Characteristics of bone metabolism markers during the healing of osteoporotic versus nonosteoporotic metaphyseal long bone fractures: a matched pair analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-04-25

AUTHORS

L. Kolios, M. Hitzler, A. Moghaddam, C. Takur, H. Schmidt-Gayk, B. Höner, M. Lehnhardt, P. Grützner, C. Wölfl

ABSTRACT

PurposeThe activity and metabolism of fracture healing can be monitored quantitatively by measuring bone turnover markers (BTMs) in serum or urine. However, in osteoporotic bone, the exact metabolism processes during the healing of metaphyseal fractures remain unknown. There is no diagnostic approach which currently allows dynamic insight into the fracture healing processes in order to monitor the progression of healing and to assist in therapeutic decision making.MethodsBetween March 2007 and February 2009, 30 patients over 50 years of age who suffered a metaphyseal fracture were included in our study. The levels of the osteoanabolic marker BAP (bone-specific alkaline phosphatase) and osteocatabolic marker β-CTX [crosslinked C-(CTX)-telopeptide-of-type-I-collagen] were monitored during the fracture healing of osteoporotic and nonosteoporotic fractures for a duration of 8 weeks.ResultsAfter an initial decrease of BAP in the first week, the BAP level steadily increased through the fourth week in both groups. The levels of BAP in the osteoporotic group surpassed the healthy group. β-CTX steadily increased in healthy bone up to the fourth week; in osteoporotic bone, β-CTX first increased and, thereafter, decreased from the first week onwards.ConclusionsIn this work, the first molecular biological aspects of osteoporotic fracture healing have been uncovered, helping to explain the mechanisms of delayed fracture healing in osteoporotic bone. The early decrease of reduced β-CTX as well as elevated BAP during the healing process may be the first aspects within the delayed healing of osteoporotic bone. Further studies are necessary in order to achieve more detailed insight to fracture healing and to ascertain the progression of fracture healing as being essential (criteria) for therapeutic decision making. More... »

PAGES

457-462

References to SciGraph publications

  • 2008-07-25. A novel model to study metaphyseal bone healing under defined biomechanical conditions in ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
  • 2008-05. Biomarkers for Osteoporosis Management in MOLECULAR DIAGNOSIS & THERAPY
  • 2005-03. B-type natriuretic peptide in patients with clinical hyperthyroidism in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2006-11-22. A comparative study of the bone-restorative efficacy of anabolic agents in aged ovariectomized rats in OSTEOPOROSIS INTERNATIONAL
  • 2004-11-03. Fixation principles in metaphyseal bone—a patent based review in OSTEOPOROSIS INTERNATIONAL
  • 2001-12. Ten Year Probabilities of Osteoporotic Fractures According to BMD and Diagnostic Thresholds in OSTEOPOROSIS INTERNATIONAL
  • 1999-10. Changes in Bone Mass and Bone Turnover Following Ankle Fracture in OSTEOPOROSIS INTERNATIONAL
  • 1999-10. Changes in Bone Mass and Bone Turnover Following Distal Forearm Fracture in OSTEOPOROSIS INTERNATIONAL
  • 2011-04-22. Biochemical markers of bone turnover as predictors of osteoporosis and osteoporotic fractures in men and women: 10-year follow-up of the Taiji cohort in MODERN RHEUMATOLOGY
  • 1994-10. Collagen turnover after tibial fractures in ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
  • 2005-12-15. Changes in bone mass and bone turnover following tibial shaft fracture in OSTEOPOROSIS INTERNATIONAL
  • 1998-01. Urinary Excretion of Type I Collagen Degradation Products in Healthy Women and Osteoporotic Patients with Vertebral and Hip Fractures in CALCIFIED TISSUE INTERNATIONAL
  • 2001-06-01. RETRACTED ARTICLE: Changes in Bone and Calcium Metabolism Following Hip Fracture in Elderly Patients in OSTEOPOROSIS INTERNATIONAL
  • 2002-05. Bone Changes due to Glucocorticoid Application in an Ovariectomized Animal Model for Fracture Treatment in Osteoporosis in OSTEOPOROSIS INTERNATIONAL
  • 1998-12. Changes of biochemical markers during fracture healing in ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
  • 1992-09. Types I and III procollagen extension peptides in serum respond to fracture in humans in ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
  • 2008-07-11. Biochemische Knochenresorptionsmarker in der Heilungsphase osteoporotischer Frakturen in DER UNFALLCHIRURG
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00068-012-0190-1

    DOI

    http://dx.doi.org/10.1007/s00068-012-0190-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038436535

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26816128


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department for Hand, Plastic and Reconstructive Surgery, Burn Care Centre, Clinic for Plastic Surgery of the University of Heidelberg, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department for Hand, Plastic and Reconstructive Surgery, Burn Care Centre, Clinic for Plastic Surgery of the University of Heidelberg, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kolios", 
            "givenName": "L.", 
            "id": "sg:person.01177550105.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177550105.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418303.d", 
              "name": [
                "Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hitzler", 
            "givenName": "M.", 
            "id": "sg:person.0662655043.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662655043.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418303.d", 
              "name": [
                "Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moghaddam", 
            "givenName": "A.", 
            "id": "sg:person.01240435544.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240435544.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418303.d", 
              "name": [
                "Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takur", 
            "givenName": "C.", 
            "id": "sg:person.01070276410.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070276410.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Laboratory Limbach, Im Breitspiel 15, 69126, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Clinical Laboratory Limbach, Im Breitspiel 15, 69126, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schmidt-Gayk", 
            "givenName": "H.", 
            "id": "sg:person.01066174210.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066174210.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Social and Legal Sciences, SRH University Heidelberg, Ludwig-Guttmann-Str. 6, 69123, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.466188.5", 
              "name": [
                "Department of Social and Legal Sciences, SRH University Heidelberg, Ludwig-Guttmann-Str. 6, 69123, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "H\u00f6ner", 
            "givenName": "B.", 
            "id": "sg:person.0631260044.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631260044.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department for Hand, Plastic and Reconstructive Surgery, Burn Care Centre, Clinic for Plastic Surgery of the University of Heidelberg, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department for Hand, Plastic and Reconstructive Surgery, Burn Care Centre, Clinic for Plastic Surgery of the University of Heidelberg, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lehnhardt", 
            "givenName": "M.", 
            "id": "sg:person.01276652626.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276652626.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418303.d", 
              "name": [
                "Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gr\u00fctzner", 
            "givenName": "P.", 
            "id": "sg:person.01060715001.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060715001.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418303.d", 
              "name": [
                "Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "W\u00f6lfl", 
            "givenName": "C.", 
            "id": "sg:person.0635517210.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635517210.18"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf00571521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044303030", 
              "https://doi.org/10.1007/bf00571521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001980170088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031001780", 
              "https://doi.org/10.1007/s001980170088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001980200047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007040493", 
              "https://doi.org/10.1007/s001980200047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03345522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047809653", 
              "https://doi.org/10.1007/bf03345522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03256280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011840081", 
              "https://doi.org/10.1007/bf03256280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-006-0240-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032515585", 
              "https://doi.org/10.1007/s00198-006-0240-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001980170006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033966487", 
              "https://doi.org/10.1007/s001980170006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00426183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001800922", 
              "https://doi.org/10.1007/bf00426183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00113-008-1465-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032179593", 
              "https://doi.org/10.1007/s00113-008-1465-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-005-2025-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052259550", 
              "https://doi.org/10.1007/s00198-005-2025-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00402-008-0692-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047983902", 
              "https://doi.org/10.1007/s00402-008-0692-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002239900391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010377529", 
              "https://doi.org/10.1007/s002239900391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001980050246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035697189", 
              "https://doi.org/10.1007/s001980050246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001980050247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018367575", 
              "https://doi.org/10.1007/s001980050247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-004-1763-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026241506", 
              "https://doi.org/10.1007/s00198-004-1763-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004020050331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041429254", 
              "https://doi.org/10.1007/s004020050331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10165-011-0455-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052137198", 
              "https://doi.org/10.1007/s10165-011-0455-2"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-04-25", 
        "datePublishedReg": "2012-04-25", 
        "description": "PurposeThe activity and metabolism of fracture healing can be monitored quantitatively by measuring bone turnover markers (BTMs) in serum or urine. However, in osteoporotic bone, the exact metabolism processes during the healing of metaphyseal fractures remain unknown. There is no diagnostic approach which currently allows dynamic insight into the fracture healing processes in order to monitor the progression of healing and to assist in therapeutic decision making.MethodsBetween March 2007 and February 2009, 30 patients over 50\u00a0years of age who suffered a metaphyseal fracture were included in our study. The levels of the osteoanabolic marker BAP (bone-specific alkaline phosphatase) and osteocatabolic marker \u03b2-CTX [crosslinked C-(CTX)-telopeptide-of-type-I-collagen] were monitored during the fracture healing of osteoporotic and nonosteoporotic fractures for a duration of 8\u00a0weeks.ResultsAfter an initial decrease of BAP in the first week, the BAP level steadily increased through the fourth week in both groups. The levels of BAP in the osteoporotic group surpassed the healthy group. \u03b2-CTX steadily increased in healthy bone up to the fourth week; in osteoporotic bone, \u03b2-CTX first increased and, thereafter, decreased from the first week onwards.ConclusionsIn this work, the first molecular biological aspects of osteoporotic fracture healing have been uncovered, helping to explain the mechanisms of delayed fracture healing in osteoporotic bone. The early decrease of reduced \u03b2-CTX as well as elevated BAP during the healing process may be the first aspects within the delayed healing of osteoporotic bone. Further studies are necessary in order to achieve more detailed insight to fracture healing and to ascertain the progression of fracture healing as being essential (criteria) for therapeutic decision making.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00068-012-0190-1", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1294996", 
            "issn": [
              "1863-9933", 
              "1615-3146"
            ], 
            "name": "European Journal of Trauma and Emergency Surgery", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "38"
          }
        ], 
        "keywords": [
          "bone turnover markers", 
          "fracture healing", 
          "osteoporotic bone", 
          "metaphyseal fractures", 
          "therapeutic decisions", 
          "first week", 
          "fourth week", 
          "healing process", 
          "bone metabolism markers", 
          "osteoporotic fracture healing", 
          "long bone fractures", 
          "years of age", 
          "fracture healing process", 
          "progression of healing", 
          "turnover markers", 
          "metabolism markers", 
          "healthy group", 
          "osteoporotic group", 
          "bone fractures", 
          "nonosteoporotic fractures", 
          "early decrease", 
          "diagnostic approach", 
          "healthy bone", 
          "molecular biological aspects", 
          "CTX", 
          "weeks", 
          "healing", 
          "BAP levels", 
          "marker \u03b2", 
          "Further studies", 
          "bone", 
          "progression", 
          "initial decrease", 
          "fractures", 
          "pair analysis", 
          "markers", 
          "group", 
          "patients", 
          "levels", 
          "ConclusionsIn", 
          "ResultsAfter", 
          "serum", 
          "urine", 
          "age", 
          "decrease", 
          "metabolism processes", 
          "study", 
          "duration", 
          "metabolism", 
          "years", 
          "biological aspects", 
          "activity", 
          "BAP", 
          "mechanism", 
          "aspects", 
          "levels of BAP", 
          "decisions", 
          "insights", 
          "analysis", 
          "characteristics", 
          "process", 
          "order", 
          "approach", 
          "detailed insight", 
          "dynamic insights", 
          "first aspect", 
          "work", 
          "PurposeThe activity", 
          "exact metabolism processes", 
          "osteoanabolic marker BAP", 
          "marker BAP", 
          "osteocatabolic marker \u03b2", 
          "first molecular biological aspects", 
          "elevated BAP", 
          "nonosteoporotic metaphyseal long bone fractures", 
          "metaphyseal long bone fractures"
        ], 
        "name": "Characteristics of bone metabolism markers during the healing of osteoporotic versus nonosteoporotic metaphyseal long bone fractures: a matched pair analysis", 
        "pagination": "457-462", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1038436535"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00068-012-0190-1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26816128"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00068-012-0190-1", 
          "https://app.dimensions.ai/details/publication/pub.1038436535"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_567.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00068-012-0190-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00068-012-0190-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00068-012-0190-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00068-012-0190-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00068-012-0190-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    271 TRIPLES      22 PREDICATES      119 URIs      94 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00068-012-0190-1 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author N340e07cd8a8642d5bf956ef258e49cc6
    4 schema:citation sg:pub.10.1007/bf00426183
    5 sg:pub.10.1007/bf00571521
    6 sg:pub.10.1007/bf03256280
    7 sg:pub.10.1007/bf03345522
    8 sg:pub.10.1007/s00113-008-1465-1
    9 sg:pub.10.1007/s00198-004-1763-6
    10 sg:pub.10.1007/s00198-005-2025-y
    11 sg:pub.10.1007/s00198-006-0240-9
    12 sg:pub.10.1007/s001980050246
    13 sg:pub.10.1007/s001980050247
    14 sg:pub.10.1007/s001980170006
    15 sg:pub.10.1007/s001980170088
    16 sg:pub.10.1007/s001980200047
    17 sg:pub.10.1007/s002239900391
    18 sg:pub.10.1007/s00402-008-0692-9
    19 sg:pub.10.1007/s004020050331
    20 sg:pub.10.1007/s10165-011-0455-2
    21 schema:datePublished 2012-04-25
    22 schema:datePublishedReg 2012-04-25
    23 schema:description PurposeThe activity and metabolism of fracture healing can be monitored quantitatively by measuring bone turnover markers (BTMs) in serum or urine. However, in osteoporotic bone, the exact metabolism processes during the healing of metaphyseal fractures remain unknown. There is no diagnostic approach which currently allows dynamic insight into the fracture healing processes in order to monitor the progression of healing and to assist in therapeutic decision making.MethodsBetween March 2007 and February 2009, 30 patients over 50 years of age who suffered a metaphyseal fracture were included in our study. The levels of the osteoanabolic marker BAP (bone-specific alkaline phosphatase) and osteocatabolic marker β-CTX [crosslinked C-(CTX)-telopeptide-of-type-I-collagen] were monitored during the fracture healing of osteoporotic and nonosteoporotic fractures for a duration of 8 weeks.ResultsAfter an initial decrease of BAP in the first week, the BAP level steadily increased through the fourth week in both groups. The levels of BAP in the osteoporotic group surpassed the healthy group. β-CTX steadily increased in healthy bone up to the fourth week; in osteoporotic bone, β-CTX first increased and, thereafter, decreased from the first week onwards.ConclusionsIn this work, the first molecular biological aspects of osteoporotic fracture healing have been uncovered, helping to explain the mechanisms of delayed fracture healing in osteoporotic bone. The early decrease of reduced β-CTX as well as elevated BAP during the healing process may be the first aspects within the delayed healing of osteoporotic bone. Further studies are necessary in order to achieve more detailed insight to fracture healing and to ascertain the progression of fracture healing as being essential (criteria) for therapeutic decision making.
    24 schema:genre article
    25 schema:inLanguage en
    26 schema:isAccessibleForFree false
    27 schema:isPartOf N16715878af9d487ba023888f3a68f4b2
    28 Nb9f9d1c631594796a972734160432769
    29 sg:journal.1294996
    30 schema:keywords BAP
    31 BAP levels
    32 CTX
    33 ConclusionsIn
    34 Further studies
    35 PurposeThe activity
    36 ResultsAfter
    37 activity
    38 age
    39 analysis
    40 approach
    41 aspects
    42 biological aspects
    43 bone
    44 bone fractures
    45 bone metabolism markers
    46 bone turnover markers
    47 characteristics
    48 decisions
    49 decrease
    50 detailed insight
    51 diagnostic approach
    52 duration
    53 dynamic insights
    54 early decrease
    55 elevated BAP
    56 exact metabolism processes
    57 first aspect
    58 first molecular biological aspects
    59 first week
    60 fourth week
    61 fracture healing
    62 fracture healing process
    63 fractures
    64 group
    65 healing
    66 healing process
    67 healthy bone
    68 healthy group
    69 initial decrease
    70 insights
    71 levels
    72 levels of BAP
    73 long bone fractures
    74 marker BAP
    75 marker β
    76 markers
    77 mechanism
    78 metabolism
    79 metabolism markers
    80 metabolism processes
    81 metaphyseal fractures
    82 metaphyseal long bone fractures
    83 molecular biological aspects
    84 nonosteoporotic fractures
    85 nonosteoporotic metaphyseal long bone fractures
    86 order
    87 osteoanabolic marker BAP
    88 osteocatabolic marker β
    89 osteoporotic bone
    90 osteoporotic fracture healing
    91 osteoporotic group
    92 pair analysis
    93 patients
    94 process
    95 progression
    96 progression of healing
    97 serum
    98 study
    99 therapeutic decisions
    100 turnover markers
    101 urine
    102 weeks
    103 work
    104 years
    105 years of age
    106 schema:name Characteristics of bone metabolism markers during the healing of osteoporotic versus nonosteoporotic metaphyseal long bone fractures: a matched pair analysis
    107 schema:pagination 457-462
    108 schema:productId N60aff64e99da4f2e93bb1fbed70f52e3
    109 N7b4932ec1c8346bd8b9f1af5953d815b
    110 Nc5efdded040441b786377eb8bfc66ba9
    111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038436535
    112 https://doi.org/10.1007/s00068-012-0190-1
    113 schema:sdDatePublished 2022-01-01T18:28
    114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    115 schema:sdPublisher Nf5b34ac03de44b86936c5c6481bafa30
    116 schema:url https://doi.org/10.1007/s00068-012-0190-1
    117 sgo:license sg:explorer/license/
    118 sgo:sdDataset articles
    119 rdf:type schema:ScholarlyArticle
    120 N13a47daa436841db8dead5f17bf2d815 rdf:first sg:person.01070276410.44
    121 rdf:rest N3bef92e23537444181676306a4a25059
    122 N16715878af9d487ba023888f3a68f4b2 schema:volumeNumber 38
    123 rdf:type schema:PublicationVolume
    124 N267f1b58d3734fb38e9973d708dbff8a rdf:first sg:person.0662655043.17
    125 rdf:rest Ndf83ea49a9d84e55bcb0fc9d04a3ed0c
    126 N340e07cd8a8642d5bf956ef258e49cc6 rdf:first sg:person.01177550105.79
    127 rdf:rest N267f1b58d3734fb38e9973d708dbff8a
    128 N3bef92e23537444181676306a4a25059 rdf:first sg:person.01066174210.35
    129 rdf:rest N6198094eb2dc48dfaac3dd76098ddf71
    130 N51531b9d17374ac6beb7e2152eac4c25 rdf:first sg:person.0635517210.18
    131 rdf:rest rdf:nil
    132 N60aff64e99da4f2e93bb1fbed70f52e3 schema:name doi
    133 schema:value 10.1007/s00068-012-0190-1
    134 rdf:type schema:PropertyValue
    135 N6198094eb2dc48dfaac3dd76098ddf71 rdf:first sg:person.0631260044.30
    136 rdf:rest Na99e0adab5fd48e0b73a68b01c4c0d82
    137 N7b072bcfc233433da887717e3acb498d rdf:first sg:person.01060715001.02
    138 rdf:rest N51531b9d17374ac6beb7e2152eac4c25
    139 N7b4932ec1c8346bd8b9f1af5953d815b schema:name pubmed_id
    140 schema:value 26816128
    141 rdf:type schema:PropertyValue
    142 Na99e0adab5fd48e0b73a68b01c4c0d82 rdf:first sg:person.01276652626.26
    143 rdf:rest N7b072bcfc233433da887717e3acb498d
    144 Nb9f9d1c631594796a972734160432769 schema:issueNumber 4
    145 rdf:type schema:PublicationIssue
    146 Nc5efdded040441b786377eb8bfc66ba9 schema:name dimensions_id
    147 schema:value pub.1038436535
    148 rdf:type schema:PropertyValue
    149 Ndf83ea49a9d84e55bcb0fc9d04a3ed0c rdf:first sg:person.01240435544.36
    150 rdf:rest N13a47daa436841db8dead5f17bf2d815
    151 Nf5b34ac03de44b86936c5c6481bafa30 schema:name Springer Nature - SN SciGraph project
    152 rdf:type schema:Organization
    153 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    154 schema:name Medical and Health Sciences
    155 rdf:type schema:DefinedTerm
    156 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    157 schema:name Clinical Sciences
    158 rdf:type schema:DefinedTerm
    159 sg:journal.1294996 schema:issn 1615-3146
    160 1863-9933
    161 schema:name European Journal of Trauma and Emergency Surgery
    162 schema:publisher Springer Nature
    163 rdf:type schema:Periodical
    164 sg:person.01060715001.02 schema:affiliation grid-institutes:grid.418303.d
    165 schema:familyName Grützner
    166 schema:givenName P.
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060715001.02
    168 rdf:type schema:Person
    169 sg:person.01066174210.35 schema:affiliation grid-institutes:None
    170 schema:familyName Schmidt-Gayk
    171 schema:givenName H.
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066174210.35
    173 rdf:type schema:Person
    174 sg:person.01070276410.44 schema:affiliation grid-institutes:grid.418303.d
    175 schema:familyName Takur
    176 schema:givenName C.
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070276410.44
    178 rdf:type schema:Person
    179 sg:person.01177550105.79 schema:affiliation grid-institutes:grid.7700.0
    180 schema:familyName Kolios
    181 schema:givenName L.
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177550105.79
    183 rdf:type schema:Person
    184 sg:person.01240435544.36 schema:affiliation grid-institutes:grid.418303.d
    185 schema:familyName Moghaddam
    186 schema:givenName A.
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240435544.36
    188 rdf:type schema:Person
    189 sg:person.01276652626.26 schema:affiliation grid-institutes:grid.7700.0
    190 schema:familyName Lehnhardt
    191 schema:givenName M.
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276652626.26
    193 rdf:type schema:Person
    194 sg:person.0631260044.30 schema:affiliation grid-institutes:grid.466188.5
    195 schema:familyName Höner
    196 schema:givenName B.
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631260044.30
    198 rdf:type schema:Person
    199 sg:person.0635517210.18 schema:affiliation grid-institutes:grid.418303.d
    200 schema:familyName Wölfl
    201 schema:givenName C.
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635517210.18
    203 rdf:type schema:Person
    204 sg:person.0662655043.17 schema:affiliation grid-institutes:grid.418303.d
    205 schema:familyName Hitzler
    206 schema:givenName M.
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662655043.17
    208 rdf:type schema:Person
    209 sg:pub.10.1007/bf00426183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001800922
    210 https://doi.org/10.1007/bf00426183
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/bf00571521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044303030
    213 https://doi.org/10.1007/bf00571521
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/bf03256280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011840081
    216 https://doi.org/10.1007/bf03256280
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/bf03345522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047809653
    219 https://doi.org/10.1007/bf03345522
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00113-008-1465-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032179593
    222 https://doi.org/10.1007/s00113-008-1465-1
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s00198-004-1763-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026241506
    225 https://doi.org/10.1007/s00198-004-1763-6
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00198-005-2025-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1052259550
    228 https://doi.org/10.1007/s00198-005-2025-y
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s00198-006-0240-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032515585
    231 https://doi.org/10.1007/s00198-006-0240-9
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s001980050246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035697189
    234 https://doi.org/10.1007/s001980050246
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s001980050247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018367575
    237 https://doi.org/10.1007/s001980050247
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s001980170006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033966487
    240 https://doi.org/10.1007/s001980170006
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1007/s001980170088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031001780
    243 https://doi.org/10.1007/s001980170088
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1007/s001980200047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007040493
    246 https://doi.org/10.1007/s001980200047
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1007/s002239900391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010377529
    249 https://doi.org/10.1007/s002239900391
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/s00402-008-0692-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047983902
    252 https://doi.org/10.1007/s00402-008-0692-9
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1007/s004020050331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041429254
    255 https://doi.org/10.1007/s004020050331
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1007/s10165-011-0455-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052137198
    258 https://doi.org/10.1007/s10165-011-0455-2
    259 rdf:type schema:CreativeWork
    260 grid-institutes:None schema:alternateName Clinical Laboratory Limbach, Im Breitspiel 15, 69126, Heidelberg, Germany
    261 schema:name Clinical Laboratory Limbach, Im Breitspiel 15, 69126, Heidelberg, Germany
    262 rdf:type schema:Organization
    263 grid-institutes:grid.418303.d schema:alternateName Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany
    264 schema:name Department for Traumatology and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany
    265 rdf:type schema:Organization
    266 grid-institutes:grid.466188.5 schema:alternateName Department of Social and Legal Sciences, SRH University Heidelberg, Ludwig-Guttmann-Str. 6, 69123, Heidelberg, Germany
    267 schema:name Department of Social and Legal Sciences, SRH University Heidelberg, Ludwig-Guttmann-Str. 6, 69123, Heidelberg, Germany
    268 rdf:type schema:Organization
    269 grid-institutes:grid.7700.0 schema:alternateName Department for Hand, Plastic and Reconstructive Surgery, Burn Care Centre, Clinic for Plastic Surgery of the University of Heidelberg, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany
    270 schema:name Department for Hand, Plastic and Reconstructive Surgery, Burn Care Centre, Clinic for Plastic Surgery of the University of Heidelberg, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen, Germany
    271 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...