Proton or Stereotactic Photon Irradiation for Posterior Uveal Melanoma? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-12

AUTHORS

Stefan Höcht, Roland Stark, Frank Seiler, Jens Heufelder, Nikolaos E. Bechrakis, Dino Cordini, Simone Marnitz, Heinz Kluge, Michael H. Foerster, Wolfgang Hinkelbein

ABSTRACT

Background and Purpose:Proton and stereotactic radiotherapy with photons (SRT) are both used to treat choroidal melanomas in proximity to optic disk and fovea centralis, a situation where plaque therapy is prone to complications. A comparative treatment– planning study was done to assess the capability of both modalities to preserve vision.Patients and Methods:In ten patients treated with 68–MeV protons, SRT with 6–MV photons was planned. Structures most important for visual acuity (fovea and optic disk, optic nerve) were contoured identically for both therapies. Safety margins of 1.5 mm for proton therapy were reduced to 1.0 mm for SRT.Results:Proton–beam therapy was superior in eight of ten situations, and this result did not differ significantly by changes in the weighting of the different parameters analyzed.Conclusion:When dose deposition to those structures most important for the preservation of vision is taken into account, under the conditions examined proton therapy offers an advantage in the majority of the patients evaluated. More... »

PAGES

783-788

References to SciGraph publications

  • 2002-07. Where is the superiority of proton radiation for ocular tumours? in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 2004-07-01. Proton Therapy of Uveal Melanomas in Berlin in STRAHLENTHERAPIE UND ONKOLOGIE
  • 2005-07. Comparative Treatment Planning on Localized Prostate Carcinoma in STRAHLENTHERAPIE UND ONKOLOGIE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00066-005-1395-6

    DOI

    http://dx.doi.org/10.1007/s00066-005-1395-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014144275

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16362788


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