A comparison of a brachytherapy and an external beam radiotherapy boost in breast-conserving therapy for breast cancer: local and any ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Isabelle Kindts, Karolien Verhoeven, Annouschka Laenen, Melissa Christiaens, Hilde Janssen, Aline Van der Vorst, Erik Van Limbergen, Caroline Weltens

ABSTRACT

PURPOSE: Adding a tumour bed boost to whole-breast irradiation in breast-conserving therapy reduces local recurrence rates. The purpose of the present study was to investigate whether the boost technique influences the magnitude of the effect. METHODS: Patients treated with breast-conserving therapy for invasive breast cancer between 2000 and 2007 were included in the analysis. Three groups were considered according to the applied boost technique: electrons, brachytherapy or photons. The endpoints were local recurrence and any recurrence. Cox regression models were used and correction for the confounders in the association between boost technique and outcome was performed using multivariable models. RESULTS: 1879 tumours were included in the analysis. 1448 tumours (77.1%) were treated with an electron boost, 334 (17.8%) with a brachytherapy boost and 97 (5.2%) with a photon boost. Median follow-up was 13.1 years. The 10-year local recurrence rate was 2.2%. In multivariable analysis with correction for age, pathological Tumour or Node stage (pT, pN), chemotherapy and hormonal therapy, there was no significant difference between the three groups for the local recurrence risk (p = 0.89). 10-year any recurrence rate was 10.8%. In multivariable analysis with correction for age, pT, pN, resection margins, radiotherapy, year of diagnosis, chemotherapy and hormonal therapy, there was no significant difference between the brachytherapy group and the electron group or the photon group (p = 0.11 and p = 0.28, respectively). The photon group had more recurrences compared to the electron group (Hazard Ratio 1.81, 95% Confidence Interval 1.12; 2.92, p = 0.02). CONCLUSIONS: The local recurrence risk reduction of the tumour bed boost in breast-conserving therapy is not influenced by the applied boost technique. More... »

PAGES

310-317

References to SciGraph publications

  • 1999-10. Breast Boost – Why, How, When ...? in STRAHLENTHERAPIE UND ONKOLOGIE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00066-018-1413-0

    DOI

    http://dx.doi.org/10.1007/s00066-018-1413-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111057163

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30603857


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Universitaire Ziekenhuizen Leuven", 
              "id": "https://www.grid.ac/institutes/grid.410569.f", 
              "name": [
                "Department of Oncology, Experimental Radiation Oncology, KU Leuven\u2014University of Leuven, 3000, Leuven, Belgium", 
                "Department of Radiation Oncology, University Hospitals Leuven, Herestraat\u00a049, 3000, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kindts", 
            "givenName": "Isabelle", 
            "id": "sg:person.0706032525.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706032525.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Maastricht University Medical Centre", 
              "id": "https://www.grid.ac/institutes/grid.412966.e", 
              "name": [
                "Department of Radiation Oncology (MAASTRO), GROW\u2014School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Verhoeven", 
            "givenName": "Karolien", 
            "id": "sg:person.01254774614.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254774614.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Leuven Biostatistics and Statistical Bioinformatics Centre (L-Biostat), KU Leuven University, Kapucijnenvoer\u00a035, 3000, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Laenen", 
            "givenName": "Annouschka", 
            "id": "sg:person.01216410605.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216410605.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universitaire Ziekenhuizen Leuven", 
              "id": "https://www.grid.ac/institutes/grid.410569.f", 
              "name": [
                "Department of Radiation Oncology, University Hospitals Leuven, Herestraat\u00a049, 3000, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Christiaens", 
            "givenName": "Melissa", 
            "id": "sg:person.01061170251.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061170251.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universitaire Ziekenhuizen Leuven", 
              "id": "https://www.grid.ac/institutes/grid.410569.f", 
              "name": [
                "Department of Oncology, Experimental Radiation Oncology, KU Leuven\u2014University of Leuven, 3000, Leuven, Belgium", 
                "Department of Radiation Oncology, University Hospitals Leuven, Herestraat\u00a049, 3000, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Janssen", 
            "givenName": "Hilde", 
            "id": "sg:person.01024235176.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024235176.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universitaire Ziekenhuizen Leuven", 
              "id": "https://www.grid.ac/institutes/grid.410569.f", 
              "name": [
                "Department of Radiation Oncology, University Hospitals Leuven, Herestraat\u00a049, 3000, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van der Vorst", 
            "givenName": "Aline", 
            "id": "sg:person.015703032753.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015703032753.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universitaire Ziekenhuizen Leuven", 
              "id": "https://www.grid.ac/institutes/grid.410569.f", 
              "name": [
                "Department of Oncology, Experimental Radiation Oncology, KU Leuven\u2014University of Leuven, 3000, Leuven, Belgium", 
                "Department of Radiation Oncology, University Hospitals Leuven, Herestraat\u00a049, 3000, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van Limbergen", 
            "givenName": "Erik", 
            "id": "sg:person.01201352600.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201352600.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universitaire Ziekenhuizen Leuven", 
              "id": "https://www.grid.ac/institutes/grid.410569.f", 
              "name": [
                "Department of Oncology, Experimental Radiation Oncology, KU Leuven\u2014University of Leuven, 3000, Leuven, Belgium", 
                "Department of Radiation Oncology, University Hospitals Leuven, Herestraat\u00a049, 3000, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weltens", 
            "givenName": "Caroline", 
            "id": "sg:person.01162221667.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162221667.73"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0360-3016(95)02378-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000144563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.prro.2016.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005772357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)60837-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008906431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.breast.2015.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010508218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4048/jbc.2013.16.3.300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010654124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.22.6662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012826173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaoncol.2016.3031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014415111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaoncol.2016.3031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014415111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(98)80231-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017405133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(11)61629-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019167359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2009.12.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019183932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000114219.71899.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022367443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000114219.71899.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022367443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdv298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022951845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2008.02.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026900016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-8140(95)01508-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029471368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19850901)56:5<979::aid-cncr2820560502>3.0.co;2-n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031176250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s000660050057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034074913", 
              "https://doi.org/10.1007/s000660050057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(14)71156-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034362695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.radonc.2004.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034854801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.radonc.2004.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034854801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-8140(91)90165-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038446303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-8140(91)90165-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038446303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-8140(94)01492-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044795770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000421-200102000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044997425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000421-200102000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044997425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0360-3016(97)00325-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046934880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0360-3016(93)90275-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048027912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.11.4991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050523736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19950501)75:9<2328::aid-cncr2820750923>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051863016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semradonc.2011.09.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053180474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd011987.pub2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092550251"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04", 
        "datePublishedReg": "2019-04-01", 
        "description": "PURPOSE: Adding a\u00a0tumour bed boost to whole-breast irradiation in breast-conserving therapy reduces local recurrence rates. The purpose of the present study was to investigate whether the boost technique influences the magnitude of the effect.\nMETHODS: Patients treated with breast-conserving therapy for invasive breast cancer between 2000 and 2007 were included in the analysis. Three groups were considered according to the applied boost technique: electrons, brachytherapy or photons. The endpoints were local recurrence and any recurrence. Cox regression models were used and correction for the confounders in the association between boost technique and outcome was performed using multivariable models.\nRESULTS: 1879 tumours were included in the analysis. 1448 tumours (77.1%) were treated with an electron boost, 334 (17.8%) with a\u00a0brachytherapy boost and 97 (5.2%) with a\u00a0photon boost. Median follow-up was 13.1 years. The 10-year local recurrence rate was 2.2%. In multivariable analysis with correction for age, pathological Tumour or Node stage (pT, pN), chemotherapy and hormonal therapy, there was no significant difference between the three groups for the local recurrence risk (p\u202f= 0.89). 10-year any recurrence rate was 10.8%. In multivariable analysis with correction for age, pT, pN, resection margins, radiotherapy, year of diagnosis, chemotherapy and hormonal therapy, there was no significant difference between the brachytherapy group and the electron group or the photon group (p\u202f= 0.11 and p\u202f= 0.28, respectively). The photon group had more recurrences compared to the electron group (Hazard Ratio 1.81, 95% Confidence Interval 1.12; 2.92, p\u202f= 0.02).\nCONCLUSIONS: The local recurrence risk reduction of the tumour bed boost in breast-conserving therapy is not influenced by the applied boost technique.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00066-018-1413-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1054450", 
            "issn": [
              "0179-7158", 
              "1439-099X"
            ], 
            "name": "Strahlentherapie und Onkologie", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "195"
          }
        ], 
        "name": "A comparison of a brachytherapy and an external beam radiotherapy boost in breast-conserving therapy for breast cancer: local and any recurrences", 
        "pagination": "310-317", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3a32a400cd7ce3b99d05cfbc9c29ab52aea8aeec388766b6f45bd98dab5d73fa"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30603857"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8603469"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00066-018-1413-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111057163"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00066-018-1413-0", 
          "https://app.dimensions.ai/details/publication/pub.1111057163"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:21", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78972_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00066-018-1413-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00066-018-1413-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00066-018-1413-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00066-018-1413-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00066-018-1413-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    207 TRIPLES      21 PREDICATES      56 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00066-018-1413-0 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author Ne17b8aa07ab846499dca55c808fc2bfd
    4 schema:citation sg:pub.10.1007/s000660050057
    5 https://doi.org/10.1001/jamaoncol.2016.3031
    6 https://doi.org/10.1002/1097-0142(19850901)56:5<979::aid-cncr2820560502>3.0.co;2-n
    7 https://doi.org/10.1002/1097-0142(19950501)75:9<2328::aid-cncr2820750923>3.0.co;2-l
    8 https://doi.org/10.1002/14651858.cd011987.pub2
    9 https://doi.org/10.1016/0167-8140(91)90165-d
    10 https://doi.org/10.1016/0167-8140(94)01492-l
    11 https://doi.org/10.1016/0167-8140(95)01508-e
    12 https://doi.org/10.1016/0360-3016(93)90275-z
    13 https://doi.org/10.1016/0360-3016(95)02378-x
    14 https://doi.org/10.1016/j.breast.2015.03.003
    15 https://doi.org/10.1016/j.ijrobp.2008.02.007
    16 https://doi.org/10.1016/j.ijrobp.2009.12.026
    17 https://doi.org/10.1016/j.prro.2016.03.005
    18 https://doi.org/10.1016/j.radonc.2004.03.007
    19 https://doi.org/10.1016/j.semradonc.2011.09.007
    20 https://doi.org/10.1016/s0140-6736(10)60837-9
    21 https://doi.org/10.1016/s0140-6736(11)61629-2
    22 https://doi.org/10.1016/s0360-3016(97)00325-8
    23 https://doi.org/10.1016/s0959-8049(98)80231-1
    24 https://doi.org/10.1016/s1470-2045(14)71156-8
    25 https://doi.org/10.1093/annonc/mdv298
    26 https://doi.org/10.1097/00000421-200102000-00004
    27 https://doi.org/10.1097/01.sla.0000114219.71899.13
    28 https://doi.org/10.1200/jco.2007.11.4991
    29 https://doi.org/10.1200/jco.2009.22.6662
    30 https://doi.org/10.4048/jbc.2013.16.3.300
    31 schema:datePublished 2019-04
    32 schema:datePublishedReg 2019-04-01
    33 schema:description PURPOSE: Adding a tumour bed boost to whole-breast irradiation in breast-conserving therapy reduces local recurrence rates. The purpose of the present study was to investigate whether the boost technique influences the magnitude of the effect. METHODS: Patients treated with breast-conserving therapy for invasive breast cancer between 2000 and 2007 were included in the analysis. Three groups were considered according to the applied boost technique: electrons, brachytherapy or photons. The endpoints were local recurrence and any recurrence. Cox regression models were used and correction for the confounders in the association between boost technique and outcome was performed using multivariable models. RESULTS: 1879 tumours were included in the analysis. 1448 tumours (77.1%) were treated with an electron boost, 334 (17.8%) with a brachytherapy boost and 97 (5.2%) with a photon boost. Median follow-up was 13.1 years. The 10-year local recurrence rate was 2.2%. In multivariable analysis with correction for age, pathological Tumour or Node stage (pT, pN), chemotherapy and hormonal therapy, there was no significant difference between the three groups for the local recurrence risk (p = 0.89). 10-year any recurrence rate was 10.8%. In multivariable analysis with correction for age, pT, pN, resection margins, radiotherapy, year of diagnosis, chemotherapy and hormonal therapy, there was no significant difference between the brachytherapy group and the electron group or the photon group (p = 0.11 and p = 0.28, respectively). The photon group had more recurrences compared to the electron group (Hazard Ratio 1.81, 95% Confidence Interval 1.12; 2.92, p = 0.02). CONCLUSIONS: The local recurrence risk reduction of the tumour bed boost in breast-conserving therapy is not influenced by the applied boost technique.
    34 schema:genre research_article
    35 schema:inLanguage en
    36 schema:isAccessibleForFree false
    37 schema:isPartOf N0304459eb64145d689efb12f895dbe6b
    38 N0bca7bd753f44c89b56f6e6fcbfb7d67
    39 sg:journal.1054450
    40 schema:name A comparison of a brachytherapy and an external beam radiotherapy boost in breast-conserving therapy for breast cancer: local and any recurrences
    41 schema:pagination 310-317
    42 schema:productId N2232b737f7044fee8b6fb2bf05bf2887
    43 N84d118fa303f45b7932cdba53bec37c3
    44 N889c3c986f7d4f3dbedbf4ce669fea9c
    45 Nb883735644354c5bba15de288561020d
    46 Ndab26496a4ee46729c2dea001b1eeb79
    47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111057163
    48 https://doi.org/10.1007/s00066-018-1413-0
    49 schema:sdDatePublished 2019-04-11T13:21
    50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    51 schema:sdPublisher N8f3fc588b4124226ba91a41037b6292e
    52 schema:url https://link.springer.com/10.1007%2Fs00066-018-1413-0
    53 sgo:license sg:explorer/license/
    54 sgo:sdDataset articles
    55 rdf:type schema:ScholarlyArticle
    56 N0304459eb64145d689efb12f895dbe6b schema:volumeNumber 195
    57 rdf:type schema:PublicationVolume
    58 N0bca7bd753f44c89b56f6e6fcbfb7d67 schema:issueNumber 4
    59 rdf:type schema:PublicationIssue
    60 N0c56356cb8f8427ba90d2676790d33eb rdf:first sg:person.01216410605.39
    61 rdf:rest Nffad48317ac94f11b7b726c200a9769e
    62 N2232b737f7044fee8b6fb2bf05bf2887 schema:name doi
    63 schema:value 10.1007/s00066-018-1413-0
    64 rdf:type schema:PropertyValue
    65 N2ab080a7dc784c09957fdc66aac7b907 rdf:first sg:person.01201352600.25
    66 rdf:rest Nb66035731a0d4cc08d1b675c1882c48c
    67 N635df1f6d73d497b9c213e464f54e7b0 rdf:first sg:person.015703032753.30
    68 rdf:rest N2ab080a7dc784c09957fdc66aac7b907
    69 N84d118fa303f45b7932cdba53bec37c3 schema:name readcube_id
    70 schema:value 3a32a400cd7ce3b99d05cfbc9c29ab52aea8aeec388766b6f45bd98dab5d73fa
    71 rdf:type schema:PropertyValue
    72 N889c3c986f7d4f3dbedbf4ce669fea9c schema:name dimensions_id
    73 schema:value pub.1111057163
    74 rdf:type schema:PropertyValue
    75 N8f3fc588b4124226ba91a41037b6292e schema:name Springer Nature - SN SciGraph project
    76 rdf:type schema:Organization
    77 N8ff181832d7f4f20b705658e8a337816 rdf:first sg:person.01254774614.48
    78 rdf:rest N0c56356cb8f8427ba90d2676790d33eb
    79 Nb314650a5bec491dbb072a780a3c517e rdf:first sg:person.01024235176.72
    80 rdf:rest N635df1f6d73d497b9c213e464f54e7b0
    81 Nb66035731a0d4cc08d1b675c1882c48c rdf:first sg:person.01162221667.73
    82 rdf:rest rdf:nil
    83 Nb883735644354c5bba15de288561020d schema:name nlm_unique_id
    84 schema:value 8603469
    85 rdf:type schema:PropertyValue
    86 Ndab26496a4ee46729c2dea001b1eeb79 schema:name pubmed_id
    87 schema:value 30603857
    88 rdf:type schema:PropertyValue
    89 Ne17b8aa07ab846499dca55c808fc2bfd rdf:first sg:person.0706032525.98
    90 rdf:rest N8ff181832d7f4f20b705658e8a337816
    91 Nffad48317ac94f11b7b726c200a9769e rdf:first sg:person.01061170251.01
    92 rdf:rest Nb314650a5bec491dbb072a780a3c517e
    93 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    94 schema:name Medical and Health Sciences
    95 rdf:type schema:DefinedTerm
    96 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    97 schema:name Oncology and Carcinogenesis
    98 rdf:type schema:DefinedTerm
    99 sg:journal.1054450 schema:issn 0179-7158
    100 1439-099X
    101 schema:name Strahlentherapie und Onkologie
    102 rdf:type schema:Periodical
    103 sg:person.01024235176.72 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
    104 schema:familyName Janssen
    105 schema:givenName Hilde
    106 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024235176.72
    107 rdf:type schema:Person
    108 sg:person.01061170251.01 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
    109 schema:familyName Christiaens
    110 schema:givenName Melissa
    111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061170251.01
    112 rdf:type schema:Person
    113 sg:person.01162221667.73 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
    114 schema:familyName Weltens
    115 schema:givenName Caroline
    116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162221667.73
    117 rdf:type schema:Person
    118 sg:person.01201352600.25 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
    119 schema:familyName Van Limbergen
    120 schema:givenName Erik
    121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201352600.25
    122 rdf:type schema:Person
    123 sg:person.01216410605.39 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    124 schema:familyName Laenen
    125 schema:givenName Annouschka
    126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216410605.39
    127 rdf:type schema:Person
    128 sg:person.01254774614.48 schema:affiliation https://www.grid.ac/institutes/grid.412966.e
    129 schema:familyName Verhoeven
    130 schema:givenName Karolien
    131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254774614.48
    132 rdf:type schema:Person
    133 sg:person.015703032753.30 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
    134 schema:familyName Van der Vorst
    135 schema:givenName Aline
    136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015703032753.30
    137 rdf:type schema:Person
    138 sg:person.0706032525.98 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
    139 schema:familyName Kindts
    140 schema:givenName Isabelle
    141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706032525.98
    142 rdf:type schema:Person
    143 sg:pub.10.1007/s000660050057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034074913
    144 https://doi.org/10.1007/s000660050057
    145 rdf:type schema:CreativeWork
    146 https://doi.org/10.1001/jamaoncol.2016.3031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014415111
    147 rdf:type schema:CreativeWork
    148 https://doi.org/10.1002/1097-0142(19850901)56:5<979::aid-cncr2820560502>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1031176250
    149 rdf:type schema:CreativeWork
    150 https://doi.org/10.1002/1097-0142(19950501)75:9<2328::aid-cncr2820750923>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1051863016
    151 rdf:type schema:CreativeWork
    152 https://doi.org/10.1002/14651858.cd011987.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092550251
    153 rdf:type schema:CreativeWork
    154 https://doi.org/10.1016/0167-8140(91)90165-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1038446303
    155 rdf:type schema:CreativeWork
    156 https://doi.org/10.1016/0167-8140(94)01492-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1044795770
    157 rdf:type schema:CreativeWork
    158 https://doi.org/10.1016/0167-8140(95)01508-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1029471368
    159 rdf:type schema:CreativeWork
    160 https://doi.org/10.1016/0360-3016(93)90275-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1048027912
    161 rdf:type schema:CreativeWork
    162 https://doi.org/10.1016/0360-3016(95)02378-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000144563
    163 rdf:type schema:CreativeWork
    164 https://doi.org/10.1016/j.breast.2015.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010508218
    165 rdf:type schema:CreativeWork
    166 https://doi.org/10.1016/j.ijrobp.2008.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026900016
    167 rdf:type schema:CreativeWork
    168 https://doi.org/10.1016/j.ijrobp.2009.12.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019183932
    169 rdf:type schema:CreativeWork
    170 https://doi.org/10.1016/j.prro.2016.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005772357
    171 rdf:type schema:CreativeWork
    172 https://doi.org/10.1016/j.radonc.2004.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034854801
    173 rdf:type schema:CreativeWork
    174 https://doi.org/10.1016/j.semradonc.2011.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053180474
    175 rdf:type schema:CreativeWork
    176 https://doi.org/10.1016/s0140-6736(10)60837-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008906431
    177 rdf:type schema:CreativeWork
    178 https://doi.org/10.1016/s0140-6736(11)61629-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019167359
    179 rdf:type schema:CreativeWork
    180 https://doi.org/10.1016/s0360-3016(97)00325-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046934880
    181 rdf:type schema:CreativeWork
    182 https://doi.org/10.1016/s0959-8049(98)80231-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017405133
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1016/s1470-2045(14)71156-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034362695
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1093/annonc/mdv298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022951845
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1097/00000421-200102000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044997425
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1097/01.sla.0000114219.71899.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022367443
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1200/jco.2007.11.4991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050523736
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1200/jco.2009.22.6662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012826173
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.4048/jbc.2013.16.3.300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010654124
    197 rdf:type schema:CreativeWork
    198 https://www.grid.ac/institutes/grid.410569.f schema:alternateName Universitaire Ziekenhuizen Leuven
    199 schema:name Department of Oncology, Experimental Radiation Oncology, KU Leuven—University of Leuven, 3000, Leuven, Belgium
    200 Department of Radiation Oncology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium
    201 rdf:type schema:Organization
    202 https://www.grid.ac/institutes/grid.412966.e schema:alternateName Maastricht University Medical Centre
    203 schema:name Department of Radiation Oncology (MAASTRO), GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
    204 rdf:type schema:Organization
    205 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
    206 schema:name Leuven Biostatistics and Statistical Bioinformatics Centre (L-Biostat), KU Leuven University, Kapucijnenvoer 35, 3000, Leuven, Belgium
    207 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...