Adapted strategy to tumor response in childhood nasopharyngeal carcinoma: the French experience. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-08

AUTHORS

Anaïs Jouin, Sylvie Helfre, Stéphanie Bolle, Line Claude, Anne Laprie, Emilie Bogart, Céline Vigneron, Hélène Potet, Anne Ducassou, Audrey Claren, François Georges Riet, Marie Pierre Castex, Cécile Faure-Conter, Brice Fresneau, Anne Sophie Defachelles, Daniel Orbach

ABSTRACT

PURPOSE: The aim of this study was to retrospectively study survival and long-term morbidities of children with nasopharyngeal carcinoma (NPC) treated by induction chemotherapy and concurrent chemoradiation (CRT). The total dose of radiation was adapted to the response following neoadjuvant chemotherapy. METHODS: Children with non-metastatic NPC treated in France between 1999 and 2015 were retrospectively included in the study. The strategy combined neoadjuvant platinum-based chemotherapy, followed by adapted CRT to tumor response. RESULTS: In total, 95 patients (median age 15 years [range, 7-23 years], male-to-female ratio 1.8) with undifferentiated NPC were included; 59% of patients had TNM stage IV. Intensity-modulated radiotherapy (IMRT) was delivered to 57 patients (60%), while the other patients were treated with conformal RT (3D-RT). After a median follow-up of 4.5 years [range, 3.6-5.5 years], 13 relapses and seven deaths had occurred. The 3‑year overall and relapse-free survival (RFS) were 94% [95% CI, 85-97%] and 86% [77-92%], respectively. The locoregional failure rate was 6% [95% CI, 2-14]. Long-term treatment-related sequelae of grade 2+ were reported by 37 (50%) patients; odynophagia was significantly reduced treated by IMRT vs. conventional 3D-RT (7% vs. 55%, p = 0.015). Using a reduction dose of 59.4 Gy, 54 Gy, and 45 Gy, respectively, to the primary, involved, and uninvolved neck nodes, after a favorable tumor response, was not associated with an increased locoregional failure rate. CONCLUSIONS: The survival rates for NPC have been considerably improved by means of multimodal therapy, but long-term locoregional morbidity remains common. Use of IMRT may induce less residual odynophagia. Radiation dose reduction adapted to chemotherapy response does not have a negative impact on outcome. These findings support the use of an RT protocol adapted to the tumor response to neoadjuvant chemotherapy for a long-lasting improvement in the patient's quality of life. More... »

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00066-019-01461-6

DOI

http://dx.doi.org/10.1007/s00066-019-01461-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113300935

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30963203


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centre Oscar Lambret", 
          "id": "https://www.grid.ac/institutes/grid.452351.4", 
          "name": [
            "Radiotherapy department, Centre Oscar Lambret, Lille, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jouin", 
        "givenName": "Ana\u00efs", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Radiotherapy department, Institut Curie, Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Helfre", 
        "givenName": "Sylvie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Gustave Roussy, Department of Radiotherapy Oncology, Universit\u00e9 Paris-Saclay, 94805, Villejuif, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bolle", 
        "givenName": "St\u00e9phanie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy department, Centre Lyon B\u00e9rard, Lyon, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Claude", 
        "givenName": "Line", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy department, IUCT Oncopole, Toulouse, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laprie", 
        "givenName": "Anne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Oscar Lambret", 
          "id": "https://www.grid.ac/institutes/grid.452351.4", 
          "name": [
            "Biostatistics department, Centre Oscar Lambret, Lille, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bogart", 
        "givenName": "Emilie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UniCancer Group", 
          "id": "https://www.grid.ac/institutes/grid.418189.d", 
          "name": [
            "Radiotherapy department, Centre Paul Strauss, Strasbourg, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vigneron", 
        "givenName": "C\u00e9line", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Antoine Lacassagne", 
          "id": "https://www.grid.ac/institutes/grid.417812.9", 
          "name": [
            "Radiotherapy department, Centre Antoine Lacassagne, Nice, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Potet", 
        "givenName": "H\u00e9l\u00e8ne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy department, IUCT Oncopole, Toulouse, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ducassou", 
        "givenName": "Anne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Antoine Lacassagne", 
          "id": "https://www.grid.ac/institutes/grid.417812.9", 
          "name": [
            "Radiotherapy department, Centre Antoine Lacassagne, Nice, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Claren", 
        "givenName": "Audrey", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Gustave Roussy, Department of Radiotherapy Oncology, Universit\u00e9 Paris-Saclay, 94805, Villejuif, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riet", 
        "givenName": "Fran\u00e7ois Georges", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Pediatric department, Claudius Regaud Hospital, Toulouse, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castex", 
        "givenName": "Marie Pierre", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre L\u00e9on B\u00e9rard", 
          "id": "https://www.grid.ac/institutes/grid.418116.b", 
          "name": [
            "Pediatric department, Centre Leon B\u00e9rard, Lyon, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Faure-Conter", 
        "givenName": "C\u00e9cile", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for research in epidemiology and population health", 
          "id": "https://www.grid.ac/institutes/grid.463845.8", 
          "name": [
            "Gustave Roussy-Grand Campus, Pediatric department, University Paris-Saclay, Villejuif, France.", 
            "CESP, INSERM, Paris-Saclay University, Paris-Sud University, Villejuif, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fresneau", 
        "givenName": "Brice", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Oscar Lambret", 
          "id": "https://www.grid.ac/institutes/grid.452351.4", 
          "name": [
            "Pediatric department, Centre Oscar Lambret, Lille, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Defachelles", 
        "givenName": "Anne Sophie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "SIREDO Oncology Center (Care, Innovation and Research for Children, Adolescents and Young Adults with cancer), PSL Research University, French Pediatric Rare Tumor group (Fracture group), Institut Curie, 26, rue d'Ulm, 75005, Paris, France. daniel.orbach@curie.fr."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orbach", 
        "givenName": "Daniel", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cncr.29869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000032386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-3-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000044825", 
          "https://doi.org/10.1186/1748-717x-3-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.27395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000959381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.27395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000959381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.20106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003774347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004622359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004622359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.24341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005275298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.24341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005275298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.22521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008408249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.22521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008408249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009204076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-014-0274-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010452002", 
          "https://doi.org/10.1186/s13014-014-0274-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-014-0274-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010452002", 
          "https://doi.org/10.1186/s13014-014-0274-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-014-0274-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010452002", 
          "https://doi.org/10.1186/s13014-014-0274-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)70126-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011634998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)70126-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011634998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijporl.2013.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014000937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijporl.2013.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014000937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semradonc.2012.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014410705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semradonc.2012.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014410705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.25326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015727545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.25326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015727545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2008.05.065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016478766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-016-4154-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017049499", 
          "https://doi.org/10.1007/s00405-016-4154-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-016-4154-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017049499", 
          "https://doi.org/10.1007/s00405-016-4154-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-016-4154-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017049499", 
          "https://doi.org/10.1007/s00405-016-4154-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canrad.2013.06.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018797592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e3181b91180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019252948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e3181b91180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019252948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e3181b91180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019252948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2008.01.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019386525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1040-8428(99)00003-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021934432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023664483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023664483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.26240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024348552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12070-013-0622-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026760570", 
          "https://doi.org/10.1007/s12070-013-0622-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.24066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031932583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.24066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031932583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(16)30410-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033796903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(16)30410-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033796903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2008.12.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034694562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(99)00493-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034713640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035393036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035393036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-9-71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037504526", 
          "https://doi.org/10.1186/1748-717x-9-71"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2015.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037626497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2015.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037626497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-015-2933-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038312177", 
          "https://doi.org/10.1007/s00280-015-2933-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-015-2933-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038312177", 
          "https://doi.org/10.1007/s00280-015-2933-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2006.08.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038892292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2012.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039547144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2012.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039547144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.21372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039721521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.12736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042214903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.12736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042214903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.8841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042333490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mpo.2950190415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043976181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd004329.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045075257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0000000000000318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048781719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0000000000000318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048781719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19810101)47:1<207::aid-cncr2820470134>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049278910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)00773-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052481564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0041-111180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057374239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01621459.1958.10501452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058299418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1684/bdc.2010.1169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078214908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2016.67.4119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079363804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-017-2401-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084022007", 
          "https://doi.org/10.1007/s00432-017-2401-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-017-2401-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084022007", 
          "https://doi.org/10.1007/s00432-017-2401-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-017-2401-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084022007", 
          "https://doi.org/10.1007/s00432-017-2401-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.oraloncology.2017.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091384371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-017-4736-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091859917", 
          "https://doi.org/10.1007/s00405-017-4736-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0000000000001054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100180040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0000000000001054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100180040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0000000000001054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100180040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0000000000001054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100180040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1615/critrevoncog.2018027528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106347838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1615/critrevoncog.2018027528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106347838"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04-08", 
    "datePublishedReg": "2019-04-08", 
    "description": "PURPOSE: The aim of this study was to retrospectively study survival and long-term morbidities of children with nasopharyngeal carcinoma (NPC) treated by induction chemotherapy and concurrent chemoradiation (CRT). The total dose of radiation was adapted to the response following neoadjuvant chemotherapy.\nMETHODS: Children with non-metastatic NPC treated in France between 1999 and 2015 were retrospectively included in the study. The strategy combined neoadjuvant platinum-based chemotherapy, followed by adapted CRT to tumor response.\nRESULTS: In total, 95 patients (median age 15\u00a0years [range, 7-23\u00a0years], male-to-female ratio\u00a01.8) with undifferentiated NPC were included; 59% of patients had TNM stage\u00a0IV. Intensity-modulated radiotherapy (IMRT) was delivered to 57\u00a0patients (60%), while the other patients were treated with conformal RT (3D-RT). After a\u00a0median follow-up of 4.5\u00a0years [range, 3.6-5.5\u00a0years], 13 relapses and seven deaths had occurred. The 3\u2011year overall and relapse-free survival (RFS) were 94% [95% CI, 85-97%] and 86% [77-92%], respectively. The locoregional failure rate was 6% [95% CI, 2-14]. Long-term treatment-related sequelae of grade\u00a02+ were reported by 37 (50%) patients; odynophagia was significantly reduced treated by IMRT vs. conventional 3D-RT (7% vs. 55%, p\u202f=\u20090.015). Using a\u00a0reduction dose of 59.4\u202fGy, 54\u202fGy, and 45\u202fGy, respectively, to the primary, involved, and uninvolved neck nodes, after a\u00a0favorable tumor response, was not associated with an increased locoregional failure rate.\nCONCLUSIONS: The survival rates for NPC have been considerably improved by means of multimodal therapy, but long-term locoregional morbidity remains common. Use of IMRT may induce less residual odynophagia. Radiation dose reduction adapted to chemotherapy response does not have a\u00a0negative impact on outcome. These findings support the use of an RT protocol adapted to the tumor response to neoadjuvant chemotherapy for a\u00a0long-lasting improvement in the patient's quality of life.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00066-019-01461-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1054450", 
        "issn": [
          "0179-7158", 
          "1439-099X"
        ], 
        "name": "Strahlentherapie und Onkologie", 
        "type": "Periodical"
      }
    ], 
    "name": "Adapted strategy to tumor response in childhood nasopharyngeal carcinoma: the French experience.", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00066-019-01461-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113300935"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8603469"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30963203"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00066-019-01461-6", 
      "https://app.dimensions.ai/details/publication/pub.1113300935"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119754_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00066-019-01461-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00066-019-01461-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00066-019-01461-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00066-019-01461-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00066-019-01461-6'


 

This table displays all metadata directly associated to this object as RDF triples.

332 TRIPLES      20 PREDICATES      73 URIs      16 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00066-019-01461-6 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N908b07f3639b490597247107e54c25be
4 schema:citation sg:pub.10.1007/s00280-015-2933-2
5 sg:pub.10.1007/s00405-016-4154-7
6 sg:pub.10.1007/s00405-017-4736-z
7 sg:pub.10.1007/s00432-017-2401-y
8 sg:pub.10.1007/s12070-013-0622-1
9 sg:pub.10.1186/1748-717x-3-4
10 sg:pub.10.1186/1748-717x-9-71
11 sg:pub.10.1186/s13014-014-0274-7
12 https://doi.org/10.1002/1097-0142(19810101)47:1<207::aid-cncr2820470134>3.0.co;2-6
13 https://doi.org/10.1002/14651858.cd004329.pub2
14 https://doi.org/10.1002/cncr.20823
15 https://doi.org/10.1002/cncr.21258
16 https://doi.org/10.1002/cncr.25376
17 https://doi.org/10.1002/cncr.26528
18 https://doi.org/10.1002/cncr.27395
19 https://doi.org/10.1002/cncr.29869
20 https://doi.org/10.1002/hed.24066
21 https://doi.org/10.1002/hed.24341
22 https://doi.org/10.1002/mpo.2950190415
23 https://doi.org/10.1002/pbc.20106
24 https://doi.org/10.1002/pbc.21372
25 https://doi.org/10.1002/pbc.22521
26 https://doi.org/10.1002/pbc.25326
27 https://doi.org/10.1002/pbc.26240
28 https://doi.org/10.1016/j.canrad.2013.06.046
29 https://doi.org/10.1016/j.ejca.2015.08.006
30 https://doi.org/10.1016/j.ijporl.2013.06.005
31 https://doi.org/10.1016/j.ijrobp.2008.01.032
32 https://doi.org/10.1016/j.ijrobp.2008.05.065
33 https://doi.org/10.1016/j.ijrobp.2008.12.030
34 https://doi.org/10.1016/j.oraloncology.2017.08.006
35 https://doi.org/10.1016/j.radonc.2006.08.019
36 https://doi.org/10.1016/j.radonc.2012.08.013
37 https://doi.org/10.1016/j.semradonc.2012.03.008
38 https://doi.org/10.1016/s0360-3016(03)00773-9
39 https://doi.org/10.1016/s0360-3016(99)00493-9
40 https://doi.org/10.1016/s1040-8428(99)00003-7
41 https://doi.org/10.1016/s1470-2045(15)70126-9
42 https://doi.org/10.1016/s1470-2045(16)30410-7
43 https://doi.org/10.1055/s-0041-111180
44 https://doi.org/10.1080/01621459.1958.10501452
45 https://doi.org/10.1097/mph.0000000000000318
46 https://doi.org/10.1097/mph.0000000000001054
47 https://doi.org/10.1097/mph.0b013e3181b91180
48 https://doi.org/10.1200/jco.2007.14.8841
49 https://doi.org/10.1200/jco.2016.67.4119
50 https://doi.org/10.1615/critrevoncog.2018027528
51 https://doi.org/10.1684/bdc.2010.1169
52 https://doi.org/10.18632/oncotarget.12736
53 schema:datePublished 2019-04-08
54 schema:datePublishedReg 2019-04-08
55 schema:description PURPOSE: The aim of this study was to retrospectively study survival and long-term morbidities of children with nasopharyngeal carcinoma (NPC) treated by induction chemotherapy and concurrent chemoradiation (CRT). The total dose of radiation was adapted to the response following neoadjuvant chemotherapy. METHODS: Children with non-metastatic NPC treated in France between 1999 and 2015 were retrospectively included in the study. The strategy combined neoadjuvant platinum-based chemotherapy, followed by adapted CRT to tumor response. RESULTS: In total, 95 patients (median age 15 years [range, 7-23 years], male-to-female ratio 1.8) with undifferentiated NPC were included; 59% of patients had TNM stage IV. Intensity-modulated radiotherapy (IMRT) was delivered to 57 patients (60%), while the other patients were treated with conformal RT (3D-RT). After a median follow-up of 4.5 years [range, 3.6-5.5 years], 13 relapses and seven deaths had occurred. The 3‑year overall and relapse-free survival (RFS) were 94% [95% CI, 85-97%] and 86% [77-92%], respectively. The locoregional failure rate was 6% [95% CI, 2-14]. Long-term treatment-related sequelae of grade 2+ were reported by 37 (50%) patients; odynophagia was significantly reduced treated by IMRT vs. conventional 3D-RT (7% vs. 55%, p = 0.015). Using a reduction dose of 59.4 Gy, 54 Gy, and 45 Gy, respectively, to the primary, involved, and uninvolved neck nodes, after a favorable tumor response, was not associated with an increased locoregional failure rate. CONCLUSIONS: The survival rates for NPC have been considerably improved by means of multimodal therapy, but long-term locoregional morbidity remains common. Use of IMRT may induce less residual odynophagia. Radiation dose reduction adapted to chemotherapy response does not have a negative impact on outcome. These findings support the use of an RT protocol adapted to the tumor response to neoadjuvant chemotherapy for a long-lasting improvement in the patient's quality of life.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree false
59 schema:isPartOf sg:journal.1054450
60 schema:name Adapted strategy to tumor response in childhood nasopharyngeal carcinoma: the French experience.
61 schema:productId N30b659785d7c40bb8209c57a7e76a32b
62 N7424f1188d8a40e7a0c1fb249a2f5b25
63 N88ccdd4bdcdf4a4899cc2927a11a6a50
64 Nc84a320152c8452898d6b6bda7239bbb
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113300935
66 https://doi.org/10.1007/s00066-019-01461-6
67 schema:sdDatePublished 2019-04-15T08:54
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N72040de1349341a08ba5e44ecfb10ea2
70 schema:url http://link.springer.com/10.1007/s00066-019-01461-6
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N022be4020cf7452192eaa1222ae9ac50 schema:name Radiotherapy department, IUCT Oncopole, Toulouse, France.
75 rdf:type schema:Organization
76 N08b0e7621d2340c8b2088da4cc190d23 rdf:first N480483b90023480295dd72aa2912a30a
77 rdf:rest N6b3c66b6a1b348b296ab68128aac549c
78 N108f97579b4d48c29553566e32ecf531 schema:affiliation N022be4020cf7452192eaa1222ae9ac50
79 schema:familyName Laprie
80 schema:givenName Anne
81 rdf:type schema:Person
82 N12246ba4cf6a4f8982a5ba9bfde79e12 rdf:first N4d2988378ed44371b46f7c413c9651e9
83 rdf:rest Nb41e1cbca45841a29d7bd7c3f3a5173f
84 N152cc25dc9244e1c8a93908ad6449bcd schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
85 schema:familyName Riet
86 schema:givenName François Georges
87 rdf:type schema:Person
88 N1ccbe6c394334e22bef4c6d4d087bf22 schema:affiliation Na764c74511a548609d32e3f499579586
89 schema:familyName Claude
90 schema:givenName Line
91 rdf:type schema:Person
92 N26c2781364494d38ae31dbad1672f776 schema:affiliation N563f1cc2beef4523bc9e61ce664be499
93 schema:familyName Ducassou
94 schema:givenName Anne
95 rdf:type schema:Person
96 N30b659785d7c40bb8209c57a7e76a32b schema:name nlm_unique_id
97 schema:value 8603469
98 rdf:type schema:PropertyValue
99 N345e663f051f4120bcef0c99045d761a rdf:first Nfc00a916059f46198d234f82d20edf15
100 rdf:rest N6049cebf224643cd88cccf814706c015
101 N3b4eb4182b0046a39af01cde10b398d8 schema:affiliation https://www.grid.ac/institutes/grid.463845.8
102 schema:familyName Fresneau
103 schema:givenName Brice
104 rdf:type schema:Person
105 N3d3beae279764331a6bb093f94fd951d rdf:first N108f97579b4d48c29553566e32ecf531
106 rdf:rest N08b0e7621d2340c8b2088da4cc190d23
107 N480483b90023480295dd72aa2912a30a schema:affiliation https://www.grid.ac/institutes/grid.452351.4
108 schema:familyName Bogart
109 schema:givenName Emilie
110 rdf:type schema:Person
111 N4ad4e082d5314431a9a91a695db02e44 schema:affiliation https://www.grid.ac/institutes/grid.452351.4
112 schema:familyName Jouin
113 schema:givenName Anaïs
114 rdf:type schema:Person
115 N4d2988378ed44371b46f7c413c9651e9 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
116 schema:familyName Bolle
117 schema:givenName Stéphanie
118 rdf:type schema:Person
119 N4f4ca433661641698c87c76cb1b1e312 rdf:first N590a2c89be5447839a25fcf4b97ff775
120 rdf:rest N9d0a9b52e7344011bec1e5a3fdcb253a
121 N563f1cc2beef4523bc9e61ce664be499 schema:name Radiotherapy department, IUCT Oncopole, Toulouse, France.
122 rdf:type schema:Organization
123 N590a2c89be5447839a25fcf4b97ff775 schema:affiliation https://www.grid.ac/institutes/grid.417812.9
124 schema:familyName Claren
125 schema:givenName Audrey
126 rdf:type schema:Person
127 N6049cebf224643cd88cccf814706c015 rdf:first N9417c9916ddd4c999bfc6e0598f150fc
128 rdf:rest rdf:nil
129 N6b3c66b6a1b348b296ab68128aac549c rdf:first N737849f27f4b4189b952588a8e11efd2
130 rdf:rest Nfd9e9b5b36b648a2a12ef48ada117c29
131 N6bd2f125f3de487b9c4bea72f36bba2f schema:name Pediatric department, Claudius Regaud Hospital, Toulouse, France.
132 rdf:type schema:Organization
133 N72040de1349341a08ba5e44ecfb10ea2 schema:name Springer Nature - SN SciGraph project
134 rdf:type schema:Organization
135 N737849f27f4b4189b952588a8e11efd2 schema:affiliation https://www.grid.ac/institutes/grid.418189.d
136 schema:familyName Vigneron
137 schema:givenName Céline
138 rdf:type schema:Person
139 N7424f1188d8a40e7a0c1fb249a2f5b25 schema:name pubmed_id
140 schema:value 30963203
141 rdf:type schema:PropertyValue
142 N7edd59abf3994ed99ad5c44f3d98fd05 schema:affiliation https://www.grid.ac/institutes/grid.417812.9
143 schema:familyName Potet
144 schema:givenName Hélène
145 rdf:type schema:Person
146 N88ccdd4bdcdf4a4899cc2927a11a6a50 schema:name dimensions_id
147 schema:value pub.1113300935
148 rdf:type schema:PropertyValue
149 N908b07f3639b490597247107e54c25be rdf:first N4ad4e082d5314431a9a91a695db02e44
150 rdf:rest Na58a120fabeb474a932c52a44f8c4397
151 N9417c9916ddd4c999bfc6e0598f150fc schema:affiliation https://www.grid.ac/institutes/grid.418596.7
152 schema:familyName Orbach
153 schema:givenName Daniel
154 rdf:type schema:Person
155 N97efc6df4f244f9682db9196d1705aaf schema:affiliation https://www.grid.ac/institutes/grid.418116.b
156 schema:familyName Faure-Conter
157 schema:givenName Cécile
158 rdf:type schema:Person
159 N9d0a9b52e7344011bec1e5a3fdcb253a rdf:first N152cc25dc9244e1c8a93908ad6449bcd
160 rdf:rest Na0618a4e74174270bdfdde44fc3228b2
161 Na0618a4e74174270bdfdde44fc3228b2 rdf:first Nb77df7ed32bf4296a0c33194852f5ca6
162 rdf:rest Nead7a2d4a9ff47428825f6c5e1a0be6b
163 Na30ed9b2b1fa45fbae82900180a5307c rdf:first N26c2781364494d38ae31dbad1672f776
164 rdf:rest N4f4ca433661641698c87c76cb1b1e312
165 Na58a120fabeb474a932c52a44f8c4397 rdf:first Nf5df9f09e4f24440b5ef6fabec3a1d76
166 rdf:rest N12246ba4cf6a4f8982a5ba9bfde79e12
167 Na764c74511a548609d32e3f499579586 schema:name Radiotherapy department, Centre Lyon Bérard, Lyon, France.
168 rdf:type schema:Organization
169 Nb41e1cbca45841a29d7bd7c3f3a5173f rdf:first N1ccbe6c394334e22bef4c6d4d087bf22
170 rdf:rest N3d3beae279764331a6bb093f94fd951d
171 Nb77df7ed32bf4296a0c33194852f5ca6 schema:affiliation N6bd2f125f3de487b9c4bea72f36bba2f
172 schema:familyName Castex
173 schema:givenName Marie Pierre
174 rdf:type schema:Person
175 Nc84a320152c8452898d6b6bda7239bbb schema:name doi
176 schema:value 10.1007/s00066-019-01461-6
177 rdf:type schema:PropertyValue
178 Ne8d74a0a2d1140519aac75b3facdf21a rdf:first N3b4eb4182b0046a39af01cde10b398d8
179 rdf:rest N345e663f051f4120bcef0c99045d761a
180 Nead7a2d4a9ff47428825f6c5e1a0be6b rdf:first N97efc6df4f244f9682db9196d1705aaf
181 rdf:rest Ne8d74a0a2d1140519aac75b3facdf21a
182 Nf5df9f09e4f24440b5ef6fabec3a1d76 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
183 schema:familyName Helfre
184 schema:givenName Sylvie
185 rdf:type schema:Person
186 Nfc00a916059f46198d234f82d20edf15 schema:affiliation https://www.grid.ac/institutes/grid.452351.4
187 schema:familyName Defachelles
188 schema:givenName Anne Sophie
189 rdf:type schema:Person
190 Nfd9e9b5b36b648a2a12ef48ada117c29 rdf:first N7edd59abf3994ed99ad5c44f3d98fd05
191 rdf:rest Na30ed9b2b1fa45fbae82900180a5307c
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
196 schema:name Oncology and Carcinogenesis
197 rdf:type schema:DefinedTerm
198 sg:journal.1054450 schema:issn 0179-7158
199 1439-099X
200 schema:name Strahlentherapie und Onkologie
201 rdf:type schema:Periodical
202 sg:pub.10.1007/s00280-015-2933-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038312177
203 https://doi.org/10.1007/s00280-015-2933-2
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/s00405-016-4154-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017049499
206 https://doi.org/10.1007/s00405-016-4154-7
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/s00405-017-4736-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1091859917
209 https://doi.org/10.1007/s00405-017-4736-z
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/s00432-017-2401-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1084022007
212 https://doi.org/10.1007/s00432-017-2401-y
213 rdf:type schema:CreativeWork
214 sg:pub.10.1007/s12070-013-0622-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026760570
215 https://doi.org/10.1007/s12070-013-0622-1
216 rdf:type schema:CreativeWork
217 sg:pub.10.1186/1748-717x-3-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000044825
218 https://doi.org/10.1186/1748-717x-3-4
219 rdf:type schema:CreativeWork
220 sg:pub.10.1186/1748-717x-9-71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037504526
221 https://doi.org/10.1186/1748-717x-9-71
222 rdf:type schema:CreativeWork
223 sg:pub.10.1186/s13014-014-0274-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010452002
224 https://doi.org/10.1186/s13014-014-0274-7
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/1097-0142(19810101)47:1<207::aid-cncr2820470134>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049278910
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/14651858.cd004329.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045075257
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/cncr.20823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009204076
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/cncr.21258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035393036
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/cncr.25376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004622359
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1002/cncr.26528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023664483
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/cncr.27395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000959381
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1002/cncr.29869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000032386
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/hed.24066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031932583
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/hed.24341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005275298
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/mpo.2950190415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043976181
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/pbc.20106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003774347
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1002/pbc.21372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039721521
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/pbc.22521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008408249
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/pbc.25326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015727545
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/pbc.26240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024348552
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.canrad.2013.06.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018797592
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.ejca.2015.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037626497
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.ijporl.2013.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014000937
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.ijrobp.2008.01.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019386525
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.ijrobp.2008.05.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016478766
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.ijrobp.2008.12.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034694562
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.oraloncology.2017.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091384371
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.radonc.2006.08.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038892292
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.radonc.2012.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039547144
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.semradonc.2012.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014410705
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0360-3016(03)00773-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052481564
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s0360-3016(99)00493-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034713640
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/s1040-8428(99)00003-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021934432
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s1470-2045(15)70126-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011634998
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s1470-2045(16)30410-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033796903
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1055/s-0041-111180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057374239
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1080/01621459.1958.10501452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058299418
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1097/mph.0000000000000318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048781719
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1097/mph.0000000000001054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100180040
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/mph.0b013e3181b91180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019252948
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1200/jco.2007.14.8841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042333490
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1200/jco.2016.67.4119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079363804
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1615/critrevoncog.2018027528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106347838
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1684/bdc.2010.1169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078214908
305 rdf:type schema:CreativeWork
306 https://doi.org/10.18632/oncotarget.12736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042214903
307 rdf:type schema:CreativeWork
308 https://www.grid.ac/institutes/grid.14925.3b schema:alternateName Institut Gustave Roussy
309 schema:name Gustave Roussy, Department of Radiotherapy Oncology, Université Paris-Saclay, 94805, Villejuif, France.
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.417812.9 schema:alternateName Centre Antoine Lacassagne
312 schema:name Radiotherapy department, Centre Antoine Lacassagne, Nice, France.
313 rdf:type schema:Organization
314 https://www.grid.ac/institutes/grid.418116.b schema:alternateName Centre Léon Bérard
315 schema:name Pediatric department, Centre Leon Bérard, Lyon, France.
316 rdf:type schema:Organization
317 https://www.grid.ac/institutes/grid.418189.d schema:alternateName UniCancer Group
318 schema:name Radiotherapy department, Centre Paul Strauss, Strasbourg, France.
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.418596.7 schema:alternateName Institute Curie
321 schema:name Radiotherapy department, Institut Curie, Paris, France.
322 SIREDO Oncology Center (Care, Innovation and Research for Children, Adolescents and Young Adults with cancer), PSL Research University, French Pediatric Rare Tumor group (Fracture group), Institut Curie, 26, rue d'Ulm, 75005, Paris, France. daniel.orbach@curie.fr.
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.452351.4 schema:alternateName Centre Oscar Lambret
325 schema:name Biostatistics department, Centre Oscar Lambret, Lille, France.
326 Pediatric department, Centre Oscar Lambret, Lille, France.
327 Radiotherapy department, Centre Oscar Lambret, Lille, France.
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.463845.8 schema:alternateName Centre for research in epidemiology and population health
330 schema:name CESP, INSERM, Paris-Saclay University, Paris-Sud University, Villejuif, France.
331 Gustave Roussy-Grand Campus, Pediatric department, University Paris-Saclay, Villejuif, France.
332 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...