Ontology type: schema:ScholarlyArticle
2013-11
AUTHORSC. Blattmann, M. Thiemann, A. Stenzinger, A. Christmann, E. Roth, V. Ehemann, J. Debus, A.E. Kulozik, W. Weichert, P.E. Huber, S. Oertel, A. Abdollahi
ABSTRACTBACKGROUND: Osteosarcomas (OS) are highly malignant and radioresistant tumors. Histone deacetylase inhibitors (HDACi) constitute a novel class of anticancer agents. We sought to investigate the effect of combined treatment with suberoylanilide hydroxamic acid (SAHA) and radiotherapy in OS in vivo. METHODS: Clonogenic survival of human OS cell lines as well as tumor growth delay of OS xenografts were tested after treatment with either vehicle, radiotherapy (XRT), SAHA, or XRT and SAHA. Tumor proliferation, necrosis, microvascular density, apoptosis, and p53/p21 were monitored by immunohistochemistry. The CD95 pathway was performed by flow cytometry, caspase (3/7/8) activity measurements, and functional inhibition of CD95 death signaling. RESULTS: Combined treatment with SAHA and XRT markedly reduced the surviving fraction of OS cells as compared to XRT alone. Likewise, dual therapy significantly inhibited OS tumor growth in vivo as compared to XRT alone, reflected by reduced tumor proliferation, impaired angiogenesis, and increased apoptosis. Addition of HDACi to XRT led to elevated p53, p21, CD95, and CD95L expression. Inhibition of CD95 signaling reduced HDACi- and XRT-induced apoptosis. CONCLUSION: Our data show that HDACi increases the radiosensitivity of osteosarcoma cells at least in part via ligand-induced apoptosis. HDACi thus emerge as potentially useful treatment components of OS. More... »
PAGES957-966
http://scigraph.springernature.com/pub.10.1007/s00066-013-0372-8
DOIhttp://dx.doi.org/10.1007/s00066-013-0372-8
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23801068
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"10.1007/s00066-013-0372-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1018706577"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00066-013-0372-8",
"https://app.dimensions.ai/details/publication/pub.1018706577"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:45",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000504.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00066-013-0372-8"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00066-013-0372-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00066-013-0372-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00066-013-0372-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00066-013-0372-8'
This table displays all metadata directly associated to this object as RDF triples.
344 TRIPLES
21 PREDICATES
82 URIs
36 LITERALS
24 BLANK NODES