Increased Metabolic Activity in the Spinal Cord of Patients with Long-Standing Lhermitte’s Sign View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-10

AUTHORS

Olga Ésik, Tibor Csere, Klára Stefanits, Szabolcs Szakáll, Zsolt Lengyel, Géza Sáfrány, Katalin Vönöczky, Erzsébet Lengyel, Judit Olajos, Gábor Bajzik, Lajos Trón

ABSTRACT

PURPOSE: To investigate the pathophysiology of the radiation-induced, chronic Lhermitte's sign (LS) on the basis of long-standing case histories with partial functional recovery. PATIENTS AND METHODS: As radiotherapy in two nasopharyngeal cancer patients, a biologically effective dose (BED) of 103.8 Gy(2) (case 1) and 94.8 Gy(2) (case 2) was delivered to the cervical spinal cord. Neurologic signs relating to the irradiated spinal cord segments developed after 2 months (case 1) and 5 years (case 2), with radiation-induced damage equivalent to grade 3 (case 1) and grade 2 (case 2) toxicity (Common Toxicity Criteria, Version 2.0). The clinical status improved to grade 2 (case 1) and grade 1 (case 2). Positron emission tomography (PET) and fibroblast clonogen assay were applied 25 and 7 years postirradiation, respectively, to characterize this rare clinical picture. RESULTS: PET demonstrated increased [(18)F]fluorodeoxyglucose (FDG) accumulation and [(15)O]butanol perfusion, but negligible [(11)C]methionine uptake in the irradiated spinal cord segments in both patients. In clonogenic assays, fibroblasts from case 1 displayed much higher radiation sensitivity than in healthy controls, while in case 2 the fibroblasts sensitivity was normal. CONCLUSIONS: These data suggests a close direct relationship between regional perfusion and metabolism of the spinal cord, similarly as in the brain. The postirradiation recovery may be related to energy-demanding conduction, explaining the increased metabolism and perfusion. The increased radiosensitivity and higher spinal cord BED may have contributed to the more severe sequelae in case 1. More... »

PAGES

690-693

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00066-003-1115-z

DOI

http://dx.doi.org/10.1007/s00066-003-1115-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005274821

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14566477


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorodeoxyglucose F18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hodgkin Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methionine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nasopharyngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Injuries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Tolerance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy Dosage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spinal Cord", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spinal Cord Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Emission-Computed", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institute of Oncology", 
          "id": "https://www.grid.ac/institutes/grid.419617.c", 
          "name": [
            "Department of Oncotherapy, Semmelweis University, Budapest, Hungary", 
            "Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "\u00c9sik", 
        "givenName": "Olga", 
        "id": "sg:person.0664222601.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664222601.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pecs", 
          "id": "https://www.grid.ac/institutes/grid.9679.1", 
          "name": [
            "Department of Oncotherapy, University of P\u00e9cs, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Csere", 
        "givenName": "Tibor", 
        "id": "sg:person.01172704032.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172704032.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pecs", 
          "id": "https://www.grid.ac/institutes/grid.9679.1", 
          "name": [
            "Department of Oncotherapy, University of P\u00e9cs, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stefanits", 
        "givenName": "Kl\u00e1ra", 
        "id": "sg:person.01241017232.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241017232.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Debrecen", 
          "id": "https://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "PET Center, University of Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szak\u00e1ll", 
        "givenName": "Szabolcs", 
        "id": "sg:person.0615751073.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615751073.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Debrecen", 
          "id": "https://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "PET Center, University of Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lengyel", 
        "givenName": "Zsolt", 
        "id": "sg:person.01031731456.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031731456.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "National Research Institute for Radiobiology and\nRadiation Hygiene, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00e1fr\u00e1ny", 
        "givenName": "G\u00e9za", 
        "id": "sg:person.0602344043.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602344043.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Oncology", 
          "id": "https://www.grid.ac/institutes/grid.419617.c", 
          "name": [
            "Outpatient Department of Neurology, National Institute of Oncology, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "V\u00f6n\u00f6czky", 
        "givenName": "Katalin", 
        "id": "sg:person.0631641532.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631641532.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Oncology", 
          "id": "https://www.grid.ac/institutes/grid.419617.c", 
          "name": [
            "Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lengyel", 
        "givenName": "Erzs\u00e9bet", 
        "id": "sg:person.01214273256.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214273256.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncoradiology, J\u00f3sa Andr\u00e1s County Hospital, Ny\u00edregyh\u00e1za, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olajos", 
        "givenName": "Judit", 
        "id": "sg:person.01027221473.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027221473.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kapsovar", 
          "id": "https://www.grid.ac/institutes/grid.163004.0", 
          "name": [
            "Department of Diagnostic Imaging, University of Kaposv\u00e1r, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bajzik", 
        "givenName": "G\u00e1bor", 
        "id": "sg:person.01147303661.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147303661.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Debrecen", 
          "id": "https://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "PET Center, University of Debrecen, Hungary", 
            "PET Study Group of the Hungarian Academy of\nSciences, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tr\u00f3n", 
        "givenName": "Lajos", 
        "id": "sg:person.053173241.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053173241.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00004728-199003000-00027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003301721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199003000-00027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003301721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-510x(98)00324-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010751812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(93)90519-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015125336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00593221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017647716", 
          "https://doi.org/10.1007/bf00593221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00593221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017647716", 
          "https://doi.org/10.1007/bf00593221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s000660050022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020194991", 
          "https://doi.org/10.1007/s000660050022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(92)90943-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028966116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)00655-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029400592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(71)90174-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031219239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(71)90174-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031219239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197606)37:6<2813::aid-cncr2820370637>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031345202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archotol.1991.01870230116020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042127940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199801293380610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042151616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02841867109130776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047623615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/95.1.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059444377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003072-199712000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060151832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003072-199712000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060151832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003072-199712000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060151832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199805000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060189434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199805000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060189434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199805000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060189434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/0007-1285-21-249-464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064542948"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-10", 
    "datePublishedReg": "2003-10-01", 
    "description": "PURPOSE: To investigate the pathophysiology of the radiation-induced, chronic Lhermitte's sign (LS) on the basis of long-standing case histories with partial functional recovery.\nPATIENTS AND METHODS: As radiotherapy in two nasopharyngeal cancer patients, a biologically effective dose (BED) of 103.8 Gy(2) (case 1) and 94.8 Gy(2) (case 2) was delivered to the cervical spinal cord. Neurologic signs relating to the irradiated spinal cord segments developed after 2 months (case 1) and 5 years (case 2), with radiation-induced damage equivalent to grade 3 (case 1) and grade 2 (case 2) toxicity (Common Toxicity Criteria, Version 2.0). The clinical status improved to grade 2 (case 1) and grade 1 (case 2). Positron emission tomography (PET) and fibroblast clonogen assay were applied 25 and 7 years postirradiation, respectively, to characterize this rare clinical picture.\nRESULTS: PET demonstrated increased [(18)F]fluorodeoxyglucose (FDG) accumulation and [(15)O]butanol perfusion, but negligible [(11)C]methionine uptake in the irradiated spinal cord segments in both patients. In clonogenic assays, fibroblasts from case 1 displayed much higher radiation sensitivity than in healthy controls, while in case 2 the fibroblasts sensitivity was normal.\nCONCLUSIONS: These data suggests a close direct relationship between regional perfusion and metabolism of the spinal cord, similarly as in the brain. The postirradiation recovery may be related to energy-demanding conduction, explaining the increased metabolism and perfusion. The increased radiosensitivity and higher spinal cord BED may have contributed to the more severe sequelae in case 1.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00066-003-1115-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1054450", 
        "issn": [
          "0179-7158", 
          "1439-099X"
        ], 
        "name": "Strahlentherapie und Onkologie", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "179"
      }
    ], 
    "name": "Increased Metabolic Activity in the Spinal Cord of Patients with Long-Standing Lhermitte\u2019s Sign", 
    "pagination": "690-693", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "19219eb51008dc02be73ed927bb43f6bf351d1af79434cafefd58f99b0b48938"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14566477"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8603469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00066-003-1115-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005274821"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00066-003-1115-z", 
      "https://app.dimensions.ai/details/publication/pub.1005274821"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000503.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00066-003-1115-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00066-003-1115-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00066-003-1115-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00066-003-1115-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00066-003-1115-z'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      21 PREDICATES      65 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00066-003-1115-z schema:about N01dde3ad6e8542bb82b78ad408eda83a
2 N023c5ed3b30541c89129a96cdf693b31
3 N03b84ccbccbe4b06b85b7c803611c235
4 N05663dabea3643d5970d0f5082520794
5 N18deb7fdd7e0465bbda58e5b43cf3c87
6 N331abffb990a44fa9dfd765a8acebb81
7 N4e14f0b225574a0398134de2e3ad750a
8 N5da86a8340f548deb06de76cae44b0d3
9 N7bdad5c273db415f82cb5c920c469718
10 N7fd579b663d4416e9a5e482037f3bd3b
11 N81a859f2978b44b1b19acf5d093b9f54
12 N8557986516ed47eaab2776ff202ee089
13 Nae6596bcfba7490488aa0e82df5f4fb7
14 Nc3ebeefc79494720942493ff990967f2
15 Ndd4302907ec244c0b9e415e644e2dfd1
16 Ne36be95d882344f9a0de5131b646a43e
17 Ne803ba865548461bb4895aa3ae62b611
18 Nf146c74cf99a499aa3c486cfd121f586
19 Nf8e9d786d3484ba8ad7e084dbeccbe95
20 Nfbb73dce44b543adbe88b9248404ef5f
21 anzsrc-for:11
22 anzsrc-for:1109
23 schema:author Na430869538754c57be58baa8a39538cc
24 schema:citation sg:pub.10.1007/bf00593221
25 sg:pub.10.1007/s000660050022
26 https://doi.org/10.1001/archotol.1991.01870230116020
27 https://doi.org/10.1002/1097-0142(197606)37:6<2813::aid-cncr2820370637>3.0.co;2-s
28 https://doi.org/10.1016/0022-510x(71)90174-2
29 https://doi.org/10.1016/0360-3016(92)90943-c
30 https://doi.org/10.1016/0360-3016(93)90519-2
31 https://doi.org/10.1016/0360-3016(94)00655-5
32 https://doi.org/10.1016/s0022-510x(98)00324-4
33 https://doi.org/10.1056/nejm199801293380610
34 https://doi.org/10.1093/brain/95.1.109
35 https://doi.org/10.1097/00003072-199712000-00019
36 https://doi.org/10.1097/00004728-199003000-00027
37 https://doi.org/10.1097/00004728-199805000-00023
38 https://doi.org/10.1259/0007-1285-21-249-464
39 https://doi.org/10.3109/02841867109130776
40 schema:datePublished 2003-10
41 schema:datePublishedReg 2003-10-01
42 schema:description PURPOSE: To investigate the pathophysiology of the radiation-induced, chronic Lhermitte's sign (LS) on the basis of long-standing case histories with partial functional recovery. PATIENTS AND METHODS: As radiotherapy in two nasopharyngeal cancer patients, a biologically effective dose (BED) of 103.8 Gy(2) (case 1) and 94.8 Gy(2) (case 2) was delivered to the cervical spinal cord. Neurologic signs relating to the irradiated spinal cord segments developed after 2 months (case 1) and 5 years (case 2), with radiation-induced damage equivalent to grade 3 (case 1) and grade 2 (case 2) toxicity (Common Toxicity Criteria, Version 2.0). The clinical status improved to grade 2 (case 1) and grade 1 (case 2). Positron emission tomography (PET) and fibroblast clonogen assay were applied 25 and 7 years postirradiation, respectively, to characterize this rare clinical picture. RESULTS: PET demonstrated increased [(18)F]fluorodeoxyglucose (FDG) accumulation and [(15)O]butanol perfusion, but negligible [(11)C]methionine uptake in the irradiated spinal cord segments in both patients. In clonogenic assays, fibroblasts from case 1 displayed much higher radiation sensitivity than in healthy controls, while in case 2 the fibroblasts sensitivity was normal. CONCLUSIONS: These data suggests a close direct relationship between regional perfusion and metabolism of the spinal cord, similarly as in the brain. The postirradiation recovery may be related to energy-demanding conduction, explaining the increased metabolism and perfusion. The increased radiosensitivity and higher spinal cord BED may have contributed to the more severe sequelae in case 1.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree false
46 schema:isPartOf Nd714fd51756f4ffe834a934d2d5ee545
47 Neb86e3667c33455eb907d93c3440a5e5
48 sg:journal.1054450
49 schema:name Increased Metabolic Activity in the Spinal Cord of Patients with Long-Standing Lhermitte’s Sign
50 schema:pagination 690-693
51 schema:productId N385ede7a374146ca9e7a210c68c7d0e9
52 N3a8b30243d594d37a14468ea50989e11
53 N984d5abdb8fa47a8b0baa251a04f5257
54 Naa00e6018a874ccd9bc5694b2fdf12d5
55 Nd86f2c20548542d2b9c5c9389137a198
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005274821
57 https://doi.org/10.1007/s00066-003-1115-z
58 schema:sdDatePublished 2019-04-11T01:58
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N45f04c0fda184e5e8193cb05df5d6047
61 schema:url http://link.springer.com/10.1007%2Fs00066-003-1115-z
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N01dde3ad6e8542bb82b78ad408eda83a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Tomography, Emission-Computed
67 rdf:type schema:DefinedTerm
68 N023c5ed3b30541c89129a96cdf693b31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Time Factors
70 rdf:type schema:DefinedTerm
71 N03b84ccbccbe4b06b85b7c803611c235 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Spinal Cord
73 rdf:type schema:DefinedTerm
74 N05663dabea3643d5970d0f5082520794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Adult
76 rdf:type schema:DefinedTerm
77 N0f04f1bb0ee445d38f2432363714c92c schema:name National Research Institute for Radiobiology and Radiation Hygiene, Budapest, Hungary
78 rdf:type schema:Organization
79 N18deb7fdd7e0465bbda58e5b43cf3c87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Fibroblasts
81 rdf:type schema:DefinedTerm
82 N215ca1c350f04844a1ab85b67bf58431 rdf:first sg:person.01241017232.34
83 rdf:rest N4aaa5467a66b46798f34fca1b8f454ff
84 N2587a599e247488faa4a5d17c8175deb rdf:first sg:person.01027221473.95
85 rdf:rest N53168758841f4d4f89449b3cf0b890db
86 N2ae41db5b98a41c6915e77ec7ea6783d rdf:first sg:person.0631641532.13
87 rdf:rest Nb35676214ca644cc98e2b61c37e884ca
88 N331abffb990a44fa9dfd765a8acebb81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Radiotherapy Dosage
90 rdf:type schema:DefinedTerm
91 N385ede7a374146ca9e7a210c68c7d0e9 schema:name dimensions_id
92 schema:value pub.1005274821
93 rdf:type schema:PropertyValue
94 N3a8b30243d594d37a14468ea50989e11 schema:name pubmed_id
95 schema:value 14566477
96 rdf:type schema:PropertyValue
97 N45f04c0fda184e5e8193cb05df5d6047 schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 N4aaa5467a66b46798f34fca1b8f454ff rdf:first sg:person.0615751073.72
100 rdf:rest N77fe3a4032b2482cb47045d553c8c979
101 N4e14f0b225574a0398134de2e3ad750a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Female
103 rdf:type schema:DefinedTerm
104 N53168758841f4d4f89449b3cf0b890db rdf:first sg:person.01147303661.51
105 rdf:rest N5af8abd2c13a42d8a2b38a788522183a
106 N5af8abd2c13a42d8a2b38a788522183a rdf:first sg:person.053173241.42
107 rdf:rest rdf:nil
108 N5da86a8340f548deb06de76cae44b0d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Spinal Cord Diseases
110 rdf:type schema:DefinedTerm
111 N77fe3a4032b2482cb47045d553c8c979 rdf:first sg:person.01031731456.55
112 rdf:rest Nddb64e6050564d8abbfc6fc7906b304b
113 N790b954481694aa5a1512b1a51a6db39 rdf:first sg:person.01172704032.06
114 rdf:rest N215ca1c350f04844a1ab85b67bf58431
115 N7bdad5c273db415f82cb5c920c469718 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Methionine
117 rdf:type schema:DefinedTerm
118 N7fd579b663d4416e9a5e482037f3bd3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Radiopharmaceuticals
120 rdf:type schema:DefinedTerm
121 N81a859f2978b44b1b19acf5d093b9f54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Magnetic Resonance Imaging
123 rdf:type schema:DefinedTerm
124 N8557986516ed47eaab2776ff202ee089 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Radiation Tolerance
126 rdf:type schema:DefinedTerm
127 N984d5abdb8fa47a8b0baa251a04f5257 schema:name nlm_unique_id
128 schema:value 8603469
129 rdf:type schema:PropertyValue
130 Na430869538754c57be58baa8a39538cc rdf:first sg:person.0664222601.06
131 rdf:rest N790b954481694aa5a1512b1a51a6db39
132 Naa00e6018a874ccd9bc5694b2fdf12d5 schema:name readcube_id
133 schema:value 19219eb51008dc02be73ed927bb43f6bf351d1af79434cafefd58f99b0b48938
134 rdf:type schema:PropertyValue
135 Nae6596bcfba7490488aa0e82df5f4fb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Radiation Injuries
137 rdf:type schema:DefinedTerm
138 Nb35676214ca644cc98e2b61c37e884ca rdf:first sg:person.01214273256.71
139 rdf:rest N2587a599e247488faa4a5d17c8175deb
140 Nc3ebeefc79494720942493ff990967f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Hodgkin Disease
142 rdf:type schema:DefinedTerm
143 Nd714fd51756f4ffe834a934d2d5ee545 schema:issueNumber 10
144 rdf:type schema:PublicationIssue
145 Nd86f2c20548542d2b9c5c9389137a198 schema:name doi
146 schema:value 10.1007/s00066-003-1115-z
147 rdf:type schema:PropertyValue
148 Ndd4302907ec244c0b9e415e644e2dfd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Nasopharyngeal Neoplasms
150 rdf:type schema:DefinedTerm
151 Nddb64e6050564d8abbfc6fc7906b304b rdf:first sg:person.0602344043.44
152 rdf:rest N2ae41db5b98a41c6915e77ec7ea6783d
153 Ne36be95d882344f9a0de5131b646a43e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Male
155 rdf:type schema:DefinedTerm
156 Ne803ba865548461bb4895aa3ae62b611 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Humans
158 rdf:type schema:DefinedTerm
159 Neb86e3667c33455eb907d93c3440a5e5 schema:volumeNumber 179
160 rdf:type schema:PublicationVolume
161 Nef11c7e16c614f3993c6dfb1405abf7c schema:name Department of Oncoradiology, Jósa András County Hospital, Nyíregyháza, Hungary
162 rdf:type schema:Organization
163 Nf146c74cf99a499aa3c486cfd121f586 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Follow-Up Studies
165 rdf:type schema:DefinedTerm
166 Nf8e9d786d3484ba8ad7e084dbeccbe95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Radiotherapy
168 rdf:type schema:DefinedTerm
169 Nfbb73dce44b543adbe88b9248404ef5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Fluorodeoxyglucose F18
171 rdf:type schema:DefinedTerm
172 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
173 schema:name Medical and Health Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
176 schema:name Neurosciences
177 rdf:type schema:DefinedTerm
178 sg:journal.1054450 schema:issn 0179-7158
179 1439-099X
180 schema:name Strahlentherapie und Onkologie
181 rdf:type schema:Periodical
182 sg:person.01027221473.95 schema:affiliation Nef11c7e16c614f3993c6dfb1405abf7c
183 schema:familyName Olajos
184 schema:givenName Judit
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027221473.95
186 rdf:type schema:Person
187 sg:person.01031731456.55 schema:affiliation https://www.grid.ac/institutes/grid.7122.6
188 schema:familyName Lengyel
189 schema:givenName Zsolt
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031731456.55
191 rdf:type schema:Person
192 sg:person.01147303661.51 schema:affiliation https://www.grid.ac/institutes/grid.163004.0
193 schema:familyName Bajzik
194 schema:givenName Gábor
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147303661.51
196 rdf:type schema:Person
197 sg:person.01172704032.06 schema:affiliation https://www.grid.ac/institutes/grid.9679.1
198 schema:familyName Csere
199 schema:givenName Tibor
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172704032.06
201 rdf:type schema:Person
202 sg:person.01214273256.71 schema:affiliation https://www.grid.ac/institutes/grid.419617.c
203 schema:familyName Lengyel
204 schema:givenName Erzsébet
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214273256.71
206 rdf:type schema:Person
207 sg:person.01241017232.34 schema:affiliation https://www.grid.ac/institutes/grid.9679.1
208 schema:familyName Stefanits
209 schema:givenName Klára
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241017232.34
211 rdf:type schema:Person
212 sg:person.053173241.42 schema:affiliation https://www.grid.ac/institutes/grid.7122.6
213 schema:familyName Trón
214 schema:givenName Lajos
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053173241.42
216 rdf:type schema:Person
217 sg:person.0602344043.44 schema:affiliation N0f04f1bb0ee445d38f2432363714c92c
218 schema:familyName Sáfrány
219 schema:givenName Géza
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602344043.44
221 rdf:type schema:Person
222 sg:person.0615751073.72 schema:affiliation https://www.grid.ac/institutes/grid.7122.6
223 schema:familyName Szakáll
224 schema:givenName Szabolcs
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615751073.72
226 rdf:type schema:Person
227 sg:person.0631641532.13 schema:affiliation https://www.grid.ac/institutes/grid.419617.c
228 schema:familyName Vönöczky
229 schema:givenName Katalin
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631641532.13
231 rdf:type schema:Person
232 sg:person.0664222601.06 schema:affiliation https://www.grid.ac/institutes/grid.419617.c
233 schema:familyName Ésik
234 schema:givenName Olga
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664222601.06
236 rdf:type schema:Person
237 sg:pub.10.1007/bf00593221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017647716
238 https://doi.org/10.1007/bf00593221
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/s000660050022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020194991
241 https://doi.org/10.1007/s000660050022
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1001/archotol.1991.01870230116020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042127940
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/1097-0142(197606)37:6<2813::aid-cncr2820370637>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1031345202
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/0022-510x(71)90174-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031219239
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0360-3016(92)90943-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1028966116
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0360-3016(93)90519-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015125336
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0360-3016(94)00655-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029400592
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0022-510x(98)00324-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010751812
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1056/nejm199801293380610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042151616
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/brain/95.1.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059444377
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1097/00003072-199712000-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060151832
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1097/00004728-199003000-00027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003301721
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1097/00004728-199805000-00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060189434
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1259/0007-1285-21-249-464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064542948
268 rdf:type schema:CreativeWork
269 https://doi.org/10.3109/02841867109130776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047623615
270 rdf:type schema:CreativeWork
271 https://www.grid.ac/institutes/grid.163004.0 schema:alternateName University of Kapsovar
272 schema:name Department of Diagnostic Imaging, University of Kaposvár, Hungary
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.419617.c schema:alternateName National Institute of Oncology
275 schema:name Department of Oncotherapy, Semmelweis University, Budapest, Hungary
276 Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
277 Outpatient Department of Neurology, National Institute of Oncology, Budapest, Hungary
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.7122.6 schema:alternateName University of Debrecen
280 schema:name PET Center, University of Debrecen, Hungary
281 PET Study Group of the Hungarian Academy of Sciences, Debrecen, Hungary
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.9679.1 schema:alternateName University of Pecs
284 schema:name Department of Oncotherapy, University of Pécs, Hungary
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...