Risk factors for early infection following hemiarthroplasty in elderly patients with a femoral neck fracture View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01-16

AUTHORS

Dirk Zajonz, Alexander Brand, Christian Lycke, Orkun Özkurtul, Jan Theopold, Ulrich J. A. Spiegl, Andreas Roth, Christoph Josten, Johannes K. M. Fakler

ABSTRACT

PurposePeriprosthetic joint infections (PJI) after hemiarthroplasty for geriatric femoral neck fractures are a devastating complication that results in serious morbidity and increased mortality. Identifying risk factors associated with early infection after HA for hip fractures may offer an opportunity to address and prevent this complication in many patients. The aim of this study was to evaluate preoperative risk factors for early PJI after HA in hip fracture patients.MethodsFrom January 2010 to December 2015, 312 femoral neck fractures (AO/OTA 31-B) in 305 patients were included in this single-center, retrospective study. PJI was defined according to the Centers for Disease Control (CDC) definition of deep incisional surgical site infection. Early infection referred to a postoperative period of 4 weeks. Binary univariable and multivariable regression analysis with backward elimination was applied to identify predictors of PJI.ResultsMedian age of all patients was 83.0 (IQR 76–89) years. We identified 16 (5.1%) early PJI which all required surgical revision. Median length of in-hospital stay (LOS) was 20.0 (IQR 10–36) days after PJI compared to 10.0 (8–15) days without deep wound infection. In-hospital mortality was 30.8 vs. 6.6%, respectively. Preoperative CRP levels (OR 1.009; 95% CI 1.002–1.018; p = 0.044), higher BMI (OR 1.092; 95% CI 1.002–1.189; p = 0.044) and prolonged surgery time (OR 1.013; 95% CI 1.000–1.025; p = 0.041) were independent risk factors for PJI. Excluding infection following major revision due to mechanical complications identified preoperative CRP levels (OR 1.012; 95% CI 1.003–1.021; p = 0.007) and chronic glucocorticoid therapy (OR 6.314; 95% CI 1.223–32.587; p = 0.028) as risk factors, a clear trend was seen for higher BMI (OR 1.114; 95% CI 1.000–1.242; p = 0.051). A cut-off value at CRP levels ≥ 14 mg/l demonstrated a sensitivity of 69% and a specificity of 70% with a fair accuracy (AUC 0.707).ConclusionPreoperative serum CRP levels, higher BMI and prolonged surgery time are independent predictors of early PJI. Excluding PJI secondary to major revision surgery revealed chronic glucocorticoid use as a risk factor apart from preoperative CRP levels. More... »

PAGES

207-212

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00068-018-0909-8

DOI

http://dx.doi.org/10.1007/s00068-018-0909-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100424378

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29340736


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Femoral Neck Fractures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemiarthroplasty", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospital Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Length of Stay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Odds Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Surgical Wound Infection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "ZESBO\u2013Zentrum zur Erforschung der St\u00fctz- und Bewegungsorgane, Semmelweisstra\u00dfe 14, 04103, Leipzig, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany", 
            "ZESBO\u2013Zentrum zur Erforschung der St\u00fctz- und Bewegungsorgane, Semmelweisstra\u00dfe 14, 04103, Leipzig, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zajonz", 
        "givenName": "Dirk", 
        "id": "sg:person.0630774640.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630774640.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411339.d", 
          "name": [
            "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brand", 
        "givenName": "Alexander", 
        "id": "sg:person.014037643206.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014037643206.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411339.d", 
          "name": [
            "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lycke", 
        "givenName": "Christian", 
        "id": "sg:person.01156456305.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156456305.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411339.d", 
          "name": [
            "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "\u00d6zkurtul", 
        "givenName": "Orkun", 
        "id": "sg:person.01311003347.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311003347.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411339.d", 
          "name": [
            "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Theopold", 
        "givenName": "Jan", 
        "id": "sg:person.01052070352.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052070352.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411339.d", 
          "name": [
            "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spiegl", 
        "givenName": "Ulrich J. A.", 
        "id": "sg:person.0621766602.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621766602.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411339.d", 
          "name": [
            "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roth", 
        "givenName": "Andreas", 
        "id": "sg:person.0731203470.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731203470.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411339.d", 
          "name": [
            "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Josten", 
        "givenName": "Christoph", 
        "id": "sg:person.01340334560.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340334560.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411339.d", 
          "name": [
            "Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fakler", 
        "givenName": "Johannes K. M.", 
        "id": "sg:person.015234603204.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015234603204.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s12891-016-0906-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049489227", 
          "https://doi.org/10.1186/s12891-016-0906-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00590-014-1449-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038202916", 
          "https://doi.org/10.1007/s00590-014-1449-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00113-017-0386-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090880721", 
          "https://doi.org/10.1007/s00113-017-0386-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00132-008-1342-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016572211", 
          "https://doi.org/10.1007/s00132-008-1342-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00113-009-1674-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034870053", 
          "https://doi.org/10.1007/s00113-009-1674-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1754-9493-4-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047507134", 
          "https://doi.org/10.1186/1754-9493-4-16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00264-006-0227-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049944505", 
          "https://doi.org/10.1007/s00264-006-0227-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11999-016-5222-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037614239", 
          "https://doi.org/10.1007/s11999-016-5222-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13037-016-0105-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013069927", 
          "https://doi.org/10.1186/s13037-016-0105-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-01-16", 
    "datePublishedReg": "2018-01-16", 
    "description": "PurposePeriprosthetic joint infections (PJI) after hemiarthroplasty for geriatric femoral neck fractures are a devastating complication that results in serious morbidity and increased mortality. Identifying risk factors associated with early infection after HA for hip fractures may offer an opportunity to address and prevent this complication in many patients. The aim of this study was to evaluate preoperative risk factors for early PJI after HA in hip fracture patients.MethodsFrom January 2010 to December 2015, 312 femoral neck fractures (AO/OTA 31-B) in 305 patients were included in this single-center, retrospective study. PJI was defined according to the Centers for Disease Control (CDC) definition of deep incisional surgical site infection. Early infection referred to a postoperative period of 4 weeks. Binary univariable and multivariable regression analysis with backward elimination was applied to identify predictors of PJI.ResultsMedian age of all patients was 83.0 (IQR 76\u201389)\u00a0years. We identified 16 (5.1%) early PJI which all required surgical revision. Median length of in-hospital stay (LOS) was 20.0 (IQR 10\u201336)\u00a0days after PJI compared to 10.0 (8\u201315)\u00a0days without deep wound infection. In-hospital mortality was 30.8 vs. 6.6%, respectively. Preoperative CRP levels (OR 1.009; 95% CI 1.002\u20131.018; p\u2009=\u20090.044), higher BMI (OR 1.092; 95% CI 1.002\u20131.189; p\u2009=\u20090.044) and prolonged surgery time (OR 1.013; 95% CI 1.000\u20131.025; p\u2009=\u20090.041) were independent risk factors for PJI. Excluding infection following major revision due to mechanical complications identified preoperative CRP levels (OR 1.012; 95% CI 1.003\u20131.021; p\u2009=\u20090.007) and chronic glucocorticoid therapy (OR 6.314; 95% CI 1.223\u201332.587; p\u2009=\u20090.028) as risk factors, a clear trend was seen for higher BMI (OR 1.114; 95% CI 1.000\u20131.242; p\u2009=\u20090.051). A cut-off value at CRP levels\u2009\u2265\u200914\u00a0mg/l demonstrated a sensitivity of 69% and a specificity of 70% with a fair accuracy (AUC 0.707).ConclusionPreoperative serum CRP levels, higher BMI and prolonged surgery time are independent predictors of early PJI. Excluding PJI secondary to major revision surgery revealed chronic glucocorticoid use as a risk factor apart from preoperative CRP levels.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00068-018-0909-8", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1294996", 
        "issn": [
          "1863-9933", 
          "1615-3146"
        ], 
        "name": "European Journal of Trauma and Emergency Surgery", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "45"
      }
    ], 
    "keywords": [
      "PurposePeriprosthetic joint infection", 
      "preoperative CRP levels", 
      "femoral neck fractures", 
      "CRP levels", 
      "risk factors", 
      "neck fractures", 
      "higher BMI", 
      "early infection", 
      "surgery time", 
      "deep incisional surgical site infection", 
      "geriatric femoral neck fractures", 
      "incisional surgical site infection", 
      "chronic glucocorticoid use", 
      "preoperative risk factors", 
      "chronic glucocorticoid therapy", 
      "serum CRP levels", 
      "hip fracture patients", 
      "Disease Control definition", 
      "deep wound infection", 
      "independent risk factor", 
      "surgical site infection", 
      "major revision surgery", 
      "multivariable regression analysis", 
      "hospital mortality", 
      "glucocorticoid therapy", 
      "glucocorticoid use", 
      "ResultsMedian age", 
      "hospital stay", 
      "devastating complication", 
      "fracture patients", 
      "postoperative period", 
      "elderly patients", 
      "serious morbidity", 
      "hip fracture", 
      "site infection", 
      "mechanical complications", 
      "independent predictors", 
      "surgical revision", 
      "joint infection", 
      "retrospective study", 
      "median length", 
      "wound infection", 
      "revision surgery", 
      "patients", 
      "infection", 
      "complications", 
      "BMI", 
      "control definition", 
      "hemiarthroplasty", 
      "regression analysis", 
      "mortality", 
      "backward elimination", 
      "fractures", 
      "predictors", 
      "days", 
      "morbidity", 
      "factors", 
      "levels", 
      "surgery", 
      "stay", 
      "therapy", 
      "weeks", 
      "age", 
      "study", 
      "revision", 
      "aim", 
      "years", 
      "specificity", 
      "period", 
      "center", 
      "clear trend", 
      "elimination", 
      "HA", 
      "sensitivity", 
      "time", 
      "major revision", 
      "fair accuracy", 
      "use", 
      "analysis", 
      "length", 
      "trends", 
      "definition", 
      "values", 
      "opportunities", 
      "accuracy"
    ], 
    "name": "Risk factors for early infection following hemiarthroplasty in elderly patients with a femoral neck fracture", 
    "pagination": "207-212", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100424378"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00068-018-0909-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29340736"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00068-018-0909-8", 
      "https://app.dimensions.ai/details/publication/pub.1100424378"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_794.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00068-018-0909-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00068-018-0909-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00068-018-0909-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00068-018-0909-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00068-018-0909-8'


 

This table displays all metadata directly associated to this object as RDF triples.

302 TRIPLES      21 PREDICATES      134 URIs      117 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00068-018-0909-8 schema:about N05122e33941c44599e02042a9d6fa454
2 N0af1368919fa422a863f946bdd23ef01
3 N23503d65a0a64fd6b7afc40de0fd17e0
4 N3c18c49fe5b546898ebecadd95651994
5 N483b474c038946528f885dffb1616b76
6 N4dedaef9c3cf4c8a813b65c14b95c208
7 N574b2f191ae6444990039edf3e050d12
8 N63d6a1e82d204760b60f8a22cc39800a
9 N7b58bdb6eaff407d8c67484be63c1aed
10 N872a6b5de5204bb8a67798f7d0dd77a5
11 Nc84be268c74640628f3eb99c1f59d2cc
12 Nd01c96c2fe1e4868b485281dcf10e607
13 Nd32f93b5c619401896e6a4d8dff7065a
14 Ndb944b51dc0945cfb4abd4b37d90d23e
15 Ne49e776b3fb84fffaf3a619a6540a47d
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N280bdee4dcbc4065930d61625129b207
19 schema:citation sg:pub.10.1007/s00113-009-1674-2
20 sg:pub.10.1007/s00113-017-0386-2
21 sg:pub.10.1007/s00132-008-1342-1
22 sg:pub.10.1007/s00264-006-0227-3
23 sg:pub.10.1007/s00590-014-1449-5
24 sg:pub.10.1007/s11999-016-5222-4
25 sg:pub.10.1186/1754-9493-4-16
26 sg:pub.10.1186/s12891-016-0906-1
27 sg:pub.10.1186/s13037-016-0105-x
28 schema:datePublished 2018-01-16
29 schema:datePublishedReg 2018-01-16
30 schema:description PurposePeriprosthetic joint infections (PJI) after hemiarthroplasty for geriatric femoral neck fractures are a devastating complication that results in serious morbidity and increased mortality. Identifying risk factors associated with early infection after HA for hip fractures may offer an opportunity to address and prevent this complication in many patients. The aim of this study was to evaluate preoperative risk factors for early PJI after HA in hip fracture patients.MethodsFrom January 2010 to December 2015, 312 femoral neck fractures (AO/OTA 31-B) in 305 patients were included in this single-center, retrospective study. PJI was defined according to the Centers for Disease Control (CDC) definition of deep incisional surgical site infection. Early infection referred to a postoperative period of 4 weeks. Binary univariable and multivariable regression analysis with backward elimination was applied to identify predictors of PJI.ResultsMedian age of all patients was 83.0 (IQR 76–89) years. We identified 16 (5.1%) early PJI which all required surgical revision. Median length of in-hospital stay (LOS) was 20.0 (IQR 10–36) days after PJI compared to 10.0 (8–15) days without deep wound infection. In-hospital mortality was 30.8 vs. 6.6%, respectively. Preoperative CRP levels (OR 1.009; 95% CI 1.002–1.018; p = 0.044), higher BMI (OR 1.092; 95% CI 1.002–1.189; p = 0.044) and prolonged surgery time (OR 1.013; 95% CI 1.000–1.025; p = 0.041) were independent risk factors for PJI. Excluding infection following major revision due to mechanical complications identified preoperative CRP levels (OR 1.012; 95% CI 1.003–1.021; p = 0.007) and chronic glucocorticoid therapy (OR 6.314; 95% CI 1.223–32.587; p = 0.028) as risk factors, a clear trend was seen for higher BMI (OR 1.114; 95% CI 1.000–1.242; p = 0.051). A cut-off value at CRP levels ≥ 14 mg/l demonstrated a sensitivity of 69% and a specificity of 70% with a fair accuracy (AUC 0.707).ConclusionPreoperative serum CRP levels, higher BMI and prolonged surgery time are independent predictors of early PJI. Excluding PJI secondary to major revision surgery revealed chronic glucocorticoid use as a risk factor apart from preoperative CRP levels.
31 schema:genre article
32 schema:isAccessibleForFree false
33 schema:isPartOf Nb285bad5ee094e8d9ee6dc9c640873f2
34 Nb90030ef13bf4c18a2a957e0bf45ec07
35 sg:journal.1294996
36 schema:keywords BMI
37 CRP levels
38 Disease Control definition
39 HA
40 PurposePeriprosthetic joint infection
41 ResultsMedian age
42 accuracy
43 age
44 aim
45 analysis
46 backward elimination
47 center
48 chronic glucocorticoid therapy
49 chronic glucocorticoid use
50 clear trend
51 complications
52 control definition
53 days
54 deep incisional surgical site infection
55 deep wound infection
56 definition
57 devastating complication
58 early infection
59 elderly patients
60 elimination
61 factors
62 fair accuracy
63 femoral neck fractures
64 fracture patients
65 fractures
66 geriatric femoral neck fractures
67 glucocorticoid therapy
68 glucocorticoid use
69 hemiarthroplasty
70 higher BMI
71 hip fracture
72 hip fracture patients
73 hospital mortality
74 hospital stay
75 incisional surgical site infection
76 independent predictors
77 independent risk factor
78 infection
79 joint infection
80 length
81 levels
82 major revision
83 major revision surgery
84 mechanical complications
85 median length
86 morbidity
87 mortality
88 multivariable regression analysis
89 neck fractures
90 opportunities
91 patients
92 period
93 postoperative period
94 predictors
95 preoperative CRP levels
96 preoperative risk factors
97 regression analysis
98 retrospective study
99 revision
100 revision surgery
101 risk factors
102 sensitivity
103 serious morbidity
104 serum CRP levels
105 site infection
106 specificity
107 stay
108 study
109 surgery
110 surgery time
111 surgical revision
112 surgical site infection
113 therapy
114 time
115 trends
116 use
117 values
118 weeks
119 wound infection
120 years
121 schema:name Risk factors for early infection following hemiarthroplasty in elderly patients with a femoral neck fracture
122 schema:pagination 207-212
123 schema:productId N6c03709b73e9479ea4cdd91bff155de6
124 N85686b84b7784708a1038f0a11c1af67
125 Na1e47b436e6c471ca7fcd413677d03d9
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100424378
127 https://doi.org/10.1007/s00068-018-0909-8
128 schema:sdDatePublished 2022-09-02T16:02
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher N73e5dd43a6b641fdb72bb7f97189956f
131 schema:url https://doi.org/10.1007/s00068-018-0909-8
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N05122e33941c44599e02042a9d6fa454 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Humans
137 rdf:type schema:DefinedTerm
138 N0af1368919fa422a863f946bdd23ef01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Aged
140 rdf:type schema:DefinedTerm
141 N1dd06c765aa14c9bb47d6bd4aa812d2c rdf:first sg:person.014037643206.83
142 rdf:rest N49ee8f0ddbd042c6b663bcb649af28ed
143 N23503d65a0a64fd6b7afc40de0fd17e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Odds Ratio
145 rdf:type schema:DefinedTerm
146 N280bdee4dcbc4065930d61625129b207 rdf:first sg:person.0630774640.46
147 rdf:rest N1dd06c765aa14c9bb47d6bd4aa812d2c
148 N3c18c49fe5b546898ebecadd95651994 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Surgical Wound Infection
150 rdf:type schema:DefinedTerm
151 N483b474c038946528f885dffb1616b76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Length of Stay
153 rdf:type schema:DefinedTerm
154 N49ee8f0ddbd042c6b663bcb649af28ed rdf:first sg:person.01156456305.30
155 rdf:rest N95224d04786b475bab676855cf877ef1
156 N4dedaef9c3cf4c8a813b65c14b95c208 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Male
158 rdf:type schema:DefinedTerm
159 N4f6a54834cf64cd78b6411db1eb70929 rdf:first sg:person.01052070352.86
160 rdf:rest Nfe6592a61358445ca4cedfa58bcb476b
161 N574b2f191ae6444990039edf3e050d12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Treatment Outcome
163 rdf:type schema:DefinedTerm
164 N63d6a1e82d204760b60f8a22cc39800a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Hospital Mortality
166 rdf:type schema:DefinedTerm
167 N6c03709b73e9479ea4cdd91bff155de6 schema:name doi
168 schema:value 10.1007/s00068-018-0909-8
169 rdf:type schema:PropertyValue
170 N725e22fa7d864168a74a07ae620b161a rdf:first sg:person.015234603204.02
171 rdf:rest rdf:nil
172 N73e5dd43a6b641fdb72bb7f97189956f schema:name Springer Nature - SN SciGraph project
173 rdf:type schema:Organization
174 N7b58bdb6eaff407d8c67484be63c1aed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Anti-Bacterial Agents
176 rdf:type schema:DefinedTerm
177 N85686b84b7784708a1038f0a11c1af67 schema:name dimensions_id
178 schema:value pub.1100424378
179 rdf:type schema:PropertyValue
180 N872a6b5de5204bb8a67798f7d0dd77a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Aged, 80 and over
182 rdf:type schema:DefinedTerm
183 N95224d04786b475bab676855cf877ef1 rdf:first sg:person.01311003347.16
184 rdf:rest N4f6a54834cf64cd78b6411db1eb70929
185 Na1e47b436e6c471ca7fcd413677d03d9 schema:name pubmed_id
186 schema:value 29340736
187 rdf:type schema:PropertyValue
188 Na20866ce245f489a8fa65fcfc81eb9ac rdf:first sg:person.0731203470.32
189 rdf:rest Nca4d93a457ef442aa6bfd27d7ee936f7
190 Nb285bad5ee094e8d9ee6dc9c640873f2 schema:issueNumber 2
191 rdf:type schema:PublicationIssue
192 Nb90030ef13bf4c18a2a957e0bf45ec07 schema:volumeNumber 45
193 rdf:type schema:PublicationVolume
194 Nc84be268c74640628f3eb99c1f59d2cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Female
196 rdf:type schema:DefinedTerm
197 Nca4d93a457ef442aa6bfd27d7ee936f7 rdf:first sg:person.01340334560.84
198 rdf:rest N725e22fa7d864168a74a07ae620b161a
199 Nd01c96c2fe1e4868b485281dcf10e607 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Risk Factors
201 rdf:type schema:DefinedTerm
202 Nd32f93b5c619401896e6a4d8dff7065a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Retrospective Studies
204 rdf:type schema:DefinedTerm
205 Ndb944b51dc0945cfb4abd4b37d90d23e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Hemiarthroplasty
207 rdf:type schema:DefinedTerm
208 Ne49e776b3fb84fffaf3a619a6540a47d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Femoral Neck Fractures
210 rdf:type schema:DefinedTerm
211 Nfe6592a61358445ca4cedfa58bcb476b rdf:first sg:person.0621766602.16
212 rdf:rest Na20866ce245f489a8fa65fcfc81eb9ac
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
217 schema:name Clinical Sciences
218 rdf:type schema:DefinedTerm
219 sg:journal.1294996 schema:issn 1615-3146
220 1863-9933
221 schema:name European Journal of Trauma and Emergency Surgery
222 schema:publisher Springer Nature
223 rdf:type schema:Periodical
224 sg:person.01052070352.86 schema:affiliation grid-institutes:grid.411339.d
225 schema:familyName Theopold
226 schema:givenName Jan
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052070352.86
228 rdf:type schema:Person
229 sg:person.01156456305.30 schema:affiliation grid-institutes:grid.411339.d
230 schema:familyName Lycke
231 schema:givenName Christian
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156456305.30
233 rdf:type schema:Person
234 sg:person.01311003347.16 schema:affiliation grid-institutes:grid.411339.d
235 schema:familyName Özkurtul
236 schema:givenName Orkun
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311003347.16
238 rdf:type schema:Person
239 sg:person.01340334560.84 schema:affiliation grid-institutes:grid.411339.d
240 schema:familyName Josten
241 schema:givenName Christoph
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340334560.84
243 rdf:type schema:Person
244 sg:person.014037643206.83 schema:affiliation grid-institutes:grid.411339.d
245 schema:familyName Brand
246 schema:givenName Alexander
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014037643206.83
248 rdf:type schema:Person
249 sg:person.015234603204.02 schema:affiliation grid-institutes:grid.411339.d
250 schema:familyName Fakler
251 schema:givenName Johannes K. M.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015234603204.02
253 rdf:type schema:Person
254 sg:person.0621766602.16 schema:affiliation grid-institutes:grid.411339.d
255 schema:familyName Spiegl
256 schema:givenName Ulrich J. A.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621766602.16
258 rdf:type schema:Person
259 sg:person.0630774640.46 schema:affiliation grid-institutes:None
260 schema:familyName Zajonz
261 schema:givenName Dirk
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630774640.46
263 rdf:type schema:Person
264 sg:person.0731203470.32 schema:affiliation grid-institutes:grid.411339.d
265 schema:familyName Roth
266 schema:givenName Andreas
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731203470.32
268 rdf:type schema:Person
269 sg:pub.10.1007/s00113-009-1674-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034870053
270 https://doi.org/10.1007/s00113-009-1674-2
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/s00113-017-0386-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090880721
273 https://doi.org/10.1007/s00113-017-0386-2
274 rdf:type schema:CreativeWork
275 sg:pub.10.1007/s00132-008-1342-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016572211
276 https://doi.org/10.1007/s00132-008-1342-1
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/s00264-006-0227-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049944505
279 https://doi.org/10.1007/s00264-006-0227-3
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s00590-014-1449-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038202916
282 https://doi.org/10.1007/s00590-014-1449-5
283 rdf:type schema:CreativeWork
284 sg:pub.10.1007/s11999-016-5222-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037614239
285 https://doi.org/10.1007/s11999-016-5222-4
286 rdf:type schema:CreativeWork
287 sg:pub.10.1186/1754-9493-4-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047507134
288 https://doi.org/10.1186/1754-9493-4-16
289 rdf:type schema:CreativeWork
290 sg:pub.10.1186/s12891-016-0906-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049489227
291 https://doi.org/10.1186/s12891-016-0906-1
292 rdf:type schema:CreativeWork
293 sg:pub.10.1186/s13037-016-0105-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013069927
294 https://doi.org/10.1186/s13037-016-0105-x
295 rdf:type schema:CreativeWork
296 grid-institutes:None schema:alternateName ZESBO–Zentrum zur Erforschung der Stütz- und Bewegungsorgane, Semmelweisstraße 14, 04103, Leipzig, Germany
297 schema:name Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany
298 ZESBO–Zentrum zur Erforschung der Stütz- und Bewegungsorgane, Semmelweisstraße 14, 04103, Leipzig, Germany
299 rdf:type schema:Organization
300 grid-institutes:grid.411339.d schema:alternateName Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany
301 schema:name Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany
302 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...