Hämangiosarkom nach brusterhaltender Therapie beim Mammakarzinom: vier Fallbeispiele mit molekulargenetischer Diagnostik und Literaturübersicht View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-08-16

AUTHORS

Carolin Nestle-Krämling, Edwin Bölke, Wilfried Budach, Matthias Peiper, Dieter Niederacher, Wolfgang Janni, Claus Ferdinand Eisenberger, Wolfram Trudo Knoefel, Axel Scherer, Stephan Ernst Baldus, Guido Lammering, Peter Arne Gerber, Christiane Matuschek

ABSTRACT

BackgroundHemangiosarcomas of the breast represent a rare disease of the breast mainly occurring as secondary neoplasias with a latency of 5–10 years after primary treatment of breast cancer and are associated with an unfavourable prognosis. Radiation therapy, which is integrated within the concept of breast conserving therapy ranks as the main risk factor.Patients and MethodsIn this report we describe the clinical course of 4 patients including their molecular genetic pattern and give a summary of the actual literature.ResultsHemangiosarcomas occur as a secondary neoplasm with a latency of 5–10 years after primary treatment of breast cancer and have an unfavorable prognosis. A genetic predisposition is assumed, but we could not find a significant role of tumor suppressor genes BRCA1, BRCA2 or p53 in our patients.ConclusionDue to limited data available for these tumors, recommendations for therapy include radical tumor resection achieving wide free margins and inconsistent regimens of chemo- and/or immunetherapy modalities. In the majority these are based on systemic therapy regimens for other cutaneous sarcomas, such as Kaposi’s sarcoma. Efforts should be taken for a nation-wide systematic registration of all cases of post-irradiation hemangiosarcomas. More... »

PAGES

656

Journal

TITLE

Strahlentherapie und Onkologie

ISSUE

10

VOLUME

187

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00066-011-2251-5

DOI

http://dx.doi.org/10.1007/s00066-011-2251-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048677283

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21858416


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