Evaluation of radiotherapy techniques for radical treatment of lateralised oropharyngeal cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08

AUTHORS

D. McQuaid, A. Dunlop, S. Nill, C. Franzese, C. M. Nutting, K. J. Harrington, K. L. Newbold, S. A. Bhide

ABSTRACT

AIM: The aim of this study was to investigate potential advantages and disadvantages of three-dimensional conformal radiotherapy (3DCRT), multiple fixed-field intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) in terms of dose to the planning target volume (PTV), organs at risk (OARs) and normal tissue complication probability (NTCP) for delivering ipsilateral radiotherapy. MATERIALS AND METHODS: 3DCRT, IMRT and VMAT were compared in patients with well-lateralised primary tonsillar cancers who underwent primary radical ipsilateral radiotherapy. The following parameters were compared: conformity index (CI); homogeneity index (HI); dose-volume histograms (DVHs) of PTVs and OARs; NTCP, risk of radiation-induced cancer and dose accumulation during treatment. RESULTS: IMRT and VMAT were superior to 3DCRT in terms of CI, HI and dose to the target volumes, as well as mandible and dose accumulation robustness. The techniques were equivalent in terms of dose and NTCP for the contralateral oral cavity, contralateral submandibular gland and mandible, when specific dose constraint objectives were used on the oral cavity volume. Although the volume of normal tissue exposed to low-dose radiation was significantly higher with IMRT and VMAT, the risk of radiation-induced secondary malignancy was dependant on the mathematical model used. CONCLUSION: This study demonstrates the superiority of IMRT/VMAT techniques over 3DCRT in terms of dose homogeneity, conformity and consistent dose delivery to the PTV throughout the course of treatment in patients with lateralised oropharyngeal cancers. Dosimetry and NTCP calculations show that these techniques are equivalent to 3DCRT with regard to the risk of acute mucositis when specific dose constraint objectives were used on the contralateral oral cavity OAR. More... »

PAGES

516-525

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00066-016-0980-1

DOI

http://dx.doi.org/10.1007/s00066-016-0980-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024862798

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27295511


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Radiation-Induced", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy Dosage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy Planning, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy, Intensity-Modulated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Assessment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tonsillar Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Burden", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Head and Neck Unit, Royal Marsden Hospital, Downs road, SM2 5PT, Sutton, Surrey, UK", 
            "Head and Neck Unit, Royal Marsden Hospital, SW3 6JJ, London, UK", 
            "The Institute of Cancer Research, SW3 6JB, London, UK", 
            "The Institute of Cancer Research, SM2 5NG, Sutton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McQuaid", 
        "givenName": "D.", 
        "id": "sg:person.01263151535.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263151535.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Head and Neck Unit, Royal Marsden Hospital, Downs road, SM2 5PT, Sutton, Surrey, UK", 
            "Head and Neck Unit, Royal Marsden Hospital, SW3 6JJ, London, UK", 
            "The Institute of Cancer Research, SW3 6JB, London, UK", 
            "The Institute of Cancer Research, SM2 5NG, Sutton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dunlop", 
        "givenName": "A.", 
        "id": "sg:person.01323327772.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323327772.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Head and Neck Unit, Royal Marsden Hospital, Downs road, SM2 5PT, Sutton, Surrey, UK", 
            "Head and Neck Unit, Royal Marsden Hospital, SW3 6JJ, London, UK", 
            "The Institute of Cancer Research, SW3 6JB, London, UK", 
            "The Institute of Cancer Research, SM2 5NG, Sutton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nill", 
        "givenName": "S.", 
        "id": "sg:person.01314161733.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314161733.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Head and Neck Unit, Royal Marsden Hospital, Downs road, SM2 5PT, Sutton, Surrey, UK", 
            "Head and Neck Unit, Royal Marsden Hospital, SW3 6JJ, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franzese", 
        "givenName": "C.", 
        "id": "sg:person.01352176212.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352176212.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Head and Neck Unit, Royal Marsden Hospital, Downs road, SM2 5PT, Sutton, Surrey, UK", 
            "Head and Neck Unit, Royal Marsden Hospital, SW3 6JJ, London, UK", 
            "The Institute of Cancer Research, SW3 6JB, London, UK", 
            "The Institute of Cancer Research, SM2 5NG, Sutton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nutting", 
        "givenName": "C. M.", 
        "id": "sg:person.07606233544.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07606233544.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Head and Neck Unit, Royal Marsden Hospital, Downs road, SM2 5PT, Sutton, Surrey, UK", 
            "Head and Neck Unit, Royal Marsden Hospital, SW3 6JJ, London, UK", 
            "The Institute of Cancer Research, SW3 6JB, London, UK", 
            "The Institute of Cancer Research, SM2 5NG, Sutton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harrington", 
        "givenName": "K. J.", 
        "id": "sg:person.01167312032.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167312032.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Head and Neck Unit, Royal Marsden Hospital, Downs road, SM2 5PT, Sutton, Surrey, UK", 
            "Head and Neck Unit, Royal Marsden Hospital, SW3 6JJ, London, UK", 
            "The Institute of Cancer Research, SW3 6JB, London, UK", 
            "The Institute of Cancer Research, SM2 5NG, Sutton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Newbold", 
        "givenName": "K. L.", 
        "id": "sg:person.07346633077.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07346633077.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Head and Neck Unit, Royal Marsden Hospital, Downs road, SM2 5PT, Sutton, Surrey, UK", 
            "Head and Neck Unit, Royal Marsden Hospital, SW3 6JJ, London, UK", 
            "The Institute of Cancer Research, SW3 6JB, London, UK", 
            "The Institute of Cancer Research, SM2 5NG, Sutton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bhide", 
        "givenName": "S. A.", 
        "id": "sg:person.0700143313.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700143313.76"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.radonc.2003.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000731952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.02.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002527309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2006.01.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005818793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-8140(83)80021-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006184010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(01)01613-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010076341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1118/1.4894702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010667108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2006.11.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011067579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(10)70290-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012239121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2011.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012290275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2005.06.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017797974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2007.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017870667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2012.11.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018005436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2008.12.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019489571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2010.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019559459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2012.05.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022051507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-8140(99)00051-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022058680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2012.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022351192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2008.12.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024365290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2009.08.078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028008977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.12.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030852419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.08.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033008673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)00073-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035380014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)00073-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035380014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2009.04.095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035895196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.oraloncology.2014.06.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041459284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2011.06.1975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050269942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2006.03.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051968383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(99)00247-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053113831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jicru/ndq010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059796268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/bjr.73.871.11089476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064567108"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-08", 
    "datePublishedReg": "2016-08-01", 
    "description": "AIM: The aim of this study was to investigate potential advantages and disadvantages of three-dimensional conformal radiotherapy (3DCRT), multiple fixed-field intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) in terms of dose to the planning target volume (PTV), organs at risk (OARs) and normal tissue complication probability (NTCP) for delivering ipsilateral radiotherapy.\nMATERIALS AND METHODS: 3DCRT, IMRT and VMAT were compared in patients with well-lateralised primary tonsillar cancers who underwent primary radical ipsilateral radiotherapy. The following parameters were compared: conformity index (CI); homogeneity index (HI); dose-volume histograms (DVHs) of PTVs and OARs; NTCP, risk of radiation-induced cancer and dose accumulation during treatment.\nRESULTS: IMRT and VMAT were superior to 3DCRT in terms of CI, HI and dose to the target volumes, as well as mandible and dose accumulation robustness. The techniques were equivalent in terms of dose and NTCP for the contralateral oral cavity, contralateral submandibular gland and mandible, when specific dose constraint objectives were used on the oral cavity volume. Although the volume of normal tissue exposed to low-dose radiation was significantly higher with IMRT and VMAT, the risk of radiation-induced secondary malignancy was dependant on the mathematical model used.\nCONCLUSION: This study demonstrates the superiority of IMRT/VMAT techniques over 3DCRT in terms of dose homogeneity, conformity and consistent dose delivery to the PTV throughout the course of treatment in patients with lateralised oropharyngeal cancers. Dosimetry and NTCP calculations show that these techniques are equivalent to 3DCRT with regard to the risk of acute mucositis when specific dose constraint objectives were used on the contralateral oral cavity OAR.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00066-016-0980-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5137829", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5134733", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1054450", 
        "issn": [
          "0179-7158", 
          "1439-099X"
        ], 
        "name": "Strahlentherapie und Onkologie", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "192"
      }
    ], 
    "name": "Evaluation of radiotherapy techniques for radical treatment of lateralised oropharyngeal cancers", 
    "pagination": "516-525", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "767272a94bc917fc2db1537f7fa6569d6960870f37743c5d6451ef5c7e9bcdbd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27295511"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8603469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00066-016-0980-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024862798"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00066-016-0980-1", 
      "https://app.dimensions.ai/details/publication/pub.1024862798"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87119_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00066-016-0980-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00066-016-0980-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00066-016-0980-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00066-016-0980-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00066-016-0980-1'


 

This table displays all metadata directly associated to this object as RDF triples.

272 TRIPLES      21 PREDICATES      72 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00066-016-0980-1 schema:about N035c37ae526e4ed88325119b9a0f2b36
2 N036164ab954a40e5abbe70413db61b0f
3 N0be4a87545ca462ebd3dbd9770a2608e
4 N15e7a27416db4ccfa324dee1a5840522
5 N40c30319dd0e4ac8acb58e2e07b5a3a5
6 N4eb4215a221549639a241a30adf29c14
7 N732e489676544066b1522152ca134e4c
8 N93363c50d1884e1cbd90820f9ed35257
9 N9a27e0d9d3a941a9ae13cb6f944a897e
10 Nb821c83e16f4437c8e70a65df5746db4
11 Nbcdb3c8ca752407bb751b719dca7f463
12 Ndefc9da98f2b4394be82453a2184d0f6
13 Ne199966b14ee4f7a8fc8aa1e0977ad20
14 Ne259a6e218794a889e2dd4037b5d6a56
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author Ndad2ff13f1064f4d9b0c0327a4a7310c
18 schema:citation https://doi.org/10.1016/j.ijrobp.2006.11.059
19 https://doi.org/10.1016/j.ijrobp.2007.02.049
20 https://doi.org/10.1016/j.ijrobp.2007.08.046
21 https://doi.org/10.1016/j.ijrobp.2007.12.033
22 https://doi.org/10.1016/j.ijrobp.2008.12.052
23 https://doi.org/10.1016/j.ijrobp.2009.04.095
24 https://doi.org/10.1016/j.ijrobp.2009.08.078
25 https://doi.org/10.1016/j.ijrobp.2011.02.003
26 https://doi.org/10.1016/j.ijrobp.2011.06.1975
27 https://doi.org/10.1016/j.ijrobp.2012.05.032
28 https://doi.org/10.1016/j.ijrobp.2012.11.031
29 https://doi.org/10.1016/j.neuroimage.2006.01.021
30 https://doi.org/10.1016/j.oraloncology.2014.06.019
31 https://doi.org/10.1016/j.radonc.2003.09.011
32 https://doi.org/10.1016/j.radonc.2005.06.039
33 https://doi.org/10.1016/j.radonc.2006.03.009
34 https://doi.org/10.1016/j.radonc.2007.06.005
35 https://doi.org/10.1016/j.radonc.2008.12.016
36 https://doi.org/10.1016/j.radonc.2010.08.013
37 https://doi.org/10.1016/j.radonc.2012.12.006
38 https://doi.org/10.1016/s0167-8140(83)80021-8
39 https://doi.org/10.1016/s0167-8140(99)00051-1
40 https://doi.org/10.1016/s0360-3016(01)01613-3
41 https://doi.org/10.1016/s0360-3016(03)00073-7
42 https://doi.org/10.1016/s0360-3016(99)00247-3
43 https://doi.org/10.1016/s1470-2045(10)70290-4
44 https://doi.org/10.1093/jicru/ndq010
45 https://doi.org/10.1118/1.4894702
46 https://doi.org/10.1259/bjr.73.871.11089476
47 schema:datePublished 2016-08
48 schema:datePublishedReg 2016-08-01
49 schema:description AIM: The aim of this study was to investigate potential advantages and disadvantages of three-dimensional conformal radiotherapy (3DCRT), multiple fixed-field intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) in terms of dose to the planning target volume (PTV), organs at risk (OARs) and normal tissue complication probability (NTCP) for delivering ipsilateral radiotherapy. MATERIALS AND METHODS: 3DCRT, IMRT and VMAT were compared in patients with well-lateralised primary tonsillar cancers who underwent primary radical ipsilateral radiotherapy. The following parameters were compared: conformity index (CI); homogeneity index (HI); dose-volume histograms (DVHs) of PTVs and OARs; NTCP, risk of radiation-induced cancer and dose accumulation during treatment. RESULTS: IMRT and VMAT were superior to 3DCRT in terms of CI, HI and dose to the target volumes, as well as mandible and dose accumulation robustness. The techniques were equivalent in terms of dose and NTCP for the contralateral oral cavity, contralateral submandibular gland and mandible, when specific dose constraint objectives were used on the oral cavity volume. Although the volume of normal tissue exposed to low-dose radiation was significantly higher with IMRT and VMAT, the risk of radiation-induced secondary malignancy was dependant on the mathematical model used. CONCLUSION: This study demonstrates the superiority of IMRT/VMAT techniques over 3DCRT in terms of dose homogeneity, conformity and consistent dose delivery to the PTV throughout the course of treatment in patients with lateralised oropharyngeal cancers. Dosimetry and NTCP calculations show that these techniques are equivalent to 3DCRT with regard to the risk of acute mucositis when specific dose constraint objectives were used on the contralateral oral cavity OAR.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf Nbfde62ec4222423e813af545648874b8
54 Nf93937e71bc545bfbf14782a18d99553
55 sg:journal.1054450
56 schema:name Evaluation of radiotherapy techniques for radical treatment of lateralised oropharyngeal cancers
57 schema:pagination 516-525
58 schema:productId N163a5057a76e4b07aec153cf70319081
59 N6d3060862e0d4cd7ad19552eee62a657
60 Nad94f843512d49908650376734bf3d5d
61 Nec9f8f81e75e4f059ea80cdcad532ba5
62 Nf11f022195e445a08ed14b2ac9f87ed3
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024862798
64 https://doi.org/10.1007/s00066-016-0980-1
65 schema:sdDatePublished 2019-04-11T12:27
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N9b123b1fc4cb439b9bf1ce1934dbf80d
68 schema:url https://link.springer.com/10.1007%2Fs00066-016-0980-1
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N007d9455d31f41e196b7c4089b221e92 rdf:first sg:person.01167312032.35
73 rdf:rest Nee4d90f39f5345f890baa28efe68ad3b
74 N0139d1c8bc564666b54fd2401f135461 rdf:first sg:person.07606233544.21
75 rdf:rest N007d9455d31f41e196b7c4089b221e92
76 N035c37ae526e4ed88325119b9a0f2b36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Radiotherapy, Intensity-Modulated
78 rdf:type schema:DefinedTerm
79 N036164ab954a40e5abbe70413db61b0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Treatment Outcome
81 rdf:type schema:DefinedTerm
82 N0be4a87545ca462ebd3dbd9770a2608e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Risk Assessment
84 rdf:type schema:DefinedTerm
85 N10afe846fc5849fe98512e5c326fee90 rdf:first sg:person.0700143313.76
86 rdf:rest rdf:nil
87 N15e7a27416db4ccfa324dee1a5840522 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Female
89 rdf:type schema:DefinedTerm
90 N163a5057a76e4b07aec153cf70319081 schema:name pubmed_id
91 schema:value 27295511
92 rdf:type schema:PropertyValue
93 N40c30319dd0e4ac8acb58e2e07b5a3a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Middle Aged
95 rdf:type schema:DefinedTerm
96 N4eb4215a221549639a241a30adf29c14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Radiometry
98 rdf:type schema:DefinedTerm
99 N6d3060862e0d4cd7ad19552eee62a657 schema:name doi
100 schema:value 10.1007/s00066-016-0980-1
101 rdf:type schema:PropertyValue
102 N732e489676544066b1522152ca134e4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Radiotherapy Dosage
104 rdf:type schema:DefinedTerm
105 N87c132b8afe84ba5932135dc1dd112e5 rdf:first sg:person.01314161733.88
106 rdf:rest Nf7dde7a4df4647448fb670063c1b96a3
107 N93363c50d1884e1cbd90820f9ed35257 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Aged
109 rdf:type schema:DefinedTerm
110 N9a27e0d9d3a941a9ae13cb6f944a897e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Humans
112 rdf:type schema:DefinedTerm
113 N9b123b1fc4cb439b9bf1ce1934dbf80d schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 Nad94f843512d49908650376734bf3d5d schema:name dimensions_id
116 schema:value pub.1024862798
117 rdf:type schema:PropertyValue
118 Nb821c83e16f4437c8e70a65df5746db4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Tumor Burden
120 rdf:type schema:DefinedTerm
121 Nbcdb3c8ca752407bb751b719dca7f463 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Radiotherapy Planning, Computer-Assisted
123 rdf:type schema:DefinedTerm
124 Nbfde62ec4222423e813af545648874b8 schema:issueNumber 8
125 rdf:type schema:PublicationIssue
126 Ndad2ff13f1064f4d9b0c0327a4a7310c rdf:first sg:person.01263151535.43
127 rdf:rest Nff1855fe31fb4a718791d5659009810d
128 Ndefc9da98f2b4394be82453a2184d0f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Neoplasms, Radiation-Induced
130 rdf:type schema:DefinedTerm
131 Ne199966b14ee4f7a8fc8aa1e0977ad20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Male
133 rdf:type schema:DefinedTerm
134 Ne259a6e218794a889e2dd4037b5d6a56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Tonsillar Neoplasms
136 rdf:type schema:DefinedTerm
137 Nec9f8f81e75e4f059ea80cdcad532ba5 schema:name nlm_unique_id
138 schema:value 8603469
139 rdf:type schema:PropertyValue
140 Nee4d90f39f5345f890baa28efe68ad3b rdf:first sg:person.07346633077.48
141 rdf:rest N10afe846fc5849fe98512e5c326fee90
142 Nf11f022195e445a08ed14b2ac9f87ed3 schema:name readcube_id
143 schema:value 767272a94bc917fc2db1537f7fa6569d6960870f37743c5d6451ef5c7e9bcdbd
144 rdf:type schema:PropertyValue
145 Nf7dde7a4df4647448fb670063c1b96a3 rdf:first sg:person.01352176212.98
146 rdf:rest N0139d1c8bc564666b54fd2401f135461
147 Nf93937e71bc545bfbf14782a18d99553 schema:volumeNumber 192
148 rdf:type schema:PublicationVolume
149 Nff1855fe31fb4a718791d5659009810d rdf:first sg:person.01323327772.11
150 rdf:rest N87c132b8afe84ba5932135dc1dd112e5
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
155 schema:name Oncology and Carcinogenesis
156 rdf:type schema:DefinedTerm
157 sg:grant.5134733 http://pending.schema.org/fundedItem sg:pub.10.1007/s00066-016-0980-1
158 rdf:type schema:MonetaryGrant
159 sg:grant.5137829 http://pending.schema.org/fundedItem sg:pub.10.1007/s00066-016-0980-1
160 rdf:type schema:MonetaryGrant
161 sg:journal.1054450 schema:issn 0179-7158
162 1439-099X
163 schema:name Strahlentherapie und Onkologie
164 rdf:type schema:Periodical
165 sg:person.01167312032.35 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
166 schema:familyName Harrington
167 schema:givenName K. J.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167312032.35
169 rdf:type schema:Person
170 sg:person.01263151535.43 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
171 schema:familyName McQuaid
172 schema:givenName D.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263151535.43
174 rdf:type schema:Person
175 sg:person.01314161733.88 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
176 schema:familyName Nill
177 schema:givenName S.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314161733.88
179 rdf:type schema:Person
180 sg:person.01323327772.11 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
181 schema:familyName Dunlop
182 schema:givenName A.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323327772.11
184 rdf:type schema:Person
185 sg:person.01352176212.98 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
186 schema:familyName Franzese
187 schema:givenName C.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352176212.98
189 rdf:type schema:Person
190 sg:person.0700143313.76 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
191 schema:familyName Bhide
192 schema:givenName S. A.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700143313.76
194 rdf:type schema:Person
195 sg:person.07346633077.48 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
196 schema:familyName Newbold
197 schema:givenName K. L.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07346633077.48
199 rdf:type schema:Person
200 sg:person.07606233544.21 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
201 schema:familyName Nutting
202 schema:givenName C. M.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07606233544.21
204 rdf:type schema:Person
205 https://doi.org/10.1016/j.ijrobp.2006.11.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011067579
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.ijrobp.2007.02.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002527309
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.ijrobp.2007.08.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033008673
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.ijrobp.2007.12.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030852419
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.ijrobp.2008.12.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024365290
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.ijrobp.2009.04.095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035895196
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.ijrobp.2009.08.078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028008977
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.ijrobp.2011.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012290275
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.ijrobp.2011.06.1975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050269942
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.ijrobp.2012.05.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022051507
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.ijrobp.2012.11.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018005436
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.neuroimage.2006.01.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005818793
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.oraloncology.2014.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041459284
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.radonc.2003.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000731952
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.radonc.2005.06.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017797974
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.radonc.2006.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051968383
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.radonc.2007.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017870667
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.radonc.2008.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019489571
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.radonc.2010.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019559459
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.radonc.2012.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022351192
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0167-8140(83)80021-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006184010
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0167-8140(99)00051-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022058680
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0360-3016(01)01613-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010076341
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0360-3016(03)00073-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035380014
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0360-3016(99)00247-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053113831
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s1470-2045(10)70290-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012239121
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1093/jicru/ndq010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059796268
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1118/1.4894702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010667108
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1259/bjr.73.871.11089476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064567108
262 rdf:type schema:CreativeWork
263 https://www.grid.ac/institutes/grid.18886.3f schema:alternateName Institute of Cancer Research
264 schema:name Head and Neck Unit, Royal Marsden Hospital, Downs road, SM2 5PT, Sutton, Surrey, UK
265 Head and Neck Unit, Royal Marsden Hospital, SW3 6JJ, London, UK
266 The Institute of Cancer Research, SM2 5NG, Sutton, UK
267 The Institute of Cancer Research, SW3 6JB, London, UK
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.424926.f schema:alternateName Royal Marsden Hospital
270 schema:name Head and Neck Unit, Royal Marsden Hospital, Downs road, SM2 5PT, Sutton, Surrey, UK
271 Head and Neck Unit, Royal Marsden Hospital, SW3 6JJ, London, UK
272 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...