Ontology type: schema:ScholarlyArticle
2018-10
AUTHORSTanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Thomas Bruckner, Tilman Bostel, Stefan Ezechiel Welte, Eric Tonndorf-Martini, Rami El Shafie, Nils Henrik Nicolay, Jürgen Debus, Harald Rief
ABSTRACTPURPOSE: Radiation therapy (RT) provides an important treatment approach in the palliative care of vertebral metastases, but radiation-induced toxicities in patients with advanced disease and low performance status can have substantial implications for quality of life. Herein, we prospectively compared toxicity profiles of intensity-modulated radiotherapy (IMRT) vs. conventional three-dimensional conformal radiotherapy (3DCRT). METHODS: This was a prospective randomized monocentric explorative pilot trial to compare radiation-induced toxicity between IMRT and 3DCRT for patients with spinal metastases. A total of 60 patients were randomized between November 2016 and May 2017. In both cohorts, RT was delivered in 10 fractions of 3 Gy each. The primary endpoint was radiation-induced toxicity at 3 months. RESULTS: Median follow-up was 4.3 months. Two patients suffered from grade 3 acute toxicities in the IMRT arm, along with 1 patient in the 3DCRT group. At 12 weeks after treatment (t2), 1 patient reported grade 3 toxicity in the IMRT arm vs. 4 patients in the 3DCRT group. No grade 4 or 5 adverse events occurred in either group. In the IMRT arm, the most common side effects by the end of irradiation (t1) were grade 1-2 xerostomia and nausea in 8 patients each (29.6%), and dyspnea in 7 patients (25.9%). In the 3DCRT group, the most frequent adverse events (t1) were similar: grade 1-2 xerostomia (n = 10, 35.7%), esophagitis (n = 10, 35.8%), nausea (n = 10, 35.8%), and dyspnea (n = 5, 17.9%). CONCLUSION: This is the first randomized trial to evaluate radiation-induced toxicities after IMRT versus 3DCRT in patients with vertebral metastases. This trial demonstrated an additional improvement for IMRT in terms of acute side effects, although longer follow-up is required to further ascertain other endpoints. More... »
PAGES911-920
http://scigraph.springernature.com/pub.10.1007/s00066-018-1333-z
DOIhttp://dx.doi.org/10.1007/s00066-018-1333-z
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1105323639
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29978307
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"description": "PURPOSE: Radiation therapy (RT) provides an important treatment approach in the palliative care of vertebral metastases, but radiation-induced toxicities in patients with advanced disease and low performance status can have substantial implications for quality of life. Herein, we prospectively compared toxicity profiles of intensity-modulated radiotherapy (IMRT) vs. conventional three-dimensional conformal radiotherapy (3DCRT).\nMETHODS: This was a\u00a0prospective randomized monocentric explorative pilot trial to compare radiation-induced toxicity between IMRT and 3DCRT for patients with spinal metastases. A\u00a0total of 60\u00a0patients were randomized between November 2016 and May 2017. In both cohorts, RT was delivered in 10\u00a0fractions of 3\u202fGy each. The primary endpoint was radiation-induced toxicity at 3\u00a0months.\nRESULTS: Median follow-up was 4.3\u00a0months. Two patients suffered from grade\u00a03 acute toxicities in the IMRT arm, along with 1\u00a0patient in the 3DCRT group. At 12\u00a0weeks after treatment (t2), 1\u00a0patient reported grade\u00a03 toxicity in the IMRT arm vs. 4\u00a0patients in the 3DCRT group. No grade\u00a04 or 5 adverse events occurred in either group. In the IMRT arm, the most common side effects by the end of irradiation (t1) were grade\u00a01-2 xerostomia and nausea in 8\u00a0patients each (29.6%), and dyspnea in 7\u00a0patients (25.9%). In the 3DCRT group, the most frequent adverse events (t1) were similar: grade\u00a01-2 xerostomia (n\u202f=\u200910, 35.7%), esophagitis (n\u202f=\u200910, 35.8%), nausea (n\u202f=\u200910, 35.8%), and dyspnea (n\u202f=\u20095, 17.9%).\nCONCLUSION: This is the first randomized trial to evaluate radiation-induced toxicities after IMRT versus 3DCRT in patients with vertebral metastases. This trial demonstrated an additional improvement for IMRT in terms of acute side effects, although longer follow-up is required to further ascertain other endpoints.",
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Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00066-018-1333-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00066-018-1333-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00066-018-1333-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00066-018-1333-z'
This table displays all metadata directly associated to this object as RDF triples.
326 TRIPLES
21 PREDICATES
75 URIs
37 LITERALS
25 BLANK NODES