Radical hypo-fractionated radiotherapy with volumetric modulated arc therapy in lung cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-05

AUTHORS

D. Franceschini, F. De Rose, L. Cozzi, P. Navarria, E. Clerici, C. Franzese, T. Comito, A. Tozzi, C. Iftode, G. D’Agostino, M. Sorsetti

ABSTRACT

BACKGROUND: This study aimed to analyse the feasibility and acute toxicity of radical hypo-fractionated radiotherapy (RT) for elderly patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: We conducted a retrospective evaluation of treatment with volumetric modulated arc therapy (VMAT) of elderly patients affected by stage III inoperable NSCLC. The dose prescription was 56 Gy in 20 fractions, 55 Gy in 22 fractions, or 50 Gy in 20 fractions. Target volume included only the primary lesion and the infiltrated lymph nodes. The primary end point was acute and late toxicity, while secondary end points were progression-free survival (PFS), and overall survival (OS). RESULTS: In all, 41 patients were included in this analysis. The mean age of the patients was 78.6 years, and 22 patients had staged IIIA while 19 patients had stage IIIB disease. All but one patient had pathological nodal involvement; 15 patients received chemotherapy before RT. Acute grade 1-2 toxicity was recorded in 25 (61%) patients. Late toxicity was recorded in 13 (32%) patients. No cases of G3 or G4 toxicity were recorded. Complete response was obtained in two (5%) patients, 26 (63%) showed a partial response, and two (5%) experience disease progression. At a mean follow-up of 9.9 months (range, 1.1-25.4), 17 patients had died from disease progression, one died from other causes, and 23 were alive. Median OS was 13.7 ± 1.5 months (95% CI: 10.7-16.7), OS at 12 and 18 months was 51.3 ± 9.5% and 35.1 ± 10.1%, respectively. Median PFS was 13.7 ± 2.3 months (95% CI: 9.1-18.2), and PFS at 12 and 18 months was 50.1 ± 9.9% and 38.9 ± 10.4%, respectively. CONCLUSION: Radical hypo-fractionated VMAT is a promising treatment for locally advanced NSCLC in the elderly. The use of hypo-fractionated radiotherapy for lung cancer in older patients can be considered a valuable approach, particularly for patients with poor performance status or refusing other treatment approaches. More... »

PAGES

385-391

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00066-017-1103-3

DOI

http://dx.doi.org/10.1007/s00066-017-1103-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083687894

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28168322


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Radiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Italy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Dose Hypofractionation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Injuries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy, Intensity-Modulated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy", 
            "Istituto Clinico Humanitas Cancer Center, Via Manzoni\u00a056, 20089, Rozzano (Milan), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franceschini", 
        "givenName": "D.", 
        "id": "sg:person.0720377501.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720377501.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Rose", 
        "givenName": "F.", 
        "id": "sg:person.01052627217.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052627217.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas University", 
          "id": "https://www.grid.ac/institutes/grid.452490.e", 
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy", 
            "Department of Biomedical Sciences, Humanitas University, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cozzi", 
        "givenName": "L.", 
        "id": "sg:person.01024140341.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024140341.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Navarria", 
        "givenName": "P.", 
        "id": "sg:person.016377306647.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016377306647.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clerici", 
        "givenName": "E.", 
        "id": "sg:person.01372474423.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372474423.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franzese", 
        "givenName": "C.", 
        "id": "sg:person.01146531026.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146531026.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Comito", 
        "givenName": "T.", 
        "id": "sg:person.01012770741.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012770741.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tozzi", 
        "givenName": "A.", 
        "id": "sg:person.0706034160.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706034160.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iftode", 
        "givenName": "C.", 
        "id": "sg:person.0643214121.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643214121.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u2019Agostino", 
        "givenName": "G.", 
        "id": "sg:person.01022526250.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022526250.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas University", 
          "id": "https://www.grid.ac/institutes/grid.452490.e", 
          "name": [
            "Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy", 
            "Department of Biomedical Sciences, Humanitas University, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sorsetti", 
        "givenName": "M.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1748-717x-7-33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001009615", 
          "https://doi.org/10.1186/1748-717x-7-33"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:qure.0000031335.02254.3b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001491197", 
          "https://doi.org/10.1023/b:qure.0000031335.02254.3b"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coc.0000000000000188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001995893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coc.0000000000000188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001995893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.41.6677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003198683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(97)00365-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003599982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdn559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003767232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2005.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006505460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2005.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006505460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2010.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007740813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(99)00130-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012880203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cllc.2014.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017571561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejim.2014.10.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020182300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2008.06.1935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023718270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(99)00364-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024383007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2014.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024879670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(00)00429-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025541076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-015-0560-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028655854", 
          "https://doi.org/10.1186/s13014-015-0560-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2011.02.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030559990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-014-1739-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031943538", 
          "https://doi.org/10.1007/s00432-014-1739-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/88.17.1210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035451877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(14)71207-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035529456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.26.2543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039864167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042069193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e3182429682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045048922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.5435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050681554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-5002(99)00019-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052947722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/83.6.417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059817056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/bjr.20150111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064565599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074586098", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-05", 
    "datePublishedReg": "2017-05-01", 
    "description": "BACKGROUND: This study aimed to analyse the feasibility and acute toxicity of radical hypo-fractionated radiotherapy (RT) for elderly patients with non-small-cell lung cancer (NSCLC).\nPATIENTS AND METHODS: We conducted a\u00a0retrospective evaluation of treatment with volumetric modulated arc therapy (VMAT) of elderly patients affected by stage\u00a0III inoperable NSCLC. The dose prescription was 56\u2009Gy in 20 fractions, 55\u2009Gy in 22\u00a0fractions, or 50\u2009Gy in 20\u00a0fractions. Target volume included only the primary lesion and the infiltrated lymph nodes. The primary end point was acute and late toxicity, while secondary end points were progression-free survival (PFS), and overall survival (OS).\nRESULTS: In all, 41\u00a0patients were included in this analysis. The mean age of the patients was 78.6\u00a0years, and 22\u00a0patients had staged IIIA while 19\u00a0patients had stage IIIB disease. All but one patient had pathological nodal involvement; 15\u00a0patients received chemotherapy before RT. Acute grade\u00a01-2 toxicity was recorded in 25 (61%) patients. Late toxicity was recorded in 13 (32%) patients. No cases of G3 or G4 toxicity were recorded. Complete response was obtained in two (5%) patients, 26 (63%) showed a\u00a0partial response, and two (5%) experience disease progression. At a\u00a0mean follow-up of 9.9\u00a0months (range, 1.1-25.4), 17\u00a0patients had died from disease progression, one died from other causes, and 23 were alive. Median OS was 13.7\u00a0\u00b1 1.5\u00a0months (95% CI: 10.7-16.7), OS at 12 and 18\u00a0months was 51.3\u00a0\u00b1 9.5% and 35.1\u00a0\u00b1 10.1%, respectively. Median PFS was 13.7\u00a0\u00b1 2.3\u00a0months (95% CI: 9.1-18.2), and PFS at 12 and 18\u00a0months was 50.1\u00a0\u00b1 9.9% and 38.9\u00a0\u00b1 10.4%, respectively.\nCONCLUSION: Radical hypo-fractionated VMAT is a\u00a0promising treatment for locally advanced NSCLC in the elderly. The use of hypo-fractionated radiotherapy for lung cancer in older patients can be considered a\u00a0valuable approach, particularly for patients with poor performance status or refusing other treatment approaches.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00066-017-1103-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1054450", 
        "issn": [
          "0179-7158", 
          "1439-099X"
        ], 
        "name": "Strahlentherapie und Onkologie", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "193"
      }
    ], 
    "name": "Radical hypo-fractionated radiotherapy with volumetric modulated arc therapy in lung cancer", 
    "pagination": "385-391", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2fd3a6ad385837e6782cd0ba165c509930d579a61031a467224e121707e2564b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28168322"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8603469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00066-017-1103-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1083687894"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00066-017-1103-3", 
      "https://app.dimensions.ai/details/publication/pub.1083687894"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89807_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00066-017-1103-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00066-017-1103-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00066-017-1103-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00066-017-1103-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00066-017-1103-3'


 

This table displays all metadata directly associated to this object as RDF triples.

326 TRIPLES      21 PREDICATES      77 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00066-017-1103-3 schema:about N0ac42be36888421ab4c0315157d2f586
2 N1ac18eca6bea47aa8979bb46035f1236
3 N1b52f2281de34e02909c5a61b1930f21
4 N1cb3b42910fd4d2fb37d3cf30725a93f
5 N2227e2ed158b4c84a93287a05a850abd
6 N2e277b2c9fd749c3bcd6db0957353a6e
7 N30961fe7d5ef45e884591da0040b0743
8 N33acdb75d14d49b1b31c11fe5dbcd9b4
9 N5245ea5996474df590e88b9e4c2d34da
10 N56c99e4a7d714af8bc84a6f293aa9823
11 N6fcf6363c9134f84999ee0dc61054020
12 N7325eaa3e73d479182a580ded933ad43
13 N8c88b796409d409cbd107181a81db607
14 N8fe23a0809c34d5ab3482ecb8f751ce5
15 Nb2b769bd828449048857725d4b6ee554
16 Nb9c4120854d54e0f8255bded26f97557
17 Ne6ffb7befcdc4196bba41d25358fd61b
18 Nee7a4b28d9094d7d8b383e48608c1724
19 Nf6e9eb643cf34bd3bf0199b9c0606f8f
20 Nf8d8dc378c444787bd986198a3b923f8
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author N2042870b75a24adb8f85c4da96091c07
24 schema:citation sg:pub.10.1007/s00432-014-1739-7
25 sg:pub.10.1023/b:qure.0000031335.02254.3b
26 sg:pub.10.1186/1748-717x-7-33
27 sg:pub.10.1186/s13014-015-0560-z
28 https://app.dimensions.ai/details/publication/pub.1074586098
29 https://doi.org/10.1016/j.cllc.2014.08.002
30 https://doi.org/10.1016/j.critrevonc.2005.06.003
31 https://doi.org/10.1016/j.ejca.2014.07.009
32 https://doi.org/10.1016/j.ejim.2014.10.024
33 https://doi.org/10.1016/j.ijrobp.2008.06.1935
34 https://doi.org/10.1016/j.ijrobp.2010.09.004
35 https://doi.org/10.1016/j.radonc.2011.02.014
36 https://doi.org/10.1016/s0169-5002(99)00019-7
37 https://doi.org/10.1016/s0360-3016(00)00429-6
38 https://doi.org/10.1016/s0360-3016(97)00365-9
39 https://doi.org/10.1016/s0360-3016(99)00130-3
40 https://doi.org/10.1016/s0360-3016(99)00364-8
41 https://doi.org/10.1016/s1470-2045(14)71207-0
42 https://doi.org/10.1093/annonc/mdn559
43 https://doi.org/10.1093/jnci/83.6.417
44 https://doi.org/10.1093/jnci/88.17.1210
45 https://doi.org/10.1097/coc.0000000000000188
46 https://doi.org/10.1097/jto.0b013e3182429682
47 https://doi.org/10.1200/jco.2007.12.5435
48 https://doi.org/10.1200/jco.2009.26.2543
49 https://doi.org/10.1200/jco.2012.41.6677
50 https://doi.org/10.1259/bjr.20150111
51 https://doi.org/10.3322/caac.20073
52 schema:datePublished 2017-05
53 schema:datePublishedReg 2017-05-01
54 schema:description BACKGROUND: This study aimed to analyse the feasibility and acute toxicity of radical hypo-fractionated radiotherapy (RT) for elderly patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: We conducted a retrospective evaluation of treatment with volumetric modulated arc therapy (VMAT) of elderly patients affected by stage III inoperable NSCLC. The dose prescription was 56 Gy in 20 fractions, 55 Gy in 22 fractions, or 50 Gy in 20 fractions. Target volume included only the primary lesion and the infiltrated lymph nodes. The primary end point was acute and late toxicity, while secondary end points were progression-free survival (PFS), and overall survival (OS). RESULTS: In all, 41 patients were included in this analysis. The mean age of the patients was 78.6 years, and 22 patients had staged IIIA while 19 patients had stage IIIB disease. All but one patient had pathological nodal involvement; 15 patients received chemotherapy before RT. Acute grade 1-2 toxicity was recorded in 25 (61%) patients. Late toxicity was recorded in 13 (32%) patients. No cases of G3 or G4 toxicity were recorded. Complete response was obtained in two (5%) patients, 26 (63%) showed a partial response, and two (5%) experience disease progression. At a mean follow-up of 9.9 months (range, 1.1-25.4), 17 patients had died from disease progression, one died from other causes, and 23 were alive. Median OS was 13.7 ± 1.5 months (95% CI: 10.7-16.7), OS at 12 and 18 months was 51.3 ± 9.5% and 35.1 ± 10.1%, respectively. Median PFS was 13.7 ± 2.3 months (95% CI: 9.1-18.2), and PFS at 12 and 18 months was 50.1 ± 9.9% and 38.9 ± 10.4%, respectively. CONCLUSION: Radical hypo-fractionated VMAT is a promising treatment for locally advanced NSCLC in the elderly. The use of hypo-fractionated radiotherapy for lung cancer in older patients can be considered a valuable approach, particularly for patients with poor performance status or refusing other treatment approaches.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N1712f8580cfa416685d4031e59021e47
59 Nd7bc467c119241579df5c09375579848
60 sg:journal.1054450
61 schema:name Radical hypo-fractionated radiotherapy with volumetric modulated arc therapy in lung cancer
62 schema:pagination 385-391
63 schema:productId N107ba895f8e5449cb292f32f12181a6f
64 N310285d8f41347e8b0c0c13edc1c1222
65 N6a8bde0cfada428fa638657a72e9af60
66 N9f2408abe18a4b8aad5c9ec22dc78b30
67 Nc8d5e4f348ba4b3c839c0b066c091c29
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083687894
69 https://doi.org/10.1007/s00066-017-1103-3
70 schema:sdDatePublished 2019-04-11T09:57
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N4b2d3a3d08214dcdb446b3577f0efdc6
73 schema:url https://link.springer.com/10.1007%2Fs00066-017-1103-3
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N0ac42be36888421ab4c0315157d2f586 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Lung Neoplasms
79 rdf:type schema:DefinedTerm
80 N0c2b652d15dc40729b344ab93ba0ba12 rdf:first sg:person.016377306647.92
81 rdf:rest Ne1f6755b2b8d4577a634edaaa0337ed1
82 N107ba895f8e5449cb292f32f12181a6f schema:name doi
83 schema:value 10.1007/s00066-017-1103-3
84 rdf:type schema:PropertyValue
85 N1433a57c2f164aea9d767173bcbf850b rdf:first sg:person.01146531026.52
86 rdf:rest N84f35adf8a11467daad7fa55285b87ae
87 N1712f8580cfa416685d4031e59021e47 schema:issueNumber 5
88 rdf:type schema:PublicationIssue
89 N1ac18eca6bea47aa8979bb46035f1236 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Middle Aged
91 rdf:type schema:DefinedTerm
92 N1b52f2281de34e02909c5a61b1930f21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Neoplasm Staging
94 rdf:type schema:DefinedTerm
95 N1cb3b42910fd4d2fb37d3cf30725a93f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Radiation Dose Hypofractionation
97 rdf:type schema:DefinedTerm
98 N1cd726e32b0c445db879224fa4bb14d2 rdf:first sg:person.01052627217.59
99 rdf:rest Nfa49d478e7cd4b618e5e6347622a0450
100 N1d4528a381fa4b6aa14db51816a55eec rdf:first N88e12d49f4364090bbc7d7456128c2e4
101 rdf:rest rdf:nil
102 N1ee62028b5124d3a8e66808247f8036e schema:name Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy
103 rdf:type schema:Organization
104 N2042870b75a24adb8f85c4da96091c07 rdf:first sg:person.0720377501.57
105 rdf:rest N1cd726e32b0c445db879224fa4bb14d2
106 N2227e2ed158b4c84a93287a05a850abd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Treatment Outcome
108 rdf:type schema:DefinedTerm
109 N29d49dfb512b4d5882c605280f5d5a7c rdf:first sg:person.0643214121.04
110 rdf:rest N92967e60958c41639cfe1bdc40ce8ab0
111 N2e277b2c9fd749c3bcd6db0957353a6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Humans
113 rdf:type schema:DefinedTerm
114 N30961fe7d5ef45e884591da0040b0743 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Retrospective Studies
116 rdf:type schema:DefinedTerm
117 N310285d8f41347e8b0c0c13edc1c1222 schema:name nlm_unique_id
118 schema:value 8603469
119 rdf:type schema:PropertyValue
120 N33acdb75d14d49b1b31c11fe5dbcd9b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Italy
122 rdf:type schema:DefinedTerm
123 N401748515c9a46cdbc65bb54286a6071 schema:name Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy
124 rdf:type schema:Organization
125 N48d032ef55144c5988a08b7e42b4fb90 schema:name Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy
126 rdf:type schema:Organization
127 N4b2d3a3d08214dcdb446b3577f0efdc6 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N4c72ded54a6344528cf4ef11b7ed3c29 schema:name Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy
130 rdf:type schema:Organization
131 N5083558135d64e6d97f694659d3b3a57 schema:name Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy
132 rdf:type schema:Organization
133 N5245ea5996474df590e88b9e4c2d34da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Prevalence
135 rdf:type schema:DefinedTerm
136 N56c99e4a7d714af8bc84a6f293aa9823 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Risk Factors
138 rdf:type schema:DefinedTerm
139 N6a8bde0cfada428fa638657a72e9af60 schema:name readcube_id
140 schema:value 2fd3a6ad385837e6782cd0ba165c509930d579a61031a467224e121707e2564b
141 rdf:type schema:PropertyValue
142 N6fcf6363c9134f84999ee0dc61054020 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Survival Rate
144 rdf:type schema:DefinedTerm
145 N7325eaa3e73d479182a580ded933ad43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Dose-Response Relationship, Radiation
147 rdf:type schema:DefinedTerm
148 N83c08bdbc34d4121ae01e6b45339cc02 rdf:first sg:person.0706034160.75
149 rdf:rest N29d49dfb512b4d5882c605280f5d5a7c
150 N84f35adf8a11467daad7fa55285b87ae rdf:first sg:person.01012770741.30
151 rdf:rest N83c08bdbc34d4121ae01e6b45339cc02
152 N88e12d49f4364090bbc7d7456128c2e4 schema:affiliation https://www.grid.ac/institutes/grid.452490.e
153 schema:familyName Sorsetti
154 schema:givenName M.
155 rdf:type schema:Person
156 N8c88b796409d409cbd107181a81db607 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Neoplasm Recurrence, Local
158 rdf:type schema:DefinedTerm
159 N8fe23a0809c34d5ab3482ecb8f751ce5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Disease-Free Survival
161 rdf:type schema:DefinedTerm
162 N92967e60958c41639cfe1bdc40ce8ab0 rdf:first sg:person.01022526250.51
163 rdf:rest N1d4528a381fa4b6aa14db51816a55eec
164 N9f2408abe18a4b8aad5c9ec22dc78b30 schema:name dimensions_id
165 schema:value pub.1083687894
166 rdf:type schema:PropertyValue
167 N9fe22d3482514c398767270229f0aa59 schema:name Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy
168 rdf:type schema:Organization
169 Na8b385e1b7bf4511969b56d5a97bb657 schema:name Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy
170 rdf:type schema:Organization
171 Naa059f6e513c48249dc3ab7093f44af8 schema:name Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy
172 rdf:type schema:Organization
173 Nb2b769bd828449048857725d4b6ee554 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Aged
175 rdf:type schema:DefinedTerm
176 Nb9c4120854d54e0f8255bded26f97557 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Radiotherapy, Intensity-Modulated
178 rdf:type schema:DefinedTerm
179 Nc8d5e4f348ba4b3c839c0b066c091c29 schema:name pubmed_id
180 schema:value 28168322
181 rdf:type schema:PropertyValue
182 Nd7bc467c119241579df5c09375579848 schema:volumeNumber 193
183 rdf:type schema:PublicationVolume
184 Ne1f6755b2b8d4577a634edaaa0337ed1 rdf:first sg:person.01372474423.15
185 rdf:rest N1433a57c2f164aea9d767173bcbf850b
186 Ne6ffb7befcdc4196bba41d25358fd61b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Male
188 rdf:type schema:DefinedTerm
189 Nee7a4b28d9094d7d8b383e48608c1724 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Aged, 80 and over
191 rdf:type schema:DefinedTerm
192 Nf6e9eb643cf34bd3bf0199b9c0606f8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Radiation Injuries
194 rdf:type schema:DefinedTerm
195 Nf8d8dc378c444787bd986198a3b923f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Female
197 rdf:type schema:DefinedTerm
198 Nfa49d478e7cd4b618e5e6347622a0450 rdf:first sg:person.01024140341.27
199 rdf:rest N0c2b652d15dc40729b344ab93ba0ba12
200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical and Health Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
204 schema:name Oncology and Carcinogenesis
205 rdf:type schema:DefinedTerm
206 sg:journal.1054450 schema:issn 0179-7158
207 1439-099X
208 schema:name Strahlentherapie und Onkologie
209 rdf:type schema:Periodical
210 sg:person.01012770741.30 schema:affiliation N1ee62028b5124d3a8e66808247f8036e
211 schema:familyName Comito
212 schema:givenName T.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012770741.30
214 rdf:type schema:Person
215 sg:person.01022526250.51 schema:affiliation N48d032ef55144c5988a08b7e42b4fb90
216 schema:familyName D’Agostino
217 schema:givenName G.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022526250.51
219 rdf:type schema:Person
220 sg:person.01024140341.27 schema:affiliation https://www.grid.ac/institutes/grid.452490.e
221 schema:familyName Cozzi
222 schema:givenName L.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024140341.27
224 rdf:type schema:Person
225 sg:person.01052627217.59 schema:affiliation N5083558135d64e6d97f694659d3b3a57
226 schema:familyName De Rose
227 schema:givenName F.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052627217.59
229 rdf:type schema:Person
230 sg:person.01146531026.52 schema:affiliation Naa059f6e513c48249dc3ab7093f44af8
231 schema:familyName Franzese
232 schema:givenName C.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146531026.52
234 rdf:type schema:Person
235 sg:person.01372474423.15 schema:affiliation N401748515c9a46cdbc65bb54286a6071
236 schema:familyName Clerici
237 schema:givenName E.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372474423.15
239 rdf:type schema:Person
240 sg:person.016377306647.92 schema:affiliation Na8b385e1b7bf4511969b56d5a97bb657
241 schema:familyName Navarria
242 schema:givenName P.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016377306647.92
244 rdf:type schema:Person
245 sg:person.0643214121.04 schema:affiliation N9fe22d3482514c398767270229f0aa59
246 schema:familyName Iftode
247 schema:givenName C.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643214121.04
249 rdf:type schema:Person
250 sg:person.0706034160.75 schema:affiliation N4c72ded54a6344528cf4ef11b7ed3c29
251 schema:familyName Tozzi
252 schema:givenName A.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706034160.75
254 rdf:type schema:Person
255 sg:person.0720377501.57 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
256 schema:familyName Franceschini
257 schema:givenName D.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720377501.57
259 rdf:type schema:Person
260 sg:pub.10.1007/s00432-014-1739-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031943538
261 https://doi.org/10.1007/s00432-014-1739-7
262 rdf:type schema:CreativeWork
263 sg:pub.10.1023/b:qure.0000031335.02254.3b schema:sameAs https://app.dimensions.ai/details/publication/pub.1001491197
264 https://doi.org/10.1023/b:qure.0000031335.02254.3b
265 rdf:type schema:CreativeWork
266 sg:pub.10.1186/1748-717x-7-33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001009615
267 https://doi.org/10.1186/1748-717x-7-33
268 rdf:type schema:CreativeWork
269 sg:pub.10.1186/s13014-015-0560-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1028655854
270 https://doi.org/10.1186/s13014-015-0560-z
271 rdf:type schema:CreativeWork
272 https://app.dimensions.ai/details/publication/pub.1074586098 schema:CreativeWork
273 https://doi.org/10.1016/j.cllc.2014.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017571561
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.critrevonc.2005.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006505460
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.ejca.2014.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024879670
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.ejim.2014.10.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020182300
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.ijrobp.2008.06.1935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023718270
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.ijrobp.2010.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007740813
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.radonc.2011.02.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030559990
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0169-5002(99)00019-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052947722
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s0360-3016(00)00429-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025541076
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s0360-3016(97)00365-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003599982
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0360-3016(99)00130-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012880203
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0360-3016(99)00364-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024383007
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s1470-2045(14)71207-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035529456
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1093/annonc/mdn559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003767232
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/jnci/83.6.417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059817056
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/jnci/88.17.1210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035451877
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1097/coc.0000000000000188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001995893
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1097/jto.0b013e3182429682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045048922
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1200/jco.2007.12.5435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050681554
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1200/jco.2009.26.2543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039864167
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1200/jco.2012.41.6677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003198683
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1259/bjr.20150111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064565599
316 rdf:type schema:CreativeWork
317 https://doi.org/10.3322/caac.20073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042069193
318 rdf:type schema:CreativeWork
319 https://www.grid.ac/institutes/grid.417728.f schema:alternateName Humanitas Research Hospital
320 schema:name Istituto Clinico Humanitas Cancer Center, Via Manzoni 56, 20089, Rozzano (Milan), Italy
321 Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy
322 rdf:type schema:Organization
323 https://www.grid.ac/institutes/grid.452490.e schema:alternateName Humanitas University
324 schema:name Department of Biomedical Sciences, Humanitas University, Milan, Italy
325 Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Milan, Italy
326 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...