Ontology type: schema:ScholarlyArticle
2019-04-01
AUTHORSIngmar Schlampp, Juliane Rieber, Sebastian Adeberg, Farastuk Bozorgmehr, Claus Peter Heußel, Martin Steins, Jutta Kappes, Hans Hoffmann, Thomas Welzel, Jürgen Debus, Stefan Rieken
ABSTRACTPURPOSE: Lung cancer remains one of the tumour diagnoses with high lethality, although innovative treatment approaches have yielded improvements in local control and survival rates. There is still no consensus on how to treat local relapse in patients after first-line treatments. Radiotherapy may be considered in this situation; however, data supporting its effectiveness are rare. The purpose of this retrospective analysis was to evaluate outcomes of patients re-irradiated for thoracic tumours in terms of overall survival (OS), local progression-free survival (LPFS), toxicity and dose-volume parameters. PATIENTS AND METHODS: Sixty-two patients with locally recurrent previously irradiated lung cancer were analysed retrospectively (NSCLC n = 52, SCLC n = 10). Target volumes both in lung and mediastinum were re-irradiated with conventional three-dimensional or intensity-modulated radiotherapy techniques. Median overall dose of re-irradiation was 38.5 Gy (range 20-60 Gy) with a median single dose per fraction of 2 Gy (1.8-3.0 Gy). Clinical documents and treatment plans were evaluated. RESULTS: Median follow-up was 8.2 months (range 0-27 months). OS following re-irradiation was 9.3 months (range: 0-27 months) and LPFS was 6.5 months (range: 0-24 months). OS and LPFS were not affected by histology, total dose or patient age and gender. OS was improved in patients whose re-irradiation volumes included less than two mediastinal lymph node stations (p = 0.016). Twelve patients suffered from pneumonitis ≥grade II (19%) and two from pneumonitis grade III. One patient presumably died from pneumonitis grade V. A slight decline in forced expiratory volume (FEV1) was detected in post-re-irradiation lung function testing. CONCLUSIONS: Re-irradiation is an option for patients with tumour recurrence to control local progression and lower the symptom burden. Oncological outcome appears to be affected by size, location of mediastinal target volumes and lung function. Prospective clinical trials are warranted to substantiate the role of re-irradiation in recurrent lung cancer. More... »
PAGES1-9
http://scigraph.springernature.com/pub.10.1007/s00066-019-01457-2
DOIhttp://dx.doi.org/10.1007/s00066-019-01457-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1113172456
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30937509
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University Hospital Heidelberg",
"id": "https://www.grid.ac/institutes/grid.5253.1",
"name": [
"University Hospital of Heidelberg, Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld\u00a0400, 69120, Heidelberg, Germany",
"HIRO \u2013 Heidelberger Institut f\u00fcr RadioOnkologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld\u00a0280, 69120, Heidelberg, Germany",
"National Center for Tumor diseases (NCT), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Schlampp",
"givenName": "Ingmar",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Heidelberg",
"id": "https://www.grid.ac/institutes/grid.5253.1",
"name": [
"University Hospital of Heidelberg, Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld\u00a0400, 69120, Heidelberg, Germany",
"HIRO \u2013 Heidelberger Institut f\u00fcr RadioOnkologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld\u00a0280, 69120, Heidelberg, Germany",
"National Center for Tumor diseases (NCT), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Rieber",
"givenName": "Juliane",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Heidelberg",
"id": "https://www.grid.ac/institutes/grid.5253.1",
"name": [
"University Hospital of Heidelberg, Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld\u00a0400, 69120, Heidelberg, Germany",
"HIRO \u2013 Heidelberger Institut f\u00fcr RadioOnkologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld\u00a0280, 69120, Heidelberg, Germany",
"National Center for Tumor diseases (NCT), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Adeberg",
"givenName": "Sebastian",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Department of Thoracic Oncology, Thoraxlinik, Translational Lung Research Centre Heidelberg (TLRC-H), Heidelberg University, Im Neuenheimer Feld\u00a0110, 69120, Heidelberg, Germany",
"Translational Lung Research Centre Heidelberg (TLRC-H), German Centre for Lung Research (DZL), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Bozorgmehr",
"givenName": "Farastuk",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Translational Lung Research Centre Heidelberg (TLRC-H), German Centre for Lung Research (DZL), Heidelberg, Germany",
"Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany",
"Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Heu\u00dfel",
"givenName": "Claus Peter",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Department of Thoracic Oncology, Thoraxlinik, Translational Lung Research Centre Heidelberg (TLRC-H), Heidelberg University, Im Neuenheimer Feld\u00a0110, 69120, Heidelberg, Germany",
"Translational Lung Research Centre Heidelberg (TLRC-H), German Centre for Lung Research (DZL), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Steins",
"givenName": "Martin",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Department of Thoracic Oncology, Thoraxlinik, Translational Lung Research Centre Heidelberg (TLRC-H), Heidelberg University, Im Neuenheimer Feld\u00a0110, 69120, Heidelberg, Germany",
"Translational Lung Research Centre Heidelberg (TLRC-H), German Centre for Lung Research (DZL), Heidelberg, Germany",
"Department of Pneumology, Thoraxklinik, Heidelberg University, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Kappes",
"givenName": "Jutta",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Dept. of Thoracic Surgery, Thoraxklinik, Heidelberg University, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Hoffmann",
"givenName": "Hans",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Heidelberg",
"id": "https://www.grid.ac/institutes/grid.5253.1",
"name": [
"University Hospital of Heidelberg, Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld\u00a0400, 69120, Heidelberg, Germany",
"HIRO \u2013 Heidelberger Institut f\u00fcr RadioOnkologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld\u00a0280, 69120, Heidelberg, Germany",
"National Center for Tumor diseases (NCT), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Welzel",
"givenName": "Thomas",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Heidelberg",
"id": "https://www.grid.ac/institutes/grid.5253.1",
"name": [
"University Hospital of Heidelberg, Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld\u00a0400, 69120, Heidelberg, Germany",
"HIRO \u2013 Heidelberger Institut f\u00fcr RadioOnkologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld\u00a0280, 69120, Heidelberg, Germany",
"National Center for Tumor diseases (NCT), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Debus",
"givenName": "J\u00fcrgen",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Heidelberg",
"id": "https://www.grid.ac/institutes/grid.5253.1",
"name": [
"University Hospital of Heidelberg, Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld\u00a0400, 69120, Heidelberg, Germany",
"HIRO \u2013 Heidelberger Institut f\u00fcr RadioOnkologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld\u00a0280, 69120, Heidelberg, Germany",
"National Center for Tumor diseases (NCT), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Rieken",
"givenName": "Stefan",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.prro.2015.02.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001358792"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdw022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007289714"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2015.63.7918",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008855401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djr325",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009817984"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/coc.0b013e31826b9950",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010888767"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/coc.0b013e31826b9950",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010888767"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.15.0375",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011587624"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1378/chest.111.6.1718",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017673266"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19820301)49:5<865::aid-cncr2820490507>3.0.co;2-h",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018227051"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.radonc.2015.09.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020561925"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2004.11.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021812631"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199901283400403",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025086407"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2008.10.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026558254"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2011.01.069",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030334463"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.radonc.2013.02.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032089551"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(14)71207-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035529456"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10147-005-0501-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036213519",
"https://doi.org/10.1007/s10147-005-0501-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10147-005-0501-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036213519",
"https://doi.org/10.1007/s10147-005-0501-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2014.59.2360",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036725399"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1209825",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037096124"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(01)02644-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037947542"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(03)00182-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039737021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(03)00182-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039737021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0144211",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044398989"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.lungcan.2013.12.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046035988"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2011.12.032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046361769"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2009.06.091",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047270914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(14)70345-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048167643"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077886921",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3978/j.issn.2224-5820.2014.03.04",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1079066588"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-04-01",
"datePublishedReg": "2019-04-01",
"description": "PURPOSE: Lung cancer remains one of the tumour diagnoses with high lethality, although innovative treatment approaches have yielded improvements in local control and survival rates. There is still no consensus on how to treat local relapse in patients after first-line treatments. Radiotherapy may be considered in this situation; however, data supporting its effectiveness are rare. The purpose of this retrospective analysis was to evaluate outcomes of patients re-irradiated for thoracic tumours in terms of overall survival (OS), local progression-free survival (LPFS), toxicity and dose-volume parameters.\nPATIENTS AND METHODS: Sixty-two patients with locally recurrent previously irradiated lung cancer were analysed retrospectively (NSCLC n\u202f=\u200952, SCLC n\u202f=\u200910). Target volumes both in lung and mediastinum were re-irradiated with conventional three-dimensional or intensity-modulated radiotherapy techniques. Median overall dose of re-irradiation was 38.5\u202fGy (range 20-60\u202fGy) with a\u00a0median single dose per fraction of 2\u202fGy (1.8-3.0\u202fGy). Clinical documents and treatment plans were evaluated.\nRESULTS: Median follow-up was 8.2\u00a0months (range 0-27\u00a0months). OS following re-irradiation was 9.3\u00a0months (range: 0-27\u00a0months) and LPFS was 6.5\u00a0months (range: 0-24\u00a0months). OS and LPFS were not affected by histology, total dose or patient age and gender. OS was improved in patients whose re-irradiation volumes included less than two mediastinal lymph node stations (p\u202f=\u20090.016). Twelve patients suffered from pneumonitis \u2265grade\u00a0II (19%) and two from pneumonitis grade\u00a0III. One patient presumably died from pneumonitis grade\u00a0V. A\u00a0slight decline in forced expiratory volume (FEV1) was detected in post-re-irradiation lung function testing.\nCONCLUSIONS: Re-irradiation is an option for patients with tumour recurrence to control local progression and lower the symptom burden. Oncological outcome appears to be affected by size, location of mediastinal target volumes and lung function. Prospective clinical trials are warranted to substantiate the role of re-irradiation in recurrent lung cancer.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00066-019-01457-2",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1054450",
"issn": [
"0179-7158",
"1439-099X"
],
"name": "Strahlentherapie und Onkologie",
"type": "Periodical"
}
],
"name": "Re-irradiation in locally recurrent lung cancer patients",
"pagination": "1-9",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"4e770985a1bf770944c7d556639a4ff2b9ac5f012be588f5a03fa6ea7e9d598f"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30937509"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8603469"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00066-019-01457-2"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1113172456"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00066-019-01457-2",
"https://app.dimensions.ai/details/publication/pub.1113172456"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:58",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130820_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs00066-019-01457-2"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00066-019-01457-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00066-019-01457-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00066-019-01457-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00066-019-01457-2'
This table displays all metadata directly associated to this object as RDF triples.
213 TRIPLES
21 PREDICATES
53 URIs
18 LITERALS
7 BLANK NODES