Ontology type: schema:ScholarlyArticle
2014-10
AUTHORSPiernicola Pedicini, Alba Fiorentino, Vittorio Simeon, Paolo Tini, Costanza Chiumento, Luigi Pirtoli, Marco Salvatore, Giovanni Storto
ABSTRACTBACKGROUND AND PURPOSE: The aim of this study was to estimate a radiobiological set of parameters from the available clinical data on glioblastoma (GB). PATIENTS AND METHODS: A number of clinical trial outcomes from patients affected by GB and treated with surgery and adjuvant radiochemotherapy were analyzed to estimate a set of radiobiological parameters for a tumor control probability (TCP) model. The analytical/graphical method employed to fit the clinical data allowed us to estimate the intrinsic tumor radiosensitivity (α), repair capability (b), and repopulation doubling time (T d ) in a first phase, and subsequently the number of clonogens (N) and kick-off time for accelerated proliferation (T(k)). The results were used to formulate a hypothesis for a schedule expected to significantly improve local control. The 95 % confidence intervals (CI(95 %)) of all parameters are also discussed. RESULTS: The pooled analysis employed to estimate the parameters summarizes the data of 559 patients, while the studies selected to verify the results summarize data of 104 patients. The best estimates and the CI(95 %) are α = 0.12 Gy⁻¹ (0.10-0.14), b = 0.015 Gy⁻² (0.013-0.020), α/b = 8 Gy (5.0-10.8), T(d) = 15.4 days (13.2-19.5), N = 1.10⁴(1.2.10³ - 1.10⁵), and T(k) = 37 days (29-46). The dose required to offset the repopulation occurring after 1 day (D(prolif)) and starting after T k was estimated as 0.30 Gy/day (0.22-0.39). CONCLUSION: The analysis confirms a high value for the α/b ratio. Moreover, a high intrinsic radiosensitivity together with a long kick-off time for accelerated repopulation and moderate repopulation kinetics were found. The results indicate a substantial independence of the duration of the overall treatment and an improvement in the treatment effectiveness by increasing the total dose without increasing the dose fraction. More... »
PAGES925-932
http://scigraph.springernature.com/pub.10.1007/s00066-014-0638-9
DOIhttp://dx.doi.org/10.1007/s00066-014-0638-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1031348006
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24699988
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Computer Simulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Data Interpretation, Statistical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dose Fractionation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glioblastoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Biological",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Statistical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Outcome Assessment (Health Care)",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiation Tolerance",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiotherapy, Conformal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reproducibility of Results",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Assessment",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sensitivity and Specificity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Unit of Nuclear Medicine, Department of Radiation and Metabolic Therapies, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, 1-Padre-Pio-Street, Rionero-in-Vulture, Italy",
"Unit of Radiotherapy, Department of Radiation and Metabolic Therapies, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, Rionero-in-Vulture, Italy"
],
"type": "Organization"
},
"familyName": "Pedicini",
"givenName": "Piernicola",
"id": "sg:person.01025255606.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025255606.84"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ospedale Sacro Cuore Don Calabria",
"id": "https://www.grid.ac/institutes/grid.416422.7",
"name": [
"Radiation Oncology Department, Sacro Cuore \u2013 Don Calabria Hospital, Negrar, Verona, Italy"
],
"type": "Organization"
},
"familyName": "Fiorentino",
"givenName": "Alba",
"id": "sg:person.013344224544.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013344224544.03"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Laboratory of Preclinical and Translational Research, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, Rionero-in-Vulture, Italy"
],
"type": "Organization"
},
"familyName": "Simeon",
"givenName": "Vittorio",
"id": "sg:person.0724312647.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724312647.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Siena",
"id": "https://www.grid.ac/institutes/grid.9024.f",
"name": [
"Unit of Radiation Oncology, Department of Medicine Surgery and Neurological Sciences, University of Siena and Tuscany Tumor Institute, Siena, Italy"
],
"type": "Organization"
},
"familyName": "Tini",
"givenName": "Paolo",
"id": "sg:person.0701414206.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701414206.34"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Unit of Radiotherapy, Department of Radiation and Metabolic Therapies, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, Rionero-in-Vulture, Italy"
],
"type": "Organization"
},
"familyName": "Chiumento",
"givenName": "Costanza",
"id": "sg:person.01314337662.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314337662.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Siena",
"id": "https://www.grid.ac/institutes/grid.9024.f",
"name": [
"Unit of Radiation Oncology, Department of Medicine Surgery and Neurological Sciences, University of Siena and Tuscany Tumor Institute, Siena, Italy"
],
"type": "Organization"
},
"familyName": "Pirtoli",
"givenName": "Luigi",
"id": "sg:person.073244505.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.073244505.52"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Unit of Nuclear Medicine, I.R.C.C.S. SDN Foundation, Napoli, Italy"
],
"type": "Organization"
},
"familyName": "Salvatore",
"givenName": "Marco",
"id": "sg:person.01156256057.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156256057.70"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Unit of Nuclear Medicine, Department of Radiation and Metabolic Therapies, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, 1-Padre-Pio-Street, Rionero-in-Vulture, Italy"
],
"type": "Organization"
},
"familyName": "Storto",
"givenName": "Giovanni",
"id": "sg:person.01007431425.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007431425.67"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.ijrobp.2013.08.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000396744"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2004.04.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003815323"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(98)00100-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004528547"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2012.03.056",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007592988"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2009.04.064",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008596180"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00066-013-0410-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008871797",
"https://doi.org/10.1007/s00066-013-0410-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2009.12.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009110560"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00066-013-0459-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013416247",
"https://doi.org/10.1007/s00066-013-0459-2"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2008.05.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014447597"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/neuonc/nor173",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014527621"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2012.11.033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017892440"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(98)00266-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020667504"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11060-010-0306-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022722236",
"https://doi.org/10.1007/s11060-010-0306-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clineuro.2013.02.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023389789"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1748-717x-7-143",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025928251",
"https://doi.org/10.1186/1748-717x-7-143"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1748-717x-7-143",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025928251",
"https://doi.org/10.1186/1748-717x-7-143"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2008.04.030",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029046324"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa043331",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029207836"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00066-011-2242-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030530221",
"https://doi.org/10.1007/s00066-011-2242-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00066-013-0390-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038093949",
"https://doi.org/10.1007/s00066-013-0390-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05236",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041233330",
"https://doi.org/10.1038/nature05236"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05236",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041233330",
"https://doi.org/10.1038/nature05236"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05236",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041233330",
"https://doi.org/10.1038/nature05236"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0360-3016(94)00475-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045695500"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.04.6979",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046675174"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00066-010-2101-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047186087",
"https://doi.org/10.1007/s00066-010-2101-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00066-010-2101-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047186087",
"https://doi.org/10.1007/s00066-010-2101-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10147-012-0462-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047770462",
"https://doi.org/10.1007/s10147-012-0462-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(97)00911-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048590035"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa043330",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052112015"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12094-013-1024-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052985062",
"https://doi.org/10.1007/s12094-013-1024-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2011.398",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053264242",
"https://doi.org/10.1038/onc.2011.398"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/01621459.1981.10477650",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058302473"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/0031-9155/48/3/308",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059025018"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4899-3115-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1109705857",
"https://doi.org/10.1007/978-1-4899-3115-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4899-3115-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1109705857",
"https://doi.org/10.1007/978-1-4899-3115-3"
],
"type": "CreativeWork"
}
],
"datePublished": "2014-10",
"datePublishedReg": "2014-10-01",
"description": "BACKGROUND AND PURPOSE: The aim of this study was to estimate a radiobiological set of parameters from the available clinical data on glioblastoma (GB).\nPATIENTS AND METHODS: A number of clinical trial outcomes from patients affected by GB and treated with surgery and adjuvant radiochemotherapy were analyzed to estimate a set of radiobiological parameters for a tumor control probability (TCP) model. The analytical/graphical method employed to fit the clinical data allowed us to estimate the intrinsic tumor radiosensitivity (\u03b1), repair capability (b), and repopulation doubling time (T d ) in a first phase, and subsequently the number of clonogens (N) and kick-off time for accelerated proliferation (T(k)). The results were used to formulate a hypothesis for a schedule expected to significantly improve local control. The 95 % confidence intervals (CI(95 %)) of all parameters are also discussed.\nRESULTS: The pooled analysis employed to estimate the parameters summarizes the data of 559 patients, while the studies selected to verify the results summarize data of 104 patients. The best estimates and the CI(95 %) are \u03b1 = 0.12 Gy\u207b\u00b9 (0.10-0.14), b = 0.015 Gy\u207b\u00b2 (0.013-0.020), \u03b1/b = 8 Gy (5.0-10.8), T(d) \u2009= 15.4 days (13.2-19.5), N = 1.10\u2074(1.2.10\u00b3 - 1.10\u2075), and T(k) \u2009= 37 days (29-46). The dose required to offset the repopulation occurring after 1 day (D(prolif)) and starting after T k was estimated as 0.30 Gy/day (0.22-0.39).\nCONCLUSION: The analysis confirms a high value for the \u03b1/b ratio. Moreover, a high intrinsic radiosensitivity together with a long kick-off time for accelerated repopulation and moderate repopulation kinetics were found. The results indicate a substantial independence of the duration of the overall treatment and an improvement in the treatment effectiveness by increasing the total dose without increasing the dose fraction.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00066-014-0638-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1054450",
"issn": [
"0179-7158",
"1439-099X"
],
"name": "Strahlentherapie und Onkologie",
"type": "Periodical"
},
{
"issueNumber": "10",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "190"
}
],
"name": "Clinical radiobiology of glioblastoma multiforme",
"pagination": "925-932",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"95561998f7c210125531d55791a022e0f1e5e73fd3c94be6a6965bc43dbf8d97"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"24699988"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8603469"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00066-014-0638-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1031348006"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00066-014-0638-9",
"https://app.dimensions.ai/details/publication/pub.1031348006"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T22:45",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000589.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00066-014-0638-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00066-014-0638-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00066-014-0638-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00066-014-0638-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00066-014-0638-9'
This table displays all metadata directly associated to this object as RDF triples.
301 TRIPLES
21 PREDICATES
76 URIs
37 LITERALS
25 BLANK NODES