Cangrelor and Stenting in Acute Ischemic Stroke View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-05-07

AUTHORS

Mahmoud Elhorany, Stephanie Lenck, Vincent Degos, Nader-Antoine Sourour, Giulia Frasca Polara, Eimad Shotar, Anne Godier, Mehdi Drir, Jugurtha Mahtout, Kevin Premat, Sonia Alamowitch, Yves Samson, Frédéric Clarençon

ABSTRACT

PurposeCangrelor is an intravenous P2Y12 receptor inhibitor with a rapid onset/offset of action and a short half-life (3–6 min). The objective was to present a preliminary experience regarding the safety and effectiveness using cangrelor, in combination with aspirin, in acute ischemic stroke patients requiring acute stenting.Material and MethodsRetrospective analysis for patients who underwent stenting (intracranial and/or extracranial) in the setting of acute ischemic stroke with cangrelor and aspirin as antiplatelet therapy.ResultsCangrelor was used in 12 patients, 4 (33%) with extracranial stenting, 6 (50%) with intracranial stenting and 2 (17%) with combined extracranial and intracranial stenting. The mean age was 67 years (44–88) and 9 patients (75%) were female. The median National Institutes of Health Stroke Score at admission was 15 (IQR: 8–22). Of the patients, six (50%) received intravenous thrombolysis. All patients (100%) obtained modified thrombolysis in cerebral infarction score ≥2b. Good clinical outcome, defined as modified Rankin scale score ≤2 at 3‑months follow-up, was observed in 7 patients (58%). None of the patients experienced intraprocedural thromboembolic complications. Postprocedural stent thrombosis after cessation of cangrelor infusion due to emergency craniotomy surgery to manage malignant cerebral infarction occurred in one patient (8%). Of the patients, two (17%) experienced asymptomatic intracranial hemorrhage (ICH), one patient (8%) experienced symptomatic ICH and one (8%) retroperitoneal hematoma was observed, which was managed conservatively.ConclusionCangrelor might be a safe and effective antiplatelet medication owing to its on/off activity for acute stenting in the setting of acute ischemic stroke. Further investigations through randomized studies with larger samples are necessary. More... »

PAGES

439-448

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00062-020-00907-0

DOI

http://dx.doi.org/10.1007/s00062-020-00907-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1127453897

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32382875


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Monophosphate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ischemic Stroke", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Faculty of Medicine, Tanta University, Tanta, Egypt", 
          "id": "http://www.grid.ac/institutes/grid.412258.8", 
          "name": [
            "Department of Neuroradiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47\u201383 Boulevard de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Sorbonne University, Paris VI University, Paris, France", 
            "GRC Biofast, Paris VI University, Paris, France", 
            "Department of Neurology, Faculty of Medicine, Tanta University, Tanta, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elhorany", 
        "givenName": "Mahmoud", 
        "id": "sg:person.014142414275.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014142414275.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroradiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47\u201383 Boulevard de l\u2019H\u00f4pital, 75013, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Department of Neuroradiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47\u201383 Boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lenck", 
        "givenName": "Stephanie", 
        "id": "sg:person.01326261372.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326261372.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuro Intensive Care, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Sorbonne University, Paris VI University, Paris, France", 
            "GRC Biofast, Paris VI University, Paris, France", 
            "Department of Neuro Intensive Care, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Degos", 
        "givenName": "Vincent", 
        "id": "sg:person.0636243456.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636243456.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroradiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47\u201383 Boulevard de l\u2019H\u00f4pital, 75013, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Department of Neuroradiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47\u201383 Boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sourour", 
        "givenName": "Nader-Antoine", 
        "id": "sg:person.01165027133.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165027133.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Vascular Neurology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Sorbonne University, Paris VI University, Paris, France", 
            "Department of Vascular Neurology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frasca Polara", 
        "givenName": "Giulia", 
        "id": "sg:person.013551276523.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013551276523.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroradiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47\u201383 Boulevard de l\u2019H\u00f4pital, 75013, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Department of Neuroradiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47\u201383 Boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shotar", 
        "givenName": "Eimad", 
        "id": "sg:person.01116022626.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116022626.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Intensive Care, H\u00f4pital Europ\u00e9en Georges Pompidou, INSERM UMRS-1140, Paris Descartes University, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "Department of Anesthesiology and Intensive Care, H\u00f4pital Europ\u00e9en Georges Pompidou, INSERM UMRS-1140, Paris Descartes University, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Godier", 
        "givenName": "Anne", 
        "id": "sg:person.0756207247.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756207247.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuro Intensive Care, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Department of Neuro Intensive Care, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drir", 
        "givenName": "Mehdi", 
        "id": "sg:person.013020223304.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013020223304.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuro Intensive Care, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Department of Neuro Intensive Care, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mahtout", 
        "givenName": "Jugurtha", 
        "id": "sg:person.016337640461.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016337640461.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne University, Paris VI University, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Department of Neuroradiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47\u201383 Boulevard de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Sorbonne University, Paris VI University, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Premat", 
        "givenName": "Kevin", 
        "id": "sg:person.014147317061.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014147317061.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Vascular Neurology, Saint-Antoine University Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.412370.3", 
          "name": [
            "Sorbonne University, Paris VI University, Paris, France", 
            "Department of Vascular Neurology, Saint-Antoine University Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alamowitch", 
        "givenName": "Sonia", 
        "id": "sg:person.01151404615.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151404615.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Vascular Neurology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Sorbonne University, Paris VI University, Paris, France", 
            "Department of Vascular Neurology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Samson", 
        "givenName": "Yves", 
        "id": "sg:person.01131216557.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131216557.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GRC Biofast, Paris VI University, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Department of Neuroradiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 47\u201383 Boulevard de l\u2019H\u00f4pital, 75013, Paris, France", 
            "Sorbonne University, Paris VI University, Paris, France", 
            "GRC Biofast, Paris VI University, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Claren\u00e7on", 
        "givenName": "Fr\u00e9d\u00e9ric", 
        "id": "sg:person.01365362254.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365362254.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00062-019-00811-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1118020050", 
          "https://doi.org/10.1007/s00062-019-00811-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11239-015-1233-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006427603", 
          "https://doi.org/10.1007/s11239-015-1233-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00234-020-02360-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1124031316", 
          "https://doi.org/10.1007/s00234-020-02360-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00062-018-0707-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106131185", 
          "https://doi.org/10.1007/s00062-018-0707-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-05-07", 
    "datePublishedReg": "2020-05-07", 
    "description": "PurposeCangrelor is an intravenous P2Y12 receptor inhibitor with a\u00a0rapid onset/offset of action and a\u00a0short half-life (3\u20136\u202fmin). The objective was to present a\u00a0preliminary experience regarding the safety and effectiveness using cangrelor, in combination with aspirin, in acute ischemic stroke patients requiring acute stenting.Material and MethodsRetrospective analysis for patients who underwent stenting (intracranial and/or extracranial) in the setting of acute ischemic stroke with cangrelor and aspirin as antiplatelet therapy.ResultsCangrelor was used in 12\u00a0patients, 4 (33%) with extracranial stenting, 6 (50%) with intracranial stenting and 2 (17%) with combined extracranial and intracranial stenting. The mean age was 67\u00a0years (44\u201388) and 9\u00a0patients (75%) were female. The median National Institutes of Health Stroke Score at admission was\u00a015 (IQR: 8\u201322). Of the patients, six (50%) received intravenous thrombolysis. All patients (100%) obtained modified thrombolysis in cerebral infarction score \u22652b. Good clinical outcome, defined as modified Rankin scale score \u22642 at 3\u2011months follow-up, was observed in 7 patients (58%). None of the patients experienced intraprocedural thromboembolic complications.  Postprocedural stent thrombosis after cessation of cangrelor infusion due to emergency craniotomy surgery to manage malignant cerebral infarction occurred in one patient (8%). Of the patients, two (17%) experienced asymptomatic intracranial hemorrhage (ICH), one patient (8%) experienced symptomatic ICH and one (8%) retroperitoneal hematoma was observed, which was managed conservatively.ConclusionCangrelor might be a\u00a0safe and effective antiplatelet medication owing to its on/off activity for acute stenting in the setting of acute ischemic stroke. Further investigations through randomized studies with larger samples are necessary.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00062-020-00907-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1043149", 
        "issn": [
          "1869-1439", 
          "1869-1447"
        ], 
        "name": "Clinical Neuroradiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "keywords": [
      "acute ischemic stroke", 
      "ischemic stroke", 
      "intracranial hemorrhage", 
      "acute stenting", 
      "intracranial stenting", 
      "acute ischemic stroke patients", 
      "P2Y12 receptor inhibitors", 
      "median National Institutes", 
      "Health Stroke Score", 
      "Cerebral Infarction score", 
      "intraprocedural thromboembolic complications", 
      "malignant cerebral infarction", 
      "asymptomatic intracranial hemorrhage", 
      "symptomatic intracranial hemorrhage", 
      "ischemic stroke patients", 
      "Rankin Scale score", 
      "better clinical outcomes", 
      "rapid onset/offset", 
      "postprocedural stent thrombosis", 
      "extracranial stenting", 
      "modified thrombolysis", 
      "cangrelor infusion", 
      "antiplatelet therapy", 
      "intravenous thrombolysis", 
      "retroperitoneal hematoma", 
      "antiplatelet medications", 
      "Stroke Score", 
      "Infarction score", 
      "cerebral infarction", 
      "thromboembolic complications", 
      "onset/offset", 
      "MethodsRetrospective analysis", 
      "clinical outcomes", 
      "stroke patients", 
      "stent thrombosis", 
      "mean age", 
      "craniotomy surgery", 
      "receptor inhibitors", 
      "stenting", 
      "patients", 
      "Scale score", 
      "preliminary experience", 
      "cangrelor", 
      "stroke", 
      "National Institute", 
      "thrombolysis", 
      "aspirin", 
      "scores", 
      "further investigation", 
      "hematoma", 
      "thrombosis", 
      "hemorrhage", 
      "medications", 
      "complications", 
      "infarction", 
      "surgery", 
      "admission", 
      "infusion", 
      "therapy", 
      "setting", 
      "large sample", 
      "cessation", 
      "age", 
      "outcomes", 
      "inhibitors", 
      "safety", 
      "years", 
      "activity", 
      "study", 
      "action", 
      "Institute", 
      "experience", 
      "objective", 
      "combination", 
      "samples", 
      "effectiveness", 
      "investigation", 
      "analysis", 
      "materials", 
      "offset", 
      "PurposeCangrelor", 
      "intravenous P2Y12 receptor inhibitor", 
      "ResultsCangrelor", 
      "emergency craniotomy surgery", 
      "ConclusionCangrelor", 
      "effective antiplatelet medication"
    ], 
    "name": "Cangrelor and Stenting in Acute Ischemic Stroke", 
    "pagination": "439-448", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1127453897"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00062-020-00907-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32382875"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00062-020-00907-0", 
      "https://app.dimensions.ai/details/publication/pub.1127453897"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_835.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00062-020-00907-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00062-020-00907-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00062-020-00907-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00062-020-00907-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00062-020-00907-0'


 

This table displays all metadata directly associated to this object as RDF triples.

329 TRIPLES      22 PREDICATES      130 URIs      118 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00062-020-00907-0 schema:about N2d5fe07f5d7d4128b12e5659eda12bd9
2 N6d9bcdb92abe4fb1a6cce252cf87398e
3 N811621adb67c4213a27025f1797dcdec
4 N879abf2a20134445aa2826c990f05b58
5 N91a49fb8804e4180bcf38d5344e18823
6 Na9b1c7322c704c798081452e3dca8bab
7 Nb447d2e2d89149859b84ea7d0f5df3d2
8 Nb93c4c153d88410b811f8bb31b1007ec
9 Nbe0c1662d8954501baf70b582b474503
10 Nd31f92c2b98f491582f934f037266af7
11 Nd8bb323e4bd644d69f0c643190273659
12 Ned8557661a744c3fb423a1cf6dabf554
13 Nf30c3a95fa93422ca9a9d94272f6493c
14 Nf409884a29a24ddeaa20e0d19429ae18
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N1ce4f5b5159c4ef8a2a3e5559927b7c5
18 schema:citation sg:pub.10.1007/s00062-018-0707-z
19 sg:pub.10.1007/s00062-019-00811-2
20 sg:pub.10.1007/s00234-020-02360-9
21 sg:pub.10.1007/s11239-015-1233-3
22 schema:datePublished 2020-05-07
23 schema:datePublishedReg 2020-05-07
24 schema:description PurposeCangrelor is an intravenous P2Y12 receptor inhibitor with a rapid onset/offset of action and a short half-life (3–6 min). The objective was to present a preliminary experience regarding the safety and effectiveness using cangrelor, in combination with aspirin, in acute ischemic stroke patients requiring acute stenting.Material and MethodsRetrospective analysis for patients who underwent stenting (intracranial and/or extracranial) in the setting of acute ischemic stroke with cangrelor and aspirin as antiplatelet therapy.ResultsCangrelor was used in 12 patients, 4 (33%) with extracranial stenting, 6 (50%) with intracranial stenting and 2 (17%) with combined extracranial and intracranial stenting. The mean age was 67 years (44–88) and 9 patients (75%) were female. The median National Institutes of Health Stroke Score at admission was 15 (IQR: 8–22). Of the patients, six (50%) received intravenous thrombolysis. All patients (100%) obtained modified thrombolysis in cerebral infarction score ≥2b. Good clinical outcome, defined as modified Rankin scale score ≤2 at 3‑months follow-up, was observed in 7 patients (58%). None of the patients experienced intraprocedural thromboembolic complications. Postprocedural stent thrombosis after cessation of cangrelor infusion due to emergency craniotomy surgery to manage malignant cerebral infarction occurred in one patient (8%). Of the patients, two (17%) experienced asymptomatic intracranial hemorrhage (ICH), one patient (8%) experienced symptomatic ICH and one (8%) retroperitoneal hematoma was observed, which was managed conservatively.ConclusionCangrelor might be a safe and effective antiplatelet medication owing to its on/off activity for acute stenting in the setting of acute ischemic stroke. Further investigations through randomized studies with larger samples are necessary.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree false
28 schema:isPartOf N540268d738bc487ba2a616e4fe143584
29 Nb214d92800f24abcbb7ffdb50c667bb8
30 sg:journal.1043149
31 schema:keywords Cerebral Infarction score
32 ConclusionCangrelor
33 Health Stroke Score
34 Infarction score
35 Institute
36 MethodsRetrospective analysis
37 National Institute
38 P2Y12 receptor inhibitors
39 PurposeCangrelor
40 Rankin Scale score
41 ResultsCangrelor
42 Scale score
43 Stroke Score
44 action
45 activity
46 acute ischemic stroke
47 acute ischemic stroke patients
48 acute stenting
49 admission
50 age
51 analysis
52 antiplatelet medications
53 antiplatelet therapy
54 aspirin
55 asymptomatic intracranial hemorrhage
56 better clinical outcomes
57 cangrelor
58 cangrelor infusion
59 cerebral infarction
60 cessation
61 clinical outcomes
62 combination
63 complications
64 craniotomy surgery
65 effective antiplatelet medication
66 effectiveness
67 emergency craniotomy surgery
68 experience
69 extracranial stenting
70 further investigation
71 hematoma
72 hemorrhage
73 infarction
74 infusion
75 inhibitors
76 intracranial hemorrhage
77 intracranial stenting
78 intraprocedural thromboembolic complications
79 intravenous P2Y12 receptor inhibitor
80 intravenous thrombolysis
81 investigation
82 ischemic stroke
83 ischemic stroke patients
84 large sample
85 malignant cerebral infarction
86 materials
87 mean age
88 median National Institutes
89 medications
90 modified thrombolysis
91 objective
92 offset
93 onset/offset
94 outcomes
95 patients
96 postprocedural stent thrombosis
97 preliminary experience
98 rapid onset/offset
99 receptor inhibitors
100 retroperitoneal hematoma
101 safety
102 samples
103 scores
104 setting
105 stent thrombosis
106 stenting
107 stroke
108 stroke patients
109 study
110 surgery
111 symptomatic intracranial hemorrhage
112 therapy
113 thromboembolic complications
114 thrombolysis
115 thrombosis
116 years
117 schema:name Cangrelor and Stenting in Acute Ischemic Stroke
118 schema:pagination 439-448
119 schema:productId N5cb9d88a01044757bfc67bd0185b12ee
120 N9ae154700a67494d8d529d52079979aa
121 Na84775b5d4ac4eb2abf4a59bcc7401a9
122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127453897
123 https://doi.org/10.1007/s00062-020-00907-0
124 schema:sdDatePublished 2022-01-01T18:54
125 schema:sdLicense https://scigraph.springernature.com/explorer/license/
126 schema:sdPublisher N7ebab5a24e354217a066468a73272219
127 schema:url https://doi.org/10.1007/s00062-020-00907-0
128 sgo:license sg:explorer/license/
129 sgo:sdDataset articles
130 rdf:type schema:ScholarlyArticle
131 N052b8f90529f46d9a482821ee5d307e2 rdf:first sg:person.01326261372.36
132 rdf:rest N57f6f1c45b314198964b0742c1ba5c7a
133 N07a89c23e2a1480b9f8c7dea2dc97a82 rdf:first sg:person.01165027133.71
134 rdf:rest Na4905dc65f03494f813bdea62c592aeb
135 N1ce4f5b5159c4ef8a2a3e5559927b7c5 rdf:first sg:person.014142414275.04
136 rdf:rest N052b8f90529f46d9a482821ee5d307e2
137 N2d5fe07f5d7d4128b12e5659eda12bd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Aged, 80 and over
139 rdf:type schema:DefinedTerm
140 N3a384648a03242a488c61b217dd9af58 rdf:first sg:person.0756207247.23
141 rdf:rest Nb09c34c536314d338a0756c4e3a8ef92
142 N540268d738bc487ba2a616e4fe143584 schema:volumeNumber 31
143 rdf:type schema:PublicationVolume
144 N57f6f1c45b314198964b0742c1ba5c7a rdf:first sg:person.0636243456.65
145 rdf:rest N07a89c23e2a1480b9f8c7dea2dc97a82
146 N5cb9d88a01044757bfc67bd0185b12ee schema:name doi
147 schema:value 10.1007/s00062-020-00907-0
148 rdf:type schema:PropertyValue
149 N62ee16533103450d9f403af6e344f564 rdf:first sg:person.01151404615.54
150 rdf:rest Ncce52b66f4fd4ee19d65d7818303f592
151 N6d9bcdb92abe4fb1a6cce252cf87398e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Humans
153 rdf:type schema:DefinedTerm
154 N716d211d4c46467bbc9b31a590f8ee8c rdf:first sg:person.01365362254.25
155 rdf:rest rdf:nil
156 N7c8ce624ab5a4a1d9845f5a4e484237b rdf:first sg:person.016337640461.92
157 rdf:rest Nea67da2187b04e26af4d266116ea0667
158 N7ebab5a24e354217a066468a73272219 schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 N811621adb67c4213a27025f1797dcdec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Brain Ischemia
162 rdf:type schema:DefinedTerm
163 N81c067e8aea5415f802e2baa96ed1955 rdf:first sg:person.01116022626.01
164 rdf:rest N3a384648a03242a488c61b217dd9af58
165 N879abf2a20134445aa2826c990f05b58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Aged
167 rdf:type schema:DefinedTerm
168 N91a49fb8804e4180bcf38d5344e18823 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Female
170 rdf:type schema:DefinedTerm
171 N9ae154700a67494d8d529d52079979aa schema:name pubmed_id
172 schema:value 32382875
173 rdf:type schema:PropertyValue
174 Na4905dc65f03494f813bdea62c592aeb rdf:first sg:person.013551276523.18
175 rdf:rest N81c067e8aea5415f802e2baa96ed1955
176 Na84775b5d4ac4eb2abf4a59bcc7401a9 schema:name dimensions_id
177 schema:value pub.1127453897
178 rdf:type schema:PropertyValue
179 Na9b1c7322c704c798081452e3dca8bab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Retrospective Studies
181 rdf:type schema:DefinedTerm
182 Nb09c34c536314d338a0756c4e3a8ef92 rdf:first sg:person.013020223304.84
183 rdf:rest N7c8ce624ab5a4a1d9845f5a4e484237b
184 Nb214d92800f24abcbb7ffdb50c667bb8 schema:issueNumber 2
185 rdf:type schema:PublicationIssue
186 Nb447d2e2d89149859b84ea7d0f5df3d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Stents
188 rdf:type schema:DefinedTerm
189 Nb93c4c153d88410b811f8bb31b1007ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Thrombectomy
191 rdf:type schema:DefinedTerm
192 Nbe0c1662d8954501baf70b582b474503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Treatment Outcome
194 rdf:type schema:DefinedTerm
195 Ncce52b66f4fd4ee19d65d7818303f592 rdf:first sg:person.01131216557.48
196 rdf:rest N716d211d4c46467bbc9b31a590f8ee8c
197 Nd31f92c2b98f491582f934f037266af7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Ischemic Stroke
199 rdf:type schema:DefinedTerm
200 Nd8bb323e4bd644d69f0c643190273659 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Middle Aged
202 rdf:type schema:DefinedTerm
203 Nea67da2187b04e26af4d266116ea0667 rdf:first sg:person.014147317061.51
204 rdf:rest N62ee16533103450d9f403af6e344f564
205 Ned8557661a744c3fb423a1cf6dabf554 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Adult
207 rdf:type schema:DefinedTerm
208 Nf30c3a95fa93422ca9a9d94272f6493c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Adenosine Monophosphate
210 rdf:type schema:DefinedTerm
211 Nf409884a29a24ddeaa20e0d19429ae18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Male
213 rdf:type schema:DefinedTerm
214 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
215 schema:name Medical and Health Sciences
216 rdf:type schema:DefinedTerm
217 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
218 schema:name Clinical Sciences
219 rdf:type schema:DefinedTerm
220 sg:journal.1043149 schema:issn 1869-1439
221 1869-1447
222 schema:name Clinical Neuroradiology
223 schema:publisher Springer Nature
224 rdf:type schema:Periodical
225 sg:person.01116022626.01 schema:affiliation grid-institutes:grid.411439.a
226 schema:familyName Shotar
227 schema:givenName Eimad
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116022626.01
229 rdf:type schema:Person
230 sg:person.01131216557.48 schema:affiliation grid-institutes:grid.411439.a
231 schema:familyName Samson
232 schema:givenName Yves
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131216557.48
234 rdf:type schema:Person
235 sg:person.01151404615.54 schema:affiliation grid-institutes:grid.412370.3
236 schema:familyName Alamowitch
237 schema:givenName Sonia
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151404615.54
239 rdf:type schema:Person
240 sg:person.01165027133.71 schema:affiliation grid-institutes:grid.411439.a
241 schema:familyName Sourour
242 schema:givenName Nader-Antoine
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165027133.71
244 rdf:type schema:Person
245 sg:person.013020223304.84 schema:affiliation grid-institutes:grid.411439.a
246 schema:familyName Drir
247 schema:givenName Mehdi
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013020223304.84
249 rdf:type schema:Person
250 sg:person.01326261372.36 schema:affiliation grid-institutes:grid.411439.a
251 schema:familyName Lenck
252 schema:givenName Stephanie
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326261372.36
254 rdf:type schema:Person
255 sg:person.013551276523.18 schema:affiliation grid-institutes:grid.411439.a
256 schema:familyName Frasca Polara
257 schema:givenName Giulia
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013551276523.18
259 rdf:type schema:Person
260 sg:person.01365362254.25 schema:affiliation grid-institutes:grid.462844.8
261 schema:familyName Clarençon
262 schema:givenName Frédéric
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365362254.25
264 rdf:type schema:Person
265 sg:person.014142414275.04 schema:affiliation grid-institutes:grid.412258.8
266 schema:familyName Elhorany
267 schema:givenName Mahmoud
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014142414275.04
269 rdf:type schema:Person
270 sg:person.014147317061.51 schema:affiliation grid-institutes:grid.462844.8
271 schema:familyName Premat
272 schema:givenName Kevin
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014147317061.51
274 rdf:type schema:Person
275 sg:person.016337640461.92 schema:affiliation grid-institutes:grid.411439.a
276 schema:familyName Mahtout
277 schema:givenName Jugurtha
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016337640461.92
279 rdf:type schema:Person
280 sg:person.0636243456.65 schema:affiliation grid-institutes:grid.411439.a
281 schema:familyName Degos
282 schema:givenName Vincent
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636243456.65
284 rdf:type schema:Person
285 sg:person.0756207247.23 schema:affiliation grid-institutes:grid.508487.6
286 schema:familyName Godier
287 schema:givenName Anne
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756207247.23
289 rdf:type schema:Person
290 sg:pub.10.1007/s00062-018-0707-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1106131185
291 https://doi.org/10.1007/s00062-018-0707-z
292 rdf:type schema:CreativeWork
293 sg:pub.10.1007/s00062-019-00811-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1118020050
294 https://doi.org/10.1007/s00062-019-00811-2
295 rdf:type schema:CreativeWork
296 sg:pub.10.1007/s00234-020-02360-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124031316
297 https://doi.org/10.1007/s00234-020-02360-9
298 rdf:type schema:CreativeWork
299 sg:pub.10.1007/s11239-015-1233-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006427603
300 https://doi.org/10.1007/s11239-015-1233-3
301 rdf:type schema:CreativeWork
302 grid-institutes:grid.411439.a schema:alternateName Department of Neuro Intensive Care, Pitié-Salpêtrière Hospital, Paris, France
303 Department of Neuroradiology, Pitié-Salpêtrière Hospital, 47–83 Boulevard de l’Hôpital, 75013, Paris, France
304 Department of Vascular Neurology, Pitié-Salpêtrière Hospital, Paris, France
305 schema:name Department of Neuro Intensive Care, Pitié-Salpêtrière Hospital, Paris, France
306 Department of Neuroradiology, Pitié-Salpêtrière Hospital, 47–83 Boulevard de l’Hôpital, 75013, Paris, France
307 Department of Vascular Neurology, Pitié-Salpêtrière Hospital, Paris, France
308 GRC Biofast, Paris VI University, Paris, France
309 Sorbonne University, Paris VI University, Paris, France
310 rdf:type schema:Organization
311 grid-institutes:grid.412258.8 schema:alternateName Department of Neurology, Faculty of Medicine, Tanta University, Tanta, Egypt
312 schema:name Department of Neurology, Faculty of Medicine, Tanta University, Tanta, Egypt
313 Department of Neuroradiology, Pitié-Salpêtrière Hospital, 47–83 Boulevard de l’Hôpital, 75013, Paris, France
314 GRC Biofast, Paris VI University, Paris, France
315 Sorbonne University, Paris VI University, Paris, France
316 rdf:type schema:Organization
317 grid-institutes:grid.412370.3 schema:alternateName Department of Vascular Neurology, Saint-Antoine University Hospital, Paris, France
318 schema:name Department of Vascular Neurology, Saint-Antoine University Hospital, Paris, France
319 Sorbonne University, Paris VI University, Paris, France
320 rdf:type schema:Organization
321 grid-institutes:grid.462844.8 schema:alternateName GRC Biofast, Paris VI University, Paris, France
322 Sorbonne University, Paris VI University, Paris, France
323 schema:name Department of Neuroradiology, Pitié-Salpêtrière Hospital, 47–83 Boulevard de l’Hôpital, 75013, Paris, France
324 GRC Biofast, Paris VI University, Paris, France
325 Sorbonne University, Paris VI University, Paris, France
326 rdf:type schema:Organization
327 grid-institutes:grid.508487.6 schema:alternateName Department of Anesthesiology and Intensive Care, Hôpital Européen Georges Pompidou, INSERM UMRS-1140, Paris Descartes University, Paris, France
328 schema:name Department of Anesthesiology and Intensive Care, Hôpital Européen Georges Pompidou, INSERM UMRS-1140, Paris Descartes University, Paris, France
329 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...