side effects
73 hemofiltration
74 high levels
75 inclusion criteria
76 increase
77 informed consent
78 infusion
79 levels
80 limited success
81 liver transplantation
82 members
83 natriuresis
84 natriuretic peptide family
85 neues Peptid
86 new approach
87 new member
88 non-controlled clinical study
89 parameters
90 patients
91 peptid
92 peptide family
93 placebo
94 placebo infusion
95 placebo patients
96 placebo-controlled study
97 postoperative acute renal failure
98 preoperative values
99 primary parameters
100 reduction
101 regimens
102 renal failure
103 renal function
104 results
105 serious complications
106 serum creatinine
107 serum creatinine levels
108 side effects
109 significant reduction
110 strong diuresis
111 study
112 success
113 therapeutic agents
114 therapeutic regimens
115 therapy-resistant postoperative ARF
116 tolerable hemodynamic side effects
117 transplantation
118 treatment
119 trials
120 urodilatin
121 values
122 schema:name Urodilatin (INN: Ularitide) Ein neues Peptid in der Intensivbehandlung des akuten Nierenversagens nach Lebertransplantation
123 schema:pagination 351-358
124 schema:productId N553c69b7a1f940bfbcce8c5642a165a9
125 N65b7e558b5284b22b30c1c050877d6e1
126 N8f77f88d255a46338a9cc6a8245c3eaf
127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054510475
128 https://doi.org/10.1007/s001010050271
129 schema:sdDatePublished 2021-12-01T19:10
130 schema:sdLicense https://scigraph.springernature.com/explorer/license/
131 schema:sdPublisher N852197c126694b2982d55c59a2766abe
132 schema:url https://doi.org/10.1007/s001010050271
133 sgo:license sg:explorer/license/
134 sgo:sdDataset articles
135 rdf:type schema:ScholarlyArticle
136 N072b463accc44a3795b3637b53e6ae35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Double-Blind Method
138 rdf:type schema:DefinedTerm
139 N23865db6d8764f6090b72fb367d6d25d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Kidney Function Tests
141 rdf:type schema:DefinedTerm
142 N29a51e786729471d914f225c85332fa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Peptide Fragments
144 rdf:type schema:DefinedTerm
145 N368d13f4d5ca46bbb405b26cecdb488a rdf:first sg:person.01316354712.56
146 rdf:rest rdf:nil
147 N3c1ba45dbf184154baa8726bfc8f4ff6 rdf:first sg:person.01003113502.88
148 rdf:rest Nde6205023df0420582492119f3e309bf
149 N4012d4add1f1432d9023234118c73c0b schema:affiliation grid-institutes:None
150 schema:familyName Constantin
151 schema:givenName R.
152 rdf:type schema:Person
153 N4151292acc704f1797407db39f24d178 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Diuretics
155 rdf:type schema:DefinedTerm
156 N553c69b7a1f940bfbcce8c5642a165a9 schema:name dimensions_id
157 schema:value pub.1054510475
158 rdf:type schema:PropertyValue
159 N65b7e558b5284b22b30c1c050877d6e1 schema:name doi
160 schema:value 10.1007/s001010050271
161 rdf:type schema:PropertyValue
162 N68328adcaf1047db9859843410820ac5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Male
164 rdf:type schema:DefinedTerm
165 N6e93b91eddc8453782b0fd6a95607347 rdf:first sg:person.014700460114.77
166 rdf:rest Nd08812103ffb4d6f89c66e11ee169a35
167 N70545292639845438ace3a0a93a273b9 rdf:first sg:person.01071356132.07
168 rdf:rest Na3a9395f58974a52841876bb59d7edda
169 N763e541103b94cc48d0462029037e197 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Acute Kidney Injury
171 rdf:type schema:DefinedTerm
172 N7b755b6293a644f39ccbe6da2825707b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Atrial Natriuretic Factor
174 rdf:type schema:DefinedTerm
175 N80f6086a3d9845819dc0128011d919cf rdf:first sg:person.0664301646.04
176 rdf:rest N3c1ba45dbf184154baa8726bfc8f4ff6
177 N852197c126694b2982d55c59a2766abe schema:name Springer Nature - SN SciGraph project
178 rdf:type schema:Organization
179 N8f77f88d255a46338a9cc6a8245c3eaf schema:name pubmed_id
180 schema:value 8702053
181 rdf:type schema:PropertyValue
182 N936e3771580e4a6da424dc6524e7b672 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Female
184 rdf:type schema:DefinedTerm
185 Na3a9395f58974a52841876bb59d7edda rdf:first sg:person.0767110303.39
186 rdf:rest N368d13f4d5ca46bbb405b26cecdb488a
187 Naff59d0f1c864cc982a4da56d77146cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Aged
189 rdf:type schema:DefinedTerm
190 Nb25d88449f5549238bac507473c8343d rdf:first sg:person.01243260701.18
191 rdf:rest N70545292639845438ace3a0a93a273b9
192 Nbe03ac30c66c4ba8820a4ef92266f76a schema:issueNumber 4
193 rdf:type schema:PublicationIssue
194 Nc1fc3338cc0b48ca917f5a72de1f3a2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Adult
196 rdf:type schema:DefinedTerm
197 Nc3b475ff819d480b97a8d814f499199b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Renal Dialysis
199 rdf:type schema:DefinedTerm
200 Nd08812103ffb4d6f89c66e11ee169a35 rdf:first sg:person.010361144542.53
201 rdf:rest Nb25d88449f5549238bac507473c8343d
202 Nd2c0e0a7773149bca92e1ea772728feb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Diuresis
204 rdf:type schema:DefinedTerm
205 Nde6205023df0420582492119f3e309bf rdf:first N4012d4add1f1432d9023234118c73c0b
206 rdf:rest N6e93b91eddc8453782b0fd6a95607347
207 Ne2ef78dccbd6414e9a251d561e78bc10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Postoperative Complications
209 rdf:type schema:DefinedTerm
210 Ne33f8f478a9c49aba89c7c67f0dd5c16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Liver Transplantation
212 rdf:type schema:DefinedTerm
213 Nf4f62ae2905341b19e04b68f7034aaaf schema:volumeNumber 45
214 rdf:type schema:PublicationVolume
215 Nf79dcaad17ee49df88817d27bc966ed8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Middle Aged
217 rdf:type schema:DefinedTerm
218 Nffed78312f5d48c7bfdffa4222425802 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Humans
220 rdf:type schema:DefinedTerm
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
225 schema:name Cardiorespiratory Medicine and Haematology
226 rdf:type schema:DefinedTerm
227 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
228 schema:name Clinical Sciences
229 rdf:type schema:DefinedTerm
230 sg:journal.1017033 schema:issn 0003-2417
231 1432-055X
232 schema:name Der Anaesthesist
233 schema:publisher Springer Nature
234 rdf:type schema:Periodical
235 sg:person.01003113502.88 schema:affiliation grid-institutes:grid.420011.6
236 schema:familyName Meyer
237 schema:givenName M.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003113502.88
239 rdf:type schema:Person
240 sg:person.010361144542.53 schema:affiliation grid-institutes:None
241 schema:familyName Schlitt
242 schema:givenName H.-J.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010361144542.53
244 rdf:type schema:Person
245 sg:person.01071356132.07 schema:affiliation grid-institutes:grid.424277.0
246 schema:familyName Überbacher
247 schema:givenName H. J.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071356132.07
249 rdf:type schema:Person
250 sg:person.01243260701.18 schema:affiliation grid-institutes:grid.420011.6
251 schema:familyName Schulz-Knappe
252 schema:givenName P.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243260701.18
254 rdf:type schema:Person
255 sg:person.01316354712.56 schema:affiliation grid-institutes:grid.420011.6
256 schema:familyName Forssmann
257 schema:givenName W.-G.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316354712.56
259 rdf:type schema:Person
260 sg:person.014700460114.77 schema:affiliation grid-institutes:None
261 schema:familyName Oldhafer
262 schema:givenName K.
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014700460114.77
264 rdf:type schema:Person
265 sg:person.0664301646.04 schema:affiliation grid-institutes:None
266 schema:familyName Kuse
267 schema:givenName E.-R.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664301646.04
269 rdf:type schema:Person
270 sg:person.0767110303.39 schema:affiliation grid-institutes:None
271 schema:familyName Pichlmayr
272 schema:givenName R.
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767110303.39
274 rdf:type schema:Person
275 grid-institutes:None schema:alternateName Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX
276 schema:name Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, XX
277 rdf:type schema:Organization
278 grid-institutes:grid.420011.6 schema:alternateName Niedersächsisches Institut für Peptid-Forschung (IPF), Hannover, XX
279 schema:name Niedersächsisches Institut für Peptid-Forschung (IPF), Hannover, XX
280 rdf:type schema:Organization
281 grid-institutes:grid.424277.0 schema:alternateName Boehringer Mannheim GmbH, Mannheim, XX
282 schema:name Boehringer Mannheim GmbH, Mannheim, XX
283 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...